Abstract:
:In this study we investigated the effect of splenectomy in combination with cyclosporine (CsA) on survival of heterotopic cardiac xenografts from hamster to rat. A 12-fold prolongation of mean cardiac xenograft survival, to 41 days, was accomplished with the combined therapy. In both untreated controls and CsA-treated recipients rejection occurred in 3 days. Splenectomy by itself prolonged xenograft function to 5 days. Evidence of humoral-mediated rejection in this cross-species combination was given for the extensive thrombosis and hemorrhage in the subepicardial area, the appearance of lymphocytotoxic titers just before graft function ceased, and the presence of IgM deposits in subepicardial vessels of the xenograft. CsA by itself could not modify this pattern of rejection. Splenectomy decreased antibody formation significantly and rejection became more cellular in nature. The regimen of splenectomy in association with CsA suppressed antibody titers and produced a CsA dose-dependent prolongation of xenograft survival. Thus, a complementary or synergistic effect is the result of the immunosuppressive regimen of splenectomy and CsA in hamster-to-rat cardiac xenografts. In this study the effect of splenectomy in controlling the humoral response in concordant xenografts and its role in future clinical xenografting is emphasized.
journal_name
Surgeryjournal_title
Surgeryauthors
Monden M,Valdivia LA,Gotoh M,Kubota N,Hasuike Y,Nakano Y,Okamura J,Mori Tsubject
Has Abstractpub_date
1989-04-01 00:00:00pages
535-42issue
4eissn
0039-6060issn
1532-7361journal_volume
105pub_type
杂志文章相关文献
SURGERY文献大全abstract::Thromboxane (Tx) inhibition prevents pulmonary leukostasis after acid aspiration. This observation prompted study of polymorphonuclear leukocyte (PMN) accumulations and products of cyclooxygenase. Experiments were conducted with a skin abrasion preparation. Five groups of six rabbits were pretreated intravenously with...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Burn-induced compartment syndrome is a severe sequela after circumferential burns of the extremities and is avoidable by immediate release of the underlying pressure under the eschar. Although the current gold standard is operative escharotomy, this procedure carries considerable morbidity. Our study evaluat...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.11.019
更新日期:2019-06-01 00:00:00
abstract::Our experience with 15 microvascular free-flap transfers is documented and discussed. We feel that the procedure is an effective means of reconstruction for complex and extensive defects. Rapid advances have been made in all areas of cancer surgery. It is important that these patients be afforded a speedy and, prefera...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1980-10-01 00:00:00
abstract::This is a report of a patient with a thrombosed Warren shunt and recurrent variceal hemorrhage who demonstrated compartmentalized venous hypertension in the mesenteric and gastrosplenic systems. Although the mesenteric presssure was normalized by the construction of a mesocaval interposition shunt, the gastrosplenic v...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract::Cadaver allograft skin, porcine xenograft skin, and amniotic membranes have been proved to be adequate temporary thermal wound coverings in four clinical situations: coverage of shallow wounds while awaiting epithelialization (SW), coverage of deep wounds after eschar excision (DEW), coverage of widely meshed autograf...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract::The isolation and characterization of oncogenes from human colon cancer and the recognition of their homology with the ras gene of the Harvey and Kirsten strain of murine sarcoma virus (MSV) led us to investigate the effect of exogenous MSV on 1,2 dimethylhydrazine (DMH)-induced colon carcinoma in rats. DMH, 20 mg bas...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1987-02-01 00:00:00
abstract:BACKGROUND:There is currently little information regarding the impact of procedure volume on outcomes after open inguinal hernia repair in the United States. Our hypothesis was that increasing procedure volume is associated with lesser rates of reoperation and resource use. METHODS:The database of the Statewide Planni...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2015.03.058
更新日期:2015-09-01 00:00:00
abstract::Metabolic alkalosis secondary to chloride depletion, especially following gastrointestinal surgery and associated with acute renal failure, is a frequent clinical occurrence. Management of the resultant acid-base disturbance mandates chloride replacement. The presence of oliguria limits the choice of accompanying cati...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1975-10-01 00:00:00
abstract::A case report of a girl with anomalous venous drainage of a lower extremity who had a successful venous transplant is presented, along with a review of some factors thought to be important in venous grafting. In our patient there are several factors that may have contributed to long-term patency. As demonstrated by ve...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1978-05-01 00:00:00
abstract::Radiation for benign problems of the head and neck area has been uniformly recognized as unacceptable practice. This includes epilation for facial hirsutism. Twelve such patients, recently encountered, have characteristic radiodermatitis facies and have demonstrated multisite neoplastic involvement--including skin, th...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract:INTRODUCTION:End-stage renal disease (ESRD) is associated with poor medical outcomes. This study aimed to compare early outcomes of elective and emergency operation for diverticulitis among older adults with and without a diagnosis of ESRD. METHODS:Patients 65 years of age and older with a primary diagnosis of diverti...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2014.03.034
更新日期:2014-08-01 00:00:00
abstract::The traditional approach to gastric outlet obstruction caused by unresectable pancreatic cancer is gastrojejunostomy performed during or after biliary bypass surgery. Previous work showed that gastrojejunostomy failed in 95% of patients with preoperative outlet obstruction, which was evidenced by nausea and vomiting. ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:Operative therapy for Crohn's disease (CD) recurrence is supposed to be more complex and demanding than primary resection. The purpose of this study was to assess a postoperative course after reoperation for the recurrence of CD. METHODS:From 1998 to 2008, 61 patients underwent reoperation for the recurrenc...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.02.001
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Hepatotoxicity from neoadjuvant chemotherapy before liver resection for colorectal metastases (CRLM) has been recently reported. The purpose of the present study was to evaluate the prevalence and the clinical relevance of this phenomenon. It was a retrospective study conducted at an academic secondary refer...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2009.01.004
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:The surgical management and follow-up strategy in patients with medullary thyroid carcinoma (MTC) remain controversial because of the lack of data on the natural history of these tumors and their patterns of progression. METHODS:We reviewed the records of all patients who underwent a cervical operation for ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(03)00408-2
更新日期:2003-12-01 00:00:00
abstract::A case of transient cerebral and retinal ischemia caused by giant cell arteritis is reported. Because of the distribution of the disease, the patient was treated with a subclavian to carotid reversed saphenous vein graft. The clinical features of giant cell arteritis affecting the branches of the aortic arch are revie...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-06-01 00:00:00
abstract:BACKGROUND:Increased epithelial permeability may contribute to septic complications after alcohol intoxication. Prior ethanol (EtOH) exposure leads to structural and functional effects on cytoskeletal components important in maintaining barrier integrity. The cytoskeleton is also important in the transcellular transpor...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2002.127553
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVE:We determined whether hepatic intra-arterial infusion of 5-fluorouracil (5-FU) in patients with synchronous hepatic metastases from colorectal cancer, in whom the primary lesion was resectable but hepatic metastatic lesions were non-resectable helped improve survival time when administered on the basis of the...
journal_title:Surgery
pub_type: 临床试验,杂志文章
doi:10.1016/j.surg.2006.03.001
更新日期:2006-09-01 00:00:00
abstract::Arteriosclerotic aneurysm of the innominate artery is an unusual lesion. A review of the literature has revealed many approaches to this problem in the past, but the mortality rate has remained significant and serious complications have been frequent. Computerized axial tomography and noninvasive cerebrovascular metho...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract:BACKGROUND:Cyclosporine causes intrarenal vasoconstriction, which may account for its nephrotoxic side effects. Plasma levels of the vasoconstrictor peptide endothelin-1 are increased after cyclosporine administration, and endothelin-1 has been shown to cause renal vasoconstriction. In this study we used in vivo micros...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:The prognosis of neuroblastoma patients remains unsatisfactory. Therefore, developing an effective treatment strategy is important. Resveratrol, a natural polyphenol, possesses chemopreventive and antitumor effects. We investigated the effects of resveratrol on the proliferation, apoptosis, and cell cycle al...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2004.01.017
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:The impact of the location of colorectal cancer on patient outcomes has been reported in several settings. The objective of this study was to assess the prognostic impact of the location of the primary colon cancer among patients with colorectal cancer peritoneal metastases undergoing complete cytoreductive ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.07.027
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:The development of pancreatic cancer involves an accumulation of genetic changes, including oncogene activation and mutations in tumor suppressor genes important in cell cycle regulation. As a step to developing gene therapies to restore cell cycle control, we hypothesized that adenoviral-mediated gene trans...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(97)90036-2
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:Combination treatments in addition to gemcitabine have failed to improve outcomes in pancreatic cancer. We tested gemcitabine in combination with the antiendothelial agent endothelial monocyte-activating polypeptide II (EMAP II). METHODS:Human pancreatic cancer cell line murine xenografts were treated with ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2009.04.015
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Transplantation of pancreatic islets is an effective treatment for select patients with type 1 diabetes. Improved cellular therapy results may be realized by altering the gene expression profile of transplanted islets. Current viral and nonviral vectors used to introduce nucleic acids for gene regulation hol...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2010.05.013
更新日期:2010-08-01 00:00:00
abstract::A prospective, randomized clinical trial of three treatment regimens: (1) Cytoxan, methotrexate, and 5-fluorouracil (CMF), (2) CMF plus the antiestrogen drug, tamoxifen (CMFT), and (3) CMFT plus bacillus Calmette-Guerin (BCG) vaccinations in women with stage 22 breast cancer is reported. All patients underwent mastect...
journal_title:Surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1980-05-01 00:00:00
abstract::Four hundred forty-one patients who were operated on for primary hyperparathyroidism were observed for up to 22 years. Mortality was significantly higher than expected during the first postoperative years, for both men and women. This was predominantly due to a higher than expected incidence of diseases of the circula...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1987-07-01 00:00:00
abstract::Myocardial high-energy phosphate and glucose-6-phosphate levels were determined in the in vivo pig heart model during ischemic arrest and reperfusion to determine the effectiveness of potassium cardioplegia in myocardial protection. Thirty-five pigs were divided into six experimental groups consisting of 2-hour normot...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1979-07-01 00:00:00
abstract:BACKGROUND:To compare operative morbidity, mortality, quality of life, and survival after pancreatoduodenectomy (PD) versus pancreatoduodenectomy with extended lymphadenectomy (PD/ELND) in patients with resectable pancreatic cancer. METHODS:From May 1997 to July 2003 there were 132 patients with biopsy examination-pro...
journal_title:Surgery
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.surg.2005.06.044
更新日期:2005-10-01 00:00:00
abstract::We found mentions of 581 resections of hilar bile duct cancer in the literature to January 1989. Resection in 499 patients, reported or updated since 1980, resulted in an operative mortality of 12% and a 5-year survival rate of 13%. Resections confined to the hepatic duct confluence or extended to the quadrate lobe le...
journal_title:Surgery
pub_type: 杂志文章,评审
doi:
更新日期:1990-09-01 00:00:00