Immunoglobulins anti-endonuclease 32 kDa from Cucurbita pepo var patissonina affect process of DNA synthesis.

Abstract:

:Immunoglobulins anti-endonuclease 32 kDa inhibit DNA synthesis. We observed that low concentrations of IgGs (about 50 micrograms IgG per 1 x 10(6) cell nuclei) temporary inhibit DNA synthesis. This inhibition concerns only the synthesis of DNA bound to the nuclear matrix (associated with isolated nuclear matrix). Preincubation of cell nuclei of White bush with IgG generates longer DNA fragments than in controls. Involvement of the 32 kDa endonuclease or an endonuclease-65 kDa protein complex from the nuclear matrix in replication or structural organisation of replication is considered.

journal_name

Acta Biochim Pol

journal_title

Acta biochimica Polonica

authors

Rzepecki R,Szopa J

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

177-82

issue

2

eissn

0001-527X

issn

1734-154X

journal_volume

42

pub_type

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