Prevalence and clinical impact of autoimmune diseases and chronic infections in malignant lymphomas at diagnosis.


:There is increasing evidence for the role of chronic antigenic stimulation (CS) in the development of cancer. Clinical data, however, are rare as is the information on outcome. In this study, the occurrence of chronic infections (CI) and autoimmune diseases (AI) in patients with malignant lymphoma at diagnosis was assessed. Of 367 patients [non-Hodgkin's lymphoma (NHL) N = 297, Hodgkin's lymphoma N = 70], 9.8% (N = 36) had a history of chronic antigenic stimulation (4.4% AI, 5.4% CI) at diagnosis. After a median observation time of 74.7 months, 118 patients have died. There were more male patients in this cohort. However, sex ratio among patients with chronic antigenic stimulation was skewed in favor of women (p = 0.018), in particular among lymphoma patients with AI (p = 0.001). NHL patients with autoimmune diseases showed a tendency to develop diffuse large B cell lymphoma [8 of 12 AI + NHL patients (66.7%) vs. 100 of 266 non-CS NHL (37.6%); p = 0.066]. No significant difference in overall survival (OS) between CS and non-CS patients could be observed (median OS after 48 months was: CS 77.7% vs. non-CS 71.8%). In conclusion, chronic antigenic stimulation at diagnosis appears to be associated with a higher prevalence in women, in particular among patients with autoimmune disease. However, no difference in overall survival was observed. This suggests that the presence of chronic inflammatory conditions does not decisively influence the outcome of lymphoma patients.


Ann Hematol


Annals of hematology


Vanura K,Späth F,Gleiss A,Le T,Porpaczy E,Skrabs C,Hauswirth A,Fleiss K,Wessely F,Gaiger A,Müllauer L,Jäger U




Has Abstract


2011-08-01 00:00:00












  • Rituximab in the treatment of idiopathic thrombocytopenic purpura (ITP).

    abstract::The objective of this study was to evaluate the efficacy and safety of rituximab in the treatment of patients with idiopathic thrombocytopenic purpura (ITP). A prospective study was performed at Mubarak Al-Kabeer University Hospital involving the use of rituximab in 14 patients who had previously been treated with ste...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Alasfoor K,Alrasheed M,Alsayegh F,Mousa SA

    更新日期:2009-03-01 00:00:00

  • Allogeneic bone marrow transplantation compared to peripheral blood stem cell transplantation for the treatment of hematologic malignancies: a meta-analysis based on time-to-event data from randomized controlled trials.

    abstract::Controversy remains regarding the transplant outcomes of human leukocyte antigen-identical related bone marrow transplantation (BMT) and peripheral blood stem cell transplantation (PBSCT) for the treatment of patients with hematological malignancies. To provide an estimate of the effect of BMT and PBSCT on clinical ou...

    journal_title:Annals of hematology

    pub_type: 杂志文章,meta分析


    authors: Chang YJ,Weng CL,Sun LX,Zhao YT

    更新日期:2012-03-01 00:00:00

  • Failure of combination therapy with recombinant granulocyte colony-stimulating factor and erythropoietin in myelodysplastic syndromes.

    abstract::Recombinant human granulocyte colony-stimulating factor (rhG-CSF) and erythropoietin (rhE-PO) were used to treat ten patients with myelodysplastic syndromes (MDS). None of the patients showed a favorable response in erythrocyte and platelet counts following 10 weeks' treatment, although favorable responses in neutroph...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Imamura M,Kobayashi M,Kobayashi S,Yoshida K,Mikuni C,Ishikawa Y,Matsumoto S,Sakamaki S,Niitsu Y,Hinoda Y

    更新日期:1994-04-01 00:00:00

  • Eltrombopag: an update on the novel, non-peptide thrombopoietin receptor agonist for the treatment of immune thrombocytopenia.

    abstract::Immune thrombocytopenia (ITP) is characterised by a transient or persistent decrease in platelets accompanied by an increased risk of bleeding, which can have a significant negative impact on patients' health-related quality of life. The condition has long been associated with an increased rate of immune-mediated plat...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审


    authors: Kühne T,Imbach P

    更新日期:2010-07-01 00:00:00

  • Busulfan, cyclophosphamide, and etoposide as high-dose conditioning regimen in patients with malignant lymphoma.

    abstract::We investigated the efficacy and toxicity of the combination of busulfan, cyclophosphamide, and etoposide (Bu/Cy/VP-16) as a preparative regimen prior to autologous hematopoietic stem cell transplantation (ASCT) in patients with Hodgkin's disease (HD) or non-Hodgkin's lymphoma (NHL). Fifty-three patients with recurren...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Hänel M,Kröger N,Sonnenberg S,Bornhäuser M,Krüger W,Kroschinsky F,Hänel A,Metzner B,Birkmann J,Schmid B,Hoffknecht MM,Fiedler F,Ehninger G,Zander AR

    更新日期:2002-02-01 00:00:00

  • Polyclonal IgG4 hypergammaglobulinemia associated with plasmacytic lymphadenopathy, anemia and nephropathy.

    abstract::Marked polyclonal immunoglobulin (Ig)G4 hypergammaglobulinemia has exceptionally been reported. Here we report on two Algerian patients who presented a syndrome characterized by anemia, plasmacytic lymphadenopathy, renal manifestations, and a marked polyclonal IgG4 hypergammaglobulinemia leading to a hyperviscosity sy...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Boulanger E,Fuentes V,Meignin V,Mougenot B,Labaume S,Gouilleux-Gruart V,Cogné M,Aucouturier P,Clauvel JP,Ronco P,Lassoued K

    更新日期:2006-12-01 00:00:00

  • The association of venous thromboembolism with survival in pediatric cancer patients: a population-based cohort study.

    abstract::Venous thromboembolism (VTE) is a well-recognized complication in pediatric oncology patients. Studies in adult oncology patients have suggested a potential negative association between VTE and survival, but this association has not been examined in pediatric patients yet. The aim of this study was to assess the assoc...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究


    authors: Forbrigger Z,Kuhle S,Brown MM,Moorehead PC,Digout C,Kulkarni K

    更新日期:2018-10-01 00:00:00

  • Steady-state sVCAM-1 serum levels in adults with sickle cell disease.

    abstract::Cytokines and adhesion molecules play an important role in the pathophysiology of vaso-occlusion in sickle cell disease (SCD), and their in vivo profiles are potential tools for assessing SCD severity. We compared steady-state soluble vascular cell adhesion molecule-1 (sVCAM-1) serum levels to clinical (painful crisis...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Schnog JB,Rojer RA,Mac Gillavry MR,Ten Cate H,Brandjes DPM,Duits AJ

    更新日期:2003-02-01 00:00:00

  • Stroke prevention in the young child with sickle cell anaemia.

    abstract::Cerebrovascular disease resulting in stroke is a serious and preventable complication of sickle cell anaemia (SCA). Children at high risk of preventable stroke can be identified by transcranial Doppler ultrasound (TCD). Current guidelines in the UK recommend annual TCD screening from 3 years, although studies suggest ...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Roberts L,O'Driscoll S,Dick MC,Height SE,Deane C,Goss DE,Pohl K,Rees DC

    更新日期:2009-10-01 00:00:00

  • Association of CD4+/CD56+/CD57+/CD8+(dim) large granular lymphocytic leukemia, splenic B-cell lymphoma with circulating villous lymphocytes, and idiopathic erythrocytosis.

    abstract::In this paper we report a rare association of a splenic marginal zone B-cell lymphoma with villous lymphocytes and a T-cell large granular lymphocytic leukemia coexpressing CD4 and CD8 as well as CD56 and CD57 natural killer-associated markers in an asymptomatic patient investigated because of an occasional finding of...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Lima M,Gonçalves C,Marques L,Martin MC,Teixeira MA,Queirós ML,Santos AH,Balanzategui A,Garcia-Sanz R,Pinto-Ribeiro AC,Justiça B,Orfão A

    更新日期:2001-11-01 00:00:00

  • Interferon alpha in the treatment of polycythemia vera.

    abstract::Interferon alpha (IFN) inhibits the growth of the abnormal clone in patients with myeloproliferative disorders, leading to a reduction of the clinical and laboratory signs of the pathologic myeloproliferation. The therapeutic efficacy of IFN in polycythemia vera (PV) is demonstrated by the summarized treatment results...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审


    authors: Lengfelder E,Berger U,Hehlmann R

    更新日期:2000-03-01 00:00:00

  • Allogeneic bone marrow transplantation for refractory mantle cell lymphoma.

    abstract::We report about a 28-year-old woman with relapsed mantle cell lymphoma (MCL, centrocytic lymphoma according to the Kiel classification) refractory to salvage chemotherapy. The patient underwent allogeneic bone marrow transplantation from a HLA-identical brother after myeloablative chemotherapy consisting of busulfan, ...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Kröger N,Hoffknecht M,Krüger W,Zeller W,Renges H,Stute N,Zschaber R,Zander AR

    更新日期:2000-10-01 00:00:00

  • Quality-adjusted survival analysis shows differences in outcome after immunosuppression or bone marrow transplantation in aplastic anemia.

    abstract::Bone marrow transplantation (BMT) and immunosuppression (IS) have improved the prognosis of aplastic anemia; both treatments have specific advantages and drawbacks but similar survival rates. Analysis of additional endpoints may help in treatment decisions. In a single-center study, patients with aplastic anemia treat...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Viollier R,Passweg J,Gregor M,Favre G,Kühne T,Nissen C,Gratwohl A,Tichelli A

    更新日期:2005-01-01 00:00:00

  • NADPH oxidase is not required for spontaneous and Staphylococcus aureus-induced apoptosis of monocytes.

    abstract::Reactive oxygen intermediates (ROI) generated in the respiratory burst reaction are crucial for the killing of bacteria and fungi in phagocytes. The key enzyme for the respiratory burst reaction is the NADPH oxidase. Reactive oxygen intermediates have additionally been proposed to be of general importance for the expr...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: v Bernuth H,Kulka C,Roesler J,Gahr M,Rösen-Wolff A

    更新日期:2004-04-01 00:00:00

  • Immunophenotyping of B lymphocytes by multiparametric flow cytometry in bone marrow aspirates of healthy adults.

    abstract::Establishing reference ranges by multiparametric immunophenotyping of mature B cells in bone marrow of healthy adults is of interest because the detection of bone marrow infiltration and persistence of light chain restriction, as well as discrimination between reactive and malignant lymphocytes are important applicati...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Höffkes HG,Schmidtke G,Schmücker U,Uppenkamp M,Brittinger G

    更新日期:1995-09-01 00:00:00

  • Nitric oxide metabolites and arginase I levels in β-thalassemic patients: an Egyptian study.

    abstract::Stored red blood cells become deficient in nitric oxide that limits their ability to transfer oxygen to tissues that need it. The aims of this study are to assess the endogenous nitric oxide metabolites (NOx) and arginase I levels in transfusion-dependent β-thalassemic patients; to compare these levels in patients tra...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: El-Hady SB,Farahat MH,Atfy M,Elhady MA

    更新日期:2012-08-01 00:00:00

  • Multiple myeloma in younger patients: the role of age as prognostic factor.

    abstract::The presenting features of 356 previously untreated multiple myeloma (MM) patients grouped according to age were analyzed in order (a) to elucidate the possible differences in initial clinical and laboratory features between patients younger than 50 years and the older ones and (b) to statistically assess the prognost...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Corso A,Klersy C,Lazzarino M,Bernasconi C

    更新日期:1998-02-01 00:00:00

  • Blood B, T, CD4+ and CD8+ lymphocytes in female Wistar rats.

    abstract::We have established reference values of peripheral blood lymphocyte subsets in healthy female Wistar rats under highly standardized conditions. Using monoclonal antibodies and flow cytometry, T lymphocytes (OX19+), B lymphocytes (OX6+ and anti-Ig+), T-helper/inducer (W3/25+), and T-suppressor/cytotoxic subsets (OX8+) ...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Franch A,Castellote C,Pelegrí C,Tolosa E,Castell M

    更新日期:1993-09-01 00:00:00

  • New prognostic model for extranodal natural killer/T cell lymphoma, nasal type.

    abstract::Extranodal natural killer/T cell lymphoma, nasal type (ENKTL) is an aggressive disease with a poor prognosis, requiring risk stratification in affected patients. We designed a new prognostic model specifically for ENKTL to identify high-risk patients who need more aggressive therapy. We retrospectively reviewed 158 pa...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Cai Q,Luo X,Zhang G,Huang H,Huang H,Lin T,Jiang W,Xia Z,Young KH

    更新日期:2014-09-01 00:00:00

  • Clinicopathological characteristics and outcomes of light chain deposition disease: an analysis of 48 patients in a single Chinese center.

    abstract::To explore the clinicopathological characteristics and outcomes of light chain deposition disease (LCDD) in a Chinese population, we retrospectively studied the clinicopathological data, treatment, and outcomes of 48 patients with biopsy-proven LCDD from a single center. Among the patients, there were 29 males and 19 ...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Li XM,Rui HC,Liang DD,Xu F,Liang SS,Zhu XD,Huang XH,Liu ZH,Zeng CH

    更新日期:2016-05-01 00:00:00

  • Notch1 signaling is irresponsible to the anti-leukemic effect of HDACis in B-ALL Nalm-6 cells.

    abstract::B cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematologic malignancy with limited treatment strategies. Histone deacetylases inhibitors (HDACis) are promising novel tools for cancer therapy, whose anti-tumor effects and the underlying mechanisms on B-ALL remain to be elucidated. Recently, Notch1 signali...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Shao N,Ma D,Wang J,Lu T,Guo Y,Ji C

    更新日期:2013-01-01 00:00:00

  • Epidemiology of chronic myeloid leukaemia: an update.

    abstract::National and regional population-based registries are, provided diagnostic accuracy and full coverage of the target population, indispensible tools for epidemiological research. Chronic myeloid leukaemia (CML) registries with more comprehensive reporting may also provide complementary data on treatment outcome to thos...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审


    authors: Höglund M,Sandin F,Simonsson B

    更新日期:2015-04-01 00:00:00

  • Effects of C282Y, H63D, and S65C HFE gene mutations, diet, and life-style factors on iron status in a general Mediterranean population from Tarragona, Spain.

    abstract::Mutations in the HFE gene result in iron overload and can produce hereditary hemochromatosis (HH), a disorder of iron metabolism characterized by increased intestinal iron absorption. Dietary quality, alcoholism and other life-style factors can increase the risk of iron overload, especially among genetically at risk p...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Aranda N,Viteri FE,Montserrat C,Arija V

    更新日期:2010-08-01 00:00:00

  • Downbeat nystagmus caused by thiamine deficiency: an unusual presentation of CNS localization of large cell anaplastic CD 30-positive non-Hodgkin's lymphoma.

    abstract::A 24-year-old woman with a large cell anaplastic CD 30-positive T-cell non-Hodgkin's lymphoma (NHL) developed downbeat nystagmus, anisocoria, and oscillopsia. Prior to overt cerebral invasion by NHL, she had a thiamine deficiency with very low thiamine concentrations in the CSF, probably caused by protracted vomiting ...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Mulder AH,Raemaekers JM,Boerman RH,Mattijssen V

    更新日期:1999-02-01 00:00:00

  • Overexpressed WT1 exhibits a specific immunophenotype in intermediate and poor cytogenetic risk acute myeloid leukemia.

    abstract::Many studies have confirmed that overexpressed WT1 exists in leukemic cells, especially in AML. However, the immunophenotypic features of this sort of leukemic cells remain to be unclarified. We retrospectively analyzed the immunophenotype of 283 newly diagnosed AML patients with intermediated and poor cytogenetic ris...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Wang XR,Chang Y,Yuan XY,Wang YZ,Qin YZ,Ruan GR,Lai YY,Liu YR

    更新日期:2020-02-01 00:00:00

  • Positron emission tomography in the staging of patients with Hodgkin's lymphoma. A prospective multicentric study by the Intergruppo Italiano Linfomi.

    abstract::In this prospective multicentric study, we investigated the contribution of positron emission tomography (PET) scanning to the staging of Hodgkin's lymphoma (HL) by computed tomography (CT) and attempted to determine whether it has any impact on therapeutic approach. One hundred eighty six consecutive patients with HL...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究


    authors: Rigacci L,Vitolo U,Nassi L,Merli F,Gallamini A,Pregno P,Alvarez I,Salvi F,Sancetta R,Castagnoli A,Versari A,Biggi A,Gregianin M,Pelosi E,Chisesi T,Bosi A,Levis A,Intergruppo Italiano Linfomi.

    更新日期:2007-12-01 00:00:00

  • Diagnostic value of bronchoscopy in patients with hematologic malignancy and pulmonary infiltrates.

    abstract::Pulmonary infections are a major cause of morbidity and mortality in patients with hematologic malignancy. Bronchoscopy is at present still the traditional first investigation in immunosuppressed patients that have developed pulmonary infiltrates. There is limited data available on the validity of fiberoptic bronchosc...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Kim SW,Rhee CK,Kang HS,Lee HY,Kang JY,Kim SJ,Kim SC,Lee SY,Kim YK,Lee JW

    更新日期:2015-01-01 00:00:00

  • Patients with primary diffuse large B-cell lymphoma of female genital tract have high risk of central nervous system relapse.

    abstract::The objective of this study was to evaluate retrospectively the clinical characteristics, treatments, and outcomes of patients with primary diffuse large B-cell lymphoma (DLBCL) of the female genital tract. The basic characteristics, treatments, and outcomes of six patients diagnosed with primary DLBCL of the female g...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Cao XX,Li J,Zhang W,Duan MH,Shen T,Zhou DB

    更新日期:2014-06-01 00:00:00

  • Genetic polymorphisms of HbE/beta thalassemia related to clinical presentation: implications for clinical diversity.

    abstract::HbE/Beta thalassemia (HbE/β-thalassemia) is one of the common genetic disorders in South East Asia. It is heterogeneous in its clinical presentation and molecular defects. There are genetic modifiers which have been reported to influence the disease severity of this disorder. The aim of this study was to determine the...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Azman NF,Abdullah WZ,Hanafi S,Diana R,Bahar R,Johan MF,Zilfalil BA,Hassan R

    更新日期:2020-04-01 00:00:00

  • sIL2R ratio as early marker for response in hairy cell leukemia and the prognostic relevance of IL28B genotype to interferon-α therapy.

    abstract::Interferon-α (IFNα) was the first effective drug therapy for hairy cell leukemia (HCL). Nowadays, it is used as an alternative treatment in selected patients. Due to unlimited treatment time, monitoring and early prediction of response are important. Moreover, IFNα is used in the therapy of chronic hepatitis C, where ...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Jud S,Goede JS,Senn O,Spanaus K,Manz MG,Benz R

    更新日期:2017-05-01 00:00:00