Abstract:
:Enemas of various solutions were administered to rats to determine if Gastrografin was specifically irritating to the colonic mucosa. Gastrografin was found to cause considerably more inflammation than Hypaque-25, or barium sulfate. Further studies with hypertonic sorbitol, Renografin-76, and Tween 80 suggested that (a) neither hyperosmolality nor the diatrizoate compound itself were damaging to the colon, and (b) Tween 80 most likely plays a major role in Gastrografin's inflammatory effect.
journal_name
Radiologyjournal_title
Radiologyauthors
Lutzger LG,Factor SMdoi
10.1148/118.3.545subject
Has Abstractpub_date
1976-03-01 00:00:00pages
545-8issue
3eissn
0033-8419issn
1527-1315journal_volume
118pub_type
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