Transcriptional activation of cathepsin D gene expression by growth factors.

abstract：:Association between the (AC)(n) dinucleotide repeat polymorphism at the 5'-end of the aldose reductase gene and the occurrence of diabetic nephropathy was conducted. We examined eight studies consisting of ten Caucasian type 1 diabetes mellitus case-control comparisons and eight studies consisting of nine type 2 diabe...

journal_title：Journal of molecular endocrinology

authors： Xu M,Chen X,Yan L,Cheng H,Chen W

更新日期：2008-05-01 00:00:00

abstract：:Whether insulin, at physiological concentrations, has direct effects on vascular smooth muscle cells (VSMCs) remains controversial. Our aim was to characterize the mechanism for insulin resistance in VSMCs. For comparison, the effects of IGF1 and IGF2 were also studied. Cultured human aortic smooth muscle cells (HASMC...

journal_title：Journal of molecular endocrinology

authors： Chisalita SI,Johansson GS,Liefvendahl E,Bäck K,Arnqvist HJ

更新日期：2009-12-01 00:00:00

abstract：:Androgens promote anabolism in the musculoskeletal system while generally repressing adiposity, leading to lean body composition. Circulating androgens decline with age, contributing to frailty, osteoporosis, and obesity; however, the mechanisms by which androgens modulate body composition are largely unknown. Here, w...

journal_title：Journal of molecular endocrinology

authors： Gentile MA,Nantermet PV,Vogel RL,Phillips R,Holder D,Hodor P,Cheng C,Dai H,Freedman LP,Ray WJ

更新日期：2010-01-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare tumour arising from neural crest-derived parafollicular C-cells. Metastatic MTC patients are incurable because the cancer does not respond to radiotherapy or chemotherapy. The REarranged during Transfection (RET) proto-oncogene plays a key role in the development of MTC. How...

journal_title：Journal of molecular endocrinology

authors： Cerrato A,De Falco V,Santoro M

更新日期：2009-10-01 00:00:00

abstract：:CRH and its structurally related peptide urocortin (Ucn) are released under stress. Ucn is a potent agonist for CRH-receptor 2 (CRH-R2), which is strongly expressed in rodent heart. Stress induces Ucn mRNA expression in the heart, where it may be cardioprotective. However, increasing evidence indicates that Ucn may al...

journal_title：Journal of molecular endocrinology

authors： Huang M,Kempuraj D,Papadopoulou N,Kourelis T,Donelan J,Manola A,Theoharides TC

更新日期：2009-05-01 00:00:00

abstract：:The mannose 6-phosphate/IGF 2 receptor (IGF2R) is comprised of 15 extra-cellular domains that bind IGF2 and mannose 6-phosphate ligands. IGF2R transports ligands from the Golgi to the pre-lysosomal compartment and thereafter to and from the cell surface. IGF2R regulates growth, placental development, tumour suppressio...

journal_title：Journal of molecular endocrinology

authors： Rezgui D,Williams C,Savage SA,Prince SN,Zaccheo OJ,Jones EY,Crump MP,Hassan AB

更新日期：2009-04-01 00:00:00

abstract：:Hypothalamic GHRH controls the release of GH from the pituitary gland and also acts as a growth factor in a variety of cancers. The mitogenetic activity of GHRH is exerted through the binding to the pituitary type receptor (pGHRH-R) and its splice variants, mainly SV1. The intracellular signaling pathways that are act...

journal_title：Journal of molecular endocrinology

authors： Barabutis N,Siejka A,Schally AV,Block NL,Cai R,Varga JL

更新日期：2010-02-01 00:00:00

abstract：:Barrett's oesophagus (BO) and oesophageal adenocarcinoma (OAC) are regarded as complications of gastro-oesophageal reflux disease, although all the factors that contribute to the development of these lesions are unknown. Acid suppressive drugs are widely used for symptomatic therapy of reflux disease but may induce hy...

journal_title：Journal of molecular endocrinology

authors： Beales IL,Ogunwobi OO

更新日期：2009-04-01 00:00:00

abstract：:We have analysed the expression of the IGF-I receptor gene in lymphocytes of patients with low levels of circulating IGF-I (four patients with isolated GH deficiency (IGHD) and one Laron-type dwarf (LTD)) in comparison with a control group exhibiting normal serum IGF-I levels and endocrine profiles. 125I-Labelled IGF-...

journal_title：Journal of molecular endocrinology

authors： Eshet R,Werner H,Klinger B,Silbergeld A,Laron Z,LeRoith D,Roberts CT Jr

更新日期：1993-04-01 00:00:00

abstract：:FSH acts through the Sertoli cell to ensure normal testicular development and function. To identify transcriptional mechanisms through which FSH acts in the testis, we have treated gonadotrophin-deficient hypogonadal (hpg) mice with recombinant FSH and measured changes in testicular transcript levels using microarrays...

journal_title：Journal of molecular endocrinology

authors： Abel MH,Baban D,Lee S,Charlton HM,O'Shaughnessy PJ

更新日期：2009-04-01 00:00:00

abstract：:Critical to an understanding of the control of 1,25-dihydroxyvitamin D (1,25D) activity is a molecular appreciation of the regulation of three genes, 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1), 25-hydroxyvitamin D-24-hydroxylase (CYP24) and vitamin D receptor (VDR). We now report the sensitivity, reproducibility...

journal_title：Journal of molecular endocrinology

authors： Anderson PH,O'Loughlin PD,May BK,Morris HA

更新日期：2003-08-01 00:00:00

abstract：:A subset of over-expressed microRNAs (miRNAs) identified in parathyroid carcinomas (Ca) compared to normal glands belongs to C19MC, a cluster on chromosome 19q13.4 involved in stem cell biology and tumourigenesis. In this study, the expression of C19MC-MIR371-3 clusters and the molecular mechanisms presiding their mod...

journal_title：Journal of molecular endocrinology

authors： Vaira V,Elli F,Forno I,Guarnieri V,Verdelli C,Ferrero S,Scillitani A,Vicentini L,Cetani F,Mantovani G,Spada A,Bosari S,Corbetta S

更新日期：2012-07-26 00:00:00

abstract：:1alpha,25-dihydroxyvitamin D(3) upregulates tumour necrosis factor superfamily member 11 (TNFSF11) that codes for the receptor activator of nuclear factor kappaB ligand (RANKL), and downregulates osteoprotegerin (OPG) expression. We have analyzed the individual effects of polymorphisms in the vitamin D receptor gene (...

journal_title：Journal of molecular endocrinology

authors： Mencej-Bedrac S,Prezelj J,Kocjan T,Teskac K,Ostanek B,Smelcer M,Marc J

更新日期：2009-03-01 00:00:00

abstract：:Porcine LH receptor ectodomain was overexpressed in insect cells and lepidopteran larvae using the recombinant baculovirus expression system. A low multiplicity of infection yielded the largest active production, of approximately 10(7) receptors/cell or 3 micrograms active receptor/mg total protein in infected cells. ...

journal_title：Journal of molecular endocrinology

authors： Pajot-Augy E,Couture L,Bozon V,Remy JJ,Biache G,Severini M,Huet JC,Pernollet JC,Salesse R

更新日期：1995-02-01 00:00:00

abstract：:Expression of the rat alpha 2u-globulin gene family is regulated in the adult male liver by a number of hormones, including growth hormone, thyroid hormone and several steroids. Upon injection into ovariectomized females, estrogens first induce alpha 2u-globulin expression and then suppress this gene after several day...

journal_title：Journal of molecular endocrinology

authors： Wang KS,Hodgetts RB,Addison WR

更新日期：1998-02-01 00:00:00

abstract：:The subcellular distribution of steroidogenic enzymes has so far been studied mostly in classical endocrine glands and in the placenta. In the peripheral intracrine organs which synthesize sex steroids there is no indication about the organelles which contain the enzymes involved in steroid biosynthesis. We have thus ...

journal_title：Journal of molecular endocrinology

authors： Pelletier G,Luu-The V,El-Alfy M,Li S,Labrie F

更新日期：2001-02-01 00:00:00

abstract：:The mechanism behind Ca(2)(+) entry into the parathyroid cells has been widely debated, and the molecular identities of the responsible ion channels have not been established yet. In this study, we show that the parathyroid cells lack voltage-operated Ca(2)(+) channels. Passive store depletion by thapsigargin, on the ...

journal_title：Journal of molecular endocrinology

authors： Lu M,Bränström R,Berglund E,Höög A,Björklund P,Westin G,Larsson C,Farnebo LO,Forsberg L

更新日期：2010-05-01 00:00:00

abstract：:Using the fluorescent indicators 2',7'-bis(2-carboxyethyl)-5'-(6')-carboxyfluorescein and Oxonol V to monitor intracellular pH (pHi) and cell membrane potential respectively, we have investigated the involvement of H(+)-dependent ATPase and H(+)-dependent K+ channels in the recovery of the rat thyroid cell strain FRTL...

journal_title：Journal of molecular endocrinology

authors： Woods DJ,Soden J,Bidey SP

更新日期：1992-02-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone that belongs to a subfamily of endocrine FGFs with evolutionarily conserved functions in C. elegans and fruit flies. FAM20C phosphorylates FGF23 post-translationally, targeting to proteolysis through subtilisin-like proprotein convertase FURIN, resulting i...

journal_title：Journal of molecular endocrinology

authors： Ho BB,Bergwitz C

更新日期：2020-12-01 00:00:00

abstract：:Screening by differential display of oestrogen-sensitive MCF7 human breast cancer cells grown in the short-term (6 days) and long-term (70 weeks) absence of oestrogen has led to the identification of a new oestrogen-regulated mRNA. The cDNA isolated by differential display has 100% homology from nucleotides 615 to 859...

journal_title：Journal of molecular endocrinology

authors： Stephen R,Corcoran D,Darbre PD

更新日期：1998-06-01 00:00:00

abstract：:Reproductive function in mammals is energetically costly and therefore tightly regulated by nutritional status. To enable this integration of metabolic and reproductive function, information regarding peripheral nutritional status must be relayed centrally to the gonadotropin-releasing hormone (GNRH) neurons that driv...

journal_title：Journal of molecular endocrinology

authors： Evans MC,Anderson GM

更新日期：2017-02-01 00:00:00

abstract：:The prevalence of non-alcoholic fatty liver disease (NAFLD), a condition characterized by an excessive accumulation of triglycerides (TGs) in hepatocytes, has dramatically increased globally during recent decades. MicroRNAs (miRs) have been suggested to play crucial roles in many complex diseases and lipid metabolism....

journal_title：Journal of molecular endocrinology

authors： Li B,Zhang Z,Zhang H,Quan K,Lu Y,Cai D,Ning G

更新日期：2014-12-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor (PPAR) is a member of the steroid hormone receptor superfamily and is activated by a variety of fibrate hypolipidaemic drugs and non-genotoxic rodent hepatocarcinogens that are collectively termed peroxisome proliferators. A key marker of peroxisome proliferator action is...

journal_title：Journal of molecular endocrinology

authors： Issemann I,Prince RA,Tugwood JD,Green S

更新日期：1993-08-01 00:00:00

abstract：:To capture immediate cellular changes during diet-induced expansion of adipocyte cell volume and number, we characterized mature adipocytes during a short-term high-fat diet (HFD) intervention. Male C57BL6/J mice were fed chow diet, and then switched to HFD for 2, 4, 6 or 14 days. Systemic glucose clearance was assess...

journal_title：Journal of molecular endocrinology

authors： Hansson B,Wasserstrom S,Morén B,Periwal V,Vikman P,Cushman SW,Göransson O,Storm P,Stenkula KG

更新日期：2018-04-01 00:00:00

abstract：:The constitutive expression of 25-hydroxyvitamin D3-24-hydroxylase (25-(OH)D3-24-hydroxylase) activity has been studied in an adherent variant (Ad-HL60) of the human promyelomonocytic leukaemia cell line HL60. The Ad-HL60 cells have a more differentiated phenotype than the non-adherent cells from which they were deriv...

journal_title：Journal of molecular endocrinology

authors： Hayes ME,Bayley D,Mawer EB

更新日期：1991-12-01 00:00:00

abstract：:Decreased suppressors of cytokine signaling (SOCS) activity in human gestational tissues may play a part in the onset/progression of term labor. Since SOCS proteins negatively regulate cytokine-mediated inflammatory processes, we hypothesized that SOCS proteins are elevated in gestational tissues from spontaneous pret...

journal_title：Journal of molecular endocrinology

authors： Blumenstein M,Keelan JA,Bowen-Shauver JM,Mitchell MD

更新日期：2005-08-01 00:00:00

abstract：:The parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor regulates extracellular calcium concentrations and is therefore important for mineral homeostasis. ROS 17/2.8 cells, a rat osteoblast-like osteosarcoma cell line, express the PTH/PTHrP receptor and provide a good model for examining the transcriptional...

journal_title：Journal of molecular endocrinology

authors： Williams LJ,Abou-Samra AB

更新日期：2000-12-01 00:00:00

abstract：:This study investigates the effectiveness and mechanisms of a serum- and glucocorticoid-inducible kinase 1 (SGK1) inhibitor in counteracting hyperglycemia. In an in vivo experiment, we demonstrated that after an 8-week treatment with an SGK1 inhibitor, the fasting blood glucose and HbA1c level significantly decreased ...

journal_title：Journal of molecular endocrinology

authors： Li P,Hao Y,Pan FH,Zhang M,Ma JQ,Zhu DL

更新日期：2016-05-01 00:00:00

abstract：:Corticotrophin-releasing hormone (CRH) has been identified in several peripheral tissues, including the female reproductive organs. CRH is expressed in the placenta, myometrium, epithelial endometrium and the endometrial stromal cells at all phases of the menstrual cycle. Similarly, CRH receptors are present in pregna...

journal_title：Journal of molecular endocrinology

authors： Karteris E,Papadopoulou N,Grammatopoulos DK,Hillhouse EW

更新日期：2004-02-01 00:00:00

abstract：:The somatostatin (SRIF) system, which includes the SRIF ligand and receptors, regulates anterior pituitary gland function, mainly inhibiting hormone secretion and to some extent pituitary tumor cell growth. SRIF-14 via its cognate G-protein-coupled receptors (subtypes 1-5) activates multiple cellular signaling pathway...

journal_title：Journal of molecular endocrinology

authors： Eigler T,Ben-Shlomo A

更新日期：2014-08-01 00:00:00