Abstract：
BACKGROUND:Plasma from laparotomized mice has been shown to stimulate in vitro tumor growth when compared to results with preoperative plasma. This study assessed the effect of plasma from patients who underwent major open (OS) or laparoscopic surgery (LS) on in vitro tumor cell growth. METHODS:Eighty-four patients undergoing major abdominal surgery were studied (45 OS, 39 LS). Peripheral blood was collected preoperatively (PreOP) and on days 1 (POD1) and 3 (POD3) after operation. HT29 human colon cancer cells were plated with samples of the plasma. Proliferation was assessed by cell counts and the bromodeoxyuridine incorporation assay. Insulin-like growth factor binding protein 3 was detected in plasma by Western blot analysis. RESULTS:Increased mitogenic activity was noted in POD1 OS plasma when compared to PreOP OS plasma results (P <.005). This increase correlated with the length of incision (r = 0.58, P <.01). No differences were noted when the PreOP LS and POD1 LS results were compared or for any of the POD3 versus PreOP comparisons. CONCLUSIONS:Major OS is associated with alterations in plasma composition that promote HT29 tumor cell proliferation in vitro. As shown, this effect was due, at least in part, to surgery-related depletion of insulin-like growth factor binding protein 3 in peripheral blood.
journal_name
Surgeryjournal_title
Surgeryauthors
Kirman I,Cekic V,Poltaratskaia N,Asi Z,Bessler M,Huang EH,Forde KA,Whelan RLdoi
10.1067/msy.2002.125308subject
Has Abstractpub_date
2002-08-01 00:00:00pages
186-92issue
2eissn
0039-6060issn
1532-7361pii
S0039606002000715journal_volume
132pub_type
杂志文章相关文献
SURGERY文献大全abstract：BACKGROUND:Catabolic illness is associated with fluid retention and extracellular space expansion. To determine the effect of human growth hormone (GH) on body water compartments, critically ill surgical patients were studied for a 2-week period during which they either continued to receive standard intensive care unit...
journal_title：Surgery
pub_type： 临床试验,杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：BACKGROUND:Anastomotic leakage represents a major complication after anterior resection of the rectum. The incidence of anastomotic leakage varies considerably among clinical studies in part owing to the lack of a standardized definition of this complication. The aim of the present article was to propose a definition a...
journal_title：Surgery
pub_type： 杂志文章,评审
doi：10.1016/j.surg.2009.10.012
更新日期：2010-03-01 00:00:00
abstract：BACKGROUND:The aims of the present study were to confirm the consumption coagulopathy of disseminated intravascular coagulation with the fibrinolytic phenotype at an early phase of trauma and to test the hypothesis that thrombin-activatable fibrinolysis inhibitor, neutrophil elastase, and plasmin contribute to the incr...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2010.06.010
更新日期：2011-02-01 00:00:00
abstract：:A unique method of computerized fluoroscopic enhancement allows direct visualization of the entire vascular system by intravenous injection of standard contrast agents, thereby avoiding the need for arterial puncture or hospitalization. This technique has been used to satisfactorily visualize the intra- and extracrani...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:This is a report of a patient with a thrombosed Warren shunt and recurrent variceal hemorrhage who demonstrated compartmentalized venous hypertension in the mesenteric and gastrosplenic systems. Although the mesenteric presssure was normalized by the construction of a mesocaval interposition shunt, the gastrosplenic v...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
abstract：BACKGROUND:Detecting metastases to the cervical lymph nodes is the main problem in the management of squamous cell carcinoma of the tongue. We investigated the ability of sentinel node (SN) biopsy to predict neck status in 11 patients with lateral T1-T2, N0, and M0 squamous cell carcinoma of the tongue who underwent ip...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2000.106809
更新日期：2000-07-01 00:00:00
abstract：:We estimated ambulatory venous pressure (AVP) noninvasively with a new technique of quantitative photoplethysmography (PPG). Postural changes of hydrostatic pressure permitted in vivo calibration of the PPG. We recorded quantitative PPG and AVP in 14 normal subjects and 14 patients with postthrombotic chronic venous i...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1983-11-01 00:00:00
abstract：:Twenty-six cases of carcinoid-related mesenteric angiopathy and intestinal infarction (three from our institution and 23 previously reported cases) were reviewed. Twenty patients presented with acute abdominal findings, including peritonitis (13 cases), intestinal obstruction (five cases), and bleeding per rectum (two...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-10-01 00:00:00
abstract：:The quantitative effects of cytomegalovirus (CMV) infection on morbidity and mortality rates were examined in 320 renal transplant cases. With the use of virus cultures and CMV antibody measurements, all patients were studied, regardless of symptoms, from a time before transplantation to at least 1 year, 11 months aft...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-06-01 00:00:00
abstract：:During the 24-year period from 1956 to 1980, 148 patients with aneurysms confined to the thoracic aortic segment, bounded above by the left subclavian artery and below the diaphragm, were treated with replacement therapy. From 1956 to 1967, 36 patients were treated by use of temporary bypass or shunts which carried a ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Tissue oxygen tensions in healing anastomoses of rabbit abdominal aortas were measured with ultramicro-oxygen cathodes with 1 to 3 mum tips. Two days after constructing the anastomosis, the over-all profile of intramural oxygen tension was different markedly from that of normal aortic wall, showing a progressive fall ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1975-08-01 00:00:00
abstract：BACKGROUND:Squamous cell carcinoma of the head and neck (SCCHN) is the sixth most common cancer worldwide. Greater than 90% of SCCHN of the oropharynx overexpress the epidermal growth factor receptor (EGFR or HER1). Cetuximab (Erbitux-TM) is a humanized anti-HER1 monoclonal antibody (mAb) that binds to HER1 overexpress...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2012.05.035
更新日期：2012-09-01 00:00:00
abstract：:The inhibition of growth by adult human venous endothelial cells in culture forms the basis of a sensitive assay of glutaraldehyde (GA) concentration, valid between 0 and 5 parts per million. This cytotoxicity assay was used to measure residual (unbound) GA in commercial vascular prostheses of biologic origin followin...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：BACKGROUND:Acute respiratory failure is a common, life-threatening complication after severe trauma. Polymorphisms in cytokine genes, linked to cytokine inducibility, may influence the susceptibility to acute respiratory failure and serve as risk predictors. METHODS:This PROSPECTIVE cohort study (n = 100) included Cau...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2007.07.040
更新日期：2008-02-01 00:00:00
abstract：:Primary aortocolic fistulas are a rare but lethal complication of aortic or iliac aneurysms. A case of fistula between a nonaneurysmal aortic bifurcation and sigmoid colon caused by an ingested chicken bone is presented. This cause of rectal bleeding, which has never been described, might have been suspected after car...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-04-01 00:00:00
abstract：BACKGROUND:Enthusiasm for neoadjuvant therapy is growing from the emerging consensus that pancreatic cancer is a systemic disease at the time of diagnosis. Those who remain in favor of upfront surgery often cite the lack of reported data to support alternative treatment sequencing. We therefore report the results of al...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.09.018
更新日期：2016-03-01 00:00:00
abstract：:The emergence of both absorbable and nonabsorbable synthetic materials has been primary among the many new developments in suture materials. This is a study of 16 types of natural and synthetic suture materials and their resistance to both gram-positive and gram-negative infections. Four hundred and twenty suture inpl...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：BACKGROUND:Preoperative noninvasive localization studies of the neck and mediastinum are beneficial before reoperation. However, the role of selective venous sampling (SVS) for parathyroid hormone (PTH) in reoperative parathyroid surgery has never been clearly defined. The purpose of this study was to evaluate the accu...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2002.128477
更新日期：2002-12-01 00:00:00
abstract：BACKGROUND:The aim of this prospective randomized controlled study was to investigate the effects of continuous venovenous hemofiltration on the hemodynamics and respiratory function of critically ill trauma patients with multiple organ dysfunction syndrome. METHODS:Thirty consecutive critically ill, mechanically vent...
journal_title：Surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0039-6060(97)90331-7
更新日期：1997-11-01 00:00:00
abstract：BACKGROUND:Publicly reported hospital scores are used by patients to make health care-related decisions; however, their relationship to clinical outcomes is unknown. METHODS:Through the use of the New York Statewide Planning and Research Cooperative System database, the association between two commonly used scores (He...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2018.12.006
更新日期：2019-05-01 00:00:00
abstract：INTRODUCTION:Computed tomography (CT) has become an essential tool in the assessment of the stable trauma patient. Intravenous (i.v.) contrast is commonly relied upon to provide superior image quality, particularly for solid-organ injury. However, a substantial proportion of injured patients have contraindications to i...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2012.07.016
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:The impact of the location of colorectal cancer on patient outcomes has been reported in several settings. The objective of this study was to assess the prognostic impact of the location of the primary colon cancer among patients with colorectal cancer peritoneal metastases undergoing complete cytoreductive ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2018.07.027
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Oxidative stress and inflammation are implicated in the pathogenesis of steatohepatitis. We hypothesize that Roux-en-Y gastric bypass reduces oxidative stress and inflammation in the liver of obese rats via activation of AMPK-α. METHODS:Obese Sprague-Dawley male rats underwent either sham operation or Roux-...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.01.012
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Interferon regulatory factor-1 (IRF-1) is a transcriptional factor originally cloned from fibroblasts that activates interferons and certain interferon-responsive genes. Because IRF-1 is an "early-immediate" nuclear protein, it can function acutely after trauma or septic stimuli. We have identified IRF-1 exp...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
abstract：BACKGROUND:Patient-reported outcomes (PRO) reflect the functional outcomes of inguinal herniorrhaphy. We studied the effect of hernia recurrence and complications on PRO for participants in the Veterans Affairs trial of Open or Laparoscopic Repair of Inguinal Hernia. METHODS:Analyzed PRO included (1) the Medical Outco...
journal_title：Surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.surg.2006.02.003
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:A new concept of surgical stress has been proposed that consists of both aggressiveness of operation and systemic reactions to an operation. METHODS AND RESULTS:We have investigated a possible modulation of such systemic reactions to operation and have demonstrated the following 3 points: (1) coagulation an...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2002.120116
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:With the large amounts of data on patient, tumor, and treatment factors available to clinicians, it has become critically important to harness this information to guide clinicians in discussing a patient's prognosis. However, no widely accepted survival calculator is available that uses national data and inc...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.08.006
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:We determined the effect of infusing the iron chelator deferoxamine complexed to hetastarch on the degree of lung dysfunction and systemic abnormalities produced by a severe smoke exposure. METHODS:Adult sheep were given a smoke exposure under anesthesia that produced a peak carboxyhemoglobin between 40% an...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(96)80121-8
更新日期：1996-03-01 00:00:00
abstract：:We studied the effect of the topical application of the nonsteroidal anti-inflammatory agent, flurbiprofen, on postburn hypermetabolism and systemic lipid peroxidation. Twelve sheep with a 15% total body surface third-degree burn were monitored over a 4-day postburn period. In six sheep, a single application of a 5% f...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：BACKGROUND:Less invasive operations such as laparoscopic surgery have been developed for treating gastrointestinal malignancies. However, the advantages of video-assisted thoracoscopic surgery for esophageal cancer (VATS-e) with regard to postoperative morbidity and mortality remains controversial. METHODS:We investig...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2011.12.006
更新日期：2012-05-01 00:00:00
