Effects of some water-soluble contrast media on the colonic mucosa.

Abstract:

:Enemas of various solutions were administered to rats to determine if Gastrografin was specifically irritating to the colonic mucosa. Gastrografin was found to cause considerably more inflammation than Hypaque-25, or barium sulfate. Further studies with hypertonic sorbitol, Renografin-76, and Tween 80 suggested that (a) neither hyperosmolality nor the diatrizoate compound itself were damaging to the colon, and (b) Tween 80 most likely plays a major role in Gastrografin's inflammatory effect.

journal_name

Radiology

journal_title

Radiology

authors

Lutzger LG,Factor SM

doi

10.1148/118.3.545

subject

Has Abstract

pub_date

1976-03-01 00:00:00

pages

545-8

issue

3

eissn

0033-8419

issn

1527-1315

journal_volume

118

pub_type

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