Abstract:
:Studies of pylmonary clearance of tantalum dust labeled with 182Ta in dogs have been extended to as far as 816 days postexposure in order to substantiate earlier pulmonary retention data, examine lymphatic uptake, and seek long-term pathological changes. Exposure to 5-mug and 10-mug powders was compared with the results of earlier 1-mug studies. The 2.1-year long-term clearance half-time of 1-mug powder was confirmed, while the 5-mug and 10-mug powders were found to have a mean long-term retention half-time of 333 days. All three particle sizes demonstrated rapid postinsufflation uptake by the pulmonary lymph nodes, followed by either retention or very slow clearance. No tantalum-induced pathological changes were found on histological examination.
journal_name
Radiologyjournal_title
Radiologyauthors
Morrow PE,Kilpper RW,Beiter HE,Gibb FRdoi
10.1148/121.2.415subject
Has Abstractpub_date
1976-11-01 00:00:00pages
415-21issue
2eissn
0033-8419issn
1527-1315journal_volume
121pub_type
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