Tissue renin-angiotensin system: its expression, localization, regulation and potential role in the pancreas.

abstract：:Oestrogens have a major impact on reproductive function in both males and females. Two oestrogen receptor genes known as ERalpha (ESR1NR3A1) and ERbeta (ESR2NR3A2) have been cloned. Splice variant isoforms of the ERbeta gene have been identified in human, bovine and rodents and it has been suggested that the existence...

journal_title：Journal of molecular endocrinology

authors： Sierens JE,Scobie GA,Wilson J,Saunders PT

更新日期：2004-06-01 00:00:00

abstract：:Angiotensin II (AII) receptors were identified in rat tissue membranes by specific binding of 125I-labelled AII. Using an isoelectric focusing technique, two forms of the high-affinity AII receptor were identified in rat adrenal zona glomerulosa and liver membranes. These migrated to isoelectric points (pI) 6.8 and 6....

journal_title：Journal of molecular endocrinology

authors： Jimenez E,Marsigliante S,Barker S,Hinson JP,Vinson GP

更新日期：1991-08-01 00:00:00

abstract：:The development and growth of prostate cancer is dependent on androgens; thus, the identification of androgen-regulated genes in prostate cancer cells is vital for defining the mechanisms of prostate cancer development and progression and developing new markers and targets for prostate cancer treatment. Glycine N-meth...

journal_title：Journal of molecular endocrinology

authors： Ottaviani S,Brooke GN,O'Hanlon-Brown C,Waxman J,Ali S,Buluwela L

更新日期：2013-11-07 00:00:00

abstract：:Glucocorticoid and androgen receptors have been shown to function through the same palindromic glucocorticoid response element (GRE) and yet have differential effects on gene transcription. In this study, we examined the functional and structural relationship of the androgen and glucocorticoid receptors with the andro...

journal_title：Journal of molecular endocrinology

authors： Kasper S,Rennie PS,Bruchovsky N,Lin L,Cheng H,Snoek R,Dahlman-Wright K,Gustafsson JA,Shiu RP,Sheppard PC,Matusik RJ

更新日期：1999-06-01 00:00:00

abstract：:Critical to an understanding of the control of 1,25-dihydroxyvitamin D (1,25D) activity is a molecular appreciation of the regulation of three genes, 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1), 25-hydroxyvitamin D-24-hydroxylase (CYP24) and vitamin D receptor (VDR). We now report the sensitivity, reproducibility...

journal_title：Journal of molecular endocrinology

authors： Anderson PH,O'Loughlin PD,May BK,Morris HA

更新日期：2003-08-01 00:00:00

abstract：:The pancreatic regenerating (reg) gene is proposed to be involved in pancreatic beta-cell growth. Up- or down-regulation of reg gene expression has been shown to parallel variations in beta-cell mass and function in the adult pancreas. In several species at least two nonallelic reg genes have been identified. In this ...

journal_title：Journal of molecular endocrinology

authors： Perfetti R,Raygada M,Wang Y,Zenilman ME,Egan JM,Denno KM,Sadler TW,Shuldiner AR

更新日期：1996-08-01 00:00:00

abstract：:Basal and thyroid hormone-regulated expression of constructs containing varying lengths of 5' flanking sequence of the human glycoprotein hormone alpha subunit gene ligated to the reporter gene encoding chloramphenicol acetyl transferase (CAT) were examined in transfected pituitary GH3 cells. CAT gene expression was q...

journal_title：Journal of molecular endocrinology

authors： Balfour NJ,Franklyn JA,Gurr JA,Sheppard MC

更新日期：1990-04-01 00:00:00

abstract：:Prolactin (PRL)-releasing peptide (PrRP) is a strong candidate stimulator of pituitary PRL transcription and secretion in teleosts. However, the role in control of extrapituitary PRL expression is unclear even in mammals. To study the possible presence of PrRP-PRL axes not only in the brain-pituitary but also in perip...

journal_title：Journal of molecular endocrinology

authors： Sakamoto T,Amano M,Hyodo S,Moriyama S,Takahashi A,Kawauchi H,Ando M

更新日期：2005-06-01 00:00:00

abstract：:The endogenous thyroid hormone (TH) metabolite 3,5-diiodo-l-thyronine (3,5-T2) acts as a metabolically active substance affecting whole-body energy metabolism and hepatic lipid handling in a desirable manner. Considering possible adverse effects regarding thyromimetic action of 3,5-T2 treatment in rodents, the current...

journal_title：Journal of molecular endocrinology

authors： Lietzow J,Golchert J,Homuth G,Völker U,Jonas W,Köhrle J

更新日期：2016-05-01 00:00:00

abstract：:Seven bovine follistatin (FS) cDNA clones were isolated from a bovine ovarian follicle cDNA library. The predicted amino acid sequences revealed that six of the cDNA clones represented an FS precursor of 344 amino acids which corresponded to a mature FS of 315 amino acids (FS 315), with one cDNA clone containing the e...

journal_title：Journal of molecular endocrinology

authors： Saleh M,Garcia S,Mercer JE,Findlay JK

更新日期：1994-12-01 00:00:00

abstract：:Translocation of protein kinase C (PKC) from the cytosol to the plasma membranes is believed to reflect activation of the enzyme. We have studied translocation of PKC in lactotroph-enriched anterior pituitary cell cultures by measuring the incorporation of gamma-32P from [gamma-32P]ATP into a synthetic peptide substra...

journal_title：Journal of molecular endocrinology

authors： Mau SE,Saermark T,Vilhardt H

更新日期：1994-06-01 00:00:00

abstract：:Tumor malignancy is associated with the epithelial-mesenchymal transition (EMT) process and resistance to chemotherapy. However, little is known about the relationship between the EMT and the multidrug-resistance gene in thyroid tumor progression. We investigated whether the expression of the ABCG2/BCRP gene is associ...

journal_title：Journal of molecular endocrinology

authors： Mato E,González C,Moral A,Pérez JI,Bell O,Lerma E,de Leiva A

更新日期：2014-04-28 00:00:00

abstract：:The main regulators of aldosterone secretion in adrenal gland zona glomerulosa (ZG) cells are the hormones angiotensin II (Ang II) and adrenocorticotrophin (ACTH) and small increases in the extracellular potassium (K(+)) concentration. The action of these agonists is mediated by different signalling systems - ACTH is ...

journal_title：Journal of molecular endocrinology

authors： Foster RH

更新日期：2004-06-01 00:00:00

abstract：:In the common brushtail possum (Trichosurus vulpecula) lactation lasts for 200 days and consists of two distinct phases. Milk composition changes dramatically between phase 2 and 3, which correspond to early and late lactation respectively (phase 1 corresponds to pregnancy). RNA expression patterns have been establish...

journal_title：Journal of molecular endocrinology

authors： Demmer J,Ross IK,Ginger MR,Piotte CK,Grigor MR

更新日期：1998-02-01 00:00:00

abstract：:Reproductive function in mammals is energetically costly and therefore tightly regulated by nutritional status. To enable this integration of metabolic and reproductive function, information regarding peripheral nutritional status must be relayed centrally to the gonadotropin-releasing hormone (GNRH) neurons that driv...

journal_title：Journal of molecular endocrinology

authors： Evans MC,Anderson GM

更新日期：2017-02-01 00:00:00

abstract：:Androgens promote anabolism in the musculoskeletal system while generally repressing adiposity, leading to lean body composition. Circulating androgens decline with age, contributing to frailty, osteoporosis, and obesity; however, the mechanisms by which androgens modulate body composition are largely unknown. Here, w...

journal_title：Journal of molecular endocrinology

authors： Gentile MA,Nantermet PV,Vogel RL,Phillips R,Holder D,Hodor P,Cheng C,Dai H,Freedman LP,Ray WJ

更新日期：2010-01-01 00:00:00

abstract：:The melanocortin 2 receptor accessory protein (MRAP) was originally discovered to be an essential co-receptor for the ACTH receptor/melanocortin 2 receptor, and it physically interacts with this receptor and is required for receptor trafficking and ligand binding. A related molecule, MRAP2, is mainly expressed in the ...

journal_title：Journal of molecular endocrinology

authors： Clark AJ,Chan LF

更新日期：2017-04-01 00:00:00

abstract：:Insulin-regulated aminopeptidase (IRAP, EC 3.4.11.3) in adipocytes is well known to traffic between high (HDM) and low (LDM) density microsomal fractions toward the plasma membrane (MF) under stimulation by insulin. However, its catalytic preference for aminoacyl substrates with N-terminal Leu or Cys is controversial....

journal_title：Journal of molecular endocrinology

authors： Alponti RF,Viana LG,Yamanouye N,Silveira PF

更新日期：2015-08-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor (PPAR) is a member of the steroid hormone receptor superfamily and is activated by a variety of fibrate hypolipidaemic drugs and non-genotoxic rodent hepatocarcinogens that are collectively termed peroxisome proliferators. A key marker of peroxisome proliferator action is...

journal_title：Journal of molecular endocrinology

authors： Issemann I,Prince RA,Tugwood JD,Green S

更新日期：1993-08-01 00:00:00

abstract：:Oligonucleotide microarrays were used to analyse gene expression profiles in human ZR75-1 breast cancer cells in the presence of 17beta-oestradiol and oestrogen antagonists. Differential gene expression of a number of genes was confirmed by quantitative RNA analysis. In addition to known oestrogen-responsive genes, an...

journal_title：Journal of molecular endocrinology

authors： Soulez M,Parker MG

更新日期：2001-12-01 00:00:00

abstract：:Several authors have shown that angiotensin II stimulates hepatic angiotensinogen synthesis in vivo, ex vivo and in vitro. In previous studies we have demonstrated that this effect of angiotensin II depends mainly on a transient inhibition of adenylyl cyclase and is the consequence of a stabilization of angiotensinoge...

journal_title：Journal of molecular endocrinology

authors： Klett C,Bader M,Schwemmle M,Ganten D,Hackenthal E

更新日期：1995-04-01 00:00:00

abstract：:We have cloned a full length cDNA coding for the activin type IIB receptor (GactRIIB) from the goldfish ovary. GactRIIB shares 73 and 70% amino acid identity in the extracellular domain, and 78 and 80% identity in the intracellular domain with the type IIB receptors of the mouse and Xenopus respectively. The intracell...

journal_title：Journal of molecular endocrinology

authors： Ge W,Tanaka M,Yoshikuni M,Eto Y,Nagahama Y

更新日期：1997-08-01 00:00:00

abstract：:Granulosa cells were prepared from small follicles (less than 3 mm) from the ovaries of 5-month-old gilts. They were cultured in plastic dishes coated with a synthetic adhesion peptide in a chemically defined medium supplemented with 2% serum substitute. After 3 days of culture, the cells reached confluence and expres...

journal_title：Journal of molecular endocrinology

authors： Goxe B,Salesse R,Remy JJ,Genty N,Garnier J

更新日期：1992-04-01 00:00:00

abstract：:Unbiased genomic screening analyses have highlighted novel immunomodulatory properties of the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D). However, clearer interpretation of the resulting gene expression data is limited by cell model specificity. The aim of the current study was to provide a broader...

journal_title：Journal of molecular endocrinology

authors： Muñoz Garcia A,Kutmon M,Eijssen L,Hewison M,Evelo CT,Coort SL

更新日期：2018-02-01 00:00:00

abstract：:Association between the (AC)(n) dinucleotide repeat polymorphism at the 5'-end of the aldose reductase gene and the occurrence of diabetic nephropathy was conducted. We examined eight studies consisting of ten Caucasian type 1 diabetes mellitus case-control comparisons and eight studies consisting of nine type 2 diabe...

journal_title：Journal of molecular endocrinology

authors： Xu M,Chen X,Yan L,Cheng H,Chen W

更新日期：2008-05-01 00:00:00

abstract：:Porcine LH receptor ectodomain was overexpressed in insect cells and lepidopteran larvae using the recombinant baculovirus expression system. A low multiplicity of infection yielded the largest active production, of approximately 10(7) receptors/cell or 3 micrograms active receptor/mg total protein in infected cells. ...

journal_title：Journal of molecular endocrinology

authors： Pajot-Augy E,Couture L,Bozon V,Remy JJ,Biache G,Severini M,Huet JC,Pernollet JC,Salesse R

更新日期：1995-02-01 00:00:00

abstract：:The genetic predisposition of the host and the virus is the most important determinant for prediction of the course of human immunodeficiency virus type I (HIV-1) viral infection and acquired immune deficiency syndrome (AIDS) progression. Transcription from the HIV-1 long terminal repeat (LTR) is a crucial step for vi...

journal_title：Journal of molecular endocrinology

authors： Nevado J,Tenbaum SP,Castillo AI,Sánchez-Pacheco A,Aranda A

更新日期：2007-06-01 00:00:00

abstract：:Receptive endometrium is a prerequisite for successful embryo implantation, and it follows that poor endometrial receptivity is a leading cause of implantation failure. miRNAs play important roles as epigenetic regulators of endometrial receptivity and embryo implantation through post-transcriptional modifications. Ho...

journal_title：Journal of molecular endocrinology

authors： Akbar R,Ullah K,Rahman TU,Cheng Y,Pang HY,Jin LY,Wang QJ,Huang HF,Sheng JZ

更新日期：2020-01-01 00:00:00

abstract：:Retinoic acid (RA) and sodium butyrate (NaB) are regulators of cell growth and differentiation. We studied their effect on normal (SVC1) or v-Ki-ras-transformed (Ki-SVC1) rat seminal vesicle (SV) epithelial cell lines. The treatment of these cells with 10(-((7( M RA did not produce significant changes in the morpholog...

journal_title：Journal of molecular endocrinology

authors： Buommino E,Pasquali D,Sinisi AA,Bellastella A,Morelli F,Metafora S

更新日期：2000-02-01 00:00:00

abstract：:This study developed a quantitative reverse transcription-polymerase chain reaction (RT-PCR) method to measure estrogen receptor-alpha (ERalpha) mRNA in the rainbow trout (Oncorhynchus mykiss). Using RT-PCR, and primers based on the known ERalpha DNA sequence in this species, cDNA sequences representing most of the pr...

journal_title：Journal of molecular endocrinology

authors： Nagler JJ,Krisfalusi M,Cyr DG

更新日期：2000-10-01 00:00:00