Sodium butyrate/retinoic acid costimulation induces apoptosis-independent growth arrest and cell differentiation in normal and ras-transformed seminal vesicle epithelial cells unresponsive to retinoic acid.

abstract：:The Siberian hamster (Phodopus sungorus) survives winter by decreasing food intake and catabolizing abdominal fat reserves, resulting in a sustained, profound loss of body weight. Hypothalamic tanycytes are pivotal for this process. In these cells, short-winter photoperiods upregulate deiodinase 3, an enzyme that regu...

journal_title：Journal of molecular endocrinology

authors： Lewis JE,Brameld JM,Hill P,Wilson D,Barrett P,Ebling FJ,Jethwa PH

更新日期：2016-02-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I), transforming growth factor alpha (TGFalpha) and epidermal growth factor (EGF) induced cathepsin D gene expression and reporter gene activity in MCF-7 human breast cancer cells transiently transfected with a construct (pCD1) containing a -2576 to -124 cathepsin D gene promoter inse...

journal_title：Journal of molecular endocrinology

authors： Wang F,Duan R,Chirgwin J,Safe SH

更新日期：2000-04-01 00:00:00

abstract：:Estrogens are essential for female reproduction and overall well-being, and estrogens in the circulation are largely synthesized in ovarian granulosa cells. Using primary cultures of ovarian granulosa cells from gonadotropin-primed immature rats, we have recently discovered that pituitary FSH and ovarian cytokine tran...

journal_title：Journal of molecular endocrinology

authors： Lai WA,Yeh YT,Fang WL,Wu LS,Harada N,Wang PH,Ke FC,Lee WL,Hwang JJ

更新日期：2014-10-01 00:00:00

abstract：:Hormones are dynamically collected by fenestrated capillaries to generate pulses, which are then decoded by target tissues to mount a biological response. To generate hormone pulses, endocrine systems have evolved mechanisms to tightly regulate blood perfusion and oxygenation, coordinate endocrine cell responses to se...

journal_title：Journal of molecular endocrinology

authors： Schaeffer M,Hodson DJ,Lafont C,Mollard P

更新日期：2011-08-25 00:00:00

abstract：:During the process of insulitis in the pathogenesis of type I (insulin-dependent) diabetes mellitus, proinflammatory cytokines induce expression of the death receptor Fas on the surface of pancreatic beta-cells and thereby contribute to the enhanced susceptibility of beta-cells for apoptosis. The aim of this study was...

journal_title：Journal of molecular endocrinology

authors： Augstein P,Wachlin G,Berg S,Bahr J,Salzsieder C,Hehmke B,Heinke P,Salzsieder E

更新日期：2003-04-01 00:00:00

abstract：:The lactating tammar wallaby progressively alters the rate of secretion and composition of its milk to provide appropriate nutrition for the developing offspring, whose needs are signalled by changes in the pattern and efficiency of its sucking. Tammars are also capable of asynchronous concurrent lactation, when the m...

journal_title：Journal of molecular endocrinology

authors： Hendry KA,Simpson KJ,Nicholas KR,Wilde CJ

更新日期：1998-10-01 00:00:00

abstract：:Androgens play an important role in male reproductive development and function. These steroid hormones mediate their actions by binding to the androgen receptor (AR). Diseases such as androgen insensitivity syndrome, prostate cancer, Kennedy's disease, and infertility can be caused by mutations in the AR. To get a bet...

journal_title：Journal of molecular endocrinology

authors： Kerkhofs S,Denayer S,Haelens A,Claessens F

更新日期：2009-01-01 00:00:00

abstract：:The arcuate nucleus of the hypothalamus is essential for metabolic homeostasis and responds to leptin by producing several neuropeptides including proopiomelanocortin (POMC). We previously reported that high-dose erythropoietin (Epo) treatment in mice while increasing hematocrit reduced body weight, fat mass, and food...

journal_title：Journal of molecular endocrinology

authors： Dey S,Li X,Teng R,Alnaeeli M,Chen Z,Rogers H,Noguchi CT

更新日期：2016-02-01 00:00:00

abstract：:Somatostatins (SSs) play important roles in the growth, development and metabolism of vertebrates. In this study, cDNAs for two unique somatostatin receptor variants were cloned and sequenced from rainbow trout. The two cDNAs, one consisting of 1755 bp and the other of 1743 bp, share 63.6% identity in nucleotide seque...

journal_title：Journal of molecular endocrinology

authors： Slagter BJ,Sheridan MA

更新日期：2004-02-01 00:00:00

abstract：:Relaxin is a peptide hormone which is produced in human reproductive tissues including the ovary and prostate gland. Little is known of the molecular events regulating relaxin gene transcription. We have studied this question using gene transfer of relaxin promoter/reporter gene constructs into a relaxin-expressing ce...

journal_title：Journal of molecular endocrinology

authors： Gunnersen JM,Roche PJ,Tregear GW,Crawford RJ

更新日期：1995-10-01 00:00:00

abstract：:17β-Estradiol (E(2)) plays important roles in functions of many tissues. E(2) effects are mediated by estrogen receptor (ER) α and β. ERs regulate transcriptions through estrogen-responsive element (ERE)-dependent and ERE-independent modes of action. ER binding to ERE constitutes the basis of the ERE-dependent pathway...

journal_title：Journal of molecular endocrinology

authors： Muyan M,Callahan LM,Huang Y,Lee AJ

更新日期：2012-10-30 00:00:00

abstract：:The p160 coactivators, steroid receptor coactivator-1 (SRC-1), transcriptional intermediary factor-2 (TIF2) and receptor-associated coactivator-3 (RAC3), as well as the coactivator/integrator CBP, mediate estrogen receptor-alpha (ERalpha)-dependent gene expression. Although these coactivators are widely expressed, ERa...

journal_title：Journal of molecular endocrinology

authors： Jaber BM,Mukopadhyay R,Smith CL

更新日期：2004-02-01 00:00:00

abstract：:Gene related to anergy in lymphocytes (GRAIL) is an E3 ubiquitin ligase that regulates energy in T-lymphocytes. Whereas, the relevance of GRAIL to T lymphocyte function is well established, the role of this protein in other cell types remains unknown. Given that GRAIL is abundant in the liver, we investigated the pote...

journal_title：Journal of molecular endocrinology

authors： Nakamichi S,Senga Y,Inoue H,Emi A,Matsuki Y,Watanabe E,Hiramatsu R,Ogawa W,Kasuga M

更新日期：2009-02-01 00:00:00

abstract：:Malic enzyme 1 (ME1) is a cytosolic protein that catalyzes the conversion of malate to pyruvate while concomitantly generating NADPH from NADP. Early studies identified ME1 as a mediator of intermediary metabolism primarily through its participatory roles in lipid and cholesterol biosynthesis. ME1 was one of the first...

journal_title：Journal of molecular endocrinology

authors： Simmen FA,Alhallak I,Simmen RCM

更新日期：2020-11-01 00:00:00

abstract：:In contrast to the classical model describing the synthesis of androgens and estrogens as restricted to somatic cells, a previous study demonstrated that Xenopus laevis oocytes participate in androgen synthesis. The objective of our study was to determine whether Xenopus oocytes are also involved in estrogen synthesis...

journal_title：Journal of molecular endocrinology

authors： Gohin M,Bodinier P,Fostier A,Bobe J,Chesnel F

更新日期：2011-09-07 00:00:00

abstract：:Activity of acetyl-CoA carboxylase (ACC)-alpha is rate limiting for de novo synthesis of fatty acids. The encoding gene is expressed by three different promoters. We characterized promoter III (PIII) from cow, previously only known from sheep. Quantitation of transcripts by RNAse protection assays and real time PCR re...

journal_title：Journal of molecular endocrinology

authors： Mao J,Molenaar AJ,Wheeler TT,Seyfert HM

更新日期：2002-08-01 00:00:00

abstract：:The hypothalamic arcuate nucleus (ARC) represents a major component of the neuroendocrine reproductive axis and plays an important role in controlling the onset of puberty as well as age-associated reproductive senescence. Although significant gene expression changes have been observed in the ARC during sexual maturat...

journal_title：Journal of molecular endocrinology

authors： Eghlidi DH,Garyfallou VT,Kohama SG,Urbanski HF

更新日期：2017-08-01 00:00:00

abstract：:The hormone human chorionic gonadotrophin (hCG) shows extensive sequence homology with LH. Thus, many of the antigenic epitopes on hCG are shared with LH, leading to immunological cross-reaction between these two hormones. Anti-fertility and anti-cancer vaccines based upon hCG should ideally target only the hCG-specif...

journal_title：Journal of molecular endocrinology

authors： Charrel-Dennis M,Jackson AM,Lund T,Lapthorn AJ,Berger P,Roitt IM,Delves PJ

更新日期：2004-04-01 00:00:00

abstract：:In vitro studies have indicated that the maturation-inducing hormone 17α,20β-dihydroxy-4-pregnen-3-one (17α,20β-DP, DHP), probably through nuclear progestin receptor (Pgr), might be involved in the proliferation of spermatogonial cells and the initiation of meiosis in several fish species. However, further in vivo evi...

journal_title：Journal of molecular endocrinology

authors： Liu G,Luo F,Song Q,Wu L,Qiu Y,Shi H,Wang D,Zhou L

更新日期：2014-08-01 00:00:00

abstract：:In this study we examine changes in the cellular properties of FRTL-5 cells as a function of passage number, with particular emphasis on gap junction expression, karyotype, morphology, growth rate and thyroxine (T(4)) release. Early passage FRTL-5 follicular cells transfer dye through gap junctions from injected cell(...

journal_title：Journal of molecular endocrinology

authors： Green LM,Murray DK,Tran DT,Nelson GA,Shah MM,Luben RA

更新日期：2001-10-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) as well as its receptors is found in mammalian ovary and follicular cells and its function in oocyte meiotic maturation has also been reported in Xenopus, hamster and rat. But the results are controversial and the physiological mechanism of ANP on oocyte maturation is not clear, especi...

journal_title：Journal of molecular endocrinology

authors： Zhang M,Tao Y,Zhou B,Xie H,Wang F,Lei L,Huo L,Sun Q,Xia G

更新日期：2005-04-01 00:00:00

abstract：:The hyperglycaemia-inducing sulphonamide diazoxide has been previously shown to mediate its effects upon insulin secretion by opening K+ channels and hyperpolarizing the beta-cell membrane. The target site has been characterized as the ATP-regulated K+ (K+ATP) channel protein. In the present study, a detailed investig...

journal_title：Journal of molecular endocrinology

authors： Jaggar JH,Harding EA,Ayton BJ,Dunne MJ

更新日期：1993-02-01 00:00:00

abstract：:Murine double minute clone 2 (MDM2) is a multifunctional protein, which modulates nuclear receptor-mediated transactivation. In this study, we show that MDM2 significantly enhanced estrogen receptor α (ERα) and ERα/specificity protein-mediated transactivation in MCF-7 and ZR-75 breast cancer cells. This was demonstrat...

journal_title：Journal of molecular endocrinology

authors： Kim K,Burghardt R,Barhoumi R,Lee SO,Liu X,Safe S

更新日期：2011-02-15 00:00:00

abstract：:A number of enzymes possessing 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (17HSD/KSR) activities have been described and cloned, but their nomenclature needs specification. To clarify the present situation, descriptions of the eight cloned 17HSD/KSRs are given and guidelines for the classification of...

journal_title：Journal of molecular endocrinology

authors： Peltoketo H,Luu-The V,Simard J,Adamski J

更新日期：1999-08-01 00:00:00

abstract：:Tamoxifen acts as an oestrogen antagonist in the breast reducing cell proliferation, but in the uterus as an oestrogen agonist resulting in increased cell proliferation. Tamoxifen exerts its tissue-specific effects through the oestrogen receptors (ERalpha or ERbeta). The levels and functions of the two ERs affect the ...

journal_title：Journal of molecular endocrinology

authors： Horner-Glister E,Maleki-Dizaji M,Guerin CJ,Johnson SM,Styles J,White IN

更新日期：2005-12-01 00:00:00

abstract：:The prevalence of non-alcoholic fatty liver disease (NAFLD), a condition characterized by an excessive accumulation of triglycerides (TGs) in hepatocytes, has dramatically increased globally during recent decades. MicroRNAs (miRs) have been suggested to play crucial roles in many complex diseases and lipid metabolism....

journal_title：Journal of molecular endocrinology

authors： Li B,Zhang Z,Zhang H,Quan K,Lu Y,Cai D,Ning G

更新日期：2014-12-01 00:00:00

abstract：:In embryonic growth cartilage, Indian hedgehog (Ihh) and parathyroid hormone-related protein (PTHrP) participate in a negative feedback loop that regulates chondrocyte differentiation. Postnatally, this region undergoes major structural and functional changes. To explore the organization of the Ihh–PTHrP system in pos...

journal_title：Journal of molecular endocrinology

authors： Chau M,Forcinito P,Andrade AC,Hegde A,Ahn S,Lui JC,Baron J,Nilsson O

更新日期：2011-08-01 00:00:00

abstract：:This study examined fetal steroidogenic enzyme expression and function during pregnancy in the pig. Northern and Western analyses were performed to detect the cytochrome P450 enzyme 17 alpha-hydroxylase/17-20 lyase (P450c17) and that for cholesterol side-chain cleavage (P450scc), as well as 3 beta-hydroxysteroid dehyd...

journal_title：Journal of molecular endocrinology

authors： Conley AJ,Rainey WE,Mason JI

更新日期：1994-04-01 00:00:00

abstract：:DNA encoding the N-terminal 415 residues of the human thyrotrophin receptor (predicted to code for the large extracellular region) was introduced into Chinese hamster ovary (CHO) cells using the glutamine synthetase/cytomegalovirus amplifiable expression system, and into E. coli using the pGEX-3X expression vector. Su...

journal_title：Journal of molecular endocrinology

authors： Harfst E,Johnstone AP,Nussey SS

更新日期：1992-12-01 00:00:00

abstract：:Glucagon-like peptide 1 (GLP1) is an intestinal incretin that regulates glucose homeostasis through stimulation of insulin secretion from pancreatic β-cells and inhibits appetite by acting on the brain. Thus, it is a promising therapeutic agent for the treatment of type 2 diabetes mellitus and obesity. Studies using s...

journal_title：Journal of molecular endocrinology

authors： Hwang JI,Yun S,Moon MJ,Park CR,Seong JY

更新日期：2014-06-01 00:00:00