abstract：PURPOSE:To develop a novel intraarticular injection of diclofenac for the treatment of arthritis. METHOD:Diclofenac loaded nanoparticles were prepared by a nanoprecipitation technique using Eudragit L 100 as the polymer and polyvinyl alcohol as the surfactant. The nanoparticles were evaluated for particle size, zeta p...

journal_title：Acta biochimica Polonica

authors： Wen X,Huang X,Wu H

更新日期：2021-01-22 00:00:00

abstract：BACKGROUND:MicroRNAs play a crucial role in diabetic peripheral neuropathic pain (DPNP). miR-590-3p is a novel miRNA and involved in multiple diseases. However, the pathological mechanism of miR-590-3p in DPNP needs to be elucidated. MATERIALS AND METHODS:The db/db mice and db/m mice were selected to mimic diabetes an...

journal_title：Acta biochimica Polonica

authors： Wu Y,Gu Y,Shi B

更新日期：2020-12-17 00:00:00

abstract：:Cancer heterogeneity is still underexplored and difficult to investigate. The whole network of factors engaged in tumor growth makes clinical cases, as well as the in vivo and in vitro experiments, of limited use in terms of understanding cancer heterogeneity. Our idea was to start from scratch and focus on the simple...

journal_title：Acta biochimica Polonica

authors： Kłóś A,Płonka PM

更新日期：2020-11-26 00:00:00

abstract：:Microbiological purity control of food products is of great importance in the food industry. Contaminated food is often characterized by a deteriorated taste, smell, and appearance, and when consumed, it can pose a threat to human health and life. Also, contamination incurs huge financial losses to the food industry. ...

journal_title：Acta biochimica Polonica

authors： Akimowicz M,Bucka-Kolendo J

更新日期：2020-09-14 00:00:00

abstract：:Previous reports indicated that long noncoding RNA 662 (LINC00662) plays a crucial role in several human cancers. Here, we studied the expression pattern of LINC00662 and explored its function in human breast cancer. The expression level of LINC00662 was determined in human breast cancer cell lines and tissues by real...

journal_title：Acta biochimica Polonica

authors： Cheng L,Xing Z,Zhang P,Xu W

更新日期：2020-06-19 00:00:00

abstract：BACKGROUND:Recent studies showed that sushi repeat containing protein X linked 2 (SRPX2) could participate in the development of various malignant tumors. However, its role in non-small cell lung cancer (NSCLC) was unknown. The aim of the study was to prospectively investigate the role of SRPX2 in NSCLC cell proliferat...

journal_title：Acta biochimica Polonica

authors： Li X,Liu J,Sun H,Zou Y,Chen J,Chen Y,Chen C,Wu X

更新日期：2020-06-18 00:00:00

abstract：:Betapapillomaviruses have been linked to the development of nonmelanoma skin cancers. A great diversity of these viruses in skin specimens requires the use of sensitive and reliable detection methods. There are currently no standardized assays for diagnostic purposes. A combination of several molecular methods has gre...

journal_title：Acta biochimica Polonica

authors： Kopeć J,Szostek S,Sułowicz J,Zawilińska B

更新日期：2020-06-08 00:00:00

abstract：:Recently, embryo muscle development, which is crucial for postnatal skeletal muscle growth, has been investigated widely. Nutrients in ovo were suggested to be critical in embryo muscle development since the chick growth mostly relies on nutrients in eggs at the early developmental stage. Phytosterol esters (PE), whic...

journal_title：Acta biochimica Polonica

authors： Wang L,Zuo X,Zhao W,Zhou G,Luo L,Yang K,Shu G,Wang S,Gao P,Zhu X,Jiang Q,Wang L

更新日期：2020-03-19 00:00:00

abstract：:Previous studies detected higher Golgi protein 73 levels in the serum of patients with chronic liver disease. The Beta-2 microglobulin levels were also observed to be higher in patients with chronic hepatitis B infection compared to the inactive carriers and the protein plays an important role in the response to viral...

journal_title：Acta biochimica Polonica

authors： Deveci O,Kaplan I,Tekin R,Celen MK,Bozkurt F,Aslan E,Cerrah S,Dayan S

更新日期：2020-03-19 00:00:00

abstract：:The present study was undertaken to evaluate the protective effects of Linum usitatissimum oil (LuO) against sub-chronic Roundup (RDP)-induced toxicity and oxidative stress in rats. Rats were divided into four groups: control group (no treatment), RDP group (Roundup at 269.9 mg/kg b.w.), LuO group (0.5 g/kg b.w. of Lu...

journal_title：Acta biochimica Polonica

authors： Djaber N,Ounaceur LS,Moubine BN,Khaldi T,Rouag M,Berrouague S,Amara H,Taibi F,Boumendjel M,Boumendjel A,Messarah M

更新日期：2020-03-18 00:00:00

abstract：:The aim of this study was to determine the level of antibodies against hemagglutinin of influenza viruses in the sera of people in the seven age groups in the epidemic season 2018/2019 in Poland. The level of anti-hemagglutinin antibodies was determined by hemagglutination inhibition test (HAI). 1050 clinical samples ...

journal_title：Acta biochimica Polonica

authors： Hallmann-Szelińska E,Szymański K,Łuniewska K,Kondratiuk K,Brydak LB

更新日期：2020-03-17 00:00:00

abstract：:Clofarabine (2-chloro-2'-fluoro-2'-deoxyarabinosyladenine, ClF), a second-generation 2'-deoxyadenosine analog, possesses manifold anti-cancer activities. Our previous reports and some of others demonstrate the potential capacity of ClF to regulate the epigenetic machinery. The study presented here is the first to inve...

journal_title：Acta biochimica Polonica

authors： Kaufman-Szymczyk A,Lubecka K

更新日期：2020-01-30 00:00:00

abstract：:The aim of the study presented here was an attempt to answer the question posed in the title: Is the mechanism of nitroglycerin tolerance associated with aldehyde dehydrogenase (ALDH) activity? Here, we investigated the effect of administration (separately or jointly) of lipoic acid (LA), nitroglycerin (GTN), and disu...

journal_title：Acta biochimica Polonica

authors： Bilska-Wilkosz A,Kotańska M,Górny M,Filipek B,Iciek M

更新日期：2019-12-28 00:00:00

abstract：:Ovine β‑lactoglobulin was characterized by spectroscopic (CD), calorimetric (ITC) and X-ray structural studies. The structure of ovine β‑lactoglobulin complex with decanol showed that tight packing of molecules in the crystalline phase enforces a distortion of protein flexible loops resulting in the formation of an as...

journal_title：Acta biochimica Polonica

authors： Loch J,Bonarek P,Lewiński K

更新日期：2019-12-27 00:00:00

abstract：:Fluorescent tri-cyclic purine analogs, derivatives of isoguanine and adenine, were examined as potential substrates of purine-nucleoside phosphorylase. It was found previously that etheno- derivatives of both compounds are ribosylated in phosphate-free media, but ribosylation places in some instances differ from purin...

journal_title：Acta biochimica Polonica

authors： Stachelska-Wierzchowska A,Wierzchowski J

更新日期：2019-12-05 00:00:00

abstract：:The fuzzy oil drop model suggests that the tertiary conformation of a protein - particularly a globular one - can be likened to a spherical micelle. During the folding process, hydrophilic residues are exposed on the surface, while hydrophobic residues are retained inside the protein. The resulting hydrophobicity dist...

journal_title：Acta biochimica Polonica

authors： Ptak-Kaczor M,Banach M,Konieczny L,Roterman I

更新日期：2019-11-20 00:00:00

abstract：:Several studies employed the genome-wide association (GWA) analysis of single-nucleotide polymorphisms (SNPs) to identify susceptibility regions in colorectal cancer (CRC). However, the functional studies exploring the role of associating SNPs with cancer biology are limited. Herein, using chromatin immunoprecipitatio...

journal_title：Acta biochimica Polonica

authors： Statkiewicz M,Maryan N,Kulecka M,Kuklinska U,Ostrowski J,Mikula M

更新日期：2019-09-17 00:00:00

abstract：:Two winter triticale (x Triticosecale Wittmack) model cultivars: Hewo (tolerant to pink snow mould) and Magnat (sensitive) were used to test the effect of cold-hardening (4 weeks at 4°C) on soluble ≤50 kDa protein profiles of the seedling leaves. The presence and abundance of individual proteins were analysed via two-...

journal_title：Acta biochimica Polonica

authors： Golebiowska GJ,Bonar E,Emami K,Wędzony M

更新日期：2019-09-10 00:00:00

abstract：:DNA methylation and histone modifications are major components of cellular epigenetic pattern determining gene expression. Cancer cells have their own epigenetic array, which can be different in cells of primary and metastatic tumors. In the present work we investigated effects of 1 mM valproic acid (VPA), a histone d...

journal_title：Acta biochimica Polonica

authors： Ghecham A,Senator A,Pawlowska E,Bouafia W,Błasiak J

更新日期：2019-07-09 00:00:00

abstract：:The root system of rice is influenced by various environmental factors. However, how the root system responds to abiotic stress has not yet been fully understood. A zinc finger protein gene, OsZFP350, is exclusively expressed in the rice root, but its biological function needs to be investigated. Expression of OsZFP35...

journal_title：Acta biochimica Polonica

authors： Kang Z,Qin T,Zhao Z

更新日期：2019-05-24 00:00:00

abstract：:The VEGF family members are important factors in promoting angiogenesis and lymphangiogenesis in malignant processes. The aim of this study was to investigate plasma concentrations of VEGF-A, VEGF-B and their soluble VEGFR-1 receptor and their diagnostic utility and potency as compared to CA 15-3 in breast cancer pati...

journal_title：Acta biochimica Polonica

authors： Zajkowska M,Lubowicka E,Malinowski P,Szmitkowski M,Ławicki S

更新日期：2018-12-13 00:00:00

abstract：:Cyclosporine A (CsA), a widely used immunosuppressive drug, exerts nephrotoxic activities, as demonstrated by increased tubulointerstitial fibrosis, inflammation and podocyte damage. Recently, a number of microRNAs expressed in the kidney have been reported to be elevated during renal damage. Our aim was to investigat...

journal_title：Acta biochimica Polonica

authors： Łoboda A,Mucha O,Podkalicka P,Sobczak M,Miksza-Cybulska A,Kaczara P,Jozkowicz A,Dulak J

更新日期：2018-11-27 00:00:00

abstract：BACKGROUND:Juvenile idiopathic arthritis (JIA) is a chronic, heterogenous inflammatory disease of unclear pathogenesis. JIA is hypothesized to be linked to a defective immune regulation. Anti-inflammatory cytokines belong to the best known regulatory factors. T-regulatory cells are a crucial cellular component of immun...

journal_title：Acta biochimica Polonica

authors： Sznurkowska K,Boćkowska M,Zieliński M,Plata-Nazar K,Trzonkowski P,Liberek A,Kamińska B,Szlagatys-Sidorkiewicz A

更新日期：2018-01-01 00:00:00

abstract：:The map of candidate genes that can potentially affect physical fitness becomes larger every year, and they are associated with such aspects as respiratory and cardiovascular stability; body build and composition - especially muscle mass and strength; carbohydrate and lipid metabolism; response to training; and exerci...

journal_title：Acta biochimica Polonica

authors： Karpowicz K,Krych K,Karpowicz M,Nowak W,Gronek P

更新日期：2018-01-01 00:00:00

abstract：:The present paper investigates the enhancement of the therapeutic effect of Paclitaxel (a potent anticancer drug) by increasing its cellular uptake in the cancerous cells with subsequent reduction in its cytotoxic effects. To fulfill these goals the Paclitaxel (PTX)-Biotinylated PAMAM dendrimer complexes were prepared...

journal_title：Acta biochimica Polonica

authors： Yao H,Ma J

更新日期：2018-01-01 00:00:00

abstract：:Leukocyte adhesion to the vascular endothelium contributes to many immunological and inflammatory disorders. These processes have been shown to be mediated by bradykinin receptor type 2 (B2R) and dopamine receptor type 2 (D2R). In a previous study, we reported the formation of a B2R-D2R heterodimer, possibly altering ...

journal_title：Acta biochimica Polonica

authors： Niewiarowska-Sendo A,Łabędź-Masłowska A,Kozik A,Guevara-Lora I

更新日期：2018-01-01 00:00:00

abstract：:The urinary tract is vulnerable to frequent challenges from environmental microflora. Uropathogenic Escherichia coli (UPEC) makes a major contribution to urinary tract infection (UTI). Previous studies have characterized positive roles of non-histone nuclear protein HMGN2 in lung epithelial innate immune response. In ...

journal_title：Acta biochimica Polonica

authors： Tian H,Miao J,Zhang F,Xiong F,Zhu F,Li J,Wang X,Chen S,Chen J,Huang N,Wang Y

更新日期：2018-01-01 00:00:00

abstract：:The relationships between bone turnover, the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and vitamin D are complex, but still not fully explained. The GH/IGF-1 axis and vitamin D can mutually modulate each other's metabolism and influence the activation of cell proliferation, maturation, and mineraliza...

journal_title：Acta biochimica Polonica

authors： Witkowska-Sędek E,Stelmaszczyk-Emmel A,Majcher A,Demkow U,Pyrżak B

更新日期：2018-01-01 00:00:00

abstract：:Cardiac fibrosis is referred to as an excessive accumulation of stromal cells and extracellular matrix proteins in the myocardium. Progressive fibrosis causes stiffening of the cardiac tissue and affects conduction of electrical impulses, leading to heart failures in a broad range of cardiac conditions. At the cellula...

journal_title：Acta biochimica Polonica

authors： Działo E,Tkacz K,Błyszczuk P

更新日期：2018-01-01 00:00:00

abstract：:The inducible metalloproteinase inhibitor (IMPI) discovered in Galleria mellonella is currently the only specific inhibitor of metalloproteinases found in animals. Its role is to inhibit the activity of metalloproteinases secreted by pathogenic organisms as virulence factors to degrade immune-relevant polypeptides of ...

journal_title：Acta biochimica Polonica

authors： Vertyporokh L,Wojda I

更新日期：2017-01-01 00:00:00

abstract：:The primary hepatocytes culture is still one of the main challenges in toxicology studies in the drug discovery process, development of in vitro models to study liver function, and cell-based therapies. Isolated hepatocytes display a rapid decline in viability and liver-specific functions including albumin production,...

journal_title：Acta biochimica Polonica

authors： Wencel A,Zakrzewska KE,Samluk A,Noszczyk BH,Pijanowska DG,Pluta KD

更新日期：2017-01-01 00:00:00

abstract：:Enteropathogenic E. coli (EPEC) is a human pathogen using type III secretion system for delivery of proteins directly into the human host. The system contains a single ATPase, EscN, which is essential for uncoupling of proteins from their complexes with chaperones before the delivery. The structure of EscN ATPase (PDB...

journal_title：Acta biochimica Polonica

authors： Bzdzion L,Krezel H,Wrzeszcz K,Grzegorek I,Nowinska K,Chodaczek G,Swietnicki W

更新日期：2017-01-01 00:00:00

abstract：:Mushroom foraging is very popular in some regions of the world. Sometimes toxic and edible mushrooms are mistaken by mushroom collectors, leading to serious human poisoning. The group of mushrooms highly dangerous for human health includes Amanita phalloides. This mushroom produces a toxic octapeptide called α-amaniti...

journal_title：Acta biochimica Polonica

authors： Muszyńska K,Ostrowska D,Bartnicki F,Kowalska E,Bodaszewska-Lubaś M,Hermanowicz P,Faulstich H,Strzałka W

更新日期：2017-01-01 00:00:00

abstract：:The dairy propionibacteria, which are traditionally used for the production of Swiss cheeses, are able to synthesize valuable biomolecules, e.g. B group vitamins, propionic acid, and trehalose with unique chemical and physical properties. Both, dairy propionibacteria cells and trehalose, have found many applications a...

journal_title：Acta biochimica Polonica

authors： Pawlicka-Kaczorowska J,Czaczyk K

更新日期：2017-01-01 00:00:00

abstract：:The aim of this study was to evaluate the accuracy of commercial gradient test (Etest) in the detection of triazole resistant Aspergillus fumigatus isolates using reference microdilution methods and the analysis of sequences of the cyp 51A gene. The study was performed on twenty clinical isolates which were identified...

journal_title：Acta biochimica Polonica

authors： Nawrot U,Sulik-Tyszka B,Kurzyk E,Mroczyńska M,Włodarczyk K,Wróblewska M,Basak GW,Brillowska-Dąbrowska A

更新日期：2017-01-01 00:00:00

abstract：:All organisms are exposed to numerous stress factors, which include harmful xenobiotics. The diversity of these compounds is enormous, thus in the course of evolution diverse biological defense mechanisms at various levels of organization have developed. One of them engages an evolutionarily conserved family of transp...

journal_title：Acta biochimica Polonica

authors： Szczygieł M,Markiewicz M,Szafraniec M,Zuziak R,Urbańska K,Fiedor L

更新日期：2017-01-01 00:00:00

abstract：:The aim of this study was to analyse the correlation between HPV16 E6 variants and the physical status of viral genome (integrated, mixed, episomal) among patients with cervical cancer (n=40) and low-grade squamous intraepithelial lesions - LSIL (n=40). The study was performed on 80 HPV16 positive samples. HPV16 E6 va...

journal_title：Acta biochimica Polonica

authors： Szostek S,Zawilinska B,Klimek M,Kosz-Vnenchak M

更新日期：2017-01-01 00:00:00

abstract：:Aberrant expression of sialic acids or altered linkage types is closely associated with malignant phenotype and metastatic potential, and can have prognostic significance in human cancer. The present study was undertaken to evaluate whether expression of sialylated derivatives on melanoma cell surface is associated wi...

journal_title：Acta biochimica Polonica

authors： Kolasińska E,Przybyło M,Janik M,Lityńska A

更新日期：2016-01-01 00:00:00

abstract：:Fucoxanthin, diadinoxanthin and diatoxanthin are carotenoids found in brown algae and most other heterokonts. These pigments are involved in photosynthetic and photoprotective reactions, and they have many potential health benefits. They can be extracted from diatom Phaeodactylum tricornutum by sonication, extraction ...

journal_title：Acta biochimica Polonica

authors： Tokarek W,Listwan S,Pagacz J,Leśniak P,Latowski D

更新日期：2016-01-01 00:00:00

abstract：:The importance of nosocomial infections caused by coagulase-negative staphylococci is constantly growing. The threat primarily affects immunocompromised patients, the elderly and neonates, particularly after invasive surgery. The problem is fundamentally exacerbated by expanding antibacterial drug resistance. A case r...

journal_title：Acta biochimica Polonica

authors： Savini V,Kosecka M,Siegwart E,Marrollo R,Polilli E,Palmieri D,Fazii P,Carretto E,Międzobrodzki J,Bukowski M

更新日期：2016-01-01 00:00:00