Prevalence and clinical impact of autoimmune diseases and chronic infections in malignant lymphomas at diagnosis.


:There is increasing evidence for the role of chronic antigenic stimulation (CS) in the development of cancer. Clinical data, however, are rare as is the information on outcome. In this study, the occurrence of chronic infections (CI) and autoimmune diseases (AI) in patients with malignant lymphoma at diagnosis was assessed. Of 367 patients [non-Hodgkin's lymphoma (NHL) N = 297, Hodgkin's lymphoma N = 70], 9.8% (N = 36) had a history of chronic antigenic stimulation (4.4% AI, 5.4% CI) at diagnosis. After a median observation time of 74.7 months, 118 patients have died. There were more male patients in this cohort. However, sex ratio among patients with chronic antigenic stimulation was skewed in favor of women (p = 0.018), in particular among lymphoma patients with AI (p = 0.001). NHL patients with autoimmune diseases showed a tendency to develop diffuse large B cell lymphoma [8 of 12 AI + NHL patients (66.7%) vs. 100 of 266 non-CS NHL (37.6%); p = 0.066]. No significant difference in overall survival (OS) between CS and non-CS patients could be observed (median OS after 48 months was: CS 77.7% vs. non-CS 71.8%). In conclusion, chronic antigenic stimulation at diagnosis appears to be associated with a higher prevalence in women, in particular among patients with autoimmune disease. However, no difference in overall survival was observed. This suggests that the presence of chronic inflammatory conditions does not decisively influence the outcome of lymphoma patients.


Ann Hematol


Annals of hematology


Vanura K,Späth F,Gleiss A,Le T,Porpaczy E,Skrabs C,Hauswirth A,Fleiss K,Wessely F,Gaiger A,Müllauer L,Jäger U




Has Abstract


2011-08-01 00:00:00












  • Transdifferentiation of mesenchymal stem cells into cardiomyocytes by direct cell-to-cell contact with neonatal cardiomyocyte but not adult cardiomyocytes.

    abstract::Recent studies have demonstrated that direct cell-to-cell interaction is one of the microenvironment factors for transdifferentiation of adult stem cells into cardiomyocytes. We investigated whether transdifferentiation of mesenchymal stem cells (MSCs) into cardiomyocytes was dependent on developmental stages of cocul...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Yoon J,Shim WJ,Ro YM,Lim DS

    更新日期:2005-10-01 00:00:00

  • Allogeneic stem cell transplantation from related and unrelated donors for aplastic anaemia in adults--a single-centre experience.

    abstract::Aplastic anaemia (AA) is a rare bone marrow failure syndrome treated either by immunosuppressive therapy or allogeneic stem cell transplantation (SCT). At present, no randomised clinical trials evaluating both treatment options, and in particular SCT from unrelated donors, are available. We here report the clinical co...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Buchholz S,Dammann E,Koenecke Ch,Stadler M,Franzke A,Blasczyk R,Bremer M,Krauter J,Hertenstein B,Ganser A,Eder M

    更新日期:2008-07-01 00:00:00

  • The Hellenic type of nondeletional hereditary persistence of fetal hemoglobin results from a novel mutation (g.-109G>T) in the HBG2 gene promoter.

    abstract::Nondeletional hereditary persistence of fetal hemoglobin (nd-HPFH), a rare hereditary condition resulting in elevated levels of fetal hemoglobin (Hb F) in adults, is associated with promoter mutations in the human fetal globin (HBG1 and HBG2) genes. In this paper, we report a novel type of nd-HPFH due to a HBG2 gene p...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Chassanidis C,Kalamaras A,Phylactides M,Pourfarzad F,Likousi S,Maroulis V,Papadakis MN,Vamvakopoulos NK,Aleporou-Marinou V,Patrinos GP,Kollia P

    更新日期:2009-06-01 00:00:00

  • A phase 1 clinical trial of flavopiridol consolidation in chronic lymphocytic leukemia patients following chemoimmunotherapy.

    abstract::Patients with chronic lymphocytic leukemia (CLL) who receive chemoimmunotherapy and do not achieve complete remission experience significantly shortened progression-free interval (PFS). Additionally, the majority of patients treated for relapsed disease demonstrate evidence of measurable disease. Eradication of minima...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章


    authors: Awan FT,Jones JA,Maddocks K,Poi M,Grever MR,Johnson A,Byrd JC,Andritsos LA

    更新日期:2016-06-01 00:00:00

  • Diffuse thyroid 18F-FDG uptake after R-CHOP therapy predicts favorable outcome in patients with DLBCL.

    abstract::Therapy-induced autoimmunity may mediate the destruction of cancer cells. Previous studies have demonstrated that presence of autoimmune thyroid disorder is associated with favorable outcome in patients with solid cancer. Patients with diffuse large B cell lymphoma (DLBCL) who achieved complete response on positron em...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Song MK,Chung JS,Kim SJ,Kim SS,Shin HJ

    更新日期:2015-06-01 00:00:00

  • Type 2B von Willebrand's disease due to Val1316Met mutation. Heterogeneity in the same sibship.

    abstract::An analysis was conducted in four members of the same family, two of whom had a history of severe bleeding associated with type 2B von Willebrand's disease (VWD) which, although found to be due to the same mutation, nevertheless exhibited different phenotype patterns in the two subjects involved. Von Willebrand's fact...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Rendal E,Penas N,Larrabeiti B,Pérez A,Vale A,López-Fernández MF,Batlle J

    更新日期:2001-06-01 00:00:00

  • A case of multicentric Castleman's disease associated with advanced systemic amyloidosis treated with chemotherapy and anti-CD20 monoclonal antibody.

    abstract::Multicentric Castleman's disease (MCD) is a rare systemic lymphoproliferative disorder with too few patient series reported in the literature to have a clear idea about the etiology, outcome and the best treatment available. Systemic reactive amyloidosis is a very rare complication of MCD and its presence worsens the ...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Gholam D,Vantelon JM,Al-Jijakli A,Bourhis JH

    更新日期:2003-12-01 00:00:00

  • Incidence and evaluation of predisposition to cardiovascular toxicity in chronic myeloid leukemia patients treated with bosutinib in the real-life practice.

    abstract::There is little information about cardiovascular adverse event (CV-AE) incidence in chronic myeloid leukemia (CML) patients treated with bosutinib in the real-life practice. We identified 54 consecutive CML patients treated with bosutinib, stratified according to the Systematic Coronary Risk Evaluation (SCORE) assessm...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Caocci G,Mulas O,Abruzzese E,Iurlo A,Annunziata M,Orlandi EM,Galimberti S,Binotto G,Sgherza N,Luciano L,Martino B,Russo Rossi A,Bonifacio M,Fozza C,Trawinska MM,Cattaneo D,Elena C,Baratè C,De Gregorio F,Molica M,L

    更新日期:2019-08-01 00:00:00

  • Pruritus in primary myelofibrosis: management options in the era of JAK inhibitors.

    abstract::Primary myelofibrosis (PMF)-associated pruritus is often severe and requires treatment. Fifty-one patients with bone marrow-proven PMF with associated pruritus were identified from a primary cohort of patients with PMF (n = 566) seen at our institution. We conducted a retrospective review of the clinical characteristi...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Vaa BE,Tefferi A,Gangat N,Pardanani A,Lasho TL,Finke CM,Wolanskyj AP

    更新日期:2016-06-01 00:00:00

  • Transplant outcomes of the triple-negative NPM1/FLT3-ITD/CEBPA mutation subgroup are equivalent to those of the favourable ELN risk group, but significantly better than the intermediate-I risk group after allogeneic transplant in normal-karyotype AML.

    abstract::The prognostic significance of molecular mutations (FLT3-ITD, NPM1, and CEBPA mutations) was examined in patients with normal-karyotype acute myeloid leukaemia (NK-AML) after allogeneic haematopoietic cell transplantation (HCT). In total, 115 patients received allogeneic HCT for NK-AML and were evaluated for FLT3-ITD,...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Ahn JS,Kim HJ,Kim YK,Jung SH,Yang DH,Lee JJ,Kim NY,Choi SH,Jung CW,Jang JH,Kim HJ,Moon JH,Sohn SK,Won JH,Kim SH,Kim DD

    更新日期:2016-03-01 00:00:00

  • MCNU in the treatment of essential thrombocythemia--a pilot study.

    abstract::The efficacy of a single dose of MCNU 150 mg was evaluated in nine symptomatic patients with essential thrombocythemia (ET). As the platelet counts increased during the following 4 weeks, an extra dose of 100 mg of MCNU was administered to three patients. All patients had thrombotic or hemorrhagic complications. Seven...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Murakami H,Tamura J,Sawamura M

    更新日期:1993-05-01 00:00:00

  • Randomized controlled trial of twice-daily versus alternate-day oral iron therapy in the treatment of iron-deficiency anemia.

    abstract::Recent studies in iron-depleted women have challenged the current approach of treating iron-deficiency anemia (IDA) with oral iron in divided daily doses. Alternate day dosing leads to more fractional absorption of iron. In this randomized controlled trial, we looked at the efficacy and safety of alternate-day (AD) ve...

    journal_title:Annals of hematology

    pub_type: 杂志文章,随机对照试验


    authors: Kaundal R,Bhatia P,Jain A,Jain A,Nampoothiri RV,Mishra K,Jandial A,Goni D,Sandal R,Jindal N,Meshram A,Sharma R,Khaire N,Singh C,Khadwal A,Prakash G,Das R,Varma N,Varma S,Malhotra P,Lad DP

    更新日期:2020-01-01 00:00:00

  • No evidence for neoantigens in human plasma after photochemical virus inactivation.

    abstract::Photodynamic virus inactivation of human fresh plasma mediated by visible light in the presence of the phenothiazine dyes methylene blue or toluidine blue was investigated to determine whether it influences functional, structural, and immunological properties of plasma proteins. The activities of the coagulation facto...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Mohr H,Knüver-Hopf J,Lambrecht B,Scheidecker H,Schmitt H

    更新日期:1992-11-01 00:00:00

  • Predictors for splenectomy among patients with primary chronic immune thrombocytopenia: a population-based cohort study from Denmark.

    abstract::We conducted a nationwide cohort study of adult Danish patients with primary chronic immune thrombocytopenia (cITP) to examine selected patient and clinical characteristics as predictors for splenectomy. We analyzed data from the Danish National Patient Registry and patient medical records from 1996 to 2007. Using Cox...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Jensen AO,Nørgaard M,Engebjerg MC,Farkas DK,Fryzek JP,Zhao S,Sørensen HT

    更新日期:2011-02-01 00:00:00

  • Platelet number and graft function predict intensive care survival in allogeneic stem cell transplantation patients.

    abstract::Despite significant advances in the treatment of complications requiring intensive care unit (ICU) admission, ICU mortality remains high for patients after allogeneic stem cell transplantation. We evaluated the role of thrombocytopenia and poor graft function in allogeneic stem cell recipients receiving ICU treatments...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章


    authors: Turki AT,Lamm W,Schmitt C,Bayraktar E,Alashkar F,Metzenmacher M,Wohlfarth P,Beelen DW,Liebregts T

    更新日期:2019-02-01 00:00:00

  • Rituximab therapy for hairy cell leukemia: a retrospective study of 41 cases.

    abstract::The purine analogs (PAs) cladribine and pentostatin have transformed the prognosis of hairy cell leukemia (HCL). However, some patients still relapse after PAs, or fail to reach an optimal response, and new agents are needed to further improve treatment outcome. We retrospectively studied 41 HCL patients from 10 cente...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究


    authors: Leclerc M,Suarez F,Noël MP,Vekhoff A,Troussard X,Claisse JF,Thieblemont C,Maloisel F,Beguin Y,Tamburini J,Barbe C,Delmer A

    更新日期:2015-01-01 00:00:00

  • Granulocyte-macrophage colony-stimulating factor and interleukin-3 in combination: a potent and consistent myelodysplastic syndrome bone marrow stimulant in vitro.

    abstract::In an effort to overcome bone marrow failure in myelodysplastic syndrome (MDS), we have investigated recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) in phase I-II clinical trials. Although these agents partially increased peripheral blood granulocyte counts, their e...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Estrov Z,Kurzrock R,Talpaz M,Blake M,Gutterman JU

    更新日期:1991-12-01 00:00:00

  • Epidemiology of chronic myeloid leukaemia: an update.

    abstract::National and regional population-based registries are, provided diagnostic accuracy and full coverage of the target population, indispensible tools for epidemiological research. Chronic myeloid leukaemia (CML) registries with more comprehensive reporting may also provide complementary data on treatment outcome to thos...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审


    authors: Höglund M,Sandin F,Simonsson B

    更新日期:2015-04-01 00:00:00

  • Myelodysplastic patients with raised percentage of hypochromic red cells have evidence of functional iron deficiency.

    abstract::Raised percentage hypochromic red cells (%HRC) were detected at diagnosis in 10 of 34 consecutive patients with low-risk myelodysplastic syndrome (MDS) [refractory anemia (RA) (4/26) and RA with ring sideroblasts (6/8)], all of whom had normal or increased serum ferritin and bone marrow iron stores. Elevated %HRC has ...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Murphy PT,Quinn JP,O'Donghaile D,Swords R,O'Donnell JR

    更新日期:2006-07-01 00:00:00

  • MicroRNAs: pivotal regulators in acute myeloid leukemia.

    abstract::MicroRNAs are a class of small non-coding RNAs that are 19-22 nucleotides in length and regulate a variety of biological processes at the post-transcriptional level. MicroRNA dysregulation disrupts normal biological processes, resulting in tumorigenesis. Acute myeloid leukemia is an invasive hematological malignancy c...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审


    authors: Li M,Cui X,Guan H

    更新日期:2020-03-01 00:00:00

  • High-dose chemotherapy with autologous stem cell support in poor-risk germ cell tumors.

    abstract::High-dose chemotherapy (HDT) and stem cell transplantation is a newer treatment option widely applied in poor-risk germ cell tumor patients. Due to the increasing practical clinical experience and the availability of hematopoietic growth factors, this treatment approach has become a relatively safe procedure. Dependin...

    journal_title:Annals of hematology

    pub_type: 杂志文章,评审


    authors: Siegert W,Rick O,Beyer J

    更新日期:1998-05-01 00:00:00

  • Evaluation of neutrophil-lymphocyte ratio in patients with early-stage mycosis fungoides.

    abstract::Neutrophil-lymphocyte ratio (NLR), an indicator of inflammation, has been lately demonstrated as a prognostic factor and an indicator of disease activity in various diseases. However, the effects of NLR have not been investigated in mycosis fungoides (MF) patients yet. The aim of this study is to investigate the relat...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Eren R,Nizam N,Doğu MH,Mercan S,Erdemir AV,Suyanı E

    更新日期:2016-10-01 00:00:00

  • Amyloid in bone marrow smears of patients affected by multiple myeloma.

    abstract::Systemic AL amyloidosis is associated with nearly 15% of cases of multiple myeloma, but data on the frequency and significance of amyloid deposits in the bone marrow of patients affected by multiple myeloma without clinical signs of systemic amyloidosis are scanty. Bone marrow smears of 166 unselected patients affecte...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Petruzziello F,Zeppa P,Catalano L,Cozzolino I,Gargiulo G,Musto P,D'Auria F,Liso V,Rizzi R,Caruso N,Califano C,Piro E,Musso M,Bonanno V,Pia Falcone A,Tafuto S,Di Raimondo F,De Laurentiis M,Pane F,Palombini L,Rotoli

    更新日期:2010-05-01 00:00:00

  • Prevalence of anemia among elderly inpatients and its association with multidimensional loss of function.

    abstract::The purpose of this cross-sectional prospective study was to determine the prevalence of anemia among elderly hospitalized patients in Germany and to investigate its association with multidimensional loss of function (MLF). One hundred participants aged 70 years or older from two distinct wards (50 each from an emerge...

    journal_title:Annals of hematology

    pub_type: 杂志文章


    authors: Zilinski J,Zillmann R,Becker I,Benzing T,Schulz RJ,Roehrig G

    更新日期:2014-10-01 00:00:00

  • Kinetics of minimal residual disease during induction/consolidation therapy in standard-risk adult B-lineage acute lymphoblastic leukemia.

    abstract::We have compared the kinetics of minimal residual disease (MRD) by simultaneous polymerase chain reaction (PCR) monitoring with oligonucleotides for the immunoglobulin heavy chain (IgH) complementarity-determining region 3 (CDR3) and the T-cell receptor gamma chain gene (TCR gamma), as well as clone-specific CDR3 sequ...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章


    authors: Scholten C,Födinger M,Mitterbauer M,Laczika K,Mitterbauer G,Haas OA,Knöbl P,Schwarzinger I,Thalhammer R,Purtscher B

    更新日期:1995-10-01 00:00:00

  • Low infectious morbidity in patients with heavily pretreated hematological malignancies receiving autologous peripheral blood stem cell transplantation without antimicrobial prophylaxis.

    abstract::The use of prophylactic antimicrobials during autologous peripheral blood stem cell transplantation (APBSCT) remains controversial. A prospective study was therefore conducted to examine whether the use of prophylactic antimicrobials is necessary. In this study, all the antimicrobials were given therapeutically rather...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章


    authors: Yeh SP,Chiu CF,Lo WJ,Lin CL,Hsueh CT,Liao YM,Shen YC

    更新日期:2003-01-01 00:00:00

  • CLIPI: a new prognostic index for indolent cutaneous B cell lymphoma proposed by the International Extranodal Lymphoma Study Group (IELSG 11).

    abstract::Indolent primary cutaneous B cell lymphomas (PCBCL) generally have a good prognosis, but they often relapse leading in some cases to extracutaneous disease and therefore, to poor survival. We developed a prognostic model to improve the therapeutic approach to these lymphomas. Two hundred and seventeen patients with di...

    journal_title:Annals of hematology

    pub_type: 杂志文章,多中心研究


    authors: Mian M,Marcheselli L,Luminari S,Federico M,Cantonetti M,Sarris AH,Rossi A,Rambaldi A,Frontani M,Devizzi L,Gianni AM,Busetto M,Berti E,Martinelli G,Tsang RW,Ferreri AJ,Pinotti G,Pogliani E,Zucca E,Cortelazzo S

    更新日期:2011-04-01 00:00:00

  • Headache prevalence following recovery from TTP and aHUS.

    abstract::Thrombotic thrombocytopenia purpura (TTP) and atypical hemolytic uremic syndromes (aHUS) are distinct clinical disorders characterized by hemolytic anemia, thrombocytopenia, microthrombi, and end organ damage. TTP is characterized by a low ADAMTS13 activity level at diagnosis of <10 % ADAMTS13 activity, while aHUS is ...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章


    authors: Saultz JN,Wu HM,Cataland S

    更新日期:2015-09-01 00:00:00

  • Bronchoscopic features, associations, and outcomes of organizing pneumonia following allogeneic hematopoietic stem cell transplantation.

    abstract::Organizing pneumonia (OP) is a poorly understood complication of hematopoietic stem cell transplant (HSCT). We identified 15 patients diagnosed with OP following HSCT and described their clinical course. CT chest findings were remarkable for multifocal infiltrates that were predominantly consolidating or ground glass ...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章


    authors: Brownback KR,Frey JW,Abhyankar S

    更新日期:2019-09-01 00:00:00

  • Treatment of primary mediastinal large B cell lymphoma with an alternating chemotherapy regimen based on high-dose methotrexate.

    abstract::Primary mediastinal large B cell lymphomas (MLCL) differ from other diffuse large cell lymphomas, leading to a description as a separate entity in the current World Health Organization classification. Dose intensification improves long-term results, but no standard therapy has been established so far. We investigated ...

    journal_title:Annals of hematology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Fietz T,Knauf WU,Hänel M,Franke A,Freund M,Thiel E,East German Study Group on Hematology and Oncology-OSHO.

    更新日期:2009-05-01 00:00:00