Noninvasive Staging of Liver Fibrosis Using 5-Minute Delayed Dual-Energy CT: Comparison with US Elastography and Correlation with Histologic Findings.


:Background Normalized iodine concentration (NIC) (ratio of iodine concentration of liver to that of aorta) of liver at delayed dual-energy CT (DECT) may reflect the amount of fibrosis based on the extent of iodine uptake. Purpose To stage liver fibrosis by using 5-minute delayed DECT and compare findings with those of transient elastography (TE), shear-wave elastography (SWE), and histologic examination. Materials and Methods This prospective study included patients with chronic liver disease who were scheduled to undergo multiphase abdominal CT and liver biopsy from January 2017 to September 2018. Fifty individuals being screened as renal donors comprised the control group. Study participants underwent TE, SWE, multiphasic DECT (including 5-minute delayed dual-energy scanning), and liver biopsy. Multiphasic DECT and SWE were performed in the control group. The NIC of the right lobe of the liver (RNIC) was compared with liver stiffness (LS) as measured with TE and SWE and with the METAVIR fibrosis stage (ranging from F0 to F4). Diagnostic performance was assessed by using areas under the receiver operating characteristic curve (AUCs). Results A total of 107 participants (mean age, 35 years ± 12 [standard deviation]; 57 men) and 50 control subjects (mean age, 47 years ± 11; 29 women) were evaluated. The RNIC showed strong correlation with METAVIR stage (Spearman ρ = 0.81, P < .001). The AUC for RNIC with each METAVIR stage ranged between 0.86 (95% CI: 0.76, 0.97) and 0.96 (95% CI: 0.92, 0.99). The cut-off value of RNIC was 0.24 (sensitivity: 85% [86 of 101 participants; 95% CI: 77%, 91%]; specificity: 83% [84 of 101 participants; 95% CI: 42%, 98%]) for stage F1 fibrosis and 0.29 (sensitivity: 84% [67 of 80 participants; 95% CI: 74%, 90%]; specificity: 81% [65 of 80 participants; 95% CI: 63%, 92%]) for stage F2 fibrosis. RNIC correlated well with LS as measured with TE and SWE (Spearman ρ = 0.60 and 0.64, respectively; P < .001). Conclusion Normalized iodine concentration of liver at 5-minute delayed dual-energy CT showed strong correlation with the histologic stages of liver fibrosis and good diagnostic performance in estimating liver fibrosis. © RSNA, 2020 Online supplemental material is available for this article. See also the editorial by Chandarana and Shanbhogue in this issue.






Marri UK,Das P,Shalimar,Kalaivani M,Srivastava DN,Madhusudhan KS




Has Abstract


2021-01-05 00:00:00








  • Screening for occlusive vascular disease with intraarterial DSA: preliminary experience with a high flow 4-F catheter.

    abstract::Forty-two patients underwent intraarterial digital subtraction angiography (DSA) of the carotid or renal arteries, utilizing a new 4-F aortic flush catheter; 37 procedures were percutaneous transbrachial, five were percutaneous transfemoral. Image quality was consistently good or excellent. The safety of nonselective ...


    pub_type: 杂志文章


    authors: Becker GJ,Hicks ME,Holden RW,Edwards MK,Jackson VP,Bendick PJ

    更新日期:1984-12-01 00:00:00

  • Acalculous gallbladder disease: US evaluation after slow-infusion cholecystokinin stimulation in symptomatic and asymptomatic adults.

    abstract:PURPOSE:To evaluate the measurement with ultrasonography (US) of the gallbladder ejection fraction after slow-infusion cholecystokinin stimulation in patients with biliary symptoms and in individuals without symptoms. MATERIALS AND METHODS:Gallbladder volumes were calculated in 60 healthy volunteers after a 30-minute ...


    pub_type: 杂志文章


    authors: Barr RG,Agnesi JN,Schaub CR

    更新日期:1997-07-01 00:00:00

  • Perimesencephalic Hemorrhage: Yield of Single versus Multiple DSA Examinations-A Single-Center Study and Meta-Analysis.

    abstract::Purpose To quantify the rate of detection of aneurysms at follow-up digital subtraction angiography (DSA) after initial DSA with results negative for aneurysms in subjects with perimesencephalic (PM) nonaneurysmal subarachnoid hemorrhage. Materials and Methods This single-center retrospective study and meta-analysis w...


    pub_type: 杂志文章


    authors: Potter CA,Fink KR,Ginn AL,Haynor DR

    更新日期:2016-12-01 00:00:00

  • Sigmoid diverticulitis: diagnostic role of CT--comparison with barium enema studies.

    abstract::The diagnostic value of computed tomography (CT) and barium enema (BE) studies was evaluated prospectively in hospitalized patients with the presumptive diagnosis of acute sigmoid diverticulitis based on the presence of left-lower-quadrant pain and tenderness, fever, and leukocytosis. Of 56 patients, 11 had sigmoid di...


    pub_type: 杂志文章


    authors: Cho KC,Morehouse HT,Alterman DD,Thornhill BA

    更新日期:1990-07-01 00:00:00

  • Appendicitis caused by carcinoid tumor.

    abstract::A previously healthy man had a carcinoid tumor that caused obstruction and dilatation of the appendiceal lumen, with subsequent inflammation of the appendix. He had acute pain in the lower right abdomen, loss of appetite, constipation, pyrexia, and an increased erythrocyte sedimentation rate without leukocytosis. Alth...


    pub_type: 杂志文章


    authors: Hermans JJ,Hermans AL,Risseeuw GA,Verhaar JC,Meradji M

    更新日期:1993-07-01 00:00:00

  • Intracranial lesions: flow-related enhancement on MR images using time-of-flight effects.

    abstract::Many physico-anatomic variables and instrument parameters influence the relative magnetic resonance signal intensity of vascular channels. The interaction of these mechanisms is complex, but their composite effects can be accounted for by two main categories of flow phenomena: time-of-flight effects and spin-phase cha...


    pub_type: 杂志文章


    authors: Kucharczyk W,Kelly WM,Davis DO,Norman D,Newton TH

    更新日期:1986-12-01 00:00:00

  • Sports-related muscle injuries: evaluation with MR imaging.

    abstract::Sports-related muscle pain is frequent in both trained and untrained persons; however, its severity and significance may be difficult to assess clinically. The authors used magnetic resonance (MR) imaging to evaluate acute strains and delayed-onset muscle soreness in sedentary subjects and postmarathon myalgia in trai...


    pub_type: 杂志文章


    authors: Fleckenstein JL,Weatherall PT,Parkey RW,Payne JA,Peshock RM

    更新日期:1989-09-01 00:00:00

  • Case 281: Thoracic Air Leak Syndrome in a Patient with Hematopoietic Stem Cell Transplantation and Graft-versus-Host Disease.

    abstract::HistoryAn 18-year-old man was diagnosed with precursor B-cell lymphoblastic leukemia and underwent transplantation of hematopoietic stem cells from his human leukocyte antigen-matched sister 1 year prior to admission. He was admitted to evaluate progressive shortness of breath and dry cough of 1-month duration. He did...


    pub_type: 杂志文章


    authors: Khoshbin AP,Aliannejad R

    更新日期:2020-09-01 00:00:00

  • Intramedullary spinal cord germinoma: case report and review of the literature.

    abstract::A 33-year-old man with an intramedullary spinal cord germinoma was treated successfully with partial resection, combined chemotherapy with carboplatin and etoposide, and reduced-dose local-field radiation therapy. The authors believe this is the first case without syncytiotrophoblastic giant cells so treated. The lite...


    pub_type: 杂志文章,评审


    authors: Hata M,Ogino I,Sakata K,Murata H,Kawano N,Matsubara S

    更新日期:2002-05-01 00:00:00

  • Jejunal fold separation in adult celiac disease: relevance of enteroclysis.

    abstract::The number of folds in the proximal jejunum was measured retrospectively in 25 studies of patients with adult celiac disease and 75 control subjects. The average number of folds per inch of proximal jejunum in the group with celiac disease was 2.88 (none to five), as against 4.88 (three to seven) in the controls. The ...


    pub_type: 杂志文章


    authors: Herlinger H,Maglinte DD

    更新日期:1986-03-01 00:00:00

  • Ferromagnetic materials in patients: detection before MR imaging.

    abstract::A number of surgical clips and other metallic materials embedded within patients have ferromagnetic properties that present a potential hazard when in the strong fields associated with magnetic resonance imaging. Several types of magnetometers and metal detectors were investigated as possible pre-imaging screening dev...


    pub_type: 杂志文章


    authors: Finn EJ,Di Chiro G,Brooks RA,Sato S

    更新日期:1985-07-01 00:00:00

  • Does multi-detector row CT pulmonary angiography reduce the incremental value of indirect CT venography compared with single-detector row CT pulmonary angiography?

    abstract:PURPOSE:To compare retrospectively the incremental value of indirect computed tomographic (CT) venography performed after multi-detector row CT pulmonary angiography and single-detector row CT pulmonary angiography for the diagnosis of venous thromboembolism (VTE). MATERIALS AND METHODS:The institutional ethics commit...


    pub_type: 杂志文章


    authors: Ghaye B,Nchimi A,Noukoua CT,Dondelinger RF

    更新日期:2006-07-01 00:00:00

  • Hemochromatosis of the pituitary gland: MR imaging.

    abstract::Magnetic resonance imaging of the pituitary gland in a patient with secondary hemochromatosis is described. On T1-weighted images, the anterior lobe had almost no signal intensity, and only the high-signal posterior lobe was seen. These findings are compatible with the distribution of iron deposition and clinical symp...


    pub_type: 杂志文章


    authors: Fujisawa I,Morikawa M,Nakano Y,Konishi J

    更新日期:1988-07-01 00:00:00

  • The energy-dependent behavior of noise Wiener spectra in their low-frequency limits: comparison with simple theory.

    abstract::The Wiener spectra of five screen-film systems were studied as a function of monoenergetic x-ray energy. These spectra, in their low-frequency limits, were seen to depend linearly on x-ray energy. The Wiener spectra also decreased in magnitude as the incident x-ray energy exceeded that of the screen phosphor K absorpt...


    pub_type: 杂志文章


    authors: Vyborny CJ,Loo LN,Doi K

    更新日期:1982-08-01 00:00:00

  • The Meckel cave: computed tomographic study. Part I: Normal anatomy; Part II: Pathology.

    abstract::A formalin-fixed cadaver head with air filling the cisternal and ventricular spaces was scanned by high-resolution computed tomography (CT) in multiple planes (axial, coronal, and sagittal) through the Meckel cave. Correlation of the CT appearance of the Meckel cave was made with an anatomic dissection and whole-head ...


    pub_type: 杂志文章


    authors: Kapila A,Chakeres DW,Blanco E

    更新日期:1984-08-01 00:00:00

  • Modic changes on MR images as studied with provocative diskography: clinical relevance--a retrospective study of 2457 disks.

    abstract:PURPOSE:To assess the value of vertebral body endplate signal intensity (Modic) changes on magnetic resonance (MR) images in predicting a painful disk, with provocative diskography as the reference standard. MATERIALS AND METHODS:Lumbar spine diskograms and prediskogram MR images of 736 patients (2457 disks) were retr...


    pub_type: 杂志文章


    authors: Thompson KJ,Dagher AP,Eckel TS,Clark M,Reinig JW

    更新日期:2009-03-01 00:00:00

  • Suspected acute appendicitis: nonenhanced helical CT in 300 consecutive patients.

    abstract:PURPOSE:To determine the accuracy of helical computed tomography (CT) without the oral, intravenous, or rectal administration of contrast material in confirming suspected acute appendicitis. MATERIALS AND METHODS:Three hundred consecutive patients referred from the departments of surgery and emergency medicine were ex...


    pub_type: 临床试验,杂志文章


    authors: Lane MJ,Liu DM,Huynh MD,Jeffrey RB Jr,Mindelzun RE,Katz DS

    更新日期:1999-11-01 00:00:00

  • Methodological problems in clinical radiology research: pituitary microadenoma detection as a paradigm.

    abstract::Forty papers on the radiologic detection of pituitary microadenomas were reviewed and used as the basis for a discussion of the sometimes tentative nature of published results in clinical research. Early articles on the radiologic evaluation of pituitary microadenomas, reporting favorable results with special plain fi...


    pub_type: 杂志文章


    authors: Taylor CR,Jaffe CC

    更新日期:1983-04-01 00:00:00

  • Posteroinferior labral cleft at direct CT arthrography of the shoulder by using multidetector CT: is this a normal variant?

    abstract:PURPOSE:To describe a posterior labral cleft at direct computed tomographic (CT) arthrography of the shoulder by using multidetector CT and to compare this finding with a true posterior labral tear. MATERIALS AND METHODS:Institutional ethics review board approval was obtained, and informed consent was waived. One hund...


    pub_type: 杂志文章


    authors: Lee GY,Choi JA,Oh JH,Choi JY,Hong SH,Kang HS

    更新日期:2009-12-01 00:00:00

  • MR imaging of blood vessels using three-dimensional reconstruction: methodology.

    abstract::Multisection, dual-echo magnetic resonance (MR) transaxial images of blood vessels contain both anatomic and qualitative information about flow. Even so, the images are produced as a series of two-dimensional tomographic sections from which full visualization of connected structures is difficult. A computer algorithm ...


    pub_type: 杂志文章


    authors: Hale JD,Valk PE,Watts JC,Kaufman L,Crooks LE,Higgins CB,Deconinck F

    更新日期:1985-12-01 00:00:00

  • Brodie abscess: reappraisal.

    abstract::Upon review, 25 cases of Brodie abscess demonstrated a radiological spectrum not previously appreciated. One third of the lesions were diaphyseal in location, and 50% had associated cortical thickening, while 40% showed a stimulated periosteal reaction, and 20% contained sequestra. The variable radiological appearance...


    pub_type: 杂志文章


    authors: Miller WB Jr,Murphy WA,Gilula LA

    更新日期:1979-07-01 00:00:00

  • The fetal external ear.

    abstract::The ridge pattern of the external ear was evaluated in 50 normal subjects during the second half of pregnancy. Definition was found to progress with gestational age, with a fully defined pattern implying maturity beyond 33 weeks. The external ear was edematous in patients with severe fetal hydrops. Anomalous shape or ...


    pub_type: 杂志文章


    authors: Birnholz JC

    更新日期:1983-06-01 00:00:00

  • Brain image manifestation in the patient with cavernous sinus occlusion.

    abstract::Radionuclide findings in a case of cavernous sinus occlusion by an intracavernous aneurysm are described. A brain image obtained 10 minutes after injection of 99Tc pertechnetate shows diminished activity in the area of the right cavernous sinus and increased activity in the area of the right sylvian veins; these are a...


    pub_type: 杂志文章


    authors: Hahn FJ,Schapiro RL

    更新日期:1976-01-01 00:00:00

  • Metabolic disorders of the brain in chronic hepatic encephalopathy detected with H-1 MR spectroscopy.

    abstract::Proton magnetic resonance (MR) spectroscopy of the brain was performed in 11 patients with chronic hepatic encephalopathy (CHE), and the results were compared with those of patients with liver disease but without CHE; clinical control subjects with diabetes, uremia, or cortical atrophy; and healthy subjects. The techn...


    pub_type: 杂志文章


    authors: Kreis R,Ross BD,Farrow NA,Ackerman Z

    更新日期:1992-01-01 00:00:00

  • Occult malignant breast lesions in 114 patients: relationship to age and the presence of microcalcifications.

    abstract::This study evaluates the mammographic findings in 352 patients, aged 30-85 years, who underwent spot localization and biopsy for evaluation of nonpalpable breast abnormalities. Malignancy was found at biopsy in 114 cases. The mammographic appearance (specifically, whether grouped microcalcifications, mass, or both wer...


    pub_type: 杂志文章


    authors: Hermann G,Janus C,Schwartz IS,Papatestas A,Hermann DG,Rabinowitz JG

    更新日期:1988-11-01 00:00:00

  • Collimator misalignment in high energy therapy machines.

    abstract::Measurements of the intensity distribution of a 60-Co beam revealed a significant field distortion caused by minor misalignment of the collimator assembly which was not detected by routine methods. Accurate monitoring of radiation intensity distribution and periodic visual inspection of collimators are suggested for ...


    pub_type: 杂志文章


    authors: Zeman GH,Rao GU,Hazra TA

    更新日期:1975-07-01 00:00:00

  • Complications of arthrography.

    abstract::Arthrography is considered extremely safe since reactions to intraarticular contrast media are rare. We have only seen one severe complication in the performance of more than 2,000 arthrographic procedures. To determine the incidence of complications, a questionnaire was sent to 84 radiologists experienced in arthrogr...


    pub_type: 杂志文章


    authors: Newberg AH,Munn CS,Robbins AH

    更新日期:1985-06-01 00:00:00

  • Comet-tail artifact from cholesterol crystals: observations in the postlithotripsy gallbladder and an in vitro model.

    abstract::The "comet tail" is a well-known ultrasound artifact that appears as a series of parallel bands radiating from a source. This artifact was observed in the gallbladder lumen in eight of 10 patients after extracorporeal shock wave lithotripsy of radiolucent calculi. To investigate the cause of the comet tail artifact, c...


    pub_type: 杂志文章


    authors: Shapiro RS,Winsberg F

    更新日期:1990-10-01 00:00:00

  • Scanning slit chest radiography: a practical and efficient scatter control design.

    abstract:PURPOSE:To design a chest radiography unit that eliminates scatter. MATERIALS AND METHODS:A scanning slit radiography unit that also incorporates a conventional grid was designed. The scanning slit geometry defined a 10-mm-wide beam at the image receptor. RESULTS:With a typical heavy-duty radiographic tube, the propo...


    pub_type: 杂志文章


    authors: Barnes GT,Wu X,Sanders PC

    更新日期:1994-02-01 00:00:00

  • Alendronate-induced esophagitis: case report of a recently recognized form of severe esophagitis with esophageal stricture--radiographic features.

    abstract::Alendronate sodium, an aminobiphosphonate used primarily to treat osteoporosis in postmenopausal women, is known to cause esophagitis. A 71-year-old woman experienced severe, acute esophagitis and severe stricture of the esophagus due to oral alendronate therapy. Unlike in previous cases, she had taken alendronate for...


    pub_type: 杂志文章


    authors: Ryan JM,Kelsey P,Ryan BM,Mueller PR

    更新日期:1998-02-01 00:00:00