当前位置： SCI文献检索 > SURGERY期刊下所有文献 > Deletion of p38-alpha mitogen-activated protein kinase within the intestinal epithelium promotes colon tumorigenesis.

Deletion of p38-alpha mitogen-activated protein kinase within the intestinal epithelium promotes colon tumorigenesis.

Abstract：

BACKGROUND:p38-Alpha mitogen-activated protein kinase (p38-MAPK) is a tumor suppressor often mutated in human cancers, but its specific role in colorectal cancer is not completely understood. Previous studies have found that p38-MAPK activity inhibits epithelial proliferation and promotes apoptosis in the intestine. Therefore, we sought to test the hypothesis that intestinal disruption of p38-MAPK would lead to increased tumorigenesis in the colon. METHODS:p38-MAPK was deleted in mice within the intestinal epithelium using a tamoxifen-inducible Cre system under control of the villin promoter [villin-Cre ERT2(+), MAPK14(f/f)]. An azoxymethane and dextran sodium sulfate protocol was used to drive intestinal tumor development. Tumor measurements were made using computer software from photographs of excised colon specimens. RESULTS:The number of mice that developed tumors was not statistically different when comparing wild-type mice (7/14) to inducible, intestine epithelial-deleted p38-MAPK (9/11) mice after azoxymethane/dextran sodium sulfate treatment (P = .21). However, the epithelial-deleted p38-MAPK mice developed significantly more tumors (3.7 vs 1.1; P = .008) and nearly 4 times the total tumor burden as wild-type mice (17.4 vs 4.8 mm(2); P = .03). Wild-type and epithelial-deleted p38-MAPK groups demonstrated a similar degree of colon inflammation. CONCLUSION:Deletion of p38-MAPK within the colonic mucosa leads to a hyperplastic state promoting greater tumor development. Because the severity of colitis was not augmented in mice with p38-MAPK deficiency, tumor development is likely mediated by impaired cell cycle regulation within the colonic epithelium. Manipulation of p38-MAPK activity may provide a novel treatment and/or prevention strategy in the management of colorectal cancer, particularly in the setting of inflammatory bowel disease.

journal_name

Surgery

journal_title

Surgery

authors

Wakeman D,Schneider JE,Liu J,Wandu WS,Erwin CR,Guo J,Stappenbeck TS,Warner BW

doi

10.1016/j.surg.2012.05.009

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

286-93

issue

2

eissn

0039-6060

issn

1532-7361

pii

S0039-6060(12)00217-6

journal_volume

152

pub_type

杂志文章

相关文献

SURGERY文献大全
  • Immune cell infiltrate-associated dysregulation of DNA repair machinery may predispose to papillary thyroid carcinogenesis.

    abstract：BACKGROUND:An altered immune microenvironment may contribute to papillary thyroid cancer development, as immune infiltrates are identified postoperatively in many papillary thyroid cancer cases with or without diagnosed thyroiditis. Oxygen radicals, endogenous or inflammation-induced, can generate DNA damage, which cau...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2019.02.024

    authors： Nicolson NG,Brown TC,Korah R,Carling T

    更新日期：2020-01-01 00:00:00

  • Teaching practicing surgeons what not to do: An analysis of instruction fluidity during a simulation-based continuing medical education course.

    abstract：BACKGROUND:Interest is growing in simulation-based continuing medical education courses for practicing surgeons. However, little research has explored the instruction employed during these courses. This study examines instruction practices used during an annual simulation-based continuing medical education course. MET...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2019.01.016

    authors： Godfrey M,Rosser AA,Pugh CM,Shaffer DW,Sachdeva AK,Jung SA

    更新日期：2019-06-01 00:00:00

  • Caroli's disease: liver resection and liver transplantation. Experience in 33 patients.

    abstract：BACKGROUND:The aim of this study was to review and discuss our observations on 33 patients who underwent surgical treatment for Caroli's disease (CD), focusing on diagnosis, current surgical management, and long-term outcome. METHODS:Between May 1993 and June 2004, 642 liver resections and 286 liver transplantations i...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2005.05.002

    authors： Kassahun WT,Kahn T,Wittekind C,Mössner J,Caca K,Hauss J,Lamesch P

    更新日期：2005-11-01 00:00:00

  • Evaluation of intrathymic islet transplantation in the prediabetic period.

    abstract：BACKGROUND:Beta-cell destruction in type I diabetes mellitus results from a chronic autoimmune process. Exposure of thymic T cells to islet antigens during the prehyperglycemic phase of diabetes may alter the likelihood of autoimmune damage to beta cells in the native pancreas. Thus we evaluated whether prophylactic ma...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Brayman KL,Nakai I,Field MJ,Lloveras JJ,Jessurun J,Najarian JS,Sutherland DE

    更新日期：1992-08-01 00:00:00

  • Real money: complications and hospital costs in trauma patients.

    abstract：BACKGROUND:Major postoperative complications are associated with a substantial increase in hospital costs. Trauma patients are known to have a higher rate of complications than the general surgery population. We used the National Surgical Quality Improvement Program (NSQIP) methodology to evaluate hospital costs, durat...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2008.05.003

    authors： Hemmila MR,Jakubus JL,Maggio PM,Wahl WL,Dimick JB,Campbell DA Jr,Taheri PA

    更新日期：2008-08-01 00:00:00

  • Dorsal duct sphincterotomy is effective long-term treatment of acute pancreatitis associated with pancreas divisum.

    abstract：:Nonbiliary, nonalcoholic pancreatic inflammatory disease was investigated by biochemical investigation, ultrasonography, endoscopic retrograde cholangiopancreatography, and secretin tests. Twenty-five consecutive cases were followed up for 12 months to 10 years after treatment of disease associated with pancreas divis...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Keith RG,Shapero TF,Saibil FG,Moore TL

    更新日期：1989-10-01 00:00:00

  • Validation of a novel patient-reported outcome measure for parathyroid and thyroid disease (PROMPT).

    abstract：BACKGROUND:Patient-reported outcome measures are being used increasingly to assess disease severity and response to surgery. The purpose of this study was to create and validate a patient-reported outcome measure for symptoms of thyroid enlargement and hyperparathyroidism, 2 conditions where the presence of preoperativ...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2018.04.091

    authors： Burneikis T,Colvin J,Jin J,Berber E,Krishnamurthy VD,Shin J,Siperstein A

    更新日期：2019-01-01 00:00:00

  • Malignant tumors of the extrahepatic bile ducts.

    abstract：:A series of 76 patients treated for carcinoma of the extrahepatic bile ducts at three Swedish hospitals during the years 1952 to 1973 was studied. The mean age of the patients was 68 years. Gallstones were found in 22 patients, whereas 11 patients had undergone cholecystectomy earlier for gallstone disease. At operati...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Andersson A,Bergdahl L,van der Linden W

    更新日期：1977-02-01 00:00:00

  • Expression of kinase genes in primary hyperparathyroidism: adenoma versus hyperplastic parathyroid tissue.

    abstract：BACKGROUND:Differentiation between parathyroid hyperplasia and adenoma is difficult and based on the surgeon's skill. Microarrays and other sophisticated research tools generate information about differential gene expression in various tissues. Exploration of genes that express differentially in 1 tissue will enable id...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1067/msy.2002.128614

    authors： Schachter PP,Ayesh S,Schneider T,Laster M,Czerniak A,Hochberg A

    更新日期：2002-12-01 00:00:00

  • Preoperative lymphocyte subsets and infectious complications after colorectal cancer surgery.

    abstract：:Peripheral lymphocytes, T cells, and T cell subsets of 141 consecutive patients with colorectal cancer were measured preoperatively to determine whether infectious complications could be predicted from derangements of T cell subsets. T cell subset abnormalities reportedly precede sepsis in patients with burn injuries....

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Tartter PI

    更新日期：1988-02-01 00:00:00

  • Identification of multiple endocrine neoplasia type 1 in patients with apparent sporadic primary hyperparathyroidism.

    abstract：BACKGROUND:In the evaluation of patients with primary hyperparathyroidism (PHP), specific query for a personal or family history of MEN1 (Hx) is recommended widely, but responses are rarely positiv. We instituted a 6-question panel (6Q) to routinely screen for MEN1 preoperatively. METHODS:The clinical database entries...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2008.07.030

    authors： Yip L,Ogilvie JB,Challinor SM,Salata RA,Thull DL,Yim JH,Carty SE

    更新日期：2008-12-01 00:00:00

  • Prognostic benefit of selective portal vein occlusion during hepatic resection for hepatocellular carcinoma.

    abstract：BACKGROUND:The aim of this study was to clarify whether the types of portal vein (PV) occlusion during hepatectomy affect the long-term outcome in patients with hepatocellular carcinoma (HCC). METHODS:Eighty-six patients who had undergone curative hepatic resection for HCC were divided on the basis of the type of PV o...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2005.02.008

    authors： Makino I,Chijiiwa K,Kondo K,Ohuchida J,Kai M

    更新日期：2005-06-01 00:00:00

  • Parathyroidectomy reduces cardiovascular events and mortality in renal hyperparathyroidism.

    abstract：BACKGROUND:Secondary hyperparathyroidism (SHPT) and its associated abnormalities in mineral metabolism increase the risk of cardiovascular morbidity and death in chronic renal failure (CRF). The effect of parathyroidectomy (PTX) on the incidence of major cardiovascular events in CRF patients with SHPT is unknown. We te...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2007.06.015

    authors： Costa-Hong V,Jorgetti V,Gowdak LH,Moyses RM,Krieger EM,De Lima JJ

    更新日期：2007-11-01 00:00:00

  • Prolonged hypoxia alters endothelial barrier function.

    abstract：BACKGROUND:It is well recognized that hypoxia/reoxygenation and exposure to inflammatory mediators such as cytokines and neutrophils alter the barrier function of the vascular endothelium. The experiments we conducted tested whether hypoxia alone could produce changes in permeability and whether a prolonged period of h...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Ali MH,Schlidt SA,Hynes KL,Marcus BC,Gewertz BL

    更新日期：1998-09-01 00:00:00

  • Does adjuvant radiation provide any survival benefit after an R1 resections for pancreatic cancer?

    abstract：BACKGROUND:The benefit of adding external beam radiation to adjuvant chemotherapy in patients that have undergone a margin positive resection for early stage, pancreatic ductal adenocarcinoma has not been determined definitively. METHODS:The National Cancer Data Base was queried to evaluate the utility of adjuvant rad...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2017.09.022

    authors： Suss NR,Talamonti MS,Bryan DS,Wang CH,Kuchta KM,Stocker SJ,Bentrem DJ,Roggin KK,Winchester DJ,Marsh R,Prinz RA,Murad FM,Baker MS

    更新日期：2018-05-01 00:00:00

  • The Michigan Surgical Home and Optimization Program is a scalable model to improve care and reduce costs.

    abstract：BACKGROUND:The Michigan Surgical Home and Optimization Program is a structured, home-based, preoperative training program targeting physical, nutritional, and psychological guidance. The purpose of this study was to determine if participation in this program was associated with reduced hospital duration of stay and hea...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2016.12.021

    authors： Englesbe MJ,Grenda DR,Sullivan JA,Derstine BA,Kenney BN,Sheetz KH,Palazzolo WC,Wang NC,Goulson RL,Lee JS,Wang SC

    更新日期：2017-06-01 00:00:00

  • District-level surgery in Uganda: Indications, interventions and perioperative mortality.

    abstract：BACKGROUND:The world's poorest 2 billion people, benefit from no more than about 3.5% of the world's operative procedures. The burden of surgical disease is greatest in Africa, where operations could save many lives. Previous facility-based studies have described operative procedure caseloads, but prospective studies i...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2015.03.022

    authors： Löfgren J,Kadobera D,Forsberg BC,Mulowooza J,Wladis A,Nordin P

    更新日期：2015-07-01 00:00:00

  • Role of serum nonsuppressible insulin-like activity (NSILA) in wound healing. I. Influence of thyroparathyroidectomy on serum NSILA and wound healing in the rat.

    abstract：:Serum contains a 90,000 molecular weight glycoprotein that exhibits insulin-like activity on adipocytes, skeletal muscle, and fibroblasts in tissue culture; however, this protein is physicochemically and immunochemically distinct from insulin and presently is termed "nonsuppressible insulin-like activity ("nsilA)." Th...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Poffenbarger PL,Haberal MA

    更新日期：1976-11-01 00:00:00

  • Practicality of using galvanic skin response to measure intraoperative physiologic autonomic activation in operating room team members.

    abstract：BACKGROUND:Physiologic and psychological stress are commonly experienced by operating room (OR) personnel, yet there is little research about the stress levels in OR teams and their impact on performance. Previously published procedures to measure physiologic activation are invasive and impractical for the OR. The purp...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2015.04.009

    authors： Phitayakorn R,Minehart RD,Pian-Smith MC,Hemingway MW,Petrusa ER

    更新日期：2015-11-01 00:00:00

  • Pneumonia is associated with a high risk of mortality after pancreaticoduodenectomy.

    abstract：BACKGROUND:Pancreatectomy is associated with a high complication rate that varies between 40-60%. Although many specific complications have been extensively studied, postoperative pneumonia has received little attention. METHODS:Patients undergoing pancreaticoduodenectomy (n = 1,090) and distal pancreatectomy (n = 436...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2016.09.028

    authors： Nagle RT,Leiby BE,Lavu H,Rosato EL,Yeo CJ,Winter JM

    更新日期：2017-04-01 00:00:00

  • Clinical experience with 118 hepatic resections for hepatocellular carcinoma.

    abstract：:During the recent 5 2/3 years, hepatic resection was performed on 118 patients with hepatocellular carcinoma. Ages ranged from 17 to 78 years with an average of 57 years. There were 101 males and 17 females. Underlying cirrhosis of the liver was found in 101 cases, and chronic hepatitis was found in 16 cases. Before s...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Nagasue N,Yukaya H,Ogawa Y,Sasaki Y,Chang YC,Niimi K

    更新日期：1986-06-01 00:00:00

  • Effects of trehalose in canine lung preservation.

    abstract：BACKGROUND:The effect of trehalose on the preservation of canine lungs was studied with the use of Euro-Collins solution (ECS). METHODS:In group 1, five lungs were perfused and preserved with a modified ECS in which trehalose (35.0 gm/L) was used instead of glucose. In group 2, six lungs were perfused and preserved wi...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Hirata T,Fukuse T,Liu CJ,Muro K,Yokomise H,Yagi K,Inui K,Hitomi S,Wada H

    更新日期：1994-01-01 00:00:00

  • Relationships of parathyroid hormone, parathyroid secretory protein, parathyroid hormone messenger RNA, parathyroid secretory protein mRNA, and replication in human parathyroid adenoma and secondary hyperplasia tissues and cultures.

    abstract：BACKGROUND:The purpose of this study was to clarify the relationships of extractable and secreted parathyroid hormone (PTH) and parathyroid secretory protein (PSP) in human parathyroid tumors to PTH messenger RNA (mRNA), PSP mRNA, and cell replication. METHODS AND RESULTS:In tissue cultures of seven adenomas and five ...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Weber CJ,Russell J,Costanzo MK,Karp F,Benjamin M,Hardy MA,Feind CR

    更新日期：1992-12-01 00:00:00

  • Desmoid tumor: musculoaponeurotic fibrosis of the abdominal wall.

    abstract：:A 26-year-old woman developed a desmoid tumor of the lower abdominal wall shortly after the birth of her fourth child. It measured 15 by 17 cm. and involved most of the lower abdominal wall of this small-framed woman. Operative removal would have been mutilating and almost surely doomed to failure. No treatment was gi...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Caldwell EH

    更新日期：1976-01-01 00:00:00

  • Depression of myocardial ATPase activity by plasma obtained during positive end-expiratory pressure.

    abstract：:Dogs treated with 15 cm H2O positive end-expiratory pressure (PEEP) invariably show a decrease in cardiac output (CO). Plasma that is obtained from PEEP-treated dogs and applied to an isometrically contracting rat papillary muscle results in a significant depression of the peak developed tension. The present study eva...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Utsunomiya T,Krausz MM,Dunham B,Shepro D,Hechtman HB

    更新日期：1982-03-01 00:00:00

  • Regulation of arginase expression by T-helper II cytokines and isoproterenol.

    abstract：BACKGROUND:Trauma causes a release of catecholamines, transforming growth factor-beta (TGF-beta), and T-helper II cytokines (TH2). Individually, these substances also induce arginase in macrophages. The purpose of this study was to determine the synergistic interactions between isoproterenol, TGF-beta, and TH2 cytokine...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2003.10.007

    authors： Barksdale AR,Bernard AC,Maley ME,Gellin GL,Kearney PA,Boulanger BR,Tsuei BJ,Ochoa JB

    更新日期：2004-05-01 00:00:00

  • Assessing the experience in complex hepatopancreatobiliary surgery among graduating chief residents: is the operative experience enough?

    abstract：INTRODUCTION:Resident operative autonomy and case volume is associated with posttraining confidence and practice plans. Accreditation Council for Graduate Medical Education requirements for graduating general surgery residents are four liver and three pancreas cases. We sought to evaluate trends in resident experience ...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1016/j.surg.2014.03.006

    authors： Sachs TE,Ejaz A,Weiss M,Spolverato G,Ahuja N,Makary MA,Wolfgang CL,Hirose K,Pawlik TM

    更新日期：2014-08-01 00:00:00

  • NBCA medical adhesive (n-butyl-2-cyanoacrylate) versus suture for patch fixation in Lichtenstein inguinal herniorrhaphy: a randomized controlled trial.

    abstract：BACKGROUND:We compared the effectiveness of n-butyl-2-cyanoacrylate (NBCA) and traditional suture for patch fixation in Lichtenstein tension-free herniorrhaphy for inguinal hernias. METHODS:A total of 110 patients with primary unilateral inguinal hernia were assigned randomly to either experimental or control groups. ...

    journal_title：Surgery

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.surg.2011.09.031

    authors： Shen YM,Sun WB,Chen J,Liu SJ,Wang MG

    更新日期：2012-04-01 00:00:00

  • Renal function after thermal trauma: the effects of treatment on renal blood flow and sodium and water excretion.

    abstract：:Effective renal plasma flow, urine sodium excretion, and glomerular filtration rates were reduced markedly to 44%, 46%, and 60% of normal, respectively, in rats subjected to thermal trauma. A sodium load of about 2 mEq. per 100 Gm. of body weight restores these functions toward normal. Doubling the concomitant water l...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：

    authors： Monafo WW,Ayvazian VH,Logel R,Deitz F,Eve M

    更新日期：1976-03-01 00:00:00

  • Screening for primary hyperparathyroidism before thyroid surgery: A prospective study.

    abstract：BACKGROUND:Misdiagnosed primary hyperparathyroidism (PHPT) during thyroid surgery may lead to a difficult reoperation. Because PHPT is often asymptomatic, calcium measurements have been recommended before thyroid surgery, but no study has focused on the results of a prospective PHPT screening. METHODS:The prospective ...

    journal_title：Surgery

    pub_type： 杂志文章

    doi：10.1067/msy.2002.121379

    authors： Denizot A,Dadoun F,Meyer-Dutour A,Alliot P,Argème M

    更新日期：2002-03-01 00:00:00