Long-term production of pre-existing alloantibodies to E and c after allogenic BMT in a patient with aplastic anemia resulting in delayed hemolytic anemia.

Abstract:

BACKGROUND:Delayed hemolysis mediated by long-term production of pre-existing recipient-derived antibodies directed against donor RBC antigens after allogenic BMT is an unusual complication of hematopoietic transplantation. CASE REPORT:A 26-year-old man with aplastic anemia had pre-existing alloantibodies to E and c. He received BMT from a donor, whose Rh phenotype was E+, c+. From about 1 month after the transplant, he showed mild hemolysis due to the antibodies. RESULTS:The patient was typed as group B, CCDee and had anti-E and c alloantibodies before BMT. The donor was typed as group O, ccDEE. Although MNCs from the donor marrow were infused into the patient, DAT became positive on Day 21, and the patient-origin antibodies remained detectable by both DAT and IAT even 20 months after BMT. However, immunomagnetically isolated peripheral circulating B cells were 100 percent donor origin. The patient received prednisolone from Day 221, and thereafter, the signs of hemolysis disappeared. CONCLUSION:It is likely that the long-term production of alloantibodies is due to the existence of long-lived recipient plasma cells, which survive the conditioning regimen. This case suggests that patients with pre- existing alloantibodies that do not belong to the ABO system should be carefully followed up after BMT.

journal_name

Transfusion

journal_title

Transfusion

authors

Izumi N,Fuse I,Furukawa T,Uesugi Y,Tsuchiyama J,Toba K,Togashi K,Yamada K,Ohtake S,Saitoh Y,Yanagisawa N,Aizawa Y

doi

10.1046/j.1537-2995.2003.00303.x

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

241-5

issue

2

eissn

0041-1132

issn

1537-2995

pii

trf303

journal_volume

43

pub_type

杂志文章
  • Le(a) and Le(b) tissue glycosphingolipids.

    abstract:BACKGROUND:The Le(a) and Le(b) antigens are synthesized by cells making exocrine secretions, but it is not well-defined where plasma and red cell Le(a) and Le(b) antigens are made. STUDY DESIGN AND METHODS:This study uses chromatographic and immunochemical methods to extract Le(a) and Le(b) glycolipids from human tiss...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1995.35795357880.x

    authors: Hauser R

    更新日期:1995-07-01 00:00:00

  • Effects of a multimodality blood conservation schema toward improvement of intraoperative hemoglobin levels and off-pump transfusions in coronary artery bypass graft surgery.

    abstract:BACKGROUND:Cardiothoracic surgery places significant demands on blood bank resources. Measures aimed at reducing intraoperative hemodilution were initiated as part of a blood conservation program. STUDY DESIGN AND METHODS:We initiated a series of measures aimed at reducing hemodilution volume: 1) reduction of intraven...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12745

    authors: Tran MH,Lin DM,Wilcox T,Schiro D,Cannesson M,Milliken J

    更新日期:2014-10-01 00:00:00

  • First report of using low-titer cold-stored type O whole blood in massive postpartum hemorrhage.

    abstract:BACKGROUND:In cases of massive hemorrhage in the US military, improved outcomes have been reported with the use of warm, fresh whole blood transfusions. Cold-stored low-titer type O whole blood (LTOWB) has become the preferred product for resuscitation of severe bleeding in deployed surgical units. Reports of LTOWB use...

    journal_title:Transfusion

    pub_type:

    doi:10.1111/trf.15492

    authors: Bahr TM,DuPont TL,Morris DS,Pierson SE,Esplin MS,Brown SM,O'Brien EA,Ilstrup SJ,Christensen RD

    更新日期:2019-10-01 00:00:00

  • The acquisition of granylocytes by leukapheresis: a comparison of continuous flow centrifugation and filtration leukapheresis in normal and corticosteroid-stimulated donors.

    abstract::Leukapheresis by continuous flow centrifugation (CFC) or filtration (FL) were compared in untreated and corticosteroid-treated donors. The administration of prednisone 60 mg orally 10 to 12 hours before leukapheresis increased significantly both the donor's prepheresis WBC counts and the total granulocyte yields by CF...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1976.16376225492.x

    authors: MacPherson JL,Nusbacher J,Bennett JM

    更新日期:1976-05-01 00:00:00

  • Effect of repeat transfusion exposure on plasma cytokine and markers of endothelial activation in the extremely preterm neonate.

    abstract:BACKGROUND:Very preterm newborns receive up to three to five red blood cell (RBC) transfusions, often early, after birth. Despite awareness of the association of transfusion with increases in cytokines and markers of endothelial activation, research has focused on single transfusions weeks after birth. With pathophysio...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15952

    authors: Crawford TM,Andersen CC,Stark MJ

    更新日期:2020-07-25 00:00:00

  • ABO antibody titers are not predictive of hemolytic reactions due to plasma-incompatible platelet transfusions.

    abstract:BACKGROUND:The overall risk of hemolytic transfusion reactions (HTRs) from plasma (minor)-incompatible platelet (PLT) transfusions and the role of a critical anti-A or anti-B titer in predicting and preventing these reactions has not been clearly established. STUDY DESIGN AND METHODS:We evaluated all apheresis PLT (AP...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2012.03574.x

    authors: Karafin MS,Blagg L,Tobian AA,King KE,Ness PM,Savage WJ

    更新日期:2012-10-01 00:00:00

  • HNA-3a-specific antibodies recognize choline transporter-like protein-2 peptides containing arginine, but not glutamine at Position 154.

    abstract:BACKGROUND:Antibodies specific for the neutrophil antigen HNA-3a cause severe, sometimes fatal transfusion-related acute lung disease (TRALI) when transfused, but it has not been possible to screen blood donors for anti-HNA-3a because using neutrophils as targets was impractical and molecular properties of the antigen ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03145.x

    authors: Curtis BR,Sullivan MJ,Holyst MT,Szabo A,Bougie DW,Aster RH

    更新日期:2011-10-01 00:00:00

  • Residual plasma in red blood cells and transfusion-related acute lung injury.

    abstract:BACKGROUND:Transfusion-related acute lung injury (TRALI) is the most common cause of death from blood transfusion and red blood cells (RBCs) now account for approximately 50% of these fatalities. RBCs from female donors have been implicated in large series and HLA Class II antibodies to cognate recipient antigens ident...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12662

    authors: Weber LL,Roberts LD,Sweeney JD

    更新日期:2014-10-01 00:00:00

  • Transfusion of frozen erythrocytes from a donor with sickle trait.

    abstract::We describe a nonanaphylactic hemoglobinuric reaction caused by transfusion of frozen red cells, deglycerolyzed by standard technique, obtained from a donor with undiagnosed sickle trait. Although significant hemoglobinemia and hemoglobinuria were noted, the recipient experienced no adverse clinical reactions. The ben...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1984.24284173352.x

    authors: Kelleher JF Jr,Luban NL

    更新日期:1984-03-01 00:00:00

  • Variability on red blood cell transfusion practices among Brazilian neonatal intensive care units.

    abstract:BACKGROUND:Guidelines for red blood cell (RBC) transfusions exist; however, transfusion practices vary among centers. This study aimed to analyze transfusion practices and the impact of patients and institutional characteristics on the indications of RBC transfusions in preterm infants. STUDY DESIGN AND METHODS:RBC tr...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1537-2995.2009.02373.x

    authors: dos Santos AM,Guinsburg R,Procianoy RS,Sadeck Ldos S,Netto AA,Rugolo LM,Luz JH,Bomfim O,Martinez FE,de Almeida MF,Brazilian Network on Neonatal Research.

    更新日期:2010-01-01 00:00:00

  • A comparison of results obtained by two different chromium-51 methods of determining platelet survival and recovery.

    abstract::A number of different methods exist that use chromium-51 to determine platelet survival and recovery. A 1986 article in TRANSFUSION described the recommended methods for conducting such studies in the hope of standardizing methodology and permitting interlaboratory comparison of results. The results obtained with the ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1990.30590296371.x

    authors: Rock G,Tittley P

    更新日期:1990-06-01 00:00:00

  • Modification of glutathione content in platelet concentrates by the use of acivicin.

    abstract:BACKGROUND:Intracellular glutathione declines progressively in platelet concentrates stored for transfusion, but little is known about the nature of this process. STUDY DESIGN AND METHODS:Acivicin, an irreversible inhibitor of gamma-glutamyl transpeptidase, was used to determine the fate of glutathione lost from plate...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1994.34594249055.x

    authors: Burch PT,Aman M,Burch JW

    更新日期:1994-05-01 00:00:00

  • Maternal human platelet antigen-1a antibody level correlates with the platelet count in the newborns: a retrospective study.

    abstract:BACKGROUND:Maternal plasma and/or serum levels of anti-HPA-1a at delivery were compared to neonatal platelet (PLT) counts. STUDY DESIGN AND METHODS:Samples from HPA-1bb women who gave birth to children with thrombocytopenia or had anamnestic information about a previous child with neonatal alloimmune thrombocytopenia ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2007.01063.x

    authors: Killie MK,Husebekk A,Kaplan C,Taaning E,Skogen B

    更新日期:2007-01-01 00:00:00

  • Comparison of antibody elution techniques by enzyme-linked antiglobulin test.

    abstract::The enzyme-linked antiglobulin test was used to determine the percentage of antibody removed from sensitized red cells by five elution methods: Rubin ether, xylene, digitonin-acid, glycine, and heat. Antibodies examined in the study included anti-D, -c, -E, and -K. With two examples of anti-D, more antibody was eluted...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1983.23483276862.x

    authors: Gibble JW,Salamon JL,Ness PM

    更新日期:1983-07-01 00:00:00

  • Estimating the incubation time distribution and expected number of cases of transfusion-associated acquired immune deficiency syndrome.

    abstract::The number of cases of transfusion-associated acquired immune deficiency syndrome (TA-AIDS) that will be seen over the next few years is difficult to estimate, because of the uncertainty about the number of persons infected with the human immunodeficiency virus (HIV) via blood transfusion and about the duration of the...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1989.29890020437.x

    authors: Kalbfleisch JD,Lawless JF

    更新日期:1989-10-01 00:00:00

  • Collection and immunoselection of CD34+ cells: the impact of age, sex, and diabetes in patients with chronic heart failure.

    abstract:BACKGROUND:Mobilized peripheral blood is the most common source of CD34+ cells intended for transplantations. The collection and enrichment of CD34+ cells could be affected by various factors and there are some controversies regarding the effects of patient-related factors. The aim of this study was to assess the impac...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/trf.13646

    authors: Kresnik PK,Krasna M,Rozman P,Vrtovec B,Malicev E

    更新日期:2016-07-01 00:00:00

  • Effective storage of granulocytes collected by centrifugation leukapheresis from donors stimulated with granulocyte-colony-stimulating factor.

    abstract:BACKGROUND:Donor stimulation with granulocyte-colony-stimulating factor (G-CSF) has increased the number of neutrophils (PMNs) that can be collected for granulocyte transfusion therapy. Clinical utility, however, has been limited by the inability to store functional PMNs ex vivo. This study was conducted to determine w...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1537-2995.2005.00636.x

    authors: Hubel K,Rodger E,Gaviria JM,Price TH,Dale DC,Liles WC

    更新日期:2005-12-01 00:00:00

  • A path analysis of intention to redonate among experienced blood donors: an extension of the theory of planned behavior.

    abstract:BACKGROUND:The need for blood products is constant and unremitting, yet only a small percentage of eligible individuals answer the appeal to donate. Further, most new donors never return to provide a repeat donation. The ongoing need to attract and retain new donors has led to the examination of psychosocial factors th...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2007.01236.x

    authors: France JL,France CR,Himawan LK

    更新日期:2007-06-01 00:00:00

  • Noninvasive determination of fetal RHD status by examination of cell-free DNA in maternal plasma.

    abstract:BACKGROUND:Cell-free fetal DNA in maternal plasma opens the way for routine risk-free diagnosis of fetal D status of D- mothers. The focus was on accuracy of RHD typing and confirmation of fetal DNA in maternal plasma while RHD was not detected. STUDY DESIGN AND METHODS:Plasma DNA was extracted (by manual and/or autom...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00559.x

    authors: Brojer E,Zupanska B,Guz K,Orziñska A,Kaliñska A

    更新日期:2005-09-01 00:00:00

  • Risk for malaria in United States donors deferred for travel to malaria-endemic areas.

    abstract:BACKGROUND:Deferral for travel to malaria-endemic areas excludes many blood donors in the United States. Most transfusion-transmitted malaria is associated with lengthy residence in malaria-endemic areas rather than routine travel. This study compares the impact of existing deferral requirements to the risk that a pres...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2009.02290.x

    authors: Spencer B,Steele W,Custer B,Kleinman S,Cable R,Wilkinson S,Wright D

    更新日期:2009-11-01 00:00:00

  • The prevalence of human parvovirus B19 DNA and antibodies in blood donors from four Chinese blood centers.

    abstract:BACKGROUND:Human parvovirus B19 is a common human pathogen that causes a variety of diseases with outcomes ranging from asymptomatic to severe, especially in immunocompromised patients. The B19 virus can be transmitted via blood and/or blood products and its resistance to common viral inactivation and/or removal method...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03067.x

    authors: Ke L,He M,Li C,Liu Y,Gao L,Yao F,Li J,Bi X,Lv Y,Wang J,Hirsch ML,Li W

    更新日期:2011-09-01 00:00:00

  • Methicillin-resistant Staphylococcus aureus sepsis associated with the transfusion of contaminated platelets: a case report.

    abstract:BACKGROUND:Platelet transfusion-associated sepsis is usually due to donor skin flora introduced into the unit during phlebotomy. An unusual case of a platelet component contaminated with methicillin-resistant Staphylococcus aureus (MRSA) is reported. CASE REPORT:A 54-year-old man, terminally ill with progressive non-H...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2001.41111426.x

    authors: Sapatnekar S,Wood EM,Miller JP,Jacobs MR,Arduino MJ,McAllister SK,Kellum ME,Roth V,Yomtovian R

    更新日期:2001-11-01 00:00:00

  • Risk of transfusion-associated dengue: screening of blood donors from Pune, western India.

    abstract:BACKGROUND:Dengue, a mosquito-borne viral disease, is endemic in >125 countries worldwide. The threat of blood-borne transmission of dengue virus (DENV) has been documented. STUDY DESIGN AND METHODS:This study was conducted to assess the potential magnitude of transfusion-associated dengue, by determination of DENV se...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15007

    authors: Kulkarni R,Tiraki D,Wani D,Mishra AC,Arankalle VA

    更新日期:2019-02-01 00:00:00

  • Radiation-induced red cell damage: role of reactive oxygen species.

    abstract:BACKGROUND:Cellular blood components are irradiated to prevent graft-versus-host disease in transfusion recipients at risk for this syndrome. Because gamma radiation can result in the production of reactive oxygen species, the role of reactive oxygen species was investigated in radiation-induced red cell damage. STUDY...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1997.37297203518.x

    authors: Anand AJ,Dzik WH,Imam A,Sadrzadeh SM

    更新日期:1997-02-01 00:00:00

  • Is placental blood a reliable source for the evaluation of neonatal hemostasis at birth?

    abstract:BACKGROUND:Phlebotomy is among the main determinants of anemia of prematurity. Blood sparing policies endorsed umbilical cord blood (here called placental) as an alternative source for laboratory testing. Little is known on the suitability of placental blood to evaluate neonatal hemostasis of newborn infants. We aimed ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15785

    authors: Raffaeli G,Tripodi A,Manzoni F,Scalambrino E,Pesenti N,Amodeo I,Cavallaro G,Villamor E,Peyvandi F,Mosca F,Ghirardello S

    更新日期:2020-05-01 00:00:00

  • Blood group incidence and Escherichia coli bacterial sepsis.

    abstract::Many strains of Escherichia coli possess an antigen that reacts with naturally occurring antibodies to human red cell B antigens. The authors tested the hypothesis that the presence of naturally occurring anti-B isoagglutinins afford protection against the development of E. coli septicemia. The blood groups found in 1...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1986.26687043620.x

    authors: Wittels EG,Lichtman HC

    更新日期:1986-11-01 00:00:00

  • Blood transfusion safety in sub-Saharan Africa: A literature review of changes and challenges in the 21st century.

    abstract:BACKGROUND:Access to a safe, adequate blood supply has proven challenging in sub-Saharan Africa, where systemic deficiencies spanning policy, collections, testing, and posttransfusion surveillance have long been recognized. Progress in transfusion safety in the early 2000s was in large part due to intervention by the W...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.14949

    authors: Weimer A,Tagny CT,Tapko JB,Gouws C,Tobian AAR,Ness PM,Bloch EM

    更新日期:2019-01-01 00:00:00

  • How to verify patient identity and blood product compatibility using an electronic bedside transfusion system.

    abstract::Transfusion of an incorrect blood component is an important avoidable serious hazard of transfusion resulting from process errors. Our group and others have taken advantage of new technology and developed electronic transfusion systems for safe transfusion practice in a previous studies. They allow the clinical staff ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16028

    authors: Staples S,O'Callaghan C,Pavord S,Staves J,Murphy MF

    更新日期:2020-09-01 00:00:00

  • Does an intrauterine exchange transfusion improve the fetal prognosis in parvovirus infection cases?

    abstract:BACKGROUND:Almost 20% of parvovirus B19 foetal infections require intrauterine transfusions. In addition, myocardial dysfunction has been observed in severe parvovirus B19 infections. One objective of an intrauterine exchange transfusion (IUET) is to avoid an overload during the transfusion. Our aim was to study the ob...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14968

    authors: Vanspranghels R,Houfflin-Debarge V,Vaast P,Coulon C,Clouqueur E,Hanssens S,Rakza T,Subtil D,Garabedian C

    更新日期:2019-01-01 00:00:00

  • Two-year follow-up of donors in a large national study of ferritin testing.

    abstract:BACKGROUND:We assessed donor return rates, donation frequency, and factors related to the evolution of ferritin levels 2 years after entering donors into a large operational study of ferritin testing. STUDY DESIGN AND METHODS:Ferritin testing was done on donors from representative clinics (n = 12,595). Low-ferritin do...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/trf.14941

    authors: Goldman M,Uzicanin S,Osmond L,Yi QL,Scalia V,O'Brien SF

    更新日期:2018-12-01 00:00:00