Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism.

Abstract:

:Malic enzyme 1 (ME1) is a cytosolic protein that catalyzes the conversion of malate to pyruvate while concomitantly generating NADPH from NADP. Early studies identified ME1 as a mediator of intermediary metabolism primarily through its participatory roles in lipid and cholesterol biosynthesis. ME1 was one of the first identified insulin-regulated genes in liver and adipose and is a transcriptional target of thyroxine. Multiple studies have since documented that ME1 is pro-oncogenic in numerous epithelial cancers. In tumor cells, the reduction of ME1 gene expression or the inhibition of its activity resulted in decreases in proliferation, epithelial-to-mesenchymal transition and in vitro migration, and conversely, in promotion of oxidative stress, apoptosis and/or cellular senescence. Here, we integrate recent findings to highlight ME1's role in oncogenesis, provide a rationale for its nexus with metabolic syndrome and diabetes, and raise the prospects of targeting the cytosolic NADPH network to improve therapeutic approaches against multiple cancers.

journal_name

J Mol Endocrinol

authors

Simmen FA,Alhallak I,Simmen RCM

doi

10.1530/JME-20-0176

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

R77-R90

issue

4

eissn

0952-5041

issn

1479-6813

pii

JME-20-0176

journal_volume

65

pub_type

杂志文章,评审
  • Transcriptional activation of cathepsin D gene expression by growth factors.

    abstract::Insulin-like growth factor-I (IGF-I), transforming growth factor alpha (TGFalpha) and epidermal growth factor (EGF) induced cathepsin D gene expression and reporter gene activity in MCF-7 human breast cancer cells transiently transfected with a construct (pCD1) containing a -2576 to -124 cathepsin D gene promoter inse...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0240193

    authors: Wang F,Duan R,Chirgwin J,Safe SH

    更新日期:2000-04-01 00:00:00

  • Thyrotrophin-releasing hormone stimulates polyphosphoinositide metabolism in the frog neurointermediate lobe.

    abstract::Previous studies have demonstrated that TRH is a potent stimulator of alpha-MSH secretion from frog pituitary melanotrophs. In order to determine the intracellular events responsible for TRH-evoked alpha-MSH release, we have investigated the effect of TRH on polyphosphoinositide breakdown in frog pars intermedia. Neur...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0050129

    authors: Desrues L,Tonon MC,Vaudry H

    更新日期:1990-10-01 00:00:00

  • Central regulation of food intake in fish: an evolutionary perspective.

    abstract::Evidence indicates that central regulation of food intake is well conserved along the vertebrate lineage, at least between teleost fish and mammals. However, several differences arise in the comparison between both groups. In this review, we describe similarities and differences between teleost fish and mammals on an ...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/JME-17-0320

    authors: Soengas JL,Cerdá-Reverter JM,Delgado MJ

    更新日期:2018-05-01 00:00:00

  • Duplication of the southern white rhinoceros (Ceratotherium simum simum) luteinizing hormone beta subunit gene.

    abstract::Luteotropic glycoprotein hormones (LGH) include luteinizing hormone (LH) and chorionic gonadotropin (CG). The order Primates is the only phylogenetic clad known to exhibit more than one LGHbeta subunit gene per haploid genome. In the present study, we report the discovery of a second case of LGHbeta gene replication, ...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0210019

    authors: Lund LA,Sherman GB

    更新日期:1998-08-01 00:00:00

  • Blocking of progestin action disrupts spermatogenesis in Nile tilapia (Oreochromis niloticus).

    abstract::In vitro studies have indicated that the maturation-inducing hormone 17α,20β-dihydroxy-4-pregnen-3-one (17α,20β-DP, DHP), probably through nuclear progestin receptor (Pgr), might be involved in the proliferation of spermatogonial cells and the initiation of meiosis in several fish species. However, further in vivo evi...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1530/JME-13-0300

    authors: Liu G,Luo F,Song Q,Wu L,Qiu Y,Shi H,Wang D,Zhou L

    更新日期:2014-08-01 00:00:00

  • The combinations of polymorphisms in vitamin D receptor, osteoprotegerin and tumour necrosis factor superfamily member 11 genes are associated with bone mineral density.

    abstract::1alpha,25-dihydroxyvitamin D(3) upregulates tumour necrosis factor superfamily member 11 (TNFSF11) that codes for the receptor activator of nuclear factor kappaB ligand (RANKL), and downregulates osteoprotegerin (OPG) expression. We have analyzed the individual effects of polymorphisms in the vitamin D receptor gene (...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/JME-08-0108

    authors: Mencej-Bedrac S,Prezelj J,Kocjan T,Teskac K,Ostanek B,Smelcer M,Marc J

    更新日期:2009-03-01 00:00:00

  • Association between (AC)n dinucleotide repeat polymorphism at the 5'-end of the aldose reductase gene and diabetic nephropathy: a meta-analysis.

    abstract::Association between the (AC)(n) dinucleotide repeat polymorphism at the 5'-end of the aldose reductase gene and the occurrence of diabetic nephropathy was conducted. We examined eight studies consisting of ten Caucasian type 1 diabetes mellitus case-control comparisons and eight studies consisting of nine type 2 diabe...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章,meta分析

    doi:10.1677/JME-07-0152

    authors: Xu M,Chen X,Yan L,Cheng H,Chen W

    更新日期:2008-05-01 00:00:00

  • The endocannabinoid pathway and the female reproductive organs.

    abstract::Endocannabinoids are endogenous ligands of cannabinoid, vanilloid and peroxisome proliferator-activated receptors that activate multiple signal transduction pathways. Together with their receptor and the enzymes responsible for their synthesis and degradation, these compounds constitute the endocannabinoid system that...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/JME-12-0182

    authors: Di Blasio AM,Vignali M,Gentilini D

    更新日期:2013-01-11 00:00:00

  • Reciprocal influences between the signalling pathways regulating proliferation and steroidogenesis in adrenal glomerulosa cells.

    abstract::The main regulators of aldosterone secretion in adrenal gland zona glomerulosa (ZG) cells are the hormones angiotensin II (Ang II) and adrenocorticotrophin (ACTH) and small increases in the extracellular potassium (K(+)) concentration. The action of these agonists is mediated by different signalling systems - ACTH is ...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章,评审

    doi:10.1677/jme.0.0320893

    authors: Foster RH

    更新日期:2004-06-01 00:00:00

  • Molecular cloning of cDNA for porcine prolactin precursor.

    abstract::Porcine prolactin cDNA clones were screened using antiserum against ovine prolactin from a cDNA library of porcine anterior pituitary, and their nucleotide sequences were determined by the chain-termination method. The nucleotide sequence of the 5' untranslated region and part of the signal peptide region were determi...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0040135

    authors: Kato Y,Hirai T,Kato T

    更新日期:1990-04-01 00:00:00

  • No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions.

    abstract::GPRC6A is a seven-transmembrane receptor mediating signaling by a wide range of L-alpha-amino acids, a signaling augmented by the divalent cations Ca(2)(+) and Mg(2)(+). GPRC6A transcripts are detected in numerous mammalian tissues, but the physiological role of the receptor is thus far elusive. Analogously to the clo...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/JME-08-0149

    authors: Wellendorph P,Johansen LD,Jensen AA,Casanova E,Gassmann M,Deprez P,Clément-Lacroix P,Bettler B,Bräuner-Osborne H

    更新日期:2009-03-01 00:00:00

  • The transfection-induced overexpression of IGF-binding protein-4 affects the secretory activity of porcine ovarian granulosa cells and their response to hormones and IGF-I.

    abstract::The aim of our studies was to examine whether IGF-binding protein (IGFBP)-4 is involved in the control of the secretion of various ovarian substances and also the mediation of the effects of several hormones and growth factors on this secretion. For this purpose, we carried out the transfection of porcine granulosa ce...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0260241

    authors: Sirotkin AV,Makarevich AV,Corkins MR,Kotwica J,Bulla J

    更新日期:2001-06-01 00:00:00

  • Contribution of a 12 kDa protein to the angiotensin II-induced stabilization of angiotensinogen mRNA: interaction with the 3' untranslated mRNA.

    abstract::Several authors have shown that angiotensin II stimulates hepatic angiotensinogen synthesis in vivo, ex vivo and in vitro. In previous studies we have demonstrated that this effect of angiotensin II depends mainly on a transient inhibition of adenylyl cyclase and is the consequence of a stabilization of angiotensinoge...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0140209

    authors: Klett C,Bader M,Schwemmle M,Ganten D,Hackenthal E

    更新日期:1995-04-01 00:00:00

  • Activation of the human immunodeficiency virus type I long terminal repeat by 1 alpha,25-dihydroxyvitamin D3.

    abstract::The genetic predisposition of the host and the virus is the most important determinant for prediction of the course of human immunodeficiency virus type I (HIV-1) viral infection and acquired immune deficiency syndrome (AIDS) progression. Transcription from the HIV-1 long terminal repeat (LTR) is a crucial step for vi...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/JME-06-0065

    authors: Nevado J,Tenbaum SP,Castillo AI,Sánchez-Pacheco A,Aranda A

    更新日期:2007-06-01 00:00:00

  • IGF-I inhibits apoptosis through the activation of the phosphatidylinositol 3-kinase/Akt pathway in pituitary cells.

    abstract::In previous studies we demonstrated that IGF-I induces proliferation of pituitary lactotrophs. In addition to its mitotrophic actions, IGF-I is known to prevent apoptosis induced by diverse stimuli in several cell types. In this study, we investigated the action of IGF-I on pituitary cell survival and the intracellula...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0330155

    authors: Fernández M,Sánchez-Franco F,Palacios N,Sánchez I,Fernández C,Cacicedo L

    更新日期:2004-08-01 00:00:00

  • Dual activity of human pituitary thyrotrophin isoforms on thyroid cell growth.

    abstract::Alkaline (pI 8.6-7.5) and neutral (pI 7.0-6.0) isoforms of human TSH have been isolated from a highly purified intrapituitary preparation by isoelectric focusing and compared for their respective actions on thyroid cell proliferation. Both TSH isoforms displayed the same ability to bind to porcine thyroid membranes as...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0130187

    authors: Medri G,Sergi I,Papandréou MJ,Beck-Peccoz P,Verrier B,Ronin C

    更新日期:1994-10-01 00:00:00

  • Role of the E3 ubiquitin ligase gene related to anergy in lymphocytes in glucose and lipid metabolism in the liver.

    abstract::Gene related to anergy in lymphocytes (GRAIL) is an E3 ubiquitin ligase that regulates energy in T-lymphocytes. Whereas, the relevance of GRAIL to T lymphocyte function is well established, the role of this protein in other cell types remains unknown. Given that GRAIL is abundant in the liver, we investigated the pote...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/JME-08-0145

    authors: Nakamichi S,Senga Y,Inoue H,Emi A,Matsuki Y,Watanabe E,Hiramatsu R,Ogawa W,Kasuga M

    更新日期:2009-02-01 00:00:00

  • Recognition of follicle stimulating hormone (alpha-subunit) by a recombinant receptor protein domain coded by an alternately spliced mRNA and expressed in Escherichia coli.

    abstract::To assess the functional significance of putative proteins encoded by alternately spliced mRNA of the sheep testicular FSH receptor, a short form cDNA comprising of the first four exons (117 residues mature protein) was engineered for expression in Escherichia coli. The expressed protein of molecular mass 15 kDa was p...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0190183

    authors: Khan H,Jiang LG,Jayashree GN,Yarney TA,Sairam MR

    更新日期:1997-10-01 00:00:00

  • Transcriptional upregulation of hepatic GH receptor and GH-binding protein expression during pregnancy in the mouse.

    abstract::In the mouse, GH-binding protein (GHBP) and GH receptor (GHR) are encoded by a single gene via alternative splicing. We previously demonstrated that the steady-state levels of the GHR and GHBP mRNAs are significantly elevated in mouse liver during pregnancy. Hepatic GHR and GHBP mRNAs are associated primarily with one...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0230085

    authors: Ilkbahar YN,Southard JN,Talamantes F

    更新日期:1999-08-01 00:00:00

  • Recombinant mouse prolactin: expression in Escherichia coli, purification and biological activity.

    abstract::Transformation of Escherichia coli cells with a recombinant plasmid containing modified mouse prolactin (mPRL) cDNA and a pKK223-3 vector resulted in efficient expression of mPRL protein. Cloned mPRL cDNA was modified by removing the 5' non-translating sequence as well as the sequence which encoded the signal peptide ...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0080165

    authors: Yamamoto M,Harigaya T,Ichikawa T,Hoshino K,Nakashima K

    更新日期:1992-04-01 00:00:00

  • Stromal-derived factor-1alpha induces a non-canonical pathway to activate the endocrine-linked Tac1 gene in non-tumorigenic breast cells.

    abstract::The chemokine Stromal-derived factor-1alpha (SDF-1alpha) interacts with seven transmembrane (TM) G-protein-coupled receptor (GPR), CXCR4. SDF-1alpha is linked to inflammation, chemoattraction, cancer metastasis, and hematopoiesis. Tachykinin (Tac1) peptides bind seven transmembrane (TM), GPR and are involved in tumor ...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/JME-07-0111

    authors: Corcoran KE,Malhotra A,Molina CA,Rameshwar P

    更新日期:2008-03-01 00:00:00

  • Somatostatin system: molecular mechanisms regulating anterior pituitary hormones.

    abstract::The somatostatin (SRIF) system, which includes the SRIF ligand and receptors, regulates anterior pituitary gland function, mainly inhibiting hormone secretion and to some extent pituitary tumor cell growth. SRIF-14 via its cognate G-protein-coupled receptors (subtypes 1-5) activates multiple cellular signaling pathway...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/JME-14-0034

    authors: Eigler T,Ben-Shlomo A

    更新日期:2014-08-01 00:00:00

  • Molecular and clinical insights from studies of calcium-sensing receptor mutations.

    abstract::Twenty-five years have elapsed since the calcium-sensing receptor (CaSR) was first identified in bovine parathyroid and the receptor is now recognized as a fundamental contributor to extracellular Ca2+ (Ca2+ e) homeostasis, regulating parathyroid hormone release and urinary calcium excretion. The CaSR is a class C G-p...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/JME-19-0104

    authors: Gorvin CM

    更新日期:2019-08-01 00:00:00

  • Characterization of NMB, GRP and their receptors (BRS3, NMBR and GRPR) in chickens.

    abstract::The two structurally and functionally related peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB) play critical roles in many physiological/pathological processes in mammals. However, the information regarding the expression and functionality of avian NMB, GRP and their receptors is limited. Here, we char...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1530/JME-17-0020

    authors: Mo C,Huang L,Cui L,Lv C,Lin D,Song L,Zhu G,Li J,Wang Y

    更新日期:2017-07-01 00:00:00

  • Heat shock modulates adipokines expression in 3T3-L1 adipocytes.

    abstract::Studies have demonstrated that heat shock is associated with alteration in energy metabolism. In this study, we investigated the effect of heat shock on gene expression and secretion of adiponectin and leptin, and gene expression of Hspa2 and Ppargamma in 3T3-L1 adipocytes. Compared with 37 degrees C, adiponectin mRNA...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/JME-08-0068

    authors: Bernabucci U,Basiricò L,Morera P,Lacetera N,Ronchi B,Nardone A

    更新日期:2009-02-01 00:00:00

  • FGF23 signalling and physiology.

    abstract::Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone that belongs to a subfamily of endocrine FGFs with evolutionarily conserved functions in C. elegans and fruit flies. FAM20C phosphorylates FGF23 post-translationally, targeting to proteolysis through subtilisin-like proprotein convertase FURIN, resulting i...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/JME-20-0178

    authors: Ho BB,Bergwitz C

    更新日期:2020-12-01 00:00:00

  • c-MET inhibition: novel treatment for sporadic and MEN1-associated GEP NETs.

    abstract::Gastroenteropancreatic neuroendocrine tumors (GEP NETs) comprise a heterogenous and diverse group of neoplasms arising from a common neuroendocrine cell origin. The majority of these tumors occur sporadically while ~20% manifest within the context of hereditary syndromes. Germline MEN1 mutations cause a syndrome with ...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章,评审

    doi:10.1530/JME-20-0020

    authors: Lee ME,Tepede AA,Mandl A,Weinstein LS,Del Rivero J,Agarwal SK,Blau JE

    更新日期:2020-08-01 00:00:00

  • Functional expression of the oxytocin receptor in Xenopus laevis oocytes primed with mRNA from bovine endometrium.

    abstract::Synthesis of the uterine receptor for the hypothalamic hormone oxytocin has been induced in oocytes from Xenopus laevis previously primed with bovine endometrium mRNA. The injected oocytes responded to oxytocin by showing dose-dependent oscillations in membrane currents as recorded by the voltage-clamp method. The res...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0010077

    authors: Morley SD,Meyerhof W,Schwarz J,Richter D

    更新日期:1988-07-01 00:00:00

  • Characterization of a new duplicate delta-opioid receptor from zebrafish.

    abstract::A new full-length cDNA (ZFOR4) that encodes an opioid receptor has been isolated from the teleost zebrafish. The encoded polypeptide is 375 amino acids long and shows high sequence similarity to other delta-opioid receptors, including ZFOR1, the other delta-opioid receptor from zebrafish previously characterized by us...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.1.02136

    authors: Pinal-Seoane N,Martin IR,Gonzalez-Nuñez V,Marron Fernandez de Velasco E,Alvarez FA,Sarmiento RG,Rodriguez RE

    更新日期:2006-12-01 00:00:00

  • A monoclonal antibody to a conserved sequence in the extracellular domain recognizes the angiotensin II AT1 receptor in mammalian target tissues.

    abstract::We have generated hybridomas which secrete monoclonal antibodies to the AT1 subtype of the angiotensin II receptor (AT1 receptor). These were obtained after immunization of Balb C/c mice with synthetic peptides representing sequences from either the extracellular domain (residues 8-17) or the intracellular domain (res...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0110241

    authors: Barker S,Marchant W,Ho MM,Puddefoot JR,Hinson JP,Clark AJ,Vinson GP

    更新日期:1993-10-01 00:00:00