Abstract：
BACKGROUND:Acute respiratory failure is a common, life-threatening complication after severe trauma. Polymorphisms in cytokine genes, linked to cytokine inducibility, may influence the susceptibility to acute respiratory failure and serve as risk predictors. METHODS:This PROSPECTIVE cohort study (n = 100) included Caucasian multiple trauma (Injury Severity Score [ISS] >15) patients at a level 1 trauma center in Berlin, Germany. Primary outcome measure acute respiratory failure was defined as a Pao(2)/fraction of inspired oxygen (Fio(2)) ratio of <200 and the need for mechanical respiratory support. We investigated the association of polymorphisms of the interleukin (IL)-1beta, IL-6, and IL-10 genes with acute respiratory failure. RESULTS:Of 100 patients with severe mechanic injury (median ISS 34, interquartile range 19-45), 49 developed acute respiratory failure. Acute respiratory failure frequency differed significantly with the IL-10 -1082 genotype (P = .007; P corrected, .03), whereas there was no significant relation to any other cytokine genotype after Bonferroni correction for multiple testing. The -1082 GG genotype was a marker of decreased risk to develop acute respiratory failure in univariate (odds ratio [OR], 0.2; 95% confidence interval [CI], 0.1-0.6; P = .004) and multivariate (OR, 0.2; 95% CI, 0.1-0.9; P = .03) logistic regression analysis, with male gender, severe abdominal injury, and an APACHE II score >19 being significant risk factors. CONCLUSION:We conclude that the IL-10 -1082 genotype may be a risk marker for development of acute respiratory failure after trauma.
journal_name
Surgeryjournal_title
Surgeryauthors
Schroeder O,Schulte KM,Schroeder J,Ekkernkamp A,Laun RAdoi
10.1016/j.surg.2007.07.040subject
Has Abstractpub_date
2008-02-01 00:00:00pages
233-42issue
2eissn
0039-6060issn
1532-7361pii
S0039-6060(07)00567-3journal_volume
143pub_type
杂志文章相关文献
SURGERY文献大全abstract：BACKGROUND:The glial cell line-derived neurotrophic factor (GDNF) is a member of neurotrophic polypeptide family, which promotes survival and rescue of various neural cells in the central and peripheral nerve systems. We previously reported that GDNF promotes tumor cell invasion in pancreatic cancer cell lines. The pur...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2005.07.007
更新日期：2005-10-01 00:00:00
abstract：BACKGROUND:Total parenteral nutrition is an etiologic factor in the formation of biliary sludge. We studied whether enteral nutrition is also a risk factor for sludge. METHODS:Fifty patients with a needle catheter jejunostomy (NCJ) placed during a major abdominal operation underwent preoperative and weekly postoperati...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.1998.92011
更新日期：1998-10-01 00:00:00
abstract：BACKGROUND:This study aimed to compare the radicality for and clinical advantages of laparoscopic liver resection, which is increasingly used, and the corresponding open procedure by propensity score matching analysis. METHODS:We analyzed 260 hepatocellular carcinoma patients who underwent initial liver resection at o...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.02.031
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate the genotype-phenotype relationship of pancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1 treated at our institution. METHODS:We conducted a retrospective chart review of all patients with multiple endocrine neoplasia type 1 treated...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.04.044
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Operative time often has been cited as an important factor for postoperative outcomes. Despite this belief, most efforts to improve liver transplant outcomes have largely focused on only patient and donor factors, and little attention has been paid on operative time. The primary objective of this project was...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.05.010
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:The management of splenic injuries has evolved with a greater emphasis on nonoperative management. Although several institutions have demonstrated that nonoperative management of splenic injuries can be performed with an increasing degree of success, the impact of this treatment shift on outcome for all pati...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2006.06.032
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND:Suppression of cellular immunity is one of the host responses to surgical stress. In cancer patients this immunosuppression may accelerate the growth and metastasis of residual cancer cells, so it is desirable to restrict immunosuppression by surgical stress to a minimum. However, the extent and duration of ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2000.103498
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND:Studies of sexual dimorphism in trauma outcomes suggest that women have a survival advantage compared to equivalently injured men. It is unknown if this gender disparity is mediated by potentially life-threatening complications. OBJECTIVE:To determine (1) if there is a sex-based differences in the odds of d...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2009.05.006
更新日期：2009-08-01 00:00:00
abstract：:Twenty-six cases of carcinoid-related mesenteric angiopathy and intestinal infarction (three from our institution and 23 previously reported cases) were reviewed. Twenty patients presented with acute abdominal findings, including peritonitis (13 cases), intestinal obstruction (five cases), and bleeding per rectum (two...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1981-10-01 00:00:00
abstract：:During the recent 5 2/3 years, hepatic resection was performed on 118 patients with hepatocellular carcinoma. Ages ranged from 17 to 78 years with an average of 57 years. There were 101 males and 17 females. Underlying cirrhosis of the liver was found in 101 cases, and chronic hepatitis was found in 16 cases. Before s...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
abstract：:Previously, we documented that nonlethal doses of endotoxin cause the translocation (escape) of bacteria from the gut to systemic organs. The purpose of this study was to determine which portion(s) of the endotoxin molecule induces bacterial translocation and to examine the role of xanthine oxidase activity in the pat...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1989-08-01 00:00:00
abstract：:Between 1978 and 1985, 88 patients underwent insertion of the Greenfield vena cava filter. In 21 of the 88 patients (23.9%) the filter was inserted prophylactically. Sixteen of the 21 prophylactic insertions were performed before total joint replacement in patients with a history of venous thromboembolism. Operative m...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:A glucose-controlled insulin and glucose infusion system (Biostator system, Miles Laboratories Inc., Elkhart, Ind.) was used during operation for removal of four suspected insulinomas. In two patients the Biostator system continuously monitored plasma glucose levels and, through a computer-controlled feedback mechanis...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1979-06-01 00:00:00
abstract：:The intestinal epithelium normally provides a barrier function that prevents absorption of potentially harmful materials from the intestinal lumen. It has been postulated but never demonstrated that a cutaneous thermal injury will result in increased small-intestinal permeability. In a standardized 20% body surface ar...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：BACKGROUND:In a dynamic health care system, strong leadership has never been more important for surgeons. Little is known about how to design and conduct effectively a leadership program specifically for surgeons. We sought to evaluate critically a Leadership Development Program for practicing surgeons by exploring how...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2016.03.011
更新日期：2016-08-01 00:00:00
abstract：:Thirty-ones limbs of 29 consecutive patients undergoing bypass grafts to the tibial or peroneal arteries were studied. Twenty-five limbs had ischemic rest pain with or without localized gangrene, and six had incapacitating claudication. The mean segmental pressure indices were upper thigh, 1.16 +/- 0.36; above knee, 0...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1979-09-01 00:00:00
abstract：:Major intra-abdominal operations result in profound immunodepression. In addition, manipulation of malignant tumors may release tumor cells into the systemic and portal circulations. The additive effects of immunodepression and tumor cell release may enhance the metastatic potential of tumors. Perioperative correction...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-08-01 00:00:00
abstract：:To further define the clinicopathologic features and determinants of survival, we reviewed the cases of 110 patients with primary hepatic malignancy managed surgically between 1975 and 1986. Presenting signs of symptoms were pain (57%), fatigue (48%), abdominal mass (40%), and weight loss (33%). Twenty-six percent of ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：INTRODUCTION:Resident operative autonomy and case volume is associated with posttraining confidence and practice plans. Accreditation Council for Graduate Medical Education requirements for graduating general surgery residents are four liver and three pancreas cases. We sought to evaluate trends in resident experience ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2014.03.006
更新日期：2014-08-01 00:00:00
abstract：:Endothelial cell (EC) seeding has been proposed as a method to improve the performance of small-caliber synthetic vascular prostheses. Seeding experiments to date have all been carried out in the dog. This study investigates EC seeding of small-caliber Dacron carotid interposition grafts compared with contralateral co...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-03-01 00:00:00
abstract：:The specific susceptibility of the intestinal mucosa to low blood flow states is related to the "physiologic" makeup of the intestinal milieu. Pancreatic proteases appear to play a crucial role in the ischemic autodigestion of the intestinal mucosa. Moreover, trypsin can activate the conversion of xanthine dehydrogena...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:Effective cytoprotection to xenoislets would circumvent the major tissue limitation for pancreatic islet transplantation (PIT). Cell-surface engineering with poly[ethylene glycol] (PEG) derivatives can successfully prevent antibody binding to the surface antigens. Gene transfer of the antiapoptotic Bcl-2 gen...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2004.05.031
更新日期：2004-09-01 00:00:00
abstract：:A 20-year-old man underwent a 9-hour operation in a left lateral position for the removal of an osteoblastoma involving the pedicles of thoracic vertebrae T-11 and T-12 and for fixation with bond grafting. Immediately after the operation, extensive swelling of the left shoulder area was noted. The radial pulse on the ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：BACKGROUND:Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases, and their pathogenesis is attributed, in part, to alterations of the mucosal immune system. This study was designed to define the possible contribution of epithelial cells to the activation of lamina propria T lymphocytes (LP...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(97)90091-x
更新日期：1997-10-01 00:00:00
abstract：BACKGROUND:Emergency medical services are important to the functioning of health systems, but these services tend to be neglected in low- and middle-income countries, such as India. In recent years, several models of pre-hospital emergency medical services have emerged in India. Research on these models holds important...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.01.026
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:In the developmental stage, pancreas derives from the endodermal cells where the transcription factor, pancreatic duodenal homeobox gene-1 (pdx-1) is expressed. In adulthood, pdx-1 expression is localized to pancreatic beta cells, which is necessary for maintenance of beta cell function. Recently, ectopic ex...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2006.06.014
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:Determination of the genetic composition of papillary thyroid cancers may help explain differences in observed clinical behavior. Comparative genomic hybridization (CGH) is a novel molecular cytogenetic assay that allows simultaneous detection of gains, losses, and amplification of genetic information, makin...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2000.110847
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:Catabolic illness is associated with fluid retention and extracellular space expansion. To determine the effect of human growth hormone (GH) on body water compartments, critically ill surgical patients were studied for a 2-week period during which they either continued to receive standard intensive care unit...
journal_title：Surgery
pub_type： 临床试验,杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：BACKGROUND:The world's poorest 2 billion people, benefit from no more than about 3.5% of the world's operative procedures. The burden of surgical disease is greatest in Africa, where operations could save many lives. Previous facility-based studies have described operative procedure caseloads, but prospective studies i...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2015.03.022
更新日期：2015-07-01 00:00:00
abstract：:Peripheral parenteral nutrition avoids the use of central lines and is a useful means of nutritional support for selected patients. Amino acids alone have been used for peripheral parenteral nutrition and have been shown to give near nitrogen equilibrium. The addition of small amounts of dextrose to amino acids furthe...
journal_title：Surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1982-10-01 00:00:00
