The herpes simplex virus type 1 U(S)11 protein interacts with protein kinase R in infected cells and requires a 30-amino-acid sequence adjacent to a kinase substrate domain.

abstract：:The objective of this investigation was to examine by electron microscopy the replicative ribonucleoprotein (RNP) structures synthesized in vesicular stomatitis virus-infected HeLa cells. Pulse-labeled in vivo products of vesicular stomatitis virus replication and transcription can be separated by centrifugation in Re...

journal_title：Journal of virology

authors： Naeve CW,Summers DF

更新日期：1980-06-01 00:00:00

abstract：:We studied the effect of filovirus infection on host cell gene expression by characterizing the regulation of gene expression responses in human liver cells infected with Zaire Ebolavirus (ZEBOV), Reston Ebolavirus (REBOV), and Marburgvirus (MARV), using transcriptional profiling and bioinformatics. Expression microar...

journal_title：Journal of virology

authors： Kash JC,Mühlberger E,Carter V,Grosch M,Perwitasari O,Proll SC,Thomas MJ,Weber F,Klenk HD,Katze MG

更新日期：2006-03-01 00:00:00

abstract：UNLABELLED:Susceptibility to alphavirus infection is age dependent, and host maturation is associated with decreased virus replication and less severe encephalitis. To identify factors associated with maturation-dependent restriction of virus replication, we studied AP-7 rat olfactory bulb neuronal cells, which can dif...

journal_title：Journal of virology

authors： Schultz KL,Vernon PS,Griffin DE

更新日期：2015-01-01 00:00:00

abstract：:Densonucleosis viruses 1 and 2 both contain the three polyamines putrescine, spermidine, and spermine in complete virus particles but not in their respective top components. The polyamines, with spermidine predominant, comprise 1.41% of the virus particle by weight, which is sufficient to neutralize 26% of the single-...

journal_title：Journal of virology

authors： Kelly DC,Elliott RM

更新日期：1977-01-01 00:00:00

abstract：:Human bocavirus 1 (HBoV1) is a human parvovirus that causes acute respiratory tract infections in young children. In this study, we confirmed that, when polarized/well-differentiated human airway epithelia are infected with HBoV1 in vitro, they develop damage characterized by barrier function disruption and cell hypot...

journal_title：Journal of virology

authors： Deng X,Zou W,Xiong M,Wang Z,Engelhardt JF,Ye SQ,Yan Z,Qiu J

更新日期：2017-11-30 00:00:00

abstract：:Recent findings suggest that most sexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs during the acute phase of infection when viral replication is most intense. Here, we show that vaccine-elicited cellular immune responses can significantly reduce simian immunodeficiency virus levels in the seme...

journal_title：Journal of virology

authors： Whitney JB,Luedemann C,Hraber P,Rao SS,Mascola JR,Nabel GJ,Letvin NL

更新日期：2009-10-01 00:00:00

abstract：:Viral manipulation of transduction pathways associated with key cellular functions such as survival, response to microbial infection, and cytoskeleton reorganization can provide the supportive milieu for a productive infection. Here, we demonstrate that vaccinia virus (VACV) infection leads to activation of the stress...

journal_title：Journal of virology

authors： Pereira AC,Leite FG,Brasil BS,Soares-Martins JA,Torres AA,Pimenta PF,Souto-Padrón T,Traktman P,Ferreira PC,Kroon EG,Bonjardim CA

更新日期：2012-01-01 00:00:00

abstract：:A novel circular DNA virus sequence is reported from grapevine. The corresponding genomic organization, coding potential, and conserved origin of replication are similar to those of members of the family Geminiviridae, but the genome of 3,206 nucleotides is 4% larger than the largest reported geminiviral genome and sh...

journal_title：Journal of virology

authors： Krenz B,Thompson JR,Fuchs M,Perry KL

更新日期：2012-07-01 00:00:00

abstract：:The bacteriophage T4 unf gene, known to be involved in the arrest of transcription from cytosine-containing DNA, is unessential except in Escherichia coli strains containing plasmid pR386. Comparative genetic and biochemical analyses of parameters of unf+ and unf- phage growth in host cells isogenic except for the pre...

journal_title：Journal of virology

authors： Herman RE,Snustad DP

更新日期：1985-02-01 00:00:00

abstract：:Three fish retroviruses infecting walleyes constitute the recently recognized genus called epsilonretrovirus. The founding member of this group, walleye dermal sarcoma virus (WDSV), induces benign skin tumors in the infected fish and replicates near 4 degrees C. While the viral genomic sequence is known, biochemical c...

journal_title：Journal of virology

authors： Fodor SK,Vogt VM

更新日期：2002-05-01 00:00:00

abstract：:In 1997, an H5N1 influenza virus outbreak occurred in chickens in Hong Kong, and the virus was transmitted directly to humans. Because there is limited information about the avian influenza virus reservoir in that region, we genetically characterized virus strains isolated in Hong Kong during the 1997 outbreak. We seq...

journal_title：Journal of virology

authors： Hoffmann E,Stech J,Leneva I,Krauss S,Scholtissek C,Chin PS,Peiris M,Shortridge KF,Webster RG

更新日期：2000-07-01 00:00:00

abstract：:The induction of alpha/beta interferon (IFN-alpha/beta) genes constitutes one of the first responses of the cell to virus infection. The IFN-beta gene is constitutively repressed in uninfected cells and is transiently activated after virus infection. In this work we demonstrate that histone deacetylation regulates the...

journal_title：Journal of virology

authors： Shestakova E,Bandu MT,Doly J,Bonnefoy E

更新日期：2001-04-01 00:00:00

abstract：:Previous studies have suggested that coxsackievirus B (CVB) activates CD8(+) T cells in vivo, but the extent of this activation and the antigen specificity of the CD8(+) T cells remain uncertain. Furthermore, CVB-induced CD4(+) T-cell responses have not been carefully investigated. Herein, we evaluate CD8(+) and CD4(+...

journal_title：Journal of virology

authors： Kemball CC,Harkins S,Whitton JL

更新日期：2008-05-01 00:00:00

abstract：:CD81 has been described as a putative receptor for hepatitis C virus (HCV); however, its role in HCV cell entry has not been characterized due to the lack of an efficient cell culture system. We have examined the role of CD81 in HCV glycoprotein-dependent entry by using a recently developed retroviral pseudotyping sys...

journal_title：Journal of virology

authors： Zhang J,Randall G,Higginbottom A,Monk P,Rice CM,McKeating JA

更新日期：2004-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) nonstructural protein 5B (NS5B) is an RNA-dependent RNA polymerase (RdRp) that acts as a key player in the HCV replication complex. Understanding the interplay between the viral and cellular components of the HCV replication complex could provide new insight for prevention of the progression of...

journal_title：Journal of virology

authors： Huang JT,Tseng CP,Liao MH,Lu SC,Yeh WZ,Sakamoto N,Chen CM,Cheng JC

更新日期：2013-05-01 00:00:00

abstract：:The physical map locations of 62 temperature-sensitive mutations of vaccinia virus WR have been determined by marker rescue experiments, using cloned HindIII fragments of wild-type DNA. Since vaccinia virus DNA is not infectious, marker rescue was performed by infecting monolayers of cells at the nonpermissive tempera...

journal_title：Journal of virology

authors： Ensinger MJ,Rovinsky M

更新日期：1983-11-01 00:00:00

abstract：:Corynebacteriophages beta and gamma are closely related but heteroimmune; hence, gamma reproduces in C7(beta). A series of gamma mutants, designated gamma-bin (beta-inhibited), has been isolated. They reproduce in only 2 to 14% of infected C7(beta) cells, and, as a result, plaque with an efficiency of 10(-4) to 10(-5)...

journal_title：Journal of virology

authors： Groman N,Rabin M

更新日期：1978-10-01 00:00:00

abstract：:A double-isotopic label difference analysis of polyacrylamide gels has been used to distinguish between cellular and viral protein accumulation in infected cells and to quantify the kinetics of accumulation of viral polypeptides. This technique, coupled with the determination of total radioactive amino acid incorporat...

journal_title：Journal of virology

authors： Hightower LE,Bratt MA

更新日期：1974-04-01 00:00:00

abstract：:Retroelements are important evolutionary forces but can be deleterious if left uncontrolled. Members of the human APOBEC3 family of cytidine deaminases can inhibit a wide range of endogenous, as well as exogenous, retroelements. These enzymes are structurally organized in one or two domains comprising a zinc-coordinat...

journal_title：Journal of virology

authors： Bulliard Y,Turelli P,Röhrig UF,Zoete V,Mangeat B,Michielin O,Trono D

更新日期：2009-12-01 00:00:00

abstract：:Animal influenza viruses pose a clear threat to public health. Transmissibility among humans is a prerequisite for a novel influenza virus to cause a human pandemic. A novel reassortant swine influenza virus acquired sustained human-to-human transmissibility and caused the 2009 influenza pandemic. However, the molecul...

journal_title：Journal of virology

authors： Zhang Y,Zhang Q,Gao Y,He X,Kong H,Jiang Y,Guan Y,Xia X,Shu Y,Kawaoka Y,Bu Z,Chen H

更新日期：2012-09-01 00:00:00

abstract：:Blattella germanica densovirus (BgDNV) is an autonomous parvovirus that infects the German cockroach. BgDNV possesses three mRNAs for NS proteins, two of which are splice variants of the unspliced transcript. The unspliced variant encodes open reading frame 5 (ORF5) (NS3), while NSspl1 encodes ORF3 (NS1) and ORF4 (NS2...

journal_title：Journal of virology

authors： Kapelinskaya TV,Martynova EU,Schal C,Mukha DV

更新日期：2011-11-01 00:00:00

abstract：:The replication and transcription of double-stranded RNA (dsRNA) viruses occur within a polymerase complex particle in which the viral genome is enclosed throughout the entire life cycle of the virus. A single protein subunit in the polymerase complex is responsible for the template-dependent RNA polymerization activi...

journal_title：Journal of virology

authors： Poranen MM,Koivunen MR,Bamford DH

更新日期：2008-09-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is the first human virus found to encode many microRNAs. It is etiologically linked to nasopharyngeal carcinoma and EBV-associated gastric carcinoma. During the latent infection period, there are only a few EBV proteins expressed, whereas EBV microRNAs, such as the BamHI-A region rightward tra...

journal_title：Journal of virology

authors： Zheng X,Wang J,Wei L,Peng Q,Gao Y,Fu Y,Lu Y,Qin Z,Zhang X,Lu J,Ou C,Li Z,Zhang X,Liu P,Xiong W,Li G,Yan Q,Ma J

更新日期：2018-11-12 00:00:00

abstract：:The vif gene of human immunodeficiency virus type 1 (HIV-1) encodes a basic Mr 23,000 protein that is necessary for production of infectious virions by nonpermissive cells (human lymphocytes and macrophages) but not by permissive cells such as HeLa-CD4. It had been proposed that permissive cells may contain an unident...

journal_title：Journal of virology

authors： Madani N,Kabat D

更新日期：1998-12-01 00:00:00

abstract：:To determine the extent and structure of genetic variation in dengue viruses (DENV) on a restricted spatial and temporal scale, we sequenced the E (envelope) genes of DENV-1, -2, and -3 isolates collected in 2001 from children enrolled in a prospective school-based study in Kamphaeng Phet, Thailand, and diagnosed with...

journal_title：Journal of virology

authors： Jarman RG,Holmes EC,Rodpradit P,Klungthong C,Gibbons RV,Nisalak A,Rothman AL,Libraty DH,Ennis FA,Mammen MP Jr,Endy TP

更新日期：2008-06-01 00:00:00

abstract：:Deletion mutants of simian virus 40 (SV40) with lesions at the three DdeI sites near the 3' end of the early region were constructed. Mutants with deletions at 0.203 and 0.219 map units (mu) which did not change the large T antigen reading frame were viable. This extends slightly the upstream boundary for the location...

journal_title：Journal of virology

authors： Tornow J,Cole CN

更新日期：1983-09-01 00:00:00

abstract：UNLABELLED:An altered intestinal microbiome during chronic human immunodeficiency virus (HIV) infection is associated with mucosal dysfunction, inflammation, and disease progression. We performed a preclinical evaluation of the safety and efficacy of fecal microbiota transplantation (FMT) as a potential therapeutic in ...

journal_title：Journal of virology

authors： Hensley-McBain T,Zevin AS,Manuzak J,Smith E,Gile J,Miller C,Agricola B,Katze M,Reeves RK,Kraft CS,Langevin S,Klatt NR

更新日期：2016-04-29 00:00:00

abstract：:A recent experiment involving simian immunodeficiency virus (SIV) infection of macaques revealed that the infectivity of this virus decreased over the first few months of infection. Based on this observation, we introduce a viral dynamic model in which viral infectivity varies over time. The model is fit to viral load...

journal_title：Journal of virology

authors： Vaidya NK,Ribeiro RM,Miller CJ,Perelson AS

更新日期：2010-05-01 00:00:00

abstract：:Reovirus infection of the murine spinal cord (SC) was used as a model system to investigate innate immune responses during viral myelitis, including the activation of glia (microglia and astrocytes) and interferon (IFN) signaling and increased expression of inflammatory mediators. Reovirus myelitis was associated with...

journal_title：Journal of virology

authors： Schittone SA,Dionne KR,Tyler KL,Clarke P

更新日期：2012-08-01 00:00:00

abstract：:A fresh inoculum of human adenovirus type 12 (Ad12) was obtained from the American Type Culture Collection and passaged once on human embryonic kidney cells, and Ad12 DNA was prepared from the first-passage yield to avoid higher passages which might have generated host-virus DNA recombinants. The 18 PstI fragments of ...

journal_title：Journal of virology

authors： Sprengel J,Schmitz B,Heuss-Neitzel D,Zock C,Doerfler W

更新日期：1994-01-01 00:00:00