Molecular cloning and nucleotide sequence analysis of complementary DNA for bullfrog prolactin.

abstract：:Transportation of vitamin C [also called ascorbic acid (AA)], an important water-soluble antioxidant and cofactor in testis, requires glucose transporter family (GLUTs) and sodium/vitamin C cotransporter family (SVCT1 and SVCT2). There is so far scant information vis-à-vis the functional roles of SVCTs in testis, alth...

journal_title：Journal of molecular endocrinology

authors： Gao G,Zhao Y,Wang K,Wang F

更新日期：2020-12-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is synthesized from a precursor, which includes the PACAP-related peptide (PRP; formerly known as GHRH-like peptide). PRP can act as a hypophysiotropic factor in teleosts by stimulating GH secretion. However, no information points to this peptide as a regulato...

journal_title：Journal of molecular endocrinology

authors： Levy G,Degani G

更新日期：2011-03-03 00:00:00

abstract：:In an attempt to define novel genetic loci involved in the pathophysiology of primary aldosteronism, a mutagenesis screen after treatment with the alkylating agent N-ethyl-N-nitrosourea was established for the parameter aldosterone. One of the generated mouse lines with hyperaldosteronism was phenotypically and geneti...

journal_title：Journal of molecular endocrinology

authors： Perez-Rivas LG,Rhayem Y,Sabrautzki S,Hantel C,Rathkolb B,Hrabě de Angelis M,Reincke M,Beuschlein F,Spyroglou A

更新日期：2017-02-01 00:00:00

abstract：:The cloning and characterization of the mouse TRH receptor (TRH-R) gene revealed an untranslated exon (exon 1), a single intron and an upstream dinucleotide repeat sequence (d(TG)16.d(AG)21) in the 5' untranslated region (UTR). The coding region was contained almost entirely on a second exon (exon 2), with the final a...

journal_title：Journal of molecular endocrinology

authors： Duthie SM,Taylor PL,Eidne KA

更新日期：1993-10-01 00:00:00

abstract：:Cytochrome P450 21-hydroxylase (P450c21) is a key enzyme for corticosteroidogenesis. To understand the regulatory mechanisms of cortisol production in fish, we have cloned a cDNA encoding P450c21, for the first time in non-mammalian vertebrates, from the head kidney of the eel (Anguilla japonica). The overall similari...

journal_title：Journal of molecular endocrinology

authors： Li YY,Inoue K,Takei Y

更新日期：2003-10-01 00:00:00

abstract：:Twenty-five years have elapsed since the calcium-sensing receptor (CaSR) was first identified in bovine parathyroid and the receptor is now recognized as a fundamental contributor to extracellular Ca2+ (Ca2+ e) homeostasis, regulating parathyroid hormone release and urinary calcium excretion. The CaSR is a class C G-p...

journal_title：Journal of molecular endocrinology

authors： Gorvin CM

更新日期：2019-08-01 00:00:00

abstract：:The two structurally and functionally related peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB) play critical roles in many physiological/pathological processes in mammals. However, the information regarding the expression and functionality of avian NMB, GRP and their receptors is limited. Here, we char...

journal_title：Journal of molecular endocrinology

authors： Mo C,Huang L,Cui L,Lv C,Lin D,Song L,Zhu G,Li J,Wang Y

更新日期：2017-07-01 00:00:00

abstract：:Studies have demonstrated that heat shock is associated with alteration in energy metabolism. In this study, we investigated the effect of heat shock on gene expression and secretion of adiponectin and leptin, and gene expression of Hspa2 and Ppargamma in 3T3-L1 adipocytes. Compared with 37 degrees C, adiponectin mRNA...

journal_title：Journal of molecular endocrinology

authors： Bernabucci U,Basiricò L,Morera P,Lacetera N,Ronchi B,Nardone A

更新日期：2009-02-01 00:00:00

abstract：:Esculetin, an antioxidant, has been used in the treatment of a variety of diseases. This study aimed to investigate the protective effect of esculetin in attenuating streptozotocin (STZ)-induced type I diabetic nephropathy and to understand the molecular mechanism involved in it. Sprague-Dawley rats were rendered diab...

journal_title：Journal of molecular endocrinology

authors： Surse VM,Gupta J,Tikoo K

更新日期：2011-06-09 00:00:00

abstract：:Hypothalamic GHRH controls the release of GH from the pituitary gland and also acts as a growth factor in a variety of cancers. The mitogenetic activity of GHRH is exerted through the binding to the pituitary type receptor (pGHRH-R) and its splice variants, mainly SV1. The intracellular signaling pathways that are act...

journal_title：Journal of molecular endocrinology

authors： Barabutis N,Siejka A,Schally AV,Block NL,Cai R,Varga JL

更新日期：2010-02-01 00:00:00

abstract：:In the last 15 years, single-cell technologies have become robust and indispensable tools to investigate cell heterogeneity. Beyond transcriptomic, genomic and epigenome analyses, technologies are constantly evolving, in particular toward multi-omics, where analyses of different source materials from a single cell are...

journal_title：Journal of molecular endocrinology

authors： Cheung LYM,Rizzoti K

更新日期：2020-08-01 00:00:00

abstract：:A unique characteristic of the primate adrenal is the ability to produce 19-carbon steroids, often called the adrenal androgens. Although it is clear that the major human adrenal androgens, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S), are produced almost solely in the adrenal reticularis, the mechanisms re...

journal_title：Journal of molecular endocrinology

authors： Sirianni R,Carr BR,Andò S,Rainey WE

更新日期：2003-06-01 00:00:00

abstract：:The classical concept of the renin-angiotensin system (RAS) is that of a blood-borne cascade, whose final and bioactive product, angiotensin II, plays an important endocrine role in the maintenance of blood pressure and electrolyte as well as fluid balance. In addition to this circulating RAS, there are an increasing ...

journal_title：Journal of molecular endocrinology

authors： Leung PS,Carlsson PO

更新日期：2001-06-01 00:00:00

abstract：:The angiotensin II (Ang II) type 2 receptor (AT(2)) is a member of the seven-transmembrane domain, G-protein coupled receptor family. This receptor is ubiquitously distributed in the fetus but, in most tIssues, its expression dramatically falls in the first few hours after birth. Based on this observation, the hypothe...

journal_title：Journal of molecular endocrinology

authors： Gendron L,Payet MD,Gallo-Payet N

更新日期：2003-12-01 00:00:00

abstract：:cDNA clones coding for rabbit prolactin were isolated from a pituitary library using a rat prolactin RNA probe. One cDNA contained 873 bases including the entire coding sequence of rabbit prolactin, its signal peptide and the 5' and 3' untranslated regions of 44 and 145 nucleotides respectively. The deduced amino acid...

journal_title：Journal of molecular endocrinology

authors： Gabou L,Boisnard M,Gourdou I,Jammes H,Dulor JP,Djiane J

更新日期：1996-02-01 00:00:00

abstract：:Natriuretic peptides (NPs) have been reported to have critical roles in follicular development and oocyte maturation in rodents. This study aimed to extend our current understanding of NP-mediated signalling pathways and mechanisms of action in the follicles of a monovulatory species. Ovine granulosa cells (GCs) and t...

journal_title：Journal of molecular endocrinology

authors： Alhamdan R,Maalouf W,Campbell BK,Hernandez-Medrano JH,Marsters P

更新日期：2020-05-01 00:00:00

abstract：:Follicle-stimulating hormone (FSH) plays fundamental roles in male and female fertility. FSH is a heterodimeric glycoprotein expressed by gonadotrophs in the anterior pituitary. The hormone-specific FSHβ-subunit is non-covalently associated with the common α-subunit that is also present in the luteinizing hormone (LH)...

journal_title：Journal of molecular endocrinology

authors： Das N,Kumar TR

更新日期：2018-04-01 00:00:00

abstract：:Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue. At a given age, bone mass results from the amount of bone acquired during growth, i.e. the peak bone mass (Bonjour et al., 1991, Theintz et al. 1992) minus the age-related bone loss which par...

journal_title：Journal of molecular endocrinology

authors： Rizzoli R,Bonjour JP,Ferrari SL

更新日期：2001-04-01 00:00:00

abstract：:The human progesterone receptor (PR) is a ligand-dependent transcription factor and two isoforms, (PRA and PRB), can be distinguished. PROGINS, a PR polymorphic variant, affects PRA and PRB and acts as a risk-modulating factor in several gynaecological disorders. Little is known about the functional consequences of th...

journal_title：Journal of molecular endocrinology

authors： Romano A,Delvoux B,Fischer DC,Groothuis P

更新日期：2007-02-01 00:00:00

abstract：:Human thyroid hormone receptor (c-erb A protein) produced by Escherichia coli expression vector plasmid was purified sequentially using polyethylenimine precipitation of DNA, hydroxylapatite column chromatography, ammonium sulphate precipitation, Sephacryl S-300 gel filtration and mono Q-Sepharose column chromatograph...

journal_title：Journal of molecular endocrinology

authors： Ichikawa K,Hashizume K,Nishii Y,Takeda T,Kobayashi M,Suzuki S,Yamada T

更新日期：1991-10-01 00:00:00

abstract：:Androgens promote anabolism in the musculoskeletal system while generally repressing adiposity, leading to lean body composition. Circulating androgens decline with age, contributing to frailty, osteoporosis, and obesity; however, the mechanisms by which androgens modulate body composition are largely unknown. Here, w...

journal_title：Journal of molecular endocrinology

authors： Gentile MA,Nantermet PV,Vogel RL,Phillips R,Holder D,Hodor P,Cheng C,Dai H,Freedman LP,Ray WJ

更新日期：2010-01-01 00:00:00

abstract：:Sucrose density gradient purified plasma membranes isolated from brown adipose tissue of cold-acclimated hamsters (4-10 weeks at 0-4 degreesC) were analysed for the content of the short (GsalphaS) and long (GsalphaL) variants of Gsalpha protein (the alpha subunit of the stimulatory G protein) and compared with the mem...

journal_title：Journal of molecular endocrinology

authors： Bourová L,Novotn J,Svoboda P

更新日期：1999-02-01 00:00:00

abstract：:The main regulators of aldosterone secretion in adrenal gland zona glomerulosa (ZG) cells are the hormones angiotensin II (Ang II) and adrenocorticotrophin (ACTH) and small increases in the extracellular potassium (K(+)) concentration. The action of these agonists is mediated by different signalling systems - ACTH is ...

journal_title：Journal of molecular endocrinology

authors： Foster RH

更新日期：2004-06-01 00:00:00

abstract：:Leptin (Lep), an adipose-derived hormone, exerts very important functions in the body mainly on energy storage and availability. The physiological effects of Lep controlling the body weight and suppressing appetite are mediated by the long form of Lep receptor in the hypothalamus. Lep receptor activates several downst...

journal_title：Journal of molecular endocrinology

authors： Folch J,Pedrós I,Patraca I,Sureda F,Junyent F,Beas-Zarate C,Verdaguer E,Pallàs M,Auladell C,Camins A

更新日期：2012-10-10 00:00:00

abstract：:About 70% of breast tumors express estrogen receptor alpha (ERα), which mediates the proliferative effects of estrogens on breast epithelial cells, and are candidates for treatment with antiestrogens, steroidal or non-steroidal molecules designed to compete with estrogens and antagonize ERs. The variable patterns of a...

journal_title：Journal of molecular endocrinology

authors： Traboulsi T,El Ezzy M,Gleason JL,Mader S

更新日期：2017-01-01 00:00:00

abstract：:Activation of the hypothalamo-pituitary-adrenal (HPA) axis during stress is associated with increased expression of genes that code for regulatory hormones such as corticotrophin-releasing factor (CRF) and ACTH. The identity of the transcription factors that mediate these changes in gene expression is not known. In th...

journal_title：Journal of molecular endocrinology

authors： Whitehead D,Carter DA

更新日期：1997-12-01 00:00:00

abstract：:The interaction of IGF binding protein-2 (IGFBP-2) with IGF-I and -II has been investigated in solution using nuclear magnetic resonance (NMR) spectroscopy. Chemical shift perturbations in 15N- and 2H/15N-labelled IGF-I or -II upon binding to unlabelled thioredoxin-tagged bovine IGFBP-2 (Trx(1-279)IGFBP-2) have been m...

journal_title：Journal of molecular endocrinology

authors： Carrick FE,Hinds MG,McNeil KA,Wallace JC,Forbes BE,Norton RS

更新日期：2005-06-01 00:00:00

abstract：:Porcine prolactin cDNA clones were screened using antiserum against ovine prolactin from a cDNA library of porcine anterior pituitary, and their nucleotide sequences were determined by the chain-termination method. The nucleotide sequence of the 5' untranslated region and part of the signal peptide region were determi...

journal_title：Journal of molecular endocrinology

authors： Kato Y,Hirai T,Kato T

更新日期：1990-04-01 00:00:00

abstract：:There is evidence that insulin-like growth factor-binding protein (IGFBP-2), a modulator of the actions of IGFs, also has IGF-independent effects in human tumor cell lines. These involve specific binding of IGFBP-2 to alpha5beta1-integrin, followed by alterations in the phosphorylation status of downstream signaling m...

journal_title：Journal of molecular endocrinology

authors： Frommer KW,Reichenmiller K,Schutt BS,Hoeflich A,Ranke MB,Dodt G,Elmlinger MW

更新日期：2006-08-01 00:00:00

abstract：:The effect of steroid hormone treatment on coho salmon (Oncorhynchus kisutch) was examined. The cDNAs for coho salmon FSH beta and LH beta subunits were cloned and sequenced using reverse transcriptase PCR. Northern blot analysis revealed that a single transcript of 1 kb for each of these subunits was present in the p...

journal_title：Journal of molecular endocrinology

authors： Dickey JT,Swanson P

更新日期：1998-12-01 00:00:00