Le(a) and Le(b) tissue glycosphingolipids.

Abstract:

BACKGROUND:The Le(a) and Le(b) antigens are synthesized by cells making exocrine secretions, but it is not well-defined where plasma and red cell Le(a) and Le(b) antigens are made. STUDY DESIGN AND METHODS:This study uses chromatographic and immunochemical methods to extract Le(a) and Le(b) glycolipids from human tissues. RESULTS:Le(a) and Le(b) antigens may be synthesized by both epithelial and mesodermal tissues. Expression of Lewis transferase activity was demonstrated in various tissues, confirming the epistatic interaction by Le and H genes to form the Leb antigen. CONCLUSION:The Le(a) and Le(b) substances found in plasma might originate from the epithelial cells of the digestive tract.

journal_name

Transfusion

journal_title

Transfusion

authors

Hauser R

doi

10.1046/j.1537-2995.1995.35795357880.x

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

577-81

issue

7

eissn

0041-1132

issn

1537-2995

journal_volume

35

pub_type

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