Splenic enlargement in neonates during ECMO.

Abstract:

PURPOSE:To determine whether hepatosplenomegaly was a reproducible finding in seven neonates who were being treated with extracorporeal membrane oxygenation (ECMO) for respiratory failure. MATERIALS AND METHODS:The authors measured splenic and hepatic dimensions with ultrasound (US) at the time ECMO was initiated and then every 24-48 hours until decannulation. Splenic volume and the index of hepatic size were calculated by using published formulas. RESULTS:Splenic volume increased in all seven patients from 8.3 cm3 +/- 1.7 to 16.4 cm3 +/- 4.4 (P < or = .001). Hepatic size did not change markedly. CONCLUSION:Hemolysis, leukopenia, and platelet activation occur during ECMO. Rapid splenic enlargement may be secondary to sequestration of red cells, platelets, and other hematologic elements that have been damaged in the ECMO circuit. Since the liver does not also increase in size, the splenic enlargement is unlikely to be the result of passive congestion.

journal_name

Radiology

journal_title

Radiology

authors

Klippenstein DL,Zerin JM,Hirschl RB,Donn SM

doi

10.1148/radiology.190.2.8284390

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

411-2

issue

2

eissn

0033-8419

issn

1527-1315

journal_volume

190

pub_type

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