Abstract:
BACKGROUND:The Le(a) and Le(b) antigens are synthesized by cells making exocrine secretions, but it is not well-defined where plasma and red cell Le(a) and Le(b) antigens are made. STUDY DESIGN AND METHODS:This study uses chromatographic and immunochemical methods to extract Le(a) and Le(b) glycolipids from human tissues. RESULTS:Le(a) and Le(b) antigens may be synthesized by both epithelial and mesodermal tissues. Expression of Lewis transferase activity was demonstrated in various tissues, confirming the epistatic interaction by Le and H genes to form the Leb antigen. CONCLUSION:The Le(a) and Le(b) substances found in plasma might originate from the epithelial cells of the digestive tract.
journal_name
Transfusionjournal_title
Transfusionauthors
Hauser Rdoi
10.1046/j.1537-2995.1995.35795357880.xsubject
Has Abstractpub_date
1995-07-01 00:00:00pages
577-81issue
7eissn
0041-1132issn
1537-2995journal_volume
35pub_type
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