Changes in progesterone and oestrogen receptor mRNA and protein and oxytocin receptors in endometrium of ewes after intrauterine injection of ovine trophoblast interferon.

abstract：:Reproductive hormone imbalance in infertile women is correlated to high levels of phthalates and alkylphenols, which are among endocrine-disrupting chemicals (EDCs). Previous studies have shown that they interfere with gene expression by deregulating levels of microRNAs (miRs), small non-coding RNAs targeting mRNAs en...

journal_title：Journal of molecular endocrinology

authors： Patiño-García D,Cruz-Fernandes L,Buñay J,Orellana R,Moreno RD

更新日期：2020-11-01 00:00:00

abstract：:We studied the effects of 2-methoxyestradiol (2-ME2) and 16alpha-hydroxyestrone (16alpha-OHE1), two metabolites of estradiol (E2), on DNA synthesis, cell cycle progression and cyclin D1 protein levels in estrogen receptor-positive MCF-7 cells. E2 and 16alpha-OHE1 stimulated DNA synthesis, and 2-ME2 inhibited the stimu...

journal_title：Journal of molecular endocrinology

authors： Lewis JS,Thomas TJ,Pestell RG,Albanese C,Gallo MA,Thomas T

更新日期：2005-02-01 00:00:00

abstract：:Endometriosis is an incurable hormone-dependent inflammatory disease that causes chronic pelvic pain and infertility characterized by implantation and growth of endometrial tissue outside the uterine cavity. Symptoms have a major impact on the quality of life of patients resulting in socioeconomic, physical and psycho...

journal_title：Journal of molecular endocrinology

authors： Piccinato CA,Malvezzi H,Gibson DA,Saunders PTK

更新日期：2018-08-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare tumour arising from neural crest-derived parafollicular C-cells. Metastatic MTC patients are incurable because the cancer does not respond to radiotherapy or chemotherapy. The REarranged during Transfection (RET) proto-oncogene plays a key role in the development of MTC. How...

journal_title：Journal of molecular endocrinology

authors： Cerrato A,De Falco V,Santoro M

更新日期：2009-10-01 00:00:00

abstract：:In the last 15 years, single-cell technologies have become robust and indispensable tools to investigate cell heterogeneity. Beyond transcriptomic, genomic and epigenome analyses, technologies are constantly evolving, in particular toward multi-omics, where analyses of different source materials from a single cell are...

journal_title：Journal of molecular endocrinology

authors： Cheung LYM,Rizzoti K

更新日期：2020-08-01 00:00:00

abstract：:Numerous mouse models of prostate carcinogenesis have been developed, but hitherto there has been no model in which the prostate gland could be imaged in live animals. The transgenic model generated here targeted mouse prostate gland using a firefly luciferase enzyme under the control of a small but highly active and ...

journal_title：Journal of molecular endocrinology

authors： Hsieh CL,Xie Z,Liu ZY,Green JE,Martin WD,Datta MW,Yeung F,Pan D,Chung LW

更新日期：2005-10-01 00:00:00

abstract：:Relaxin is a peptide hormone which is produced in human reproductive tissues including the ovary and prostate gland. Little is known of the molecular events regulating relaxin gene transcription. We have studied this question using gene transfer of relaxin promoter/reporter gene constructs into a relaxin-expressing ce...

journal_title：Journal of molecular endocrinology

authors： Gunnersen JM,Roche PJ,Tregear GW,Crawford RJ

更新日期：1995-10-01 00:00:00

abstract：:Oligonucleotide microarrays were used to analyse gene expression profiles in human ZR75-1 breast cancer cells in the presence of 17beta-oestradiol and oestrogen antagonists. Differential gene expression of a number of genes was confirmed by quantitative RNA analysis. In addition to known oestrogen-responsive genes, an...

journal_title：Journal of molecular endocrinology

authors： Soulez M,Parker MG

更新日期：2001-12-01 00:00:00

abstract：:A number of enzymes possessing 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (17HSD/KSR) activities have been described and cloned, but their nomenclature needs specification. To clarify the present situation, descriptions of the eight cloned 17HSD/KSRs are given and guidelines for the classification of...

journal_title：Journal of molecular endocrinology

authors： Peltoketo H,Luu-The V,Simard J,Adamski J

更新日期：1999-08-01 00:00:00

abstract：:The steroidogenic acute regulatory protein (StAR) is critical to the regulated synthesis of steroids in vertebrates. We have isolated cDNA sequences encoding StAR in the freshwater stingrays Potamotrygon hystrix and P. motoro. A single P. hystrix StAR transcript (3376 bp) and two overlapping P. motoro StAR transcripts...

journal_title：Journal of molecular endocrinology

authors： Nunez BS,Piermarini PM,Evans AN,Applebaum SL

更新日期：2005-12-01 00:00:00

abstract：:Whether insulin, at physiological concentrations, has direct effects on vascular smooth muscle cells (VSMCs) remains controversial. Our aim was to characterize the mechanism for insulin resistance in VSMCs. For comparison, the effects of IGF1 and IGF2 were also studied. Cultured human aortic smooth muscle cells (HASMC...

journal_title：Journal of molecular endocrinology

authors： Chisalita SI,Johansson GS,Liefvendahl E,Bäck K,Arnqvist HJ

更新日期：2009-12-01 00:00:00

abstract：:The monocarboxylate transporter 8 (MCT8) is a member of the major facilitator superfamily (MFS). These membrane-spanning proteins facilitate translocation of a variety of substrates, MCT8 specifically transports iodothyronines. Mutations in MCT8 are the underlying cause of severe X-linked psychomotor retardation. At t...

journal_title：Journal of molecular endocrinology

authors： Fischer J,Kleinau G,Müller A,Kühnen P,Zwanziger D,Kinne A,Rehders M,Moeller LC,Führer D,Grüters A,Krude H,Brix K,Biebermann H

更新日期：2015-02-01 00:00:00

abstract：:This study aimed to determine whether and how the glucagon-like peptide 1 receptor (GLP-1R) agonist liraglutide affects the chemoresistance and chemosensitivity of pancreatic cancer cells to gemcitabine in vitro and in vivo. The GLP-1R and protein kinase A (PKA) levels were compared between the human pancreatic cancer...

journal_title：Journal of molecular endocrinology

authors： Zhao HJ,Jiang X,Hu LJ,Yang L,Deng LD,Wang YP,Ren ZP

更新日期：2020-02-01 00:00:00

abstract：:The neurohypophysial nonapeptides vasotocin (VT) and mesotocin (MT) are the amphibian counterparts of arginine vasopressin (AVP) and oxytocin (OT). We have here reported the cloning and functional characterization of the receptors for vasotocin (VTR) and mesotocin (MTR) in two species of frog, Rana catesbeiana and Ran...

journal_title：Journal of molecular endocrinology

authors： Acharjee S,Do-Rego JL,Oh DY,Moon JS,Ahn RS,Lee K,Bai DG,Vaudry H,Kwon HB,Seong JY

更新日期：2004-08-01 00:00:00

abstract：:Microarray studies have identified many genes that are down-regulated in uterine leiomyoma compared with myometrium, including early growth response gene-1 (EGR1). However, the mechanisms underlying coordinated down-regulation of this gene cohort remain unknown. To address the transcriptional role of EGR1 in leiomyoma...

journal_title：Journal of molecular endocrinology

authors： Ishikawa H,Shozu M,Okada M,Inukai M,Zhang B,Kato K,Kasai T,Inoue M

更新日期：2007-11-01 00:00:00

abstract：:Tight regulation of fatty acid metabolism in pancreatic beta-cells is important for beta-cell viability and function. Chronic exposure to elevated concentrations of fatty acid is associated with beta-cell lipotoxicity. Glucose is known to repress fatty acid oxidation and hence to augment the toxicity of fatty acids. T...

journal_title：Journal of molecular endocrinology

authors： Ravnskjaer K,Boergesen M,Dalgaard LT,Mandrup S

更新日期：2006-04-01 00:00:00

abstract：:In the common brushtail possum (Trichosurus vulpecula) lactation lasts for 200 days and consists of two distinct phases. Milk composition changes dramatically between phase 2 and 3, which correspond to early and late lactation respectively (phase 1 corresponds to pregnancy). RNA expression patterns have been establish...

journal_title：Journal of molecular endocrinology

authors： Demmer J,Ross IK,Ginger MR,Piotte CK,Grigor MR

更新日期：1998-02-01 00:00:00

abstract：:Previous studies have shown that, in unstimulated mammary epithelial cells from virgin mice, prolactin receptors are retained intracellularly because of their incomplete N-glycosylation. Activation of the nitric oxide/cGMP pathway stimulates Nacetylglucosamine (NAG) transferase I activity, completion of terminal glyco...

journal_title：Journal of molecular endocrinology

authors： Bolander FF Jr

更新日期：2000-06-01 00:00:00

abstract：:Glucagon-like peptide 1 (GLP1) is an intestinal incretin that regulates glucose homeostasis through stimulation of insulin secretion from pancreatic β-cells and inhibits appetite by acting on the brain. Thus, it is a promising therapeutic agent for the treatment of type 2 diabetes mellitus and obesity. Studies using s...

journal_title：Journal of molecular endocrinology

authors： Hwang JI,Yun S,Moon MJ,Park CR,Seong JY

更新日期：2014-06-01 00:00:00

abstract：:A unique characteristic of the primate adrenal is the ability to produce 19-carbon steroids, often called the adrenal androgens. Although it is clear that the major human adrenal androgens, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S), are produced almost solely in the adrenal reticularis, the mechanisms re...

journal_title：Journal of molecular endocrinology

authors： Sirianni R,Carr BR,Andò S,Rainey WE

更新日期：2003-06-01 00:00:00

abstract：:Activins are cytokines of the transforming growth factor beta family, which plays a central role in the determination of cell fate and the regulation of tissue balance. Family members are composed of two subunits and this dimerization is critical for liganding their cognate receptors and execution of proper functions....

journal_title：Journal of molecular endocrinology

authors： Vejda S,Cranfield M,Peter B,Mellor SL,Groome N,Schulte-Hermann R,Rossmanith W

更新日期：2002-04-01 00:00:00

abstract：:Synthesis of the uterine receptor for the hypothalamic hormone oxytocin has been induced in oocytes from Xenopus laevis previously primed with bovine endometrium mRNA. The injected oocytes responded to oxytocin by showing dose-dependent oscillations in membrane currents as recorded by the voltage-clamp method. The res...

journal_title：Journal of molecular endocrinology

authors： Morley SD,Meyerhof W,Schwarz J,Richter D

更新日期：1988-07-01 00:00:00

abstract：:A transgenic mouse line (EGF/Tag) has been established in which expression of SV40 T-antigen is directed by a 5.5 kb fragment of the 5'-flanking region of the mouse epidermal growth factor (EGF) gene. Of the two principal sites of EGF expression in mice, submaxillary gland and kidney, T-antigen mRNA and protein were d...

journal_title：Journal of molecular endocrinology

authors： Pascall IC,Surani MA,Barton SC,Vaughan TJ,Brown KD

更新日期：1994-06-01 00:00:00

abstract：:Inhibition of aromatase, a key enzyme in the biosynthesis of oestradiol-17 beta, by the addition of 1,4,6-androstatrien-3,17-dione resulted in a significant increase in the levels of immunoreactive human chorionic gonadotrophin (hCG) in the medium and tissue. This increase was partially reversed by the simultaneous ad...

journal_title：Journal of molecular endocrinology

authors： Sharma SC,Purohit P,Rao AJ

更新日期：1993-08-01 00:00:00

abstract：:Studies were performed to determine whether ARP-1, which is an orphan receptor of the steroid receptor superfamily, inhibits basal activity of the human placental lactogen (hPL) promoter and the increase in hPL promoter activity in response to the receptors for thyroid hormone (TR) and retinoic acid (RAR). Co-transfec...

journal_title：Journal of molecular endocrinology

authors： Stephanou A,Shah M,Richardson B,Handwerger S

更新日期：1996-06-01 00:00:00

abstract：:1,25-(OH)2-Vitamin D3 (1,25-D3) and the thyroid hormone tri-iodothyronine (T3) were previously shown to behave as adipogenic agents in murine Ob17 preadipocytes. Moreover, these agents interfere with each other's action during adipocyte differentiation. T3 receptor (TR) expression and a downmodulation of T3 binding si...

journal_title：Journal of molecular endocrinology

authors： Schneider L,El-Yazidi C,Dace A,Maraninchi M,Planells R,Margotat A,Torresani J

更新日期：2005-02-01 00:00:00

abstract：:Follicle-stimulating hormone (FSH) plays fundamental roles in male and female fertility. FSH is a heterodimeric glycoprotein expressed by gonadotrophs in the anterior pituitary. The hormone-specific FSHβ-subunit is non-covalently associated with the common α-subunit that is also present in the luteinizing hormone (LH)...

journal_title：Journal of molecular endocrinology

authors： Das N,Kumar TR

更新日期：2018-04-01 00:00:00

abstract：:In vitro studies have indicated that the maturation-inducing hormone 17α,20β-dihydroxy-4-pregnen-3-one (17α,20β-DP, DHP), probably through nuclear progestin receptor (Pgr), might be involved in the proliferation of spermatogonial cells and the initiation of meiosis in several fish species. However, further in vivo evi...

journal_title：Journal of molecular endocrinology

authors： Liu G,Luo F,Song Q,Wu L,Qiu Y,Shi H,Wang D,Zhou L

更新日期：2014-08-01 00:00:00

abstract：:cDNA clones coding for rabbit prolactin were isolated from a pituitary library using a rat prolactin RNA probe. One cDNA contained 873 bases including the entire coding sequence of rabbit prolactin, its signal peptide and the 5' and 3' untranslated regions of 44 and 145 nucleotides respectively. The deduced amino acid...

journal_title：Journal of molecular endocrinology

authors： Gabou L,Boisnard M,Gourdou I,Jammes H,Dulor JP,Djiane J

更新日期：1996-02-01 00:00:00

abstract：:In embryonic growth cartilage, Indian hedgehog (Ihh) and parathyroid hormone-related protein (PTHrP) participate in a negative feedback loop that regulates chondrocyte differentiation. Postnatally, this region undergoes major structural and functional changes. To explore the organization of the Ihh–PTHrP system in pos...

journal_title：Journal of molecular endocrinology

authors： Chau M,Forcinito P,Andrade AC,Hegde A,Ahn S,Lui JC,Baron J,Nilsson O

更新日期：2011-08-01 00:00:00