Pulmonary retention and translocation of insufflated tantalum.

Abstract:

:Studies of pylmonary clearance of tantalum dust labeled with 182Ta in dogs have been extended to as far as 816 days postexposure in order to substantiate earlier pulmonary retention data, examine lymphatic uptake, and seek long-term pathological changes. Exposure to 5-mug and 10-mug powders was compared with the results of earlier 1-mug studies. The 2.1-year long-term clearance half-time of 1-mug powder was confirmed, while the 5-mug and 10-mug powders were found to have a mean long-term retention half-time of 333 days. All three particle sizes demonstrated rapid postinsufflation uptake by the pulmonary lymph nodes, followed by either retention or very slow clearance. No tantalum-induced pathological changes were found on histological examination.

journal_name

Radiology

journal_title

Radiology

authors

Morrow PE,Kilpper RW,Beiter HE,Gibb FR

doi

10.1148/121.2.415

subject

Has Abstract

pub_date

1976-11-01 00:00:00

pages

415-21

issue

2

eissn

0033-8419

issn

1527-1315

journal_volume

121

pub_type

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