Metabolic adaptation in small for gestational age infants.

Abstract:

:Hypoglycaemia has long been recognised as a feature of the failure of metabolic adaptation in infants who are small for gestational age (SGA). This study examined the process of metabolic adaptation by measuring, longitudinally, the concentrations of metabolic fuels and substrates in 33 SGA infants in the first postnatal week, and relating these to cross sectional data in 218 infants of appropriate weight for gestational age (AGA). SGA term infants had higher mean blood lactate concentrations than AGA term infants at delivery (2.98 v 2.10 mmol/l) and in the first few postnatal hours (3.05 v 1.91 mmol/l). Subsequently, although there were no differences in blood glucose concentrations, SGA term infants had lower mean ketone body concentrations (for example day 2: 0.07 v 0.41 mmol/l), and failed to mount a ketogenic response to low blood glucose concentrations. At birth, SGA preterm infants had lower mean blood glucose concentrations than AGA preterm infants (3.17 v 4.16 mmol/l), but there were few postnatal metabolic differences between the two groups. Mean blood glucose concentrations did not differ between AGA and SGA preterm infants. For variables that differed between the groups, multiple regression analysis suggested that both the degree and asymmetry of growth retardation were related to the severity of the metabolic abnormalities. These data suggest that, although there are early metabolic differences between SGA and AGA infants, it is possible that current clinical management is effective in preventing subsequent hypoglycaemia. This is important because of the failure of SGA infants to mount a ketogenic response.

journal_name

Arch Dis Child

authors

Hawdon JM,Ward Platt MP

doi

10.1136/adc.68.3_spec_no.262

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

262-8

issue

3 Spec No

eissn

0003-9888

issn

1468-2044

journal_volume

68

pub_type

杂志文章
  • Relationship between the chest radiograph, regional lung function studies, exercise tolerance, and clinical condition in cystic fibrosis.

    abstract::This study evaluated the accuracy of the interpretation of the chest film in delineating localised abnormalities of ventilation and perfusion, as well as the overall severity of airways obstruction, exercise tolerance, and clinical condition in children with cystic fibrosis. Radiographic findings in various regions of...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.2.106

    authors: Coates AL,Boyce P,Shaw DG,Godfrey S,Mearns M

    更新日期:1981-02-01 00:00:00

  • Psychological outcome and quality of life in children born with congenital diaphragmatic hernia.

    abstract:OBJECTIVE:To assess psychological and social functioning and health related quality of life and its early determinants in children born with congenital diaphragmatic hernia (CDH). DESIGN:Cross-sectional follow-up study. SETTING:Outpatient clinic of a tertiary care hospital. PARTICIPANTS:33 CDH survivors aged 6-16 ye...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2008.156158

    authors: Peetsold MG,Huisman J,Hofman VE,Heij HA,Raat H,Gemke RJ

    更新日期:2009-11-01 00:00:00

  • Air leaks and vasopressin release.

    abstract::Eleven very low birthweight babies being ventilated for respiratory problems during the first week of life developed air leaks on 22 occasions. On 16 out of 19 occasions the infants showed increases in urinary excretion of vasopressin after these events and on 10 occasions out of 13 there was a rise in the plasma argi...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.65.11.1259

    authors: McIntosh N,Prakash P,Smith A

    更新日期:1990-11-01 00:00:00

  • Risk factors for breakthrough varicella in healthy children.

    abstract:AIM:To evaluate the risk factors for breakthrough varicella in a follow up study of a cohort of 181 healthy children immunised when aged 9-24 months with a reformulated Oka strain varicella vaccine (SmithKline Beecham Biologicals/Oka). DESIGN:The children were randomised in a double blind manner into one of four group...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.79.6.478

    authors: Lim YJ,Chew FT,Tan AY,Lee BW

    更新日期:1998-12-01 00:00:00

  • A special conditions register.

    abstract::A special conditions register (SCR) linked to the child health system's register of all children has been in use in West Sussex since 1977. This paper describes the aims, organisation, and use of the SCR and gives examples of the aggregated data that may be obtained. Of the 155,000 children aged 0-17 resident in West ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.66.8.927

    authors: Woodroffe C,Abra A

    更新日期:1991-08-01 00:00:00

  • Head covering - a major modifiable risk factor for sudden infant death syndrome: a systematic review.

    abstract:BACKGROUND:Some victims of sudden infant death syndrome (SIDS) are found with their heads covered with bedclothes, but the significance of this is uncertain. The aim of this review is to describe the prevalence of head covering, the magnitude of the risk and how far the suggested causal mechanisms agree with current ep...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.2007.136366

    authors: Blair PS,Mitchell EA,Heckstall-Smith EM,Fleming PJ

    更新日期:2008-09-01 00:00:00

  • Continuous sodium valproate or phenobarbitone in the prevention of 'simple' febrile convulsions. Comparison by a double-blind trial.

    abstract::Of the 265 children aged between 6 and 18 months admitted to hospital in a 26-month period each with his first febrile convulsion, there were 64 who satisfied our criteria for a simple febrile convulsion. Of these, 43 (random) were entered into a double-blind trial of continuous sodium valproate versus phenobarbitone,...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章

    doi:10.1136/adc.55.3.171

    authors: Ngwane E,Bower B

    更新日期:1980-03-01 00:00:00

  • Risk of skin cancer after neonatal phototherapy: retrospective cohort study.

    abstract:OBJECTIVE:To assess the risk of skin cancer in persons treated with neonatal phototherapy (NNPT) for jaundice. DESIGN:Retrospective cohort study. SETTING:Grampian Region, Scotland, UK. DATA SOURCE:Aberdeen Maternity and Neonatal Databank. NNPT exposure was abstracted from paper records spanning 1976-1990. Follow-up ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2009.179275

    authors: Brewster DH,Tucker JS,Fleming M,Morris C,Stockton DL,Lloyd DJ,Bhattacharya S,Chalmers JW

    更新日期:2010-10-01 00:00:00

  • Trends in body mass index distribution and prevalence of thinness, overweight and obesity in two cohorts of Surinamese South Asian children in The Netherlands.

    abstract:OBJECTIVES:Asians have a smaller muscle mass and a larger fat mass at the same body mass index (BMI) than most other ethnic groups. Due to a resulting higher cardiometabolic risk, the BMI cut-offs for overweight and obesity were lowered for adults. For Asian children universal criteria apply. The objectives of this stu...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2012-303045

    authors: de Wilde JA,Zandbergen-Harlaar S,van Buuren S,Middelkoop BJ

    更新日期:2013-04-01 00:00:00

  • Plethysmographic validation of near infrared spectroscopic monitoring of cerebral blood volume.

    abstract::The validation of measurement of cerebral blood volume (CBV) and cerebral blood flow (CBF) using near infrared spectroscopy (NIRS) against jugular venous occlusion plethysmography is described. Repeated measurements in six infants were made using both techniques simultaneously. A close relationship between the two mea...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.67.4_spec_no.407

    authors: Wickramasinghe YA,Livera LN,Spencer SA,Rolfe P,Thorniley MS

    更新日期:1992-04-01 00:00:00

  • Hospitalisation for gastroenteritis in Western Australia.

    abstract:AIMS:To document gastroenteritis hospitalisations of the 1995-96 cohort of infants born in Western Australia to mid-2002, and to assess factors associated with their hospitalisations and readmissions. METHODS:Retrospective analysis of the State's hospitalisation data, Midwives' Notification of Births data, the Austral...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.2003.037531

    authors: Gracey M,Lee AH,Yau KK

    更新日期:2004-08-01 00:00:00

  • Dissolution of bilateral staghorn cystine renal calculi.

    abstract::Bilateral staghorn renal calculi in a 7-year-old girl with cystinuria were dissolved over a period of 6 months, using a high fluid intake, urinary alkalinisation, and D-penicillamine. Even in children with extensive cystine urolithiasis, medical management may avert the need for surgery. ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.54.10.795

    authors: Van Dugteren GR,Wiggelinkhuizen J

    更新日期:1979-10-01 00:00:00

  • The Human Rights Act 1998 and medical treatment: time for re-examination.

    abstract::There was much speculation about the potential impact of the Human Rights Act 1998 on established principles of health care practice. Now the statute has been "bedded in", predictions that existing good practice would not fall foul of the legislation provided it was demonstrable, have proved to be broadly accurate. Th...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.2003.037218

    authors: Hagger LE

    更新日期:2004-05-01 00:00:00

  • Unilateral proptosis.

    abstract::Twenty-seven children with unilateral proptosis were investigated over a period of 8 1/2 years. Seventeen (63%) of them had local or disseminated malignancy, a higher proportion than in earlier reports. The frequency of inflammatory lesions, particularly ethmoiditis progressing to proptosis, appeared to have decreased...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.7.549

    authors: Oakhill A,Willshaw H,Mann JR

    更新日期:1981-07-01 00:00:00

  • Asymptomatic type II hyperprolinaemia associated with hyperglycinaemia in three sibs.

    abstract::Three clinically normal sibs were discovered to have type II hyperprolinaemia in a routine serum amino acid screening programme in Sicily. In addition to the basic biochemical features of type II hyperprolinaemia, all 3 children had marked hyperglycinaemia, whereas their parents had both normal blood proline and glyci...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.50.8.637

    authors: Pavone L,Mollica F,Levy HL

    更新日期:1975-08-01 00:00:00

  • Diffuse nephrocalcinosis and idiopathic renal hypercalciuria.

    abstract::A 12 year old boy presented with primary nocturnal enuresis. Investigation showed extensive bilateral nephrocalcinosis of no obvious or recognised cause. Persistent severe renal hypercalciuria was confirmed by an intravenous calcium infusion. Idiopathic hypercalciuria is not a common cause of nephrocalcinosis and has ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.64.7.1055

    authors: Aggarwal VK,Jones KV

    更新日期:1989-07-01 00:00:00

  • Videourodynamic assessment of diurnal urinary incontinence.

    abstract::Persistent daytime incontinence is a fairly uncommon but important problem. Videourodynamic studies were carried out in 215 children presenting with this problem in whom there were no neurological signs and who had not responded to simple measures. Over 90% of symptomatic children were shown to have an abnormality, of...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.62.2.128

    authors: Borzyskowski M,Mundy AR

    更新日期:1987-02-01 00:00:00

  • Recovery of intralipid from lumbar puncture after migration of saphenous vein catheter.

    abstract::A term female infant was admitted to the intensive care unit with the diagnosis of tetralogy of Fallot with critical pulmonary stenosis. On the seventh day of life a long saphenous line was inserted that remained without complications until seven days later when the infant appeared septic. A lumbar puncture demonstrat...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.67.10_spec_no.1201

    authors: Odaibo F,Fajardo CA,Cronin C

    更新日期:1992-10-01 00:00:00

  • Plasma cholecystokinin concentrations after breast feeding in healthy 4 day old infants.

    abstract::The aim of the present study was to characterise plasma concentrations of cholecystokinin (CCK) after breast feeding in newborn infants. Fifty eight healthy full term exclusively breast fed infants were investigated at 4 (1) (2-6) days of age. Each infant contributed one blood sample collected just before, immediately...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.68.1_spec_no.46

    authors: Uvnäs-Moberg K,Marchini G,Winberg J

    更新日期:1993-01-01 00:00:00

  • Anthropometry of patients with osteogenesis imperfecta.

    abstract::Standing height, sitting height, armspan, subischial leg length, head circumference, and growth hormone-insulin-like growth factor I (IGF-I) axis were determined in 86 patients with osteogenesis imperfecta. The aim of this study was to determine standing height and body proportions and their variability among osteogen...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.80.6.524

    authors: Lund AM,Müller J,Skovby F

    更新日期:1999-06-01 00:00:00

  • Ketamine anaesthesia for medical procedures in children.

    abstract::Ketamine hydrochloride 2 mg/kg, together with atropine 0.2 mg, has been given intravenously on 100 occasions on a general paediatric ward. No serious side effects occurred. Dreams followed in 4 children but did not reduce acceptability of the drug. In our hands it has greatly reduced the pain and distress of children ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.51.1.56

    authors: Elliott E,Hanid TK,Arthur LJ,Kay B

    更新日期:1976-01-01 00:00:00

  • Impact of functional severity on self concept in young people with spina bifida.

    abstract::This study examines the relationship between medical and functional severity of disability and levels of self esteem and self concept in 79 young people with spina bifida. Greater feelings of global self worth and of self esteem in physical appearance were associated with greater severity of disability. This was only ...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.73.1.48

    authors: Minchom PE,Ellis NC,Appleton PL,Lawson V,Böll V,Jones P,Elliott CE

    更新日期:1995-07-01 00:00:00

  • Inhaled budesonide for chronic wheezing under 18 months of age.

    abstract::The role of budesonide in controlling chest symptoms in infants was assessed. It was administered from a metered dose inhaler into a large volume spacer (Nebuhaler) with attached Laerdal mask. Twenty nine infants were recruited into a double blind crossover trial. Five defaulted. The remaining 24 (mean age 11 months) ...

    journal_title:Archives of disease in childhood

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/adc.67.3.285

    authors: Noble V,Ruggins NR,Everard ML,Milner AD

    更新日期:1992-03-01 00:00:00

  • Interleukin-2 in relation to T cell subpopulations in rheumatic heart disease.

    abstract::Interleukin-2 (IL-2) and T cell subpopulations were evaluated in children with rheumatic heart disease (RHD). Three groups were included: 13 patients with active RHD, 12 with non-active RHD, and 14 control children. Serum IL-2 and T cell subpopulations were measured by radioimmunoassay and monoclonal antibodies respec...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.67.11.1373

    authors: Zedan MM,el-Shennawy FA,Abou-Bakr HM,al-Basousy AM

    更新日期:1992-11-01 00:00:00

  • ASSESSING PHARMACEUTICAL CARE NEEDS OF PAEDIATRIC IN-PATIENTS: A TEAM BASED APPROACH.

    abstract:AIMS:To pilot a novel approach to providing pharmaceutical care to paediatric inpatients using structured referral and assessment tools. Using standardised referral criteria to ensure patients are assessed by appropriately skilled pharmacists. METHOD:Three wards of varying acuity and specialism were selected in a tert...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2016-311535.4

    authors: Mott A,Kafka S,Sutherland A

    更新日期:2016-09-01 00:00:00

  • Symptomatic congenital cytomegalovirus infection in two consecutive sisters.

    abstract::The occurrence of symptomatic congenital cytomegalovirus (CMV) infection in two consecutive sisters is reported. The first sibling showed hepatosplenomegaly with slight hyperbilirubinaemia and abnormal liver function tests, right inguinal hernia, and peripheral lymphoedema. Her sister, the product of an uneventful pre...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.69.5_spec_no.527

    authors: Nigro G,Clerico A,Mondaini C

    更新日期:1993-11-01 00:00:00

  • The implications of the David Glass case for future clinical practice in the UK.

    abstract::A recent decision of the European Court of Human Rights (ECtHR) raises issues of considerable importance to medical practitioners and paediatricians in particular. The case concerns the parental right to withhold consent to medical intervention that doctors believe to be necessary in a child's best interests. The dram...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章,评审

    doi:10.1136/adc.2004.070672

    authors: Elias-Jones AC,Samanta J

    更新日期:2005-08-01 00:00:00

  • Hydrogen breath test in schoolchildren.

    abstract::The frequency of negative hydrogen breath tests due to colonic bacterial flora which are unable to produce hydrogen was determined after oral lactulose challenge in 98 healthy Dutch schoolchildren. There was a negative result in 9.2%. The probability of a false normal lactose breath test (1:77) was calculated from the...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.60.4.333

    authors: Douwes AC,Schaap C,van der Klei-van Moorsel JM

    更新日期:1985-04-01 00:00:00

  • Benign (non-paroxysmal) familial chorea. Paediatric perspectives.

    abstract::We describe a non-progressive choreo-athetoid disorder of early onset, present in three families. There were no appreciable abnormalities in pregnancy, during the perinatal period, or in infancy. In each case the family history suggested transmission as an autosomal dominant trait, the gene showing diminished penetran...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/adc.56.8.616

    authors: Sleigh G,Lindenbaum RH

    更新日期:1981-08-01 00:00:00

  • The changing UK paediatric consultant workforce: report from the Royal College of Paediatrics and Child Health.

    abstract:OBJECTIVES:To determine if there had been changes in the size of the UK paediatric workforce and working patterns between 1999 and 2013. DESIGN:Analysis of prospectively collected datasets. SETTING:UK consultant paediatricians. INTERVENTIONS:Data from the Royal College of Paediatrics and Child Health's workforce cen...

    journal_title:Archives of disease in childhood

    pub_type: 杂志文章

    doi:10.1136/archdischild-2016-312055

    authors: McColgan M,Winch R,Clark SJ,Ewing C,Modi N,Greenough A

    更新日期:2017-02-01 00:00:00