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T cell clones from a Sjögren's syndrome salivary gland biopsy produce high levels of IL-10.

Abstract：

:Sjögren's syndrome (SS) is characterized by a focal periductal salivary gland infiltrate consisting mainly of T and B lymphocytes. Most of the T cells bear the memory CD4+ Th1-like phenotype and express high levels of class II, though CD8+ cells are also present. We have studied 17 labial salivary gland and 15 peripheral blood T cell clones from a patient with primary SS. The tissue clones were 71% CD8+ and 29% CD4+, and the peripheral blood-derived clones were 60% CD8+ and 40% CD4+. The CD4+ T cell clones from both the salivary gland and autologous peripheral blood were of the Th1 phenotype, in that they produced interferon-gamma (IFN-gamma) and IL-2 but very little IL-4 after 24 h stimulation with phorbol myristate acetate and anti-CD3 antibody. The salivary gland-derived CD4+ clones produced 15 times more IL-10 (7.92 ng/ml) than peripheral blood-derived CD4+ clones (0.52 ng/ml, P < or = 0.02). The tissue CD8+ clones produced 1.2 times (P < 0.04) more IFN-gamma and CD4+ clones produced 3.5 times less IL-2 (P < 0.02) than the respective PBM-derived clones. The accumulation of Th1-type cells producing high levels of IL-10 in the salivary gland suggests a specific immunoregulatory function at the site of inflammation in SS.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Brookes SM,Cohen SB,Price EJ,Webb LM,Feldmann M,Maini RN,Venables PJ

doi

10.1046/j.1365-2249.1996.d01-623.x

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

268-72

issue

2

eissn

0009-9104

issn

1365-2249

journal_volume

103

pub_type

杂志文章

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