Depletion of white cells from platelet concentrates with a new adsorption filter.

Abstract:

:Removal of white cells (WBCs) from platelets may reduce alloimmunization to WBC antigens, prevent febrile reactions, and improve platelet increments in multiply transfused patients receiving HLA-matched platelets. A new surface-modified fibrous polyester filter was evaluated; it requires no special processing of pooled platelet concentrates and can be used at the patient's bedside. The studies were designed to measure WBC removal, platelet function, in vitro platelet recovery, and in vivo platelet survival. WBC mean removal was 99.8 percent +/- 0.56 (n = 37) when a pool similar in volume to 6 platelet concentrates was tested. The mean number of residual WBCs after filtration was 5.6 x 10(5). In vitro mean platelet recovery was 86.9 percent for a pool size of 6 units (n = 37). Clot retraction and platelet aggregation were unaffected by filtration. Survival studies of 111Indium-labeled platelets done with filtered autologous platelets showed no reduction in the normally expected survival. These studies indicated that the filter efficiently removes WBCs without substantially decreasing platelet number, survival, or function. This device offers the potential of considerably improving platelet transfusion therapy.

journal_name

Transfusion

journal_title

Transfusion

authors

Kickler TS,Bell W,Drew H,Pall D

doi

10.1046/j.1537-2995.1989.29589284140.x

subject

Has Abstract

pub_date

1989-06-01 00:00:00

pages

411-4

issue

5

eissn

0041-1132

issn

1537-2995

journal_volume

29

pub_type

杂志文章
  • Effect of storage time and donor sex of transfused red blood cells on 1-year survival in patients undergoing cardiac surgery: an observational study.

    abstract:BACKGROUND:Red blood cell (RBC) storage lesions and RBCs from females transfused into male recipients may have adverse effects on transfusion recipients' survival. We hypothesized that the effect of donor sex and the effect of age of blood on mortality would be most apparent in cardiac surgery patients. STUDY DESIGN A...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究

    doi:10.1111/trf.13537

    authors: Desmarets M,Bardiaux L,Benzenine E,Dussaucy A,Binda D,Tiberghien P,Quantin C,Monnet E

    更新日期:2016-05-01 00:00:00

  • The effects of dilution on the outcome of pooled plasma testing with HIV type 1 (HIV-1) RNA genome amplification as compared to the outcome of individual-unit testing with other HIV-1 markers.

    abstract:BACKGROUND:Proposed testing of large plasma pools with genome amplification technology (GAT) for detection of transfusion-transmissible viruses may have unanticipated complications not associated with individual unit testing. One such potential complication, the effect of dilution resulting from pool formation, was the...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1998.38598297216.x

    authors: Kemper M,Witt D,Madsen T,Kuramoto K,Holland P

    更新日期:1998-05-01 00:00:00

  • Reducing reactions to blood donation with applied muscle tension: a randomized controlled trial.

    abstract:BACKGROUND:Unpleasant blood donation-related symptoms may discourage otherwise healthy, altruistic individuals from becoming repeat donors. This study examined a behavioral technique called applied muscle tension (AMT) that might reduce reactions. STUDY DESIGN AND METHODS:A total of 605 donors at mobile clinics were a...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1537-2995.2003.00488.x

    authors: Ditto B,France CR,Lavoie P,Roussos M,Adler PS

    更新日期:2003-09-01 00:00:00

  • Absence of transfusion-associated microchimerism in pediatric and adult recipients of leukoreduced and gamma-irradiated blood components.

    abstract:BACKGROUND:Transfusion-associated microchimerism (TA-MC), the persistence of significant levels of donor white blood cells (WBCs) in blood recipients for prolonged periods, has been demonstrated after nonleukoreduced and leukoreduced transfusion to patients with severe traumatic injury. Development of TA-MC has not bee...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03366.x

    authors: Sanchez R,Lee TH,Wen L,Montalvo L,Schechterly C,Colvin C,Alter HJ,Luban NL,Busch MP

    更新日期:2012-05-01 00:00:00

  • Incorporation of plasticizer into red cells during storage.

    abstract::The development of flexible plastic blood bags has permitted effective blood component production and therapy. However, the plasticizer di(2-ethylhexyl)phthalate (DEHP), whose toxicity in humans is still undefined, is known to leach from the plastic into stored blood. Despite the availability of bags made of plastics ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1984.24685066808.x

    authors: Rock G,Tocchi M,Ganz PR,Tackaberry ES

    更新日期:1984-11-01 00:00:00

  • Detection of bacterial contamination of platelet components: six years' experience with the BacT/ALERT system.

    abstract:BACKGROUND:Hemovigilance has shown that bacteria cause more fatalities than other infections together. Surveillance for detection of bacteria in platelets (PLTs) was initiated. Concomitantly, the storage period for PLTs was extended from 5 to 7 days to reduce cost. STUDY DESIGN AND METHODS:Analysis was performed of al...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.04019.x

    authors: Munksgaard L,Albjerg L,Lillevang ST,Gahrn-Hansen B,Georgsen J

    更新日期:2004-08-01 00:00:00

  • Heme-related molecules induce rapid production of neutrophil extracellular traps.

    abstract:BACKGROUND:Pulmonary endothelial cell damages caused by neutrophil overactivation could result in acute lung injuries including transfusion-related acute lung injury (TRALI). We previously reported that heme-related molecules derived from hemolysis induced the production of reactive oxygen species from neutrophils. Rec...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/trf.12700

    authors: Kono M,Saigo K,Takagi Y,Takahashi T,Kawauchi S,Wada A,Hashimoto M,Minami Y,Imoto S,Takenokuchi M,Morikawa T,Funakoshi K

    更新日期:2014-11-01 00:00:00

  • Genetic diversity of KELnull and KELel: a nationwide Austrian survey.

    abstract:BACKGROUND:Besides ABO and RH, the KEL blood group system, including the two antithetical antigens KEL1 and KEL2, is the most important owing to the frequent appearance of anti-KEL alloantibodies and their considerable clinical significance. So far, only limited information was available on KEL variant alleles determin...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2007.01174.x

    authors: Körmöczi GF,Wagner T,Jungbauer C,Vadon M,Ahrens N,Moll W,Mühlbacher A,Ozgül-Gülce S,Kleinrath T,Kilga-Nogler S,Schönitzer D,Gassner C

    更新日期:2007-04-01 00:00:00

  • Comparison of human umbilical cord blood processing with or without hydroxyethyl starch.

    abstract:BACKGROUND:Umbilical cord blood (UCB) processing with hydroxyethyl starch (HES) is the most common protocol in the cord blood banks. The quality of UCB volume reduction was guaranteed by minimum manipulation of cord blood samples in the closed system. This study aimed to analyze and compare cell recovery and viability ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14290

    authors: Souri M,Nikougoftar Zarif M,Rasouli M,Golzadeh K,Nakhlestani Hagh M,Ezzati N,Atarodi K

    更新日期:2017-11-01 00:00:00

  • Identifying mild and severe preeclampsia in asymptomatic pregnant women by levels of cell-free fetal DNA.

    abstract:BACKGROUND:The objective was to investigate whether women who develop preeclampsia can be identified in a routine analysis when determining fetal RHD status at 25 weeks' gestation in combination with PAPP-A levels at the first-trimester combined risk assessment for Trisomy 21. STUDY DESIGN AND METHODS:D- women partici...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12073

    authors: Jakobsen TR,Clausen FB,Rode L,Dziegiel MH,Tabor A

    更新日期:2013-09-01 00:00:00

  • Impact of cytomegalovirus (CMV) antibody reflex testing in the transfusion service on management of CMV-seronegative blood inventory.

    abstract:BACKGROUND:Our goal is to minimize unnecessary cytomegalovirus (CMV)-seronegative blood transfusion to preserve the CMV-seronegative blood inventory for patients who are identified as CMV seronegative. STUDY DESIGN AND METHODS:We implemented a CMV antibody reflex testing protocol for patients who require CMV-compatibl...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.02643.x

    authors: Fontaine MJ,Jurado C,Miller E,Viele M,Goodnough LT

    更新日期:2010-08-01 00:00:00

  • Anti-hepatitis C virus (HCV) screening at a Canadian Red Cross center: significance of a positive c100 HCV enzyme-linked immunosorbent assay.

    abstract::The c100 hepatitis C virus (HCV) enzyme-linked immunosorbent assay (ELISA) has been used to screen blood donors to prevent transfusion-associated non-A,non-B hepatitis. This test is not specific, and only about 25 percent of c100 HCV ELISA-positive blood samples appear to transmit hepatitis C. However, the intensity o...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1992.32492263442.x

    authors: Giulivi A,Aye MT,Gray E,Scalia V,Gill P,Cheng G

    更新日期:1992-05-01 00:00:00

  • Epidemiological trends of HIV-1 infection in blood donors from Catalonia, Spain (2005-2014).

    abstract:BACKGROUND:Human immunodeficiency virus 1 (HIV-1) subtype B is predominant in Spain. However, the recent arrival of immigrant populations has increased the prevalence of non-B subtypes and circulating recombinant forms. The objective of this study was to determine the prevalence of HIV-1 subtypes and transmitted drug-r...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14195

    authors: Bes M,Piron M,Casamitjana N,Gregori J,Esteban JI,Ribera E,Quer J,Puig L,Sauleda S

    更新日期:2017-09-01 00:00:00

  • Antibodies to vaccine antigens in pooled polyclonal human IgG products.

    abstract::Immune-deficient patients depend on the antibodies in pooled human immunoglobulin G (IgG) preparations to remain free from serious infections. The potency of IgG preparations is therefore an ongoing concern. The use of pooled IgG to prevent infection is based on the concept that healthy adults have recovered from infe...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.15017

    authors: Berger M

    更新日期:2018-12-01 00:00:00

  • Heterogeneity of the phenotype Jk(a-b-) found in Japanese.

    abstract::Fourteen Jk(a-b-) persons were detected by testing 638,460 Osaka blood donors with an automated 2 M urea technique. Two of these 14 Jk(a-b-) samples were quite different from the hitherto reported Jk(a-b-) phenotype, and a family study showed that the mode of the inheritance was dominant. The red cell membranes of the...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1986.26386209377.x

    authors: Okubo Y,Yamaguchi H,Nagao N,Tomita T,Seno T,Tanaka M

    更新日期:1986-05-01 00:00:00

  • Blood group A immunodeterminants on human red cells differ in biologic activity and sensitivity to alpha-N-acetylgalactosaminidase.

    abstract:BACKGROUND:Epitopes of blood group A antigen can be enzymatically cleaved from red cells (RBCs), but the extent of cleavage required for normal survival in allogeneic blood transfusion recipients is unknown. Therefore, the cleavage rates were studied for A antigen epitope binding of 1) complement-activating anti-A, 2) ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1995.351096026361.x

    authors: Hoskins LC,Larson G,Naff GB

    更新日期:1995-10-01 00:00:00

  • Ammonia accumulation in platelet concentrates during storage.

    abstract::Newly prepared platelet concentrates (PC) and platelet poor plasma (PPP) stored at either room temperature (RT) or 4 C were analyzed for ammonia content initially, and after storage at 24, 48, and 72 hours. These studies demonstrate that ammonia rapidly accumulates in PC stored at RT. This accumulation appears to be t...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:

    authors: Ukrainski CT,Goldfinger D,Pomerance JJ,Lee HC,Farber S,Sanchez R

    更新日期:1981-01-01 00:00:00

  • Real-time symptomatic case of transfusion-transmitted dengue.

    abstract:BACKGROUND:Dengue virus transmission by blood transfusion is a rarely reported event. CASE REPORT:During a dengue outbreak in São Paulo city, a regular plateletpheresis donor informed the blood bank of being diagnosed a few days after donation. The recipient was hospitalized and displayed symptoms and laboratory evide...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12944

    authors: Levi JE,Nishiya A,Félix AC,Salles NA,Sampaio LR,Hangai F,Sabino EC,Mendrone A Jr

    更新日期:2015-05-01 00:00:00

  • Anti-Holley (hy): characterization of another example.

    abstract::Anti-Hy, in a serum of a black man who had received multiple blood transfusions, was found to be a warm reactive and polyclonal IgG antibody which did not bind complement in vitro. 51Cr-labeled Hy-positive red blood cells in the patient showed a shortened "2-component" survival curve. Hy antigens were not detected on ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1975.15676082238.x

    authors: Hsu TC,Jagathambal K,Sabo BH,Sawitsky A

    更新日期:1975-11-01 00:00:00

  • Stability after thawing of RBCs frozen with the high- and low-glycerol method.

    abstract:BACKGROUND:RBCs can be frozen with either the high-glycerol method (HGM) or the low-glycerol method (LGM). To date, the use of frozen RBCs is hampered by a 24-hour outdating period after thawing. A closed washing system (ACP 215) may solve this problem. STUDY DESIGN AND METHODS:We compared the effects of high- (40%) a...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2003.00293.x

    authors: Lelkens CC,Noorman F,Koning JG,Truijens-de Lange R,Stekkinger PS,Bakker JC,Lagerberg JW,Brand A,Verhoeven AJ

    更新日期:2003-02-01 00:00:00

  • A comprehensive assessment program to improve blood-administering practices using the FOCUS-PDCA model.

    abstract:BACKGROUND:The Joint Commission on the Accreditation of Healthcare Organizations requires that hospitals have a planned approach to systematically collect data on processes related to the use, ordering, and administering of blood components. This study describes how a comprehensive blood-administering assessment progra...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2004.03117.x

    authors: Saxena S,Ramer L,Shulman IA

    更新日期:2004-09-01 00:00:00

  • The successful implementation of an automated institution-wide assessment of hemoglobin and ABO typing to dynamically estimate red blood cell inventory requirements.

    abstract:BACKGROUND:Blood bank inventories must balance adequate supply with minimal outdate rates. The day-to-day practice of ordering red blood cell (RBC) inventory usually involves manually comparing current inventory levels with predetermined thresholds calculated from historical usage and ordering the difference. To date, ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15272

    authors: Quinn J,Campbell C,Gomez A,Kumar-Misir A,Watson S,Liwski D,Covello T,Tennankore KK,Chisholm N,Sadek I,Cheng C

    更新日期:2019-07-01 00:00:00

  • Photodynamic sterilization of red cells and its effect on contaminating white cells: viability and mechanism of cell death.

    abstract:BACKGROUND:Phthalocyanines are useful sensitizers for photodynamic sterilization of red cell concentrates. Various lipid-enveloped viruses can be inactivated with only limited red cell damage. Because white cells are involved in the immunomodulatory effects of blood transfusions, the study of the effect of photodynamic...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1999.39060599.x

    authors: Moor AC,van der Veen A,Dubbelman TM,VanSteveninck J,Brand A

    更新日期:1999-06-01 00:00:00

  • The role of the paternal health history in cord blood banking.

    abstract:BACKGROUND:Umbilical cord blood (UCB) transplantation is becoming more widely used, yet ethical and policy issues regarding consent and health history persist. Whereas most UCB banks do not require paternal consent or paternal health history (PHH), both are obtained at this institution whenever possible. This study ass...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2002.00188.x

    authors: Askari S,Miller J,Clay M,Moran S,Chrysler G,McCullough J

    更新日期:2002-10-01 00:00:00

  • Validation of new real-time polymerase chain reaction assays for detection of hepatitis A virus RNA and parvovirus B19 DNA.

    abstract:BACKGROUND:To meet European guidelines for plasma for fractionation, plasma fractionators have implemented parvovirus B19 (B19V) and hepatitis A virus (HAV) nucleic acid test (NAT) screening on test pools. In this study we evaluate recently developed in-house NAT assays for B19V DNA and HAV RNA. The B19V NAT was design...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13334

    authors: Molenaar-de Backer MW,de Waal M,Sjerps MC,Koppelman MH

    更新日期:2016-02-01 00:00:00

  • Improved plasma removal efficiency for therapeutic plasma exchange using a new apheresis platform.

    abstract:BACKGROUND:The Spectra Optia (SPO; CaridianBCT) is a new apheresis device based on the COBE Spectra (CSP; CaridianBCT) platform. This study was designed to evaluate the safety and efficiency of the SPO in comparison to the predicate CSP device. STUDY DESIGN AND METHODS:Twenty patients were recruited for a randomized, ...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1537-2995.2009.02412.x

    authors: Tormey CA,Peddinghaus ME,Erickson M,King KE,Cushing MM,Bill J,Goodrich T,Snyder EL

    更新日期:2010-02-01 00:00:00

  • How we handled the dextran shortage: an alternative washing or dilution solution for cord blood infusions.

    abstract::Dextran 40 is the main component of the solution used to wash or dilute thawed cord blood unit (CBU) products for stem cell transplant. Dextran 40 became unavailable in the United States as of April 2014. Like many other cellular therapy laboratories in the United States, we found ourselves with limited dextran 40 inv...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.13015

    authors: Reich-Slotky R,Bachegowda LS,Ancharski M,Mendeleyeva L,Rubinstein P,Rennert H,Shore T,van Besien K,Cushing M

    更新日期:2015-06-01 00:00:00

  • Incidence of Wra antigen and anti-Wra in a Spanish population.

    abstract:BACKGROUND:This study reports the incidence of Wr(a) antigen and anti-Wr(a) in Valencia, Spain. STUDY DESIGN AND METHODS:The incidence of the Wr(a) antigen in 110,000 healthy blood donors was estimated. Likewise, the incidence of anti-Wr(a) was analyzed in a population consisting of 730 healthy blood donors, 356 pregn...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.00196.x

    authors: Arriaga F,Llopis F,de la Rubia J,Carpio N,Moscardó J,Marty ML

    更新日期:2005-08-01 00:00:00

  • Platelet storage in a plasma-free medium.

    abstract::Currently, platelet concentrates are stored in 50 to 60 ml of plasma. A major drawback to storage in plasma is the considerable loss of platelet function which occurs during storage. A modified Tyrodes medium has been developed for storage of platelets. A comparison between platelet concentrates stored in this medium ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1985.25686071429.x

    authors: Rock G,Swenson SD,Adams GA

    更新日期:1985-11-01 00:00:00

  • Frozen preoperative autologous blood donation for heart transplantation at the Mayo Clinic from 1988 to 1999.

    abstract:BACKGROUND:Preoperative autologous blood donation (PABD) has been used to reduce the need for allogeneic RBC transfusion, decreasing risk and conserving supply. A frozen PABD program for heart transplant patients was instituted at the Mayo Clinic in 1988, but participation has steadily declined. The aims of this study ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2003.00357.x

    authors: Fontaine MJ,Winters JL,Moore SB,McGregor CG,Santrach PJ

    更新日期:2003-04-01 00:00:00