Human aortic smooth muscle cells are insulin resistant at the receptor level but sensitive to IGF1 and IGF2.

abstract：:We have cloned a full length cDNA coding for the activin type IIB receptor (GactRIIB) from the goldfish ovary. GactRIIB shares 73 and 70% amino acid identity in the extracellular domain, and 78 and 80% identity in the intracellular domain with the type IIB receptors of the mouse and Xenopus respectively. The intracell...

journal_title：Journal of molecular endocrinology

authors： Ge W,Tanaka M,Yoshikuni M,Eto Y,Nagahama Y

更新日期：1997-08-01 00:00:00

abstract：:1alpha,25-dihydroxyvitamin D(3) upregulates tumour necrosis factor superfamily member 11 (TNFSF11) that codes for the receptor activator of nuclear factor kappaB ligand (RANKL), and downregulates osteoprotegerin (OPG) expression. We have analyzed the individual effects of polymorphisms in the vitamin D receptor gene (...

journal_title：Journal of molecular endocrinology

authors： Mencej-Bedrac S,Prezelj J,Kocjan T,Teskac K,Ostanek B,Smelcer M,Marc J

更新日期：2009-03-01 00:00:00

abstract：:cAMP-response element-binding protein (CREB) is required for the induction of adipogenic transcription factors such as CCAAT/enhancer-binding proteins (C/EBPs). Interestingly, it is known from studies in other tissues that LKB1 and its substrates AMP-activated protein kinase (AMPK) and salt-inducible kinases (SIKs) ne...

journal_title：Journal of molecular endocrinology

authors： Gormand A,Berggreen C,Amar L,Henriksson E,Lund I,Albinsson S,Göransson O

更新日期：2014-08-01 00:00:00

abstract：:The somatostatin receptor subtype 2 (sst2) mediates inhibition of hormone secretion and cell proliferation, and modulates neurotransmission. Its expression is widespread in various normal tissues and many malignant cells, and is up-regulated by estrogen in breast cancer cells. This study was undertaken to investigate ...

journal_title：Journal of molecular endocrinology

authors： Kimura N,Takamatsu N,Yaoita Y,Osamura RY,Kimura N

更新日期：2008-02-01 00:00:00

abstract：:Metformin improves obesity-associated metabolic dysregulation, but has controversial effects on adipose tissue inflammation. The objective of the study is to examine the direct effect of metformin on adipocyte inflammatory responses and elucidate the underlying mechanisms. Adipocytes were differentiated from 3T3-L1 ce...

journal_title：Journal of molecular endocrinology

authors： Qi T,Chen Y,Li H,Pei Y,Woo SL,Guo X,Zhao J,Qian X,Awika J,Huo Y,Wu C

更新日期：2017-07-01 00:00:00

abstract：:Tumour necrosis factor superfamily member 11 (TNFSF11) gene, that codes for receptor activator of nuclear factor-kappaB ligand, is one of the candidate genes for the genetic susceptibility to osteoporosis. As variations in the TNFSF11 gene promoter could alter its expression, the aim of the study was to evaluate the f...

journal_title：Journal of molecular endocrinology

authors： Mencej S,Albagha OM,Prezelj J,Kocjan T,Marc J

更新日期：2008-06-01 00:00:00

abstract：:The lactating tammar wallaby progressively alters the rate of secretion and composition of its milk to provide appropriate nutrition for the developing offspring, whose needs are signalled by changes in the pattern and efficiency of its sucking. Tammars are also capable of asynchronous concurrent lactation, when the m...

journal_title：Journal of molecular endocrinology

authors： Hendry KA,Simpson KJ,Nicholas KR,Wilde CJ

更新日期：1998-10-01 00:00:00

abstract：:We have previously shown that arginine vasopressin (AVP) stimulates the production of aldosterone in isolated superfused adrenal glomerulosa cells by a mechanism that involves an increased turnover of phosphoinositides. In the present study we compared the characteristics of AVP- and angiotensin II (AII)-induced chang...

journal_title：Journal of molecular endocrinology

authors： Enyedi P,Balla T,Antoni FA,Spät A

更新日期：1988-09-01 00:00:00

abstract：:Differences in binding and structural properties of ovine testicular FSH and LH receptors were investigated. The ovine FSH receptor did not discriminate between FSH of different species, although equine FSH was more reactive. In the same tissue, however, the LH receptor showed marked preference for ovine and bovine LH...

journal_title：Journal of molecular endocrinology

authors： Yarney TA,Sairam MR

更新日期：1991-06-01 00:00:00

abstract：:Parathyroid hormone (PTH) is secreted by the chief cells of the parathyroid gland in response to changes in ionized calcium (Ca(2+)) concentrations. In this study, we measured PTH secretion, and PTH mRNA and calcium-sensing receptor (CaR) mRNA expression by equine parathyroid chief cells in vitro. We also evaluated th...

journal_title：Journal of molecular endocrinology

authors： Toribio RE,Kohn CW,Capen CC,Rosol TJ

更新日期：2003-12-01 00:00:00

abstract：:In an attempt to define novel genetic loci involved in the pathophysiology of primary aldosteronism, a mutagenesis screen after treatment with the alkylating agent N-ethyl-N-nitrosourea was established for the parameter aldosterone. One of the generated mouse lines with hyperaldosteronism was phenotypically and geneti...

journal_title：Journal of molecular endocrinology

authors： Perez-Rivas LG,Rhayem Y,Sabrautzki S,Hantel C,Rathkolb B,Hrabě de Angelis M,Reincke M,Beuschlein F,Spyroglou A

更新日期：2017-02-01 00:00:00

abstract：:Both 17beta-estradiol and prolactin play important roles in the mammary gland, raising the possibility of functional cross-talk between the two signaling pathways. Here, we demonstrate that estrogen receptor-alpha (ERalpha) and -beta (ERbeta) are both able to potentiate transcription from a Stat5-responsive promoter w...

journal_title：Journal of molecular endocrinology

authors： Björnström L,Kilic E,Norman M,Parker MG,Sjöberg M

更新日期：2001-08-01 00:00:00

abstract：:During the process of insulitis in the pathogenesis of type I (insulin-dependent) diabetes mellitus, proinflammatory cytokines induce expression of the death receptor Fas on the surface of pancreatic beta-cells and thereby contribute to the enhanced susceptibility of beta-cells for apoptosis. The aim of this study was...

journal_title：Journal of molecular endocrinology

authors： Augstein P,Wachlin G,Berg S,Bahr J,Salzsieder C,Hehmke B,Heinke P,Salzsieder E

更新日期：2003-04-01 00:00:00

abstract：:Reproductive hormone imbalance in infertile women is correlated to high levels of phthalates and alkylphenols, which are among endocrine-disrupting chemicals (EDCs). Previous studies have shown that they interfere with gene expression by deregulating levels of microRNAs (miRs), small non-coding RNAs targeting mRNAs en...

journal_title：Journal of molecular endocrinology

authors： Patiño-García D,Cruz-Fernandes L,Buñay J,Orellana R,Moreno RD

更新日期：2020-11-01 00:00:00

abstract：:Numerous mouse models of prostate carcinogenesis have been developed, but hitherto there has been no model in which the prostate gland could be imaged in live animals. The transgenic model generated here targeted mouse prostate gland using a firefly luciferase enzyme under the control of a small but highly active and ...

journal_title：Journal of molecular endocrinology

authors： Hsieh CL,Xie Z,Liu ZY,Green JE,Martin WD,Datta MW,Yeung F,Pan D,Chung LW

更新日期：2005-10-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I), transforming growth factor alpha (TGFalpha) and epidermal growth factor (EGF) induced cathepsin D gene expression and reporter gene activity in MCF-7 human breast cancer cells transiently transfected with a construct (pCD1) containing a -2576 to -124 cathepsin D gene promoter inse...

journal_title：Journal of molecular endocrinology

authors： Wang F,Duan R,Chirgwin J,Safe SH

更新日期：2000-04-01 00:00:00

abstract：:The major mission of the ovarian follicle is the timely production of the mature fertilizable oocyte, and this is achieved by gonadotropin-regulated, gap junction-mediated cell-cell communication between the oocyte and surrounding nurturing granulosa cells. We have demonstrated that FSH and transforming growth factor ...

journal_title：Journal of molecular endocrinology

authors： Fang WL,Lai SY,Lai WA,Lee MT,Liao CF,Ke FC,Hwang JJ

更新日期：2015-12-01 00:00:00

abstract：:Successful human embryo implantation requires a proper differentiation of endometrial stromal cells (ESCs) into decidual cells, during a process called decidualization. ESCs express specific molecules, such as prolactin, insulin-like growth factor-binding protein-1 (IGFBP-1) and connexin-43. Decidual cells are also in...

journal_title：Journal of molecular endocrinology

authors： Duval F,Dos Santos E,Moindjie H,Serazin V,Swierkowski-Blanchard N,Vialard F,Dieudonné MN

更新日期：2017-10-01 00:00:00

abstract：:The nociceptin receptor (NOP) and its endogenous ligand, nociceptin/orphanin FQ (OFQ), are involved in a wide range of biological functions, such as pain, anxiety, learning, and memory. The zebrafish has been proposed as a candidate to study the in vivo effects of several drugs of abuse and to discover new pharmacolog...

journal_title：Journal of molecular endocrinology

authors： Rivas-Boyero AA,Herrero-Turrión MJ,Gonzalez-Nunez V,Sánchez-Simón FM,Barreto-Valer K,Rodríguez RE

更新日期：2011-03-03 00:00:00

abstract：:It has recently been shown that 20 kDa human growth hormone (hGH) forms the 1:2 hGH:hGH receptor (hGHR) complex and expresses full agonistic activity, although it hardly forms the 1:1 GH:GHR complex as compared with 22 kDa hGH. To clarify this mechanism, we analyzed the mode of receptor dimerization of 20 kDa hGH usin...

journal_title：Journal of molecular endocrinology

authors： Uchida H,Banba S,Wada M,Matsumoto K,Ikeda M,Naito N,Tanaka E,Honjo M

更新日期：1999-12-01 00:00:00

abstract：:Transportation of vitamin C [also called ascorbic acid (AA)], an important water-soluble antioxidant and cofactor in testis, requires glucose transporter family (GLUTs) and sodium/vitamin C cotransporter family (SVCT1 and SVCT2). There is so far scant information vis-à-vis the functional roles of SVCTs in testis, alth...

journal_title：Journal of molecular endocrinology

authors： Gao G,Zhao Y,Wang K,Wang F

更新日期：2020-12-01 00:00:00

abstract：:A prolactin cDNA was cloned from a cDNA expression library constructed from total RNA of bullfrog (Rana catesbeiana) adenohypophyses by immunoscreening with antiserum against bullfrog prolactin. The cDNA clone thus obtained contained a 249 bp insert. Using this clone as a probe, plaque hybridizations were performed an...

journal_title：Journal of molecular endocrinology

authors： Takahashi N,Yoshihama K,Kikuyama S,Yamamoto K,Wakabayashi K,Kato Y

更新日期：1990-12-01 00:00:00

abstract：:Mammary explants can be hormonally stimulated to mimic the biochemical changes that occur during lactogenesis. Previous studies using mammary explants concluded that the addition of exogenous macromolecules were required for mammary epithelial cells to remain viable in culture. The present study examines the survival ...

journal_title：Journal of molecular endocrinology

authors： Brennan AJ,Sharp JA,Lefèvre CM,Nicholas KR

更新日期：2008-09-01 00:00:00

abstract：:Parathyroid hormone (PTH), a powerful bone-resorbing agent, is capable of stimulating interstitial collagenase (MMP-13) mRNA production in osteoblastic cells. In this study, a PEA3 consensus binding sequence (-80; AGGAAGT) in addition to a 'TRE-like' sequence (-89; CGACTCA) in the 5' upstream regulatory region of the ...

journal_title：Journal of molecular endocrinology

authors： Quinn CO,Rajakumar RA,Agapova OA

更新日期：2000-08-01 00:00:00

abstract：:The endogenous thyroid hormone (TH) metabolite 3,5-diiodo-l-thyronine (3,5-T2) acts as a metabolically active substance affecting whole-body energy metabolism and hepatic lipid handling in a desirable manner. Considering possible adverse effects regarding thyromimetic action of 3,5-T2 treatment in rodents, the current...

journal_title：Journal of molecular endocrinology

authors： Lietzow J,Golchert J,Homuth G,Völker U,Jonas W,Köhrle J

更新日期：2016-05-01 00:00:00

abstract：:We have generated hybridomas which secrete monoclonal antibodies to the AT1 subtype of the angiotensin II receptor (AT1 receptor). These were obtained after immunization of Balb C/c mice with synthetic peptides representing sequences from either the extracellular domain (residues 8-17) or the intracellular domain (res...

journal_title：Journal of molecular endocrinology

authors： Barker S,Marchant W,Ho MM,Puddefoot JR,Hinson JP,Clark AJ,Vinson GP

更新日期：1993-10-01 00:00:00

abstract：:Several authors have shown that angiotensin II stimulates hepatic angiotensinogen synthesis in vivo, ex vivo and in vitro. In previous studies we have demonstrated that this effect of angiotensin II depends mainly on a transient inhibition of adenylyl cyclase and is the consequence of a stabilization of angiotensinoge...

journal_title：Journal of molecular endocrinology

authors： Klett C,Bader M,Schwemmle M,Ganten D,Hackenthal E

更新日期：1995-04-01 00:00:00

abstract：:GPRC6A is a seven-transmembrane receptor mediating signaling by a wide range of L-alpha-amino acids, a signaling augmented by the divalent cations Ca(2)(+) and Mg(2)(+). GPRC6A transcripts are detected in numerous mammalian tissues, but the physiological role of the receptor is thus far elusive. Analogously to the clo...

journal_title：Journal of molecular endocrinology

authors： Wellendorph P,Johansen LD,Jensen AA,Casanova E,Gassmann M,Deprez P,Clément-Lacroix P,Bettler B,Bräuner-Osborne H

更新日期：2009-03-01 00:00:00

abstract：:The mechanism behind Ca(2)(+) entry into the parathyroid cells has been widely debated, and the molecular identities of the responsible ion channels have not been established yet. In this study, we show that the parathyroid cells lack voltage-operated Ca(2)(+) channels. Passive store depletion by thapsigargin, on the ...

journal_title：Journal of molecular endocrinology

authors： Lu M,Bränström R,Berglund E,Höög A,Björklund P,Westin G,Larsson C,Farnebo LO,Forsberg L

更新日期：2010-05-01 00:00:00

abstract：:The development of an efficient expression system for insulin-like growth factor-I (IGF-I) in Escherichia coli as a fusion protein is described. The fusion protein consists of an N-terminal extension made up of the first 46 amino acids of methionyl porcine GH ([Met1]-pGH) followed by the dipeptide Val-Asn. The latter ...

journal_title：Journal of molecular endocrinology

authors： King R,Wells JR,Krieg P,Snoswell M,Brazier J,Bagley CJ,Wallace JC,Ballard FJ,Ross M,Francis GL

更新日期：1992-02-01 00:00:00