Le(a) and Le(b) tissue glycosphingolipids.


BACKGROUND:The Le(a) and Le(b) antigens are synthesized by cells making exocrine secretions, but it is not well-defined where plasma and red cell Le(a) and Le(b) antigens are made. STUDY DESIGN AND METHODS:This study uses chromatographic and immunochemical methods to extract Le(a) and Le(b) glycolipids from human tissues. RESULTS:Le(a) and Le(b) antigens may be synthesized by both epithelial and mesodermal tissues. Expression of Lewis transferase activity was demonstrated in various tissues, confirming the epistatic interaction by Le and H genes to form the Leb antigen. CONCLUSION:The Le(a) and Le(b) substances found in plasma might originate from the epithelial cells of the digestive tract.






Hauser R




Has Abstract


1995-07-01 00:00:00












  • Retrograde transmission of Proteus mirabilis during platelet transfusion and the use of arbitrarily primed polymerase chain reaction for bacteria typing in suspected cases of transfusion transmission of infection.

    abstract:BACKGROUND:When bacteria are found, after a platelet transfusion, in the recipient's blood as well as in the platelet concentrate (PC), a causal relationship is normally suspected, with the PC as the causative agent. The other alternative, that the patient has bacteremia and contaminated the PC, is less well documented...


    pub_type: 杂志文章


    authors: Engstrand M,Engstrand L,Högman CF,Hambraeus A,Branth S

    更新日期:1995-10-01 00:00:00

  • The value of transfusion of phenotyped blood units for thalassemia and sickle cell anemia patients at an academic center.

    abstract:BACKGROUND:Blood transfusion is the first-line treatment for patients with thalassemia and many sickle cell patients. However, cases of unregulated blood transfusion are shown to carry a high risk of alloimmunization to red blood cells (RBCs), which can lead to a hemolytic transfusion reaction and be fatal to patients....


    pub_type: 杂志文章


    authors: Hindawi S,Badawi M,Elfayoumi R,Elgemmezi T,Al Hassani A,Raml M,Alamoudi S,Gholam K

    更新日期:2020-02-01 00:00:00

  • Exchange transfusion in sickle cell disease using a continuous-flow blood cell separator.

    abstract::An exchange transfusion was performed preoperatively on a patient with sickle cell disease using a continuous-flow blood cell separator. An exchange of 2,825 ml red blood cells achieved a hemoglobin A level of 90.8 per cent. The continuous-flow blood cell separator appears to offer a safe and effective method of excha...


    pub_type: 杂志文章


    authors: Kernoff LM,Botha MC,Jacobs P

    更新日期:1977-05-01 00:00:00

  • AABB Committee Report: reducing transfusion-transmitted cytomegalovirus infections.

    abstract::Transfusion-transmitted cytomegalovirus (TT-CMV) is often asymptomatic, but certain patient populations, such as very low birth weight neonates, fetuses requiring intrauterine transfusion, pregnant women, patients with primary immunodeficiencies, transplant recipients, and patients receiving chemotherapy or transplant...


    pub_type: 杂志文章,评审


    authors: AABB, Clinical Transfusion Medicine Committee.,Heddle NM,Boeckh M,Grossman B,Jacobson J,Kleinman S,Tobian AA,Webert K,Wong EC,Roback JD

    更新日期:2016-06-01 00:00:00

  • A newly developed gel centrifugation test for quantification of RBC-bound IgG antibodies and their subclasses IgG1 and IgG3: comparison with flow cytometry.

    abstract:BACKGROUND:Novel gel centrifugation test (GCT) cards were evaluated with respect to their ability to estimate the quantity of IgG on RBCs and the determination of the IgG subclasses IgG1 and IgG3. STUDY DESIGN AND METHODS:In 65 patients with a positive DAT, the amount of IgG-gamma-, IgG1, and IgG3 on RBCs was examined...


    pub_type: 杂志文章


    authors: Lynen R,Krone O,Legler TJ,Köhler M,Mayr WR

    更新日期:2002-05-01 00:00:00

  • The influence of irradiation on stored platelets.

    abstract::Platelet concentrates intended for transfusion to immunosuppressed patients are irradiated to minimize transfusion-induced graft-versus-host disease. Because few reports describe how irradiation influences stored platelets, the authors studied whether 5000 rad of gamma irradiation, the maximum dose currently used clin...


    pub_type: 杂志文章


    authors: Moroff G,George VM,Siegl AM,Luban NL

    更新日期:1986-09-01 00:00:00

  • Removal of prion challenge from an immune globulin preparation by use of a size-exclusion filter.

    abstract:BACKGROUND:A size-exclusion filter (Viresolve 180, Millipore Corp.) was tested for its ability to remove transmissible spongiform encephalopathies prion protein from an immune globulin preparation during ultrafiltration. STUDY DESIGN AND METHODS:Hamster-adapted 263K scrapie brain homogenate (SBH) was spiked into Rh0(D...


    pub_type: 杂志文章


    authors: Van Holten RW,Autenrieth S,Boose JA,Hsieh WT,Dolan S

    更新日期:2002-08-01 00:00:00

  • Anti-Cob causing acute hemolytic transfusion reaction.

    abstract::An example of anti-Cob which caused an acute hemolytic transfusion reaction is reported. Immunohematologic studies showed this antibody to be an IgG immunoglobulin that weakly bound complement and reacted in the antiglobulin phase of the crossmatch. The unit of whole blood implicated in the hemolytic transfusion react...


    pub_type: 杂志文章


    authors: Lee EL,Bennett C

    更新日期:1982-03-01 00:00:00

  • The symbolic roots of blood donation.

    abstract:BACKGROUND:Throughout history, blood has been embedded with powerful and paradoxical connotations. In the last decades, a more rational conception based on scientific knowledge has emerged, portraying blood as a "disenchanted" and utilitarian object, hence more apt for donation between strangers. This study aims to exa...


    pub_type: 杂志文章


    authors: Charbonneau J,Tran NY

    更新日期:2013-12-01 00:00:00

  • Can family or replacement blood donors become regular volunteer donors?

    abstract:BACKGROUND:In sub-Saharan Africa (SSA) confirmed viral marker prevalence between family donors (FDs) and first-time volunteer nonremunerated donors (VNRDs) is similar. In a blood service collecting 10 units/1000 inhabitants, a questionnaire examined FD donation conditions and willingness of becoming repeat VNRDs. STUD...


    pub_type: 杂志文章


    authors: Asenso-Mensah K,Achina G,Appiah R,Owusu-Ofori S,Allain JP

    更新日期:2014-03-01 00:00:00

  • A multicenter evaluation of reproducibility of swirling in platelet concentrates. Biomedical Excellence for Safer Transfusion (BEST) Working Party of the International Society of Blood Transfusion.

    abstract:BACKGROUND:Eleven laboratories participated in a study investigating whether swirling can be used in monitoring platelet discoid morphology in platelet concentrates (PCs). STUDY DESIGN AND METHODS:In each laboratory, two readers observed the swirling pattern in 1- to 5-day-old PCs, in PCs containing spherical platelet...


    pub_type: 杂志文章


    authors: Bertolini F,Murphy S

    更新日期:1994-09-01 00:00:00

  • Effective storage of granulocytes collected by centrifugation leukapheresis from donors stimulated with granulocyte-colony-stimulating factor.

    abstract:BACKGROUND:Donor stimulation with granulocyte-colony-stimulating factor (G-CSF) has increased the number of neutrophils (PMNs) that can be collected for granulocyte transfusion therapy. Clinical utility, however, has been limited by the inability to store functional PMNs ex vivo. This study was conducted to determine w...


    pub_type: 临床试验,杂志文章


    authors: Hubel K,Rodger E,Gaviria JM,Price TH,Dale DC,Liles WC

    更新日期:2005-12-01 00:00:00

  • A single-center prospective study on the safety of plasma exchange procedures using a double-viral-inactivated and prion-reduced solvent/detergent fresh-frozen plasma as the replacement fluid in the treatment of thrombotic microangiopathy.

    abstract:BACKGROUND:Patients presenting with acute episodes of thrombotic microangiopathies (TMAs) require urgent access to plasma exchange (PEX). OctaplasLG, a solvent/detergent fresh-frozen plasma product that has undergone viral inactivation and prion reduction step, has been used in our institution since 2013, replacing Oct...


    pub_type: 临床试验,杂志文章


    authors: Vendramin C,McGuckin S,Alwan F,Westwood JP,Thomas M,Scully M

    更新日期:2017-01-01 00:00:00

  • Plasma treated with amotosalen and ultraviolet A light retains activity for hemostasis after 5 days post-thaw storage at 1 to 6o C.

    abstract:BACKGROUND:Plasma thawed and stored at 1 to 6° C for up to 5 days (thawed plasma [TP]) provides rapid availability in emergencies and reduces plasma waste, but it carries risks of coagulation factor loss or activation, bacterial outgrowth, and viral contamination. We characterized changes in amotosalen/ultraviolet A (U...


    pub_type: 杂志文章


    authors: Erickson A,Waldhaus K,David T,Huang N,Rico S,Corash L,Mufti N,Benjamin RJ

    更新日期:2017-04-01 00:00:00

  • RUNX1 mutation in a patient with myelodysplastic syndrome and decreased erythrocyte expression of blood group A antigen.

    abstract:BACKGROUND:Loss of blood group ABO antigens on red blood cells (RBCs) is well known in patients with leukemias, and such decreased ABO expression has been reported to be strongly associated with hypermethylation of the ABO promoter. We investigated the underlying mechanism responsible for A-antigen reduction on RBCs in...


    pub_type: 杂志文章


    authors: Hayakawa A,Sano R,Takahashi Y,Kubo R,Harada M,Omata M,Yokohama A,Handa H,Tsukada J,Takeshita H,Tsuneyama H,Ogasawara K,Kominato Y

    更新日期:2020-01-01 00:00:00

  • Acquisition of cytomegalovirus infection in infants following exchange transfusion: a prospective study.

    abstract::A prospective study of newborn infants who required exchange transfusion was undertaken to evaluate the risk of transmission of cytomegalovirus (CMV). Buffy coat-, urine- and saliva-saturated throat swabs for viral cultures and serum specimens for CMV complement-fixing (CF) antibody were obtained from 45 infant-mother...


    pub_type: 杂志文章


    authors: Kumar A,Nankervis GA,Cooper AR,Gold E,Kumar ML

    更新日期:1980-05-01 00:00:00

  • Risk factors for HCV infection among blood donors confirmed to be positive for the presence of HCV RNA and not reactive for the presence of anti-HCV.

    abstract:BACKGROUND:In 1999, NAT of blood donations was implemented to detect "window-period" infections. Blood donors who have confirmed NAT results positive for the presence of HCV in the absence of anti-HCV are likely to have been recently infected. Of over 26.8 million donations tested between March 3, 1999, and March 31, 2...


    pub_type: 杂志文章


    authors: Orton SL,Stramer SL,Dodd RY,Alter MJ

    更新日期:2004-02-01 00:00:00

  • Does therapeutic plasma exchange have a role in the treatment of prosthetic hip-associated cobalt toxicity? A case report and literature review.

    abstract:BACKGROUND:Prosthetic hip-associated cobalt toxicity (PHACT) is an uncommon, but potentially devastating, complication for patients with metal-on-metal hip implants (MoMs). Clinical management of PHACT is poorly defined, with primary intervention being MoM explant followed by chelation therapy. Therapeutic plasma excha...


    pub_type: 杂志文章,评审


    authors: Grant ML,Karp JK,Palladino M,Le N,Hall N,Herman JH

    更新日期:2016-09-01 00:00:00

  • Noninvasive determination of fetal RHD status by examination of cell-free DNA in maternal plasma.

    abstract:BACKGROUND:Cell-free fetal DNA in maternal plasma opens the way for routine risk-free diagnosis of fetal D status of D- mothers. The focus was on accuracy of RHD typing and confirmation of fetal DNA in maternal plasma while RHD was not detected. STUDY DESIGN AND METHODS:Plasma DNA was extracted (by manual and/or autom...


    pub_type: 杂志文章


    authors: Brojer E,Zupanska B,Guz K,Orziñska A,Kaliñska A

    更新日期:2005-09-01 00:00:00

  • First-time blood donors: demographic trends.

    abstract:BACKGROUND:With changing demographics of the United States population and the continuous need to recruit new donors, it is important to monitor the demographic profile of first-time donors and to evaluate changes in the donor pool to improve recruitment targeting. STUDY DESIGN AND METHODS:First-time whole blood (n = 9...


    pub_type: 杂志文章


    authors: Wu Y,Glynn SA,Schreiber GB,Wright DJ,Lo A,Murphy EL,Kleinman SH,Garratty G,Retrovirus Epidemiology Donor Study (REDS) Group.

    更新日期:2001-03-01 00:00:00

  • Analysis of apheresis content of progenitor cell collections from normal donors to whom granulocyte-colony-stimulating factor is administered.

    abstract:BACKGROUND:Allogeneic blood cell transplantation is a new alternative to bone marrow transplantation. Preliminary data suggest that granulocyte-colony-stimulating factor (G-CSF)-mobilized peripheral blood progenitor cells from normal donors can provide rapid hematopoietic engraftment without significant increases in tr...


    pub_type: 杂志文章


    authors: Weinthal JA,Nemunaitis JJ,Aston S,Magsamen MJ,Rosenfeld CS

    更新日期:1996-11-01 00:00:00

  • Investigation of whether the acute hemolysis associated with Rh(o)(D) immune globulin intravenous (human) administration for treatment of immune thrombocytopenic purpura is consistent with the acute hemolytic transfusion reaction model.

    abstract:BACKGROUND:Immune thrombocytopenic purpura and secondary thrombocytopenia patients treated with Rh(o)(D) immune globulin intravenous (human; anti-D IGIV) have experienced acute hemolysis, which is inconsistent with the typical presentation of extravascular hemolysis -- the presumed mechanism of action of anti-D IGIV. A...


    pub_type: 杂志文章


    authors: Gaines AR,Lee-Stroka H,Byrne K,Scott DE,Uhl L,Lazarus E,Stroncek DF

    更新日期:2009-06-01 00:00:00

  • Effect of storage of red blood cells on alloimmunization.

    abstract:BACKGROUND:Red blood cells (RBCs) undergo changes during storage. Various studies have suggested a higher risk of adverse and often multifactorial clinical outcomes associated with older-stored RBCs. Our aim therefore was to examine if storage of transfused RBCs is also associated with the risk of RBC-specific alloanti...


    pub_type: 杂志文章,多中心研究


    authors: Zalpuri S,Schonewille H,Middelburg R,van de Watering L,de Vooght K,Zimring J,van der Bom JG,Zwaginga JJ

    更新日期:2013-11-01 00:00:00

  • Lack of effect of donor-recipient Rh mismatch on outcomes after allogeneic hematopoietic stem cell transplantation.

    abstract:BACKGROUND:A recently published study has reported that donor-recipient Rhesus (Rh)-mismatched allogeneic hematopoietic stem cell transplantation independently led to significantly poorer survival. This suggests that donor-recipient Rh mismatching is a risk factor in allogeneic hematopoietic stem cell transplantation a...


    pub_type: 杂志文章


    authors: Wirk B,Klumpp TR,Ulicny J,Herman JH,Gajewski JL,Martin ME,Emmons RV,Mangan KF

    更新日期:2008-01-01 00:00:00

  • Effects of immediate or delayed addition of platelet additive solution on the in vitro quality of apheresis platelets.

    abstract:BACKGROUND:There is little knowledge how different hold times of hyperconcentrated platelet (PLT) suspensions (HPSs) before the addition of platelet additive solution (PAS) might affect PLT quality. We compared the in vitro quality of single-donor PLT concentrates (SDPs) with immediate or delayed PAS addition and studi...


    pub_type: 杂志文章


    authors: Ringwald J,Tully S,Geier C,Hauck B,Weiss D,Callaert M,Eckstein R

    更新日期:2012-06-01 00:00:00

  • Bloodless medicine: current strategies and emerging treatment paradigms.

    abstract:BACKGROUND:Advances in our understanding of the risks associated with allogeneic blood transfusions (ABTs) and the growing number of patients who wish to avoid ABTs have led to the emergence of new treatment paradigms for "bloodless" medicine and surgery. STUDY DESIGN AND METHODS:Here, we review prior studies and summ...


    pub_type: 杂志文章,评审


    authors: Resar LM,Wick EC,Almasri TN,Dackiw EA,Ness PM,Frank SM

    更新日期:2016-10-01 00:00:00

  • Hemolysis in patients with antibody deficiencies on immunoglobulin replacement treatment.

    abstract:BACKGROUND:Immunoglobulin (Ig)G replacement with intravenous or subcutaneous immunoglobulins is a lifelong substitutive therapy in patients with primary antibody deficiencies (PADs). Hemolysis after immunoglobulin therapy was described in patients receiving high immunoglobulin dosages. The issue of hemolysis after immu...


    pub_type: 杂志文章


    authors: Quinti I,Pulvirenti F,Milito C,Granata G,Giovannetti G,La Marra F,Pesce AM,Farrugia A,Coluzzi S,Girelli G

    更新日期:2015-05-01 00:00:00

  • Red blood cell (RBC) survival determined in humans using RBCs labeled at multiple biotin densities.

    abstract:BACKGROUND:Safe, accurate methods permitting simultaneous and/or repeated measurement of red blood cell (RBC) survival (RCS) are important to investigate pathophysiology and therapy of anemia. Methods using chromium 51 ((51) Cr)-labeled RBCs are unacceptable for infants, children, and pregnant women. We report RCS meas...


    pub_type: 杂志文章


    authors: Mock DM,Matthews NI,Zhu S,Strauss RG,Schmidt RL,Nalbant D,Cress GA,Widness JA

    更新日期:2011-05-01 00:00:00

  • Maternal human platelet antigen-1a antibody level correlates with the platelet count in the newborns: a retrospective study.

    abstract:BACKGROUND:Maternal plasma and/or serum levels of anti-HPA-1a at delivery were compared to neonatal platelet (PLT) counts. STUDY DESIGN AND METHODS:Samples from HPA-1bb women who gave birth to children with thrombocytopenia or had anamnestic information about a previous child with neonatal alloimmune thrombocytopenia ...


    pub_type: 杂志文章


    authors: Killie MK,Husebekk A,Kaplan C,Taaning E,Skogen B

    更新日期:2007-01-01 00:00:00

  • Clinical and serologic management of patients with methyldopa-induced positive antiglobulin tests.

    abstract::Methyldopa can produce both a positive direct antiglobulin test and less commonly a positive indirect antiglobulin test. When the drug-induced antibody is present in the serum, it acts as a panagglutinin and reacts with all normal red blood cells; consequently crossmatch-compatible blood cannot be prepared. Although t...


    pub_type: 杂志文章


    authors: Snyder EL,Spivack M

    更新日期:1979-05-01 00:00:00