Le(a) and Le(b) tissue glycosphingolipids.


BACKGROUND:The Le(a) and Le(b) antigens are synthesized by cells making exocrine secretions, but it is not well-defined where plasma and red cell Le(a) and Le(b) antigens are made. STUDY DESIGN AND METHODS:This study uses chromatographic and immunochemical methods to extract Le(a) and Le(b) glycolipids from human tissues. RESULTS:Le(a) and Le(b) antigens may be synthesized by both epithelial and mesodermal tissues. Expression of Lewis transferase activity was demonstrated in various tissues, confirming the epistatic interaction by Le and H genes to form the Leb antigen. CONCLUSION:The Le(a) and Le(b) substances found in plasma might originate from the epithelial cells of the digestive tract.






Hauser R




Has Abstract


1995-07-01 00:00:00












  • A comparative study of the postoperative allogeneic blood-sparing effects of tranexamic acid and of desmopressin after total knee replacement.

    abstract:BACKGROUND:Tissue hypoxia and reperfusion induce abnormal hemostatic function. Therefore, bleeding after total knee replacement (TKR) may be a result of a tourniquet-induced imbalance of the procoagulant and fibrinolytic systems. Because laboratory confirmation of tourniquet-induced abnormal hemostasis is difficult to ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Zohar E,Fredman B,Ellis MH,Ifrach N,Stern A,Jedeikin R

    更新日期:2001-10-01 00:00:00

  • A possible role for the production of multiple HLA antibodies in fatal platelet transfusion refractoriness after peripheral blood progenitor cell transplantation from the mother in a patient with relapsed leukemia.

    abstract:BACKGROUND:There has been controversy over whether HLA alloimmunization is a risk factor for platelet (PLT) transfusion refractoriness (PTR) in hematopoietic peripheral blood progenitor cell transplantation (HPBPCT). STUDY DESIGN AND METHODS:Reported here is a boy with relapsed leukemia who developed fatal PTR after a...


    pub_type: 杂志文章


    authors: Nakazawa Y,Saito S,Hasegawa Y,Yanagisawa R,Sakashita K,Kamijo T,Miyazaki T,Sato S,Ikeda H,Ikebuchi K,Koike K

    更新日期:2007-02-01 00:00:00

  • Granulocyte transfusion kinetics measured by chemiluminescence, nitroblue tetrazolium reduction, and recovery of indium-111-labeled granulocytes.

    abstract::A 20-year-old man with chronic granulomatous disease (CGD) and who was receiving granulocyte transfusions for a refractory liver abscess was studied to compare the kinetics of 111In-labeled granulocytes with those of two functional granulocyte assays, nitroblue tetrazolium reduction and chemiluminescence. Transfused g...


    pub_type: 杂志文章


    authors: Elliott GR,Clay ME,Mills EL,Abramson JS,McCullough J,Quie PG

    更新日期:1987-01-01 00:00:00

  • A new method for monitoring the sterility of blood donation.

    abstract::Sterility of blood products is a cardinal contributor to patient safety. Bacteriologic controls of stable products comply with strict regulations, but legislation imposes only limited constraints in the case of perishable products, such as packed red cells (RBCs) or fresh-frozen plasma (FFP). Therefore, it is essentia...


    pub_type: 杂志文章


    authors: Guéguen M,Durand F,Delamaire D,Beauplet A,Tardivel R,Genetet B,Chalumeau H,Balme MC

    更新日期:1986-05-01 00:00:00

  • Plasma treated with amotosalen and ultraviolet A light retains activity for hemostasis after 5 days post-thaw storage at 1 to 6o C.

    abstract:BACKGROUND:Plasma thawed and stored at 1 to 6° C for up to 5 days (thawed plasma [TP]) provides rapid availability in emergencies and reduces plasma waste, but it carries risks of coagulation factor loss or activation, bacterial outgrowth, and viral contamination. We characterized changes in amotosalen/ultraviolet A (U...


    pub_type: 杂志文章


    authors: Erickson A,Waldhaus K,David T,Huang N,Rico S,Corash L,Mufti N,Benjamin RJ

    更新日期:2017-04-01 00:00:00

  • Risk for malaria in United States donors deferred for travel to malaria-endemic areas.

    abstract:BACKGROUND:Deferral for travel to malaria-endemic areas excludes many blood donors in the United States. Most transfusion-transmitted malaria is associated with lengthy residence in malaria-endemic areas rather than routine travel. This study compares the impact of existing deferral requirements to the risk that a pres...


    pub_type: 杂志文章


    authors: Spencer B,Steele W,Custer B,Kleinman S,Cable R,Wilkinson S,Wright D

    更新日期:2009-11-01 00:00:00

  • Transfusion of frozen erythrocytes from a donor with sickle trait.

    abstract::We describe a nonanaphylactic hemoglobinuric reaction caused by transfusion of frozen red cells, deglycerolyzed by standard technique, obtained from a donor with undiagnosed sickle trait. Although significant hemoglobinemia and hemoglobinuria were noted, the recipient experienced no adverse clinical reactions. The ben...


    pub_type: 杂志文章


    authors: Kelleher JF Jr,Luban NL

    更新日期:1984-03-01 00:00:00

  • Effect of delayed centrifugation or reading on the detection of ABO incompatibility by the immediate-spin crossmatch.

    abstract::The immediate-spin (IS) crossmatch is a method that detects ABO incompatibility. However, under certain circumstances, this test may show unwanted negative or weak results, even though the red cells (RBCs) and serum being tested are ABO incompatible with each other. The present study investigated the potential effect ...


    pub_type: 杂志文章


    authors: Shulman IA,Calderón C

    更新日期:1991-03-01 00:00:00

  • Frequent blood donation and offspring scholastic attainment: an assessment of long-term consequences of prenatal iron deficiency.

    abstract:BACKGROUND:Due to physiological demands, children and premenopausal women are at risk of developing iron deficiency. In premenopausal women, the risk may be further increased by repeated whole blood donations. Short-term consequences of iron deficiency in infancy include impaired cognitive development and lower IQ scor...


    pub_type: 杂志文章


    authors: Rigas AS,Pedersen OB,Rostgaard K,Sørensen E,Erikstrup C,Hjalgrim H,Ullum H

    更新日期:2019-05-01 00:00:00

  • Preparation of white cell-depleted red cells for 42-day storage using an integral in-line filter.

    abstract::A new blood pack system for the preparation of white cell-depleted red cells was studied. The system is a modified additive-solution quadruple-unit blood pack that incorporates a cellulose-acetate fiber depth filter in-line between the AS-3 additive bag and the CP2D collection bag. Mean +/- SD white cell removal from ...


    pub_type: 杂志文章


    authors: Davey RJ,Carmen RA,Simon TL,Nelson EJ,Leng BS,Chong C,Garcez RB,Sohmer PR

    更新日期:1989-07-01 00:00:00

  • Detection of dengue, chikungunya, and Zika RNA in blood donors from Southeast Asia.

    abstract:BACKGROUND:Chikungunya (CHIKV), dengue (DENV), and Zika (ZIKV) viruses are of concern due to the potential of transfusion transmission in blood, especially in regions such as Southeast Asia where the viruses are endemic. The recent availability of nucleic acid testing (NAT) to screen blood donations on an automated pla...


    pub_type: 杂志文章


    authors: Stanley J,Chongkolwatana V,Duong PT,Kitpoka P,Stramer SL,Dung NTT,Grimm KE,Pojanasingchod A,Suksomboonvong P,Galel SA

    更新日期:2020-10-07 00:00:00

  • Barriers to blood donation in African communities in Australia: the role of home and host country culture and experience.

    abstract:BACKGROUND:An influx of African migrants and refugees can strain a host country's blood services, because often migrants have unique blood needs that cannot be sourced from local donors. To increase blood donation by the new migrants, host country blood services need to understand how blood and blood donations are view...


    pub_type: 杂志文章


    authors: Polonsky MJ,Renzaho AM,Brijnath B

    更新日期:2011-08-01 00:00:00

  • Genetic diversity of KELnull and KELel: a nationwide Austrian survey.

    abstract:BACKGROUND:Besides ABO and RH, the KEL blood group system, including the two antithetical antigens KEL1 and KEL2, is the most important owing to the frequent appearance of anti-KEL alloantibodies and their considerable clinical significance. So far, only limited information was available on KEL variant alleles determin...


    pub_type: 杂志文章


    authors: Körmöczi GF,Wagner T,Jungbauer C,Vadon M,Ahrens N,Moll W,Mühlbacher A,Ozgül-Gülce S,Kleinrath T,Kilga-Nogler S,Schönitzer D,Gassner C

    更新日期:2007-04-01 00:00:00

  • Effects of interruptions of controlled-rate freezing on the viability of umbilical cord blood stem cells.

    abstract:BACKGROUND:An optimal cooling rate is critical for cryopreserving cord blood stem cells, so it is generally achieved by using controlled-rate freezers (CRFs). The cooling rate can be interrupted by many factors during cooling; therefore, a proper response to the interruption in cryopreservation is crucial to prevent th...


    pub_type: 杂志文章


    authors: Yang H,Pidgorna A,Loutfy MR,Shuen P

    更新日期:2015-01-01 00:00:00

  • Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells.

    abstract:BACKGROUND:The relationship between length of storage of red blood cell (RBC) units and biochemical changes has been well studied, but little is known about the progression of cellular immunomodulative properties in blood recipients. This study aims to quantify in vitro T-cell activation and cytokine release by white b...


    pub_type: 杂志文章


    authors: Karam O,Tucci M,Toledano BJ,Robitaille N,Cousineau J,Thibault L,Lacroix J,Le Deist F

    更新日期:2009-11-01 00:00:00

  • The impact of e-mail in acquiring and retaining whole-blood donors: a comparative analysis of the Puget Sound Blood Center donor e-mail communication program.

    abstract:BACKGROUND:With the emergence of e-mail as a common form of communication, it is important to understand the role and impact e-mail can have on acquiring and retaining whole-blood donors. STUDY DESIGN AND METHODS:Whole-blood donors who opted in to receive e-mail communications (n = 43,232) from the Puget Sound Blood C...


    pub_type: 杂志文章


    authors: Geyer ME

    更新日期:2005-12-01 00:00:00

  • Clinical predictors of postoperative hemoglobin drift.

    abstract:BACKGROUND:The decision to transfuse red blood cells in surgical patients should be based on multiple clinical variables, rather than on isolated hemoglobin (Hb) measurements alone. An important but often unrecognized clinical variable is the postoperative downward drift in Hb concentration (Hb drift), but the etiology...


    pub_type: 杂志文章


    authors: Grant MC,Whitman GJ,Savage WJ,Ness PM,Frank SM

    更新日期:2014-06-01 00:00:00

  • Risk of iatrogenic human immunodeficiency virus infection through transfusion of blood tested by inappropriately stored or expired rapid antibody assays in a Zambian hospital.

    abstract:BACKGROUND:The purpose of this study was to estimate the risk of human immunodeficiency virus (HIV) infection via the transfusion of blood tested by inappropriately stored or expired rapid antibody assays in Zambia. STUDY DESIGN AND METHODS:Surgical patients (n = 370) were tested with antibody assays (HIV-spot and HIV...


    pub_type: 杂志文章


    authors: Consten EC,van der Meer JT,de Wolf F,Heij HA,Henny PC,van Lanschot JJ

    更新日期:1997-09-01 00:00:00

  • The Dc(G48)e(s) haplotype is frequent among the Dce haplotypes within a white population.

    abstract:BACKGROUND:The absence of hybrid Rhesus boxes denotes an RHD homozygous status and helps to detect the presence of Dce haplotypes instead of dce. RHCE exon 1 C48, characteristic of RHC alleles, and RHCE exon 5 G733, responsible for VS antigenicity, have been noted in many RHce alleles but it was not clearly established...


    pub_type: 杂志文章


    authors: Cotorruelo CM,Munini GM,García Borrás SE,Racca LL,Biondi CS,Racca AL

    更新日期:2007-03-01 00:00:00

  • The effect of hydroxyethyl starch on in vitro platelet and granulocyte function.

    abstract::The effect of hydroxyethyl starch (HES) on granulocyte and platelet functions was assessed. No alteration of granulocyte viability, morphology, phagocytic ability, or bactericidal capacity was detected after incubation with 6 per cent HES at 25 C for two hours. Platelet morphology, size distribution, aggregation, nucl...


    pub_type: 杂志文章


    authors: Schiffer CA,Aisner J,Schmukler M,Whitaker CL,Wolff JH

    更新日期:1975-09-01 00:00:00

  • Prolonged platelet preservation by transient metabolic suppression.

    abstract:BACKGROUND:In this study whether metabolic suppression can be used to preserve platelet (PLT) function during prolonged storage was investigated. STUDY DESIGN AND METHODS:Washed human PLTs were incubated without glucose and with antimycin A to block energy generation. Metabolic suppressed PLTs (MSPs) were stored for 7...


    pub_type: 杂志文章


    authors: Badlou BA,Ijseldijk MJ,Smid WM,Akkerman JW

    更新日期:2005-02-01 00:00:00

  • Alteration of red cell aggregability and shape during blood storage.

    abstract:BACKGROUND:Storage of blood units (for 35-42 days, depending on the preservative solution) has been reported to induce changes (e.g., reduction of sialic acid level) in red cells that are expected to alter their aggregability. STUDY DESIGN AND METHODS:The aggregability of stored red cells was monitored in their autolo...


    pub_type: 杂志文章


    authors: Hovav T,Yedgar S,Manny N,Barshtein G

    更新日期:1999-03-01 00:00:00

  • Evaluation and improvement of blood donor educational materials: results from a multicenter randomized controlled trial.

    abstract:BACKGROUND:Blood collection centers are charged with creating donor educational materials (DnEM) that are easily understood across all prospective donor populations, while addressing mandates and recommendations from regulatory agencies and professional standard setting organizations. Donors must have sufficient inform...


    pub_type: 杂志文章


    authors: Wehrli G,Rossmann SN,Waxman DA,Katz LM

    更新日期:2020-08-01 00:00:00

  • The prevalence, immunogenicity, and evanescence of alloantibodies to MUT and Mur antigens of GP.Mur red blood cells in a Southeast Asian patient cohort.

    abstract:BACKGROUND:Antibodies to Mia , MUT, and Mur are among the most frequently identified alloantibodies in Southeast Asia. Understanding the characteristics of these antibodies in terms of induction and evanescence would aid in optimizing methods for their detection. STUDY DESIGN AND METHODS:Antibody testing results betwe...


    pub_type: 杂志文章


    authors: Nadarajan VS

    更新日期:2018-05-01 00:00:00

  • Evaluation of two viral inactivation methods for the preparation of safer factor VIII and factor IX concentrates.

    abstract::We report here the results of our evaluation of two procedures to eliminate viruses in factor VIII and factor IX coagulation factor concentrates. Both procedures were equally effective in the in vitro destruction of marker viruses. However, in a controlled infectivity test in chimpanzees, treatment at 60 degrees C for...


    pub_type: 临床试验,杂志文章


    authors: Heldebrant CM,Gomperts ED,Kasper CK,McDougal JS,Friedman AE,Hwang DS,Muchmore E,Jordan S,Miller R,Sergis-Davenport E

    更新日期:1985-11-01 00:00:00

  • Enhanced HPC recruitment in children using LVL and a new automated apheresis system.

    abstract:BACKGROUND:A new automated apheresis system has recently been reported as useful in improving peripheral blood HPC collection in adults. The aim of this study has been to verify the utility of this system (AutoPBSC, COBE BCT) for standard leukapheresis and for LVL in the pediatric setting. STUDY DESIGN AND METHODS:A p...


    pub_type: 杂志文章


    authors: Torrabadella M,Olivé T,Ortega JJ,Massuet L

    更新日期:2000-04-01 00:00:00

  • Prevalence of selected viral infections among temporarily deferred donors who returned to donate blood: American Red Cross blood donor study.

    abstract:BACKGROUND:Health history questions are introduced into the predonation interview to identify blood donors believed to pose a higher risk of infectious diseases to recipients. This study assesses the current impact of some of those questions. STUDY DESIGN AND METHODS:Donor deferral and donation data were extracted fro...


    pub_type: 杂志文章


    authors: Zou S,Musavi F,Notari EP 4th,Fujii KE,Dodd RY,ARCNET Study Group.

    更新日期:2005-10-01 00:00:00

  • Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016.

    abstract::The US Food and Drug Administration (FDA) held a workshop on red blood cell (RBC) product regulatory science on October 6 and 7, 2016, at the Natcher Conference Center on the National Institutes of Health (NIH) Campus in Bethesda, Maryland. The workshop was supported by the National Heart, Lung, and Blood Institute, N...




    authors: Vostal JG,Buehler PW,Gelderman MP,Alayash AI,Doctor A,Zimring JC,Glynn SA,Hess JR,Klein H,Acker JP,Spinella PC,D'Alessandro A,Palsson B,Raife TJ,Busch MP,McMahon TJ,Intaglietta M,Swartz HM,Dubick MA,Cardin S,Patel

    更新日期:2018-01-01 00:00:00

  • Granulocyte-colony-stimulatory factor: a strong inhibitor of natural killer cell function.

    abstract:BACKGROUND:The human cytokine granulocyte-colony stimulatory factor (G-CSF) has found widespread application in the medical treatment of neutropenia and to mobilize hematopoietic stem cells used for transplantation. So far, the effect of G-CSF on natural killer (NK) cells has not been fully investigated. STUDY DESIGN ...


    pub_type: 杂志文章


    authors: Schlahsa L,Jaimes Y,Blasczyk R,Figueiredo C

    更新日期:2011-02-01 00:00:00

  • Comparison of the recovery and half-life of a high-purity factor IX concentrate with those of a factor IX complex concentrate. Factor IX Study Group.

    abstract:BACKGROUND:Recovery and half-life estimations were carried out to compare a high-purity factor IX concentrate with an established factor IX complex concentrate. STUDY DESIGN AND METHODS:Two high-purity factor IX concentrates, which are identical except for the presence or absence of heparin (Immuninehep-plus and Immun...


    pub_type: 临床试验,杂志文章


    authors: Poon MC,Aledort LM,Anderle K,Kunschak M,Morfini M

    更新日期:1995-04-01 00:00:00