Comparative effectiveness of bariatric surgery and nonsurgical therapy in adults with type 2 diabetes mellitus and body mass index

Abstract:

BACKGROUND:Outcomes of bariatric surgery in patients with a body mass index (BMI) <35 kg/m(2) have been an active area of investigation. We examined the comparative effectiveness of Roux-en-Y gastric bypass (RYGB) to routine medical management (nonsurgical controls; NSCs) in achieving appropriate targets defined by the American Diabetes Association for type 2 diabetes mellitus (T2DM) in patients with class I obesity (BMI 30.0-34.9 kg/m(2)) T2DM at 1 year. METHODS:We identified patients undergoing RYGB (N = 17) with both class I obesity and T2DM and compared them to similar NSC (N = 17) treated in the Primary Care Center. Data were collected at baseline and 1 year for systolic blood pressure (SBP), as well as blood levels for low-density lipoprotein (LDL) cholesterol and hemoglobin A1c (HbA1c). RESULTS:After RYGB, BMI decreased from 34.6 ± 0.8 kg/m(2) to 25.8 ± 2.5 kg/m(2) (P < .001) and HbA1c decreased from 8.2 ± 2.0% to 6.1 ± 2.7% (P < .001). The NSC cohort had no significant change in either BMI or HbA1c. SBP and LDL did not significantly change in either group. The RYGB group had a decrease in medication use compared to the NSC group (P < .001). The RYGB group ceased the use of antihypertensive and antihyperlipidemia medications by 1 year despite abnormal values. CONCLUSION:RYGB can be performed in patients with both a BMI <35 kg/m(2) and T2DM with better weight loss, glycemic control, and fewer antihyperglycemic medications than NSC. Inappropriate cessation of medications may partially explain the persistent increase in both SBP and LDL after RYGB.

journal_name

Surgery

journal_title

Surgery

authors

Serrot FJ,Dorman RB,Miller CJ,Slusarek B,Sampson B,Sick BT,Leslie DB,Buchwald H,Ikramuddin S

doi

10.1016/j.surg.2011.07.069

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

684-91

issue

4

eissn

0039-6060

issn

1532-7361

pii

S0039-6060(11)00425-9

journal_volume

150

pub_type

杂志文章

相关文献

SURGERY文献大全
  • Computed tomography measured psoas density predicts outcomes in trauma.

    abstract:BACKGROUND:Age-related loss of muscle mass and function (sarcopenia) is linked to poor outcomes after operation and trauma. Here we evaluate computed tomography measured psoas muscle density and area using quick and simple tools available to the bedside clinician. We hypothesize these measures will predict poor outcome...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2017.03.014

    authors: Yoo T,Lo WD,Evans DC

    更新日期:2017-08-01 00:00:00

  • In situ bacteriologic diagnosis of total parenteral nutrition catheter infection.

    abstract::An evaluation of the in situ bacteriologic status of a total parenteral nutrition (TPN) catheter, when the patient is pyretic but the cause of infection is not obvious, permits continued use of the catheter if the result is negative, as opposed to removal of the suspected catheter. To find a predictive value for the i...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Vanhuynegem L,Parmentier P,Potvliege C

    更新日期:1988-02-01 00:00:00

  • Clinical implications of portal hemodynamics after small-diameter portacaval H graft.

    abstract::To assess the role of portal hemodynamics in the development of postshunt encephalopathy, we studied 19 patients after small-diameter portacaval H grafting (SD-PCHG). We used contrast studies as well as technetium-labeled macroaggregated albumin injected into the portal vein to assess direction of portal flow. We then...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Sarfeh IJ,Rypins EB,Fardi M,Conroy RM,Mason GR,Lyons KP

    更新日期:1984-08-01 00:00:00

  • Surgery as primary treatment in patients with liver metastases from carcinoid tumors: a retrospective, unicentric study over 13 years.

    abstract:BACKGROUND:The heterogeneous nature of carcinoid tumors makes it difficult to develop a standardized treatment strategy for the primary tumor itself and for probable liver metastases. However, prolongation of the 5-year survival rate (5-ysr) and amelioration of the incapacitating symptoms after resection of the primary...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1067/msy.2001.110426

    authors: Nave H,Mössinger E,Feist H,Lang H,Raab H

    更新日期:2001-02-01 00:00:00

  • Internal pancreatic fistula to the pericardium and pleura.

    abstract::A report of a 38-year-old man with a 10 month course of illness characterized by recurrent pericardial and pleural high-protein, high-amylase effusions is presented. Operative pancreatogram demonstrated fistulization from the mid-pancreas through the mediastinum into both pleural spaces and the pericardium. Surgical d...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Davidson ED,Horney JT,Salter PP 3rd

    更新日期:1979-04-01 00:00:00

  • Intrahepatic biliary cystadenoma: role of cyst fluid analysis and surgical management in the laparoscopic era.

    abstract:BACKGROUND:Recent interest in cyst fluid analysis (CFA) for carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA), and the introduction of laparoscopic surgery (LS) in the management of hepatic cysts have resulted in sporadic reports of elevated CA 19-9 and CEA levels in intrahepatic biliary cystadenom...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2004.06.031

    authors: Koffron A,Rao S,Ferrario M,Abecassis M

    更新日期:2004-10-01 00:00:00

  • Histamine type-2 receptor antagonist immune modulation. II. Cimetidine and ranitidine increase interleukin-2 production.

    abstract::The effect of cimetidine and ranitidine (histamine type-2 receptor antagonists) on the production of interleukin-2 (IL-2) by mitogen-activated, normal murine spleen cells was studied in vitro. Cimetidine (10(-4) mol/L to 10(-6) mol/L) increased IL-2 production to a maximal 8.8 +/- 1.6 U (IL-2 activity), as compared wi...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Gifford RR,Tilberg AF

    更新日期:1987-08-01 00:00:00

  • The myelopoietic effects of a Serratia marcescens-derived biologic response modifier in a mouse model of thermal injury.

    abstract::The proliferative defects observed in phagocytic stem cells after major thermal injuries may be caused by an inadequate production of colony-stimulating factors (CSFs), a family of hemopoietic cytokines necessary for the production and function of granulocytes and monocytes. In this study a biologic response modifier ...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Peterson VM,Rundus CH,Reinoehl PJ,Schroeter SR,McCall CA,Bartle EJ

    更新日期:1992-04-01 00:00:00

  • A novel technique for heterotopic vascularized pancreas transplantation in mice to assess ischemia reperfusion injury and graft pancreatitis.

    abstract:BACKGROUND:Although various suture techniques for murine pancreas transplantation have been described, severe limitations have limited their widespread use. We therefore designed a surgical model for cervical heterotopic pancreas transplantation using a cuff technique. METHODS:C57BL6 mice were used as donor and recipi...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2006.07.037

    authors: Maglione M,Hermann M,Hengster P,Schneeberger S,Mark W,Obrist P,Margreiter R,Brandacher G

    更新日期:2007-05-01 00:00:00

  • Description of a universal data entry and retrieval program for vascular surgeons.

    abstract::Until recently, vascular surgeons have had to make judgments based on an impression of their experiences rather than upon the actual facts. Presently, with the simplified and less costly use of computers, the establishment of a computerized data base is feasible. Our goal had been to develop a system suitable for micr...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Jacobson JH 2nd,Karipineni RC,Weisberg M,Radna R

    更新日期:1980-12-01 00:00:00

  • The relative value of carotid noninvasive testing as determined by receiver operator characteristic curves.

    abstract::To determine the relative value of carotid phonoangiography (CPA), oculoplethysmography-Kartchner (OPG-K), and Doppler ultrasonic arteriography (UA), 90 vessels undergoing carotid endarterectomy were prospectively examined. By analyzing the data on receiver operator characteristic curves, the dynamic relationship betw...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: O'Donnell TF Jr,Pauker SG,Callow AD,Kelly JJ,McBride KJ,Korwin S

    更新日期:1980-01-01 00:00:00

  • Cholestasis induces murine hepatocyte apoptosis and DNA synthesis with preservation of the immediate-early gene response.

    abstract:BACKGROUND:Major hepatic resection in patients with unrelieved obstructive jaundice carries an increased risk of postoperative liver failure. We hypothesized that cholestasis induces hepatocyte apoptosis and impairs hepatic regeneration by inhibiting up-regulation of the known immediate-early response genes, nuclear fa...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1067/msy.2002.122375

    authors: Bird MA,Lange PA,Schrum LW,Grisham JW,Rippe RA,Behrns KE

    更新日期:2002-05-01 00:00:00

  • Sepsis and endotoxemia stimulate intestinal interleukin-6 production.

    abstract:BACKGROUND:Endotoxemia stimulates tumor necrosis factor (TNF) and interleukin-1 (IL-1) production in mucosa of the small intestine, but the effect on IL-6 production is not known. Intestinal IL-6 may be especially important, considering its role in the acute phase response. We tested the influence of endotoxemia and se...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/s0039-6060(05)80342-3

    authors: Meyer TA,Wang J,Tiao GM,Ogle CK,Fischer JE,Hasselgren PO

    更新日期:1995-08-01 00:00:00

  • The use of monofilament suture in vascular surgery.

    abstract::The blood lost through the suture line holes of vessels closed with braided polyester sutures is compared with that lost when a monofilament polypropylene suture is employed. In a retrospective analysis of blood replacement during saphenous vein aortorenal bypasses, twice as much blood replacement was required when th...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Dean RH,Pinkerton JA,Foster JH

    更新日期:1975-08-01 00:00:00

  • Fluid resuscitation with deferoxamine hetastarch complex attenuates the lung and systemic response to smoke inhalation.

    abstract:BACKGROUND:We determined the effect of infusing the iron chelator deferoxamine complexed to hetastarch on the degree of lung dysfunction and systemic abnormalities produced by a severe smoke exposure. METHODS:Adult sheep were given a smoke exposure under anesthesia that produced a peak carboxyhemoglobin between 40% an...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/s0039-6060(96)80121-8

    authors: Demling R,LaLonde C,Ikegami K

    更新日期:1996-03-01 00:00:00

  • Deficiency of the transcription factor c-fos increases lipopolysaccharide-induced macrophage interleukin 12 production.

    abstract:BACKGROUND:Interleukin 12 (IL-12) p70 is a heterodimeric protein (p35, p40 subunits) that promotes T-helper TH1-type cytokine response. In critically ill patients, after severe trauma or sepsis, IL-12 production is markedly impaired. We tested the hypothesis that deficiency of the transcription factor c-fos will increa...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Roy S,Charboneau R,Cain K,DeTurris S,Melnyk D,Barke RA

    更新日期:1999-08-01 00:00:00

  • Pretreatment but not treatment with probiotics abolishes mouse intestinal barrier dysfunction in acute pancreatitis.

    abstract:BACKGROUND:Intestinal barrier failure during acute pancreatitis (AP) is associated with translocation of luminal bacteria, resulting in infectious complications. We examined the effects of multispecies probiotics on the intestinal barrier impairment in a murine model of AP. METHODS:Mice were injected with cerulein to ...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2008.09.011

    authors: Rychter JW,van Minnen LP,Verheem A,Timmerman HM,Rijkers GT,Schipper ME,Gooszen HG,Akkermans LM,Kroese AB

    更新日期:2009-02-01 00:00:00

  • Are postoperative intravenous fluids in patients undergoing elective laparoscopic cholecystectomy a necessity? A randomized clinical trial.

    abstract:BACKGROUND:Intravenous (IV) fluid therapy should be individualized according to each patient's weight, disease, and comorbidities, as well as the type and duration of the operative procedure. Laparoscopic cholecystectomy represents one of the most common, short-duration operations; thus, the aim of this study was to as...

    journal_title:Surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.surg.2017.10.030

    authors: Henriques JR,Correia MITD

    更新日期:2018-04-01 00:00:00

  • Etiologic factors for recurrent carotid artery stenosis.

    abstract::Since 1966, 29 patients with recurrent carotid artery stenosis have been encountered. The mean (+/- SEM) internal between initial carotid endarterectomy and secondary presentation was 67.5 +/- 9.2 months (range 6 to 180 months). There was a disproportionate number of women with recurrent stenosis. The mean age at init...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Clagett GP,Rich NM,McDonald PT,Salander JM,Youkey JR,Olson DW,Hutton JE Jr

    更新日期:1983-02-01 00:00:00

  • The efficacy of a hyaluronate-carboxymethylcellulose bioresorbable membrane that reduces postoperative adhesions is increased by the intra-operative co-administration of a neurokinin 1 receptor antagonist in a rat model.

    abstract:BACKGROUND:Bioresorbable membranes composed of hyaluronic acid and carboxymethylcellulose (HA/CMC) are the most effective method to prevent intra-abdominal adhesions; however, their efficacy may be limited to the site of application. Previous studies in our laboratory have shown that the intraperitoneal administration ...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2010.01.024

    authors: Lim R,Stucchi AF,Morrill JM,Reed KL,Lynch R,Becker JM

    更新日期:2010-11-01 00:00:00

  • Laparoscopic-assisted cecectomy is associated with decreased formation of postoperative pulmonary metastases compared with open cecectomy in a murine model.

    abstract:BACKGROUND:It was shown in a murine model that sham laparotomy is associated with a higher incidence of postoperative lung metastases when compared with results seen after carbon dioxide pneumoperitoneum. Using the same tumor model, the present study was undertaken to determine if the addition of bowel resection to the...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1067/s0039-6060(03)00136-3

    authors: Carter JJ,Feingold DL,Kirman I,Oh A,Wildbrett P,Asi Z,Fowler R,Huang E,Whelan RL

    更新日期:2003-09-01 00:00:00

  • Early and late complications after pancreatic necrosectomy.

    abstract:BACKGROUND:Surgery for pancreatic necrosis is associated with a high morbidity and mortality. The aim of this study was to review the incidence of early and late complications after pancreatic necrosectomy in a large contemporary series of patients. METHODS:The clinical outcomes of 88 patients who underwent pancreatic...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2005.01.003

    authors: Connor S,Alexakis N,Raraty MG,Ghaneh P,Evans J,Hughes M,Garvey CJ,Sutton R,Neoptolemos JP

    更新日期:2005-05-01 00:00:00

  • Postprandial motor activity and its relationship to transit in the canine ileum.

    abstract:BACKGROUND:The purpose of this study was to elucidate the mechanism of reduced intestinal transit rate in the ileum as compared with the jejunum. METHODS:Twenty-one dogs were each instrumented with 12 strain gauge transducers, 2 collection cannulas, and an infusion catheter defining a 100 cm study in the midjejunum (n...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/s0039-6060(97)90288-9

    authors: Johnson CP,Sarna SK,Baytiyeh R,Zhu YR,Cowles VE,Telford GL,Roza AM,Adams MB

    更新日期:1997-02-01 00:00:00

  • Internal biliary drainage improves decreased number of gut mucosal T lymphocytes and MAdCAM-1 expression in jaundiced rats.

    abstract:BACKGROUND:Although the effect of preoperative biliary drainage in patients with obstructive jaundice is controversial, bacterial or endotoxin translocation is one of the main postoperative problem in jaundiced patients. Failure in gut barrier functions causes bacterial translocation; homing and distribution of T lymph...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2004.02.001

    authors: Sano T,Ajiki T,Takeyama Y,Kuroda Y

    更新日期:2004-09-01 00:00:00

  • Quality of post-treatment surveillance of early stage breast cancer in Texas.

    abstract:BACKGROUND:Only annual mammography and physical examination are recommended for the post-treatment surveillance of early stage breast cancer. METHODS:We used Texas Cancer Registry-Medicare linked data (2001-2007) to identify physician visits and use of mammography, magnetic resonance imaging (MRI), computed tomography...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2013.04.004

    authors: Parmar AD,Sheffield KM,Vargas GM,Han Y,Chao C,Riall TS

    更新日期:2013-08-01 00:00:00

  • Multiglandular disease in seemingly sporadic primary hyperparathyroidism revisited: where are we in the early 1990s? A plea against unilateral parathyroid exploration.

    abstract:BACKGROUND:Most of the available data on multiglandular disease (MGD) originate from long-term series. The spectrum of the disease has changed now because of earlier diagnosis. We decided to assess the current frequency of MGD in seemingly sporadic primary hyperparathyroidism. METHODS:MGD was defined as the finding th...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Proye CA,Carnaille B,Bizard JP,Quievreux JL,Lecomte-Houcke M

    更新日期:1992-12-01 00:00:00

  • The effect on protein and amino acid metabolism of an intravenous nutrition regimen providing seventy percent of nonprotein calories as lipid.

    abstract:BACKGROUND:The purpose of this study was to determine which peripheral intravenous nutrition (IVN) regimen, one containing 70% nonprotein calories as lipid IVN or one containing all nonprotein calories as glucose IVN, was most effective at reversing some effects of surgery on protein metabolism. METHODS:Twenty patient...

    journal_title:Surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Smith RC,Mackie W,Kohlhardt SR,Kee AJ

    更新日期:1992-01-01 00:00:00

  • Intraatrial extension of thyroid cancer: technique and results of a radical surgical approach.

    abstract::An occlusion of the superior vena cava by a tumor thrombus extending into the right atrium was diagnosed in three patients with a follicular thyroid cancer. All patients showed the typical clinical picture of the superior vena cava syndrome. A right parasternal thoracotomy was performed for preparation of the major ve...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Niederle B,Hausmaninger C,Kretschmer G,Polterauer P,Neuhold N,Mirza DF,Roka R

    更新日期:1990-12-01 00:00:00

  • Long-term results of entry closure and aneurysmal wall plication with axillofemoral bypass: a new procedure for repair of DeBakey type 3 dissecting aneurysm.

    abstract::To prevent aneurysm rupture, avoid pseudoaneurysm formation, and preserve intercostal arteries, a new procedure for repair of DeBakey type 3 dissecting aneurysm was developed. Since January 1977, 28 patients have undergone repair of type 3 dissecting aneurysm. Fifteen patients with type 3b underwent this new procedure...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:

    authors: Kawashima Y,Shirakura R,Nakano S,Matsuda H,Taniguchi K,Kaneko M,Kawaguchi AT,Kadoba K,Matsuwaka R

    更新日期:1993-01-01 00:00:00

  • Endothelium-dependent pulmonary artery vasorelaxation is dysfunctional in males but not females after acute lung injury.

    abstract:BACKGROUND:Mortality after acute respiratory distress syndrome is higher in males than in females. Gender differences in pulmonary vascular reactivity and local inflammatory response may explain this disparity. We hypothesized that endothelium-dependent pulmonary vasorelaxation is impaired in males and that this effect...

    journal_title:Surgery

    pub_type: 杂志文章

    doi:10.1016/j.surg.2005.03.002

    authors: Tsai BM,Wang M,Pitcher JM,Kher A,Brown JW,Meldrum DR

    更新日期:2005-07-01 00:00:00