Abstract：
:The clinical targets for which new generations of antithrombotics have been or are currently under clinical development are those associated with a high risk for thromboembolism, (a) patients undergoing general, orthopedic, major abdominal, and cancer surgery, to prevent venous thromboembolism; (b) patients with deep-vein thrombosis and/or pulmonary embolism who are at high risk for extension or recurrence of thromboembolism; (c) patients with unstable angina or myocardial infarction treated with percutaneous transfemoral coronary angioplasty, in whom antithrombotic treatment aims to prevent subsequent arterial thrombus formation and reocclusion. In most of these conditions standard heparin at prophylactic or therapeutic doses has proven to be only moderately effective. Furthermore, standard heparin has a rather poor bioavailability, a large and unpredictable variability in anticoagulant response, and a non-specific binding to many plasma proteins. Moreover, heparin treatment is associated with side effects such as bleeding, heparin-induced thrombocytopenia, and osteopenia. New antithrombotics have been designed which more specifically inhibit pivotal activated coagulation factors, i.e., Xa and IIa, and have potentially fewer undesired interactions and side effects. In this review we first provide an overview of recent insights on the mechanism of blood coagulation and the levels at which antithrombotics interfere with this system. Subsequently, we discuss specific new antithrombotic agents, and in particular the results of recent clinical investigations.
journal_name
Ann Hematoljournal_title
Annals of hematologyauthors
Beijering RJ,ten Cate H,ten Cate JWdoi
10.1007/s002770050158subject
Has Abstractpub_date
1996-04-01 00:00:00pages
177-83issue
4eissn
0939-5555issn
1432-0584journal_volume
72pub_type
杂志文章,评审abstract：:Paul Kaznelson is credited with describing the first case of pure red cell aplasia. He was also known for his contribution to the discovery of the therapeutic role of splenectomy in idiopathic thrombocytopenic purpura. Most of his academic works appeared in 1910s and 1920s, when he used to work in Karl-Ferdinand Unive...
journal_title：Annals of hematology
pub_type： 传,历史文章,杂志文章
doi：10.1007/s00277-008-0553-1
更新日期：2008-11-01 00:00:00
abstract：:Although cytopenia is a common manifestation of myelodysplastic syndrome (MDS), isolated thrombocytopenia is rare. The term "refractory thrombocytopenia" (RTC) has been proposed as a counterpart of refractory anemia. We describe here a case of RTC associated with chromosome abnormality on 11q23. A 59-year-old man was ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050209
更新日期：1996-08-01 00:00:00
abstract：:Follicular lymphoma (FL) is generally considered an indolent disorder. With modern day treatments, long remissions are often achieved both in the front-line and relapsed setting. However, a subset of patients has a more aggressive course and a worse outcome. Their identification is the main purpose of modern day progn...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-017-3154-z
更新日期：2018-02-01 00:00:00
abstract：:Autologous stem cell transplant (ASCT) is an effective treatment for non-Hodgkin lymphoma (NHL). However, recent supply issues and toxicity of carmustine have necessitated a new conditioning regimen. We conducted a multicenter, phase II study of BEB (busulfan, etoposide, and bendamustine) conditioning regimen for ASCT...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-020-03942-6
更新日期：2020-04-01 00:00:00
abstract：:Recombinant human granulocyte colony-stimulating factor (rhG-CSF) and erythropoietin (rhE-PO) were used to treat ten patients with myelodysplastic syndromes (MDS). None of the patients showed a favorable response in erythrocyte and platelet counts following 10 weeks' treatment, although favorable responses in neutroph...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01834360
更新日期：1994-04-01 00:00:00
abstract：:There is increasing evidence for the role of chronic antigenic stimulation (CS) in the development of cancer. Clinical data, however, are rare as is the information on outcome. In this study, the occurrence of chronic infections (CI) and autoimmune diseases (AI) in patients with malignant lymphoma at diagnosis was ass...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-011-1178-3
更新日期：2011-08-01 00:00:00
abstract：:We report a factor X (FX)-deficient Chinese family with two novel FX gene (F10) mutations. Two sibling probands had a bleeding tendency since childhood. Both had very low FX:C (<0.01 IU/ml) and FX:Ag (5-6%) levels and were heterozygous for two novel F10 mutations, a 2-bp GC deletion involving nucleotides 33 and 34, le...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0803-1
更新日期：2004-05-01 00:00:00
abstract：:MicroRNAs are a class of small non-coding RNAs that are 19-22 nucleotides in length and regulate a variety of biological processes at the post-transcriptional level. MicroRNA dysregulation disrupts normal biological processes, resulting in tumorigenesis. Acute myeloid leukemia is an invasive hematological malignancy c...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-019-03887-5
更新日期：2020-03-01 00:00:00
abstract：:Interstitial pneumonia (IP) is a lethal complication in lymphoma patients undergoing chemotherapy. A total of 2212 consecutive patients diagnosed with lymphoma between 2009 and 2014 were enrolled in the present study. IP was defined as diffuse pulmonary interstitial infiltrate found on computed tomography scans. IP wa...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-017-3157-9
更新日期：2018-01-01 00:00:00
abstract：:We present a patient with chronic myelomonocytic leukemia who showed disseminated papules and nodules. Arguments in favor of leukemia cutis are the clinical appearance, the cyclic pattern with which the lesions appeared and disappeared, and the histologic features. The lesions reproducibly responded to treatment with ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770000156
更新日期：2000-07-01 00:00:00
abstract：:Primary non-Hodgkin's lymphoma of bone (PLB) is a rare entity. We present three new cases and a review of the literature. If PLB is suspected radiologically, the diagnosis must be confirmed by open biopsy. Histopathologically, PLB usually represents diffuse large B-cell lymphoma or lymphoma of the follicular center ty...
journal_title：Annals of hematology
pub_type： 杂志文章,评审
doi：10.1007/s00277-003-0674-5
更新日期：2003-07-01 00:00:00
abstract：:Parenteral human immunoglobulin (IVIG) administration is widely used in low birth weight (LBW) infants for prevention and therapy of neonatal infection. In previous studies, IVIG preparations containing IgG and low IgM concentrations were commonly used. In this study we compare immunoglobulin serum levels in two group...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01703445
更新日期：1991-10-01 00:00:00
abstract：:In this prospective multicentric study, we investigated the contribution of positron emission tomography (PET) scanning to the staging of Hodgkin's lymphoma (HL) by computed tomography (CT) and attempted to determine whether it has any impact on therapeutic approach. One hundred eighty six consecutive patients with HL...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-007-0356-9
更新日期：2007-12-01 00:00:00
abstract：:This retrospective single-center analysis studied the impact of the conditioning and the graft-versus-host disease (GVHD) prophylaxis on outcome in unselected patients allografted for chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML) secondary to documented prior CMML. A total of 44 patients (med...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-020-03952-4
更新日期：2020-04-01 00:00:00
abstract：:Established risk factors for thrombosis in essential thrombocythemia (ET) include age (≥ 60 years) and previous vascular events. Recently, also leukocytosis has been proposed in risk stratification of ET patients. We report a retrospective study on 532 ET patients followed for a median of 7.6 years. Sixty-four patient...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-010-1154-3
更新日期：2011-08-01 00:00:00
abstract：:Neutral red is a vital stain known to be accumulated in the lysosomes of neutrophils and monocytes. It is used mainly to identify and detect the activated state of these cells. We have found that the extracellular application of physiological ceramide, i.e., a product of sphingomyelin hydrolysis and a newly defined in...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770050015
更新日期：2000-02-01 00:00:00
abstract：:Most cases of erythrocytosis occur secondary to chronic tissue hypoxia or as a clonal disease such as polycythemia vera with somatic mutations in the Janus kinase 2 (JAK2) gene. Rarely, erythrocytosis is caused by hereditary gene mutations. This study investigated hereditary gene mutations in 38 unrelated Korean patie...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-014-2006-3
更新日期：2014-06-01 00:00:00
abstract：:To investigate whether cytokine genetic polymorphisms influence the outcome of diffuse large B cell lymphoma (DLBCL), we tested 337 consecutive DLBCL treated with CHOP or rituximab-CHOP (R-CHOP) from interleukin 10 (IL10), Bcl-2, and tumor necrosis factor (TNF)-α polymorphisms. Patients who carried the IL10 rs1800871 ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2857-x
更新日期：2017-02-01 00:00:00
abstract：:The use of prophylactic antimicrobials during autologous peripheral blood stem cell transplantation (APBSCT) remains controversial. A prospective study was therefore conducted to examine whether the use of prophylactic antimicrobials is necessary. In this study, all the antimicrobials were given therapeutically rather...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-002-0567-z
更新日期：2003-01-01 00:00:00
abstract：:Somatic mutations in the SF3B1 gene, a gene encoding the splicing factor 3B subunit 1, were recently reported in myelodysplastic syndromes (MDS), particularly in the presence of ring sideroblasts (RS). The authors investigated the prevalence and clinical significance of SF3B1 mutations in Korean patients with myeloid ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1915-x
更新日期：2014-04-01 00:00:00
abstract：:Thrombotic thrombocytopenic purpura (TTP) is a hematologic disorder which is clinically characterized by thrombocytopenia, microangiopathic hemolytic anemia, fever, neurologic symptoms, and cardiac and renal involvement. The pathogenic mechanisms of this disease are poorly understood. It is well known that TTP is asso...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/BF01738304
更新日期：1992-05-01 00:00:00
abstract：:Primary myelofibrosis (PMF)-associated pruritus is often severe and requires treatment. Fifty-one patients with bone marrow-proven PMF with associated pruritus were identified from a primary cohort of patients with PMF (n = 566) seen at our institution. We conducted a retrospective review of the clinical characteristi...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2674-2
更新日期：2016-06-01 00:00:00
abstract：:We analyzed the prognostic factors for a successful mobilization and peripheral blood stem cell collection in a series of 57 consecutive patients with multiple myeloma (MM); a new scoring system to predict an adequate mobilization in this subset of patients was also constructed. A total of 221 aphereses were performed...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s002770100351
更新日期：2001-10-01 00:00:00
abstract：:Although the outcome of patients with acute myeloid leukemia (AML) has improved by optimized chemotherapy regimens and bone marrow transplantation, leukemia relapse remains one of the most challenging problems during therapy. Sustained existence of AML blasts is a fundamental determinant for the development of leukemi...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-016-2913-6
更新日期：2017-04-01 00:00:00
abstract：:Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an uncommon type of cutaneous lymphoma with an aggressive natural history. It generally carries a poor prognosis despite standard anthracycline-based chemotherapy. The optimum therapy is unknown. We report the case of a 66-year-old man with CD4/CD8 double negat...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-003-0638-9
更新日期：2003-04-01 00:00:00
abstract：:Relapse remains one of the major obstacles in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) even after allogeneic hematopoietic stem cell transplantation. The persistence of leukemia-propagating cells (LPCs) may lead to the recurrence of Ph+ALL. Using a xenograft assay, LPCs enrichment in the ...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-018-3253-5
更新日期：2018-05-01 00:00:00
abstract：:The aims of this study are to determine the replacement rate of damaged hepatocytes by donor-derived cells in sex-mismatched recipient patients with thalassemia major and to determine whether co-transplantation of mesenchymal stem cells and hematopoietic stem cells (HSCs) can alleviate liver fibrosis. Ten sex-mismatch...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-017-3181-9
更新日期：2018-02-01 00:00:00
abstract：:Chronic hepatitis C (CHC) and iron overload are the main causes of liver disease in β-thalassemia major (βTM). There is limited data regarding the course of CHC in this population. All patients (n=144) from the thalassemia centre of the University Hospital of Patras were evaluated (January 1981 to June 2012). Patients...
journal_title：Annals of hematology
pub_type： 杂志文章
doi：10.1007/s00277-013-1692-6
更新日期：2013-06-01 00:00:00
abstract：:Hematopoietic chimerism can be used as a tool for patient management after allogeneic hematopoietic stem cell transplantation (HSCT). An increase in the proportion of recipient cells after transplantation is strongly associated with relapse in chronic myeloid leukemia. However, in acute myeloid leukemia (AML) the sign...
journal_title：Annals of hematology
pub_type： 临床试验,杂志文章
doi：10.1007/s00277-013-1858-2
更新日期：2014-02-01 00:00:00
abstract：:The benefits of intensive post-remission chemotherapy have not been verified in elderly patients with acute myeloid leukemia (AML). To reduce fatal complications caused by intensive post-remission therapy, we performed a prospective phase II multicenter trial of standard induction chemotherapy ('7+3' of cytarabine plu...
journal_title：Annals of hematology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00277-006-0110-8
更新日期：2006-06-01 00:00:00
