当前位置： SCI文献检索 > TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE期刊下所有文献 > Royal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 18th January 2001. Pathogen genomes and human health. Mycobacterial genomics.

Royal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 18th January 2001. Pathogen genomes and human health. Mycobacterial genomics.

Abstract：

:The small size of their genomes made bacterial ideal model organisms for the emerging field of genomics. Elucidating the genome sequences of mycobacteria was particularly attractive owing to the difficulties inherent in their manipulation. The slow growth rate, clumping, and requirement for category III containment make manipulation of Mycobacterium tuberculosis-complex strains laborious. M. leprae presents even greater problems as it has resisted all attempts at axenic culture. Availability of genome sequence data promised to accelerate our knowledge of the fundamental biology of these organisms, and to offer clues to the basis for their virulence, tropism and persistence in the host. This article will focus on what the genome sequences of M. tuberculosis and M. leprae have taught us about these pathogens, and how comparative genomics has exposed some of the fundamental differences between the species.

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

Gordon SV,Brosch R,Eiglmeier K,Garnier T,Hewinson RG,Cole ST

doi

10.1016/s0035-9203(02)90222-1

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

1-6

issue

1

eissn

0035-9203

issn

1878-3503

journal_volume

96

pub_type

杂志文章

相关文献

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE文献大全
  • Trypanosoma brucei gambiense African trypanosomiasis: differences between men and women in severity of disease and response to treatment.

    abstract：:To compare the characteristics of women and men with Trypanosoma brucei gambiense trypanosomiasis, all 3231 cases treated in Nioki hospital, Democratic Republic of Congo, from 1982 to 2000 were reviewed for demographic information, date and mode of diagnosis, pre-treatment cerebrospinal fluid (CSF) examination, treatm...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/s0035-9203(02)90380-9

    authors： Pépin J,Mpia B,Iloasebe M

    更新日期：2002-07-01 00:00:00

  • Identification of Naegleria fowleri in fresh isolates of environmental amoebae using a staphylococcal coagglutination technique.

    abstract：:A coagglutination test using Staphylococcus aureus Cowan strain 1 sensitized with specific antiserum successfully identified Naegleria fowleri in axenic and monoxenic culture by detection of a heat stable antigen released into the culture medium during growth. Strong coagglutination, visible to the naked eye, occurred...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(86)90141-0

    authors： Kilvington S,White DG

    更新日期：1986-01-01 00:00:00

  • Serum concentrations of chloroquine in a patient with a late recrudescence of Kenyan Plasmodium falciparum malaria.

    abstract：:A Swedish tourist who had visited Kenya fell ill with Plasmodium falciparum malaria 11 days after returning home, in spite of taking pyrimethamine (50 mg weekly) as malaria prophylaxis. Chloroquine treatment (25 mg base/kg body-weight) giving serum concentrations of 0.30 mumol/l cleared the patent parasitaemia and the...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(81)90093-6

    authors： Faehlmann M,Rombo L,Hedman P

    更新日期：1981-01-01 00:00:00

  • Prevalence and associated risk factors of Taenia solium taeniasis in a rural pig farming community of north India.

    abstract：:There is a lack of information on the disease burden due to Taenia solium taeniasis and its associated risk factors in pig farming communities throughout the world. The present study was conducted in a rural pig farming community of north India to estimate the prevalence of T. solium taeniasis and associated factors. ...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/j.trstmh.2007.04.019

    authors： Prasad KN,Prasad A,Gupta RK,Pandey CM,Singh U

    更新日期：2007-12-01 00:00:00

  • The duration of the antibody response to meningococcal vaccination in an African village.

    abstract：:Sera were obtained from 119 Nigerian villagers two years after immunization with group A and group C meningococcal polysaccharide vaccines. Measurement of meningococcal antibody levels in individual serum samples by the haemagglutination technique showed that two years after vaccination the mean group A meningococcal ...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(80)90195-9

    authors： Greenwood BM,Whittle HC,Bradley AK,Fayet MT,Gilles HM

    更新日期：1980-01-01 00:00:00

  • Malaria transmission and rice cultivation in Lagdo, northern Cameroon.

    abstract：:Cross-sectional entomological surveys were carried out during the 2006 dry and rainy seasons in Lagdo, Cameroon to measure the impact of rice cultivation on malaria transmission and to monitor vector susceptibility to insecticides. Adult anopheline mosquitoes were captured on human volunteers and by pyrethrum spray co...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/j.trstmh.2007.12.010

    authors： Antonio-Nkondjio C,Atangana J,Ndo C,Awono-Ambene P,Fondjo E,Fontenille D,Simard F

    更新日期：2008-04-01 00:00:00

  • A method for diagnosis of microsporidiosis adapted for use in developing countries.

    abstract：:Microsporidiosis in AIDS patients has emerged as an important cause of morbidity, but diagnosis requires special stains, equipment and expertise. Here we describe a modification to an existing staining technique to allow more rapid preparation, without additional equipment, facilitating research in the tropics into th...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/s0035-9203(01)90093-8

    authors： Sianongo S,McDonald V,Kelly P

    更新日期：2001-11-01 00:00:00

  • Case reports: acute hookworm infection: an unusual cause of profuse watery diarrhoea in returned travellers.

    abstract：:We describe 3 returned travellers who developed profuse watery diarrhoea associated with marked blood eosinophilia. Delayed appearance of ova in stool samples caused difficulty in establishing diagnoses of acute hookworm infection. Low activity of ivermectin against hookworm resulted in failure of empiric treatment wi...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/s0035-9203(03)90073-3

    authors： Lawn SD,Grant AD,Wright SG

    更新日期：2003-07-01 00:00:00

  • Epidemic dropsy following transcutaneous absorption of Argemone mexicana oil.

    abstract：:Four cases manifesting features characteristic of epidemic dropsy following body massage with contaminated mustard oil are reported. A transcutaneous route of absorption for the toxin (sanguinarine) resulting in epidemic dropsy has not been documented previously in man. Oil used for body massage was found to be adulte...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(85)90079-3

    authors： Sood NN,Sachdev MS,Mohan M,Gupta SK,Sachdev HP

    更新日期：1985-01-01 00:00:00

  • Evaluation of a 200-kDa amastigote-specific antigen of L. donovani by enzyme-linked immunosorbent assay (ELISA) for the diagnosis of visceral leishmaniasis.

    abstract：:A purified 200-kDa antigenic fraction from Leishmania donovani axenic amastigotes was evaluated by ELISA for the detection of antibody response in visceral leishmaniasis (VL) patients, post kala-azar dermal leishmaniasis (PKDL) patients and controls, for the diagnosis of visceral leishmaniasis. A positive antibody res...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/s0035-9203(00)90264-5

    authors： Kaul P,Malla N,Kaur S,Mahajan RC,Ganguly NK

    更新日期：2000-03-01 00:00:00

  • Parenteral sulphadoxine-pyrimethamine (Fansidar): an effective and safe but under-used method of anti-malarial treatment.

    abstract：:One hundred and eighteen patients with acute falciparum malaria were randomized into treatment with either intramuscular or oral sulfadoxine-pyrimethamine (Fansidar, Roche) and the results were compared with those from 68 patients treated in parallel with chloroquine. Parasitological cure rate was 97% with oral sulfad...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0035-9203(90)90131-w

    authors： Salako LA,Adio RA,Sowunmi A,Walker O

    更新日期：1990-09-01 00:00:00

  • Prognostic significance of rises in parasitaemia during treatment of falciparum malaria.

    abstract：:Transient rises in parasitaemia occur commonly during the treatment of falciparum malaria but their prognostic significance has not been well defined. Twelve-hourly parasite counts from 133 malaria patients who were ultimately cured were therefore compared with counts from 97 therapeutic failures to determine if incre...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(92)90217-z

    authors： Watt G,Shanks GD,Phintuyothin P

    更新日期：1992-07-01 00:00:00

  • Procalcitonin and neopterin levels do not accurately distinguish bacterial from viral infections in ill-returned travellers with fever.

    abstract：:The diagnostic performance of procalcitonin and neopterin as markers for bacterial and viral causes of fever was evaluated in a cohort of 69 febrile travellers with known etiological agents. Our aim was to establish a decision rule to minimize empirical antibiotic treatment. Compared with C-reactive protein (CRP) and ...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/j.trstmh.2012.01.001

    authors： te Witt R,Hassing RJ,Petit PP,van Belkum A,van Genderen PJ

    更新日期：2012-04-01 00:00:00

  • Opisthorchis viverrini infection in Thailand: symptoms and signs of infection--a population-based study.

    abstract：:A population-based study of the clinical, laboratory and ultrasonographic findings in patients suffering from mild or moderate opisthorchiasis in Prachinburi province, Thailand was conducted in 1990-1992. The effectiveness of treatment with praziquantel at 40 mg/kg body weight was evaluated. After treatment, a long-la...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(94)90164-3

    authors： Pungpak S,Chalermrut K,Harinasuta T,Viravan C,Schelp PF,Hempfling A,Schlattmann P,Bunnag D

    更新日期：1994-09-01 00:00:00

  • In vitro susceptibility of Plasmodium falciparum malaria to pyrimethamine, sulfadoxine, trimethoprim and sulfamethoxazole, singly and in combination.

    abstract：:Two isolates of Plasmodium falciparum (F 32 and K 1) were tested against sulfadoxine (SDX), sulfamethoxazole (SMZ), pyrimethamine (PYR) and trimethoprim (TMP), using a 48 h microtest, with RPMI-1640 low in PABA and folic acid. The IC50 for F 32 was: PYR 6.1 X 10(-9) M (mol/litre), TMP 1.3 X 10(-7) M, Fansidar (SDX/PYR...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(87)90226-4

    authors： Petersen E

    更新日期：1987-01-01 00:00:00

  • Ethiopian visceral leishmaniasis patients co-infected with human immunodeficiency virus.

    abstract：:This communication reports 7 Ethiopian visceral leishmaniasis (VL) patients co-infected with human immunodeficiency virus (HIV). The clinical and laboratory findings in 6 patients did not differ from classical VL. All patients had highly elevated anti-leishmanial antibody titres, determined by immunoglobulin G-based e...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(95)90497-2

    authors： Berhe N,Hailu A,Wolday D,Negesse Y,Cenini P,Frommel D

    更新日期：1995-03-01 00:00:00

  • Echinococcosis in Ningxia Hui Autonomous Region, northwest China.

    abstract：:Cystic echinococcosis (CE), caused by Echinococcus granulosus, and alveolar echinococcosis (AE), due to E. multilocularis, are endemic to large areas of north and northwest China. Here we review features of a severe focus of AE and CE in Ningxia Hui Autonomous Region (NHAR), northwest China. We describe for NHAR the r...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章,评审

    doi：10.1016/j.trstmh.2008.01.007

    authors： Yang YR,Craig PS,Sun T,Vuitton DA,Giraudoux P,Jones MK,Williams GM,McManus DP

    更新日期：2008-04-01 00:00:00

  • Medicinal plants and Malaria: an historical case study of research at the London School of Hygiene and Tropical Medicine in the twentieth century.

    abstract：:Interest in medicinal plants has increased in recent years. This article examines the history of medicinal plant research through a case study of the London School of Hygiene and Tropical Medicine (LSHTM) over the past 100 years. Papers published by members of the School and documents in the School archives show a flu...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.trstmh.2005.11.017

    authors： Taylor S,Berridge V

    更新日期：2006-08-01 00:00:00

  • Antigenic activity in adult Dipetalonema viteae in the indirect immunofluorescent test against sera from filariasis patients--the immunofluorescent histological search for "pure" antigen.

    abstract：:Using IFAT, it has been shown that isolated egg-shells and uterine fluid of Dipetalonema viteae are the most potent antigens in heterologous systems using human sera from patients infected with Wuchereria bancrofti, Onchocerca volvulus and Loa loa, as well as in homologous systems using sera from animals infected with...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(79)90045-2

    authors： Diesfeld HJ,Kirsten C

    更新日期：1979-01-01 00:00:00

  • Interruption of shigellosis by hand washing.

    abstract：:High attack rates, increasing resistance to antibiotics and high mortality make shigellosis a serious problem. As Shigella is associated with poor hygiene we examined the effectiveness of a simple intervention, washing hands with soap and water, in checking the spread of the disease. The study population was comprised...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(82)90266-8

    authors： Khan MU

    更新日期：1982-01-01 00:00:00

  • The seroprevalence of Helicobacter pylori and its relationship to malaria in Ugandan children.

    abstract：:Helicobacter pylori epidemiology in sub-Saharan Africa, particularly among children, has been little investigated. A secondary endpoint of our study was to examine for associations between the seroprevalence of H. pylori and the incidence of malaria. We explored H. pylori prevalence by measuring serum IgG antibodies t...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/j.trstmh.2011.09.001

    authors： Gupta V,Perez-Perez GI,Dorsey G,Rosenthal PJ,Blaser MJ

    更新日期：2012-01-01 00:00:00

  • Tuberculous lymphadenitis, a diagnostic problem in areas of high prevalence of HIV and tuberculosis.

    abstract：:The human immunodeficiency virus (HIV) epidemic is associated with a marked increase of tuberculosis cases. The influence of HIV on diagnostic methods for tuberculous lymphadenitis is less clear. In an environment of high HIV and tuberculosis prevalence in Blantyre, Malawi, a prospective study compared results of basi...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/s0035-9203(97)90081-x

    authors： Bekedam HJ,Boeree M,Kamenya A,Liomba G,Ngwira B,Subramanyam VR,Harries AD

    更新日期：1997-05-01 00:00:00

  • Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns.

    abstract：:Leishmaniasis is a worldwide disease, but due to the absence of surveillance systems is under-reported from low- and middle-income countries. In Ethiopia, the disease is found in the rural highlands and the incidence of Leishmania/HIV co-infection is increasing. Although some studies have been carried out in areas of ...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/j.trstmh.2009.02.023

    authors： Padovese V,Terranova M,Toma L,Barnabas GA,Morrone A

    更新日期：2009-07-01 00:00:00

  • Mycetoma - a history of the first contributions to the description of the disease and its pathogenesis.

    abstract：:Tracking the history of the discovery of mycetoma is not simple because identifying the roots of medical knowledge depends on utilising sources that employ imprecise and sometimes confusing descriptions when compared with those based on modern medical terminology. Ancient sources of information include writings, such ...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1093/trstmh/traa134

    authors： Hay RJ

    更新日期：2020-11-17 00:00:00

  • National scale-up of tuberculosis-human immunodeficiency virus collaborative activities in Myanmar from 2005 to 2016 and tuberculosis treatment outcomes for patients with human immunodeficiency virus-positive tuberculosis in the Mandalay Region in 2015.

    abstract：Background:HIV-associated TB is a serious public health problem in Myanmar. Study objectives were to describe national scale-up of collaborative activities to reduce the double burden of TB and HIV from 2005 to 2016 and to describe TB treatment outcomes of individuals registered with HIV-associated TB in 2015 in the Ma...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1093/trstmh/trx073

    authors： Theingi P,Harries AD,Wai KT,Shewade HD,Saw S,Win T,Thein S,Kyi MS,Nyunt Oo H,Aung ST

    更新日期：2017-09-01 00:00:00

  • alpha1-acid glycoprotein and alpha1-antitrypsin as early markers of treatment response in patients receiving the intensive phase of tuberculosis therapy.

    abstract：:The identification of early markers that predict the response to anti-tuberculosis treatment would facilitate evaluation of new drugs and improve patient management. This study aimed to determine whether selected acute phase proteins and micronutrients measured at the time of diagnosis and during the first weeks of tr...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/j.trstmh.2008.11.024

    authors： Almeida ML,Barbieri MA,Gurgel RQ,Abdurrahman ST,Baba UA,Hart CA,Shenkin A,Silva AM,de Souza L,Cuevas LE

    更新日期：2009-06-01 00:00:00

  • Strongyloides stercoralis septicaemia following steroid therapy for eosinophilia: report of three cases.

    abstract：:Three apparently immunocompetent patients died in the intensive care unit at Loni Hospital, Ahmednagar, Maharashtra, India, between 2001 and 2006 due to multiorgan failure and Strongyloides stercoralis septicaemia following a short course of corticosteroid (prednisolone) therapy of 6-17 days for peripheral blood eosin...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/j.trstmh.2007.05.021

    authors： Ghosh K,Ghosh K

    更新日期：2007-11-01 00:00:00

  • Guinea worm (Dracunculiasis) eradication: update on progress and endgame challenges.

    abstract：:The International Commission for the Certification of Dracunculiasis Eradication (ICCDE) met in December to review progress towards eradication. The status of the programme was presented by WHO and The Carter Center, Atlanta. The Commission received reports from international certification teams that Cote d'Ivoire, Ni...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1093/trstmh/tru039

    authors： Al-Awadi AR,Al-Kuhlani A,Breman JG,Doumbo O,Eberhard ML,Guiguemde RT,Magnussen P,Molyneux DH,Nadim A

    更新日期：2014-05-01 00:00:00

  • Semi-quantitative detection of Mycobacterium leprae antigens in skin scrapings: suitability as a laboratory aid for field diagnosis of leprosy.

    abstract：:We describe here a method, potentially suitable for field applications, for semi-quantitative detection of Mycobacterium leprae antigens in skin scrapings, which are taken normally for smear microscopy. Thirty acid-fast bacilli-negative paucibacillary (PB) leprosy patients comprised the main study group; eight acid-fa...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/j.trstmh.2007.02.026

    authors： Chaturvedi V,Girdhar BK,Sengupta U,Sinha S

    更新日期：2007-07-01 00:00:00

  • Comparison of antibiotic regimens for treating louse-borne relapsing fever: a meta-analysis.

    abstract：:The optimum treatment for louse-borne relapsing fever (LBRF) has not been fully established. Eliminating spirochetes is often associated with the potentially lethal Jarisch-Herxheimer reaction (JHR). The objective of this meta-analysis was to review the evidence supporting the use of antibiotics usually employed for t...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.trstmh.2011.04.004

    authors： Guerrier G,Doherty T

    更新日期：2011-09-01 00:00:00