17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes.

abstract：:Activins are cytokines of the transforming growth factor beta family, which plays a central role in the determination of cell fate and the regulation of tissue balance. Family members are composed of two subunits and this dimerization is critical for liganding their cognate receptors and execution of proper functions....

journal_title：Journal of molecular endocrinology

authors： Vejda S,Cranfield M,Peter B,Mellor SL,Groome N,Schulte-Hermann R,Rossmanith W

更新日期：2002-04-01 00:00:00

abstract：:The type 1 form of 17beta-hydroxysteroid dehydrogenase (17betaHSD1) was the first isoform to be identified and is capable of converting estrone to 17beta-estradiol. This study was aimed at characterizing the molecular structure of the equine 17betaHSD1 gene and cDNA, as well as its molecular regulation during human ch...

journal_title：Journal of molecular endocrinology

authors： Brown KA,Sayasith K,Bouchard N,Lussier JG,Sirois J

更新日期：2007-02-01 00:00:00

abstract：:Retinoic acid (RA) and sodium butyrate (NaB) are regulators of cell growth and differentiation. We studied their effect on normal (SVC1) or v-Ki-ras-transformed (Ki-SVC1) rat seminal vesicle (SV) epithelial cell lines. The treatment of these cells with 10(-((7( M RA did not produce significant changes in the morpholog...

journal_title：Journal of molecular endocrinology

authors： Buommino E,Pasquali D,Sinisi AA,Bellastella A,Morelli F,Metafora S

更新日期：2000-02-01 00:00:00

abstract：:In contrast to the classical model describing the synthesis of androgens and estrogens as restricted to somatic cells, a previous study demonstrated that Xenopus laevis oocytes participate in androgen synthesis. The objective of our study was to determine whether Xenopus oocytes are also involved in estrogen synthesis...

journal_title：Journal of molecular endocrinology

authors： Gohin M,Bodinier P,Fostier A,Bobe J,Chesnel F

更新日期：2011-09-07 00:00:00

abstract：:The cloning and characterization of the mouse TRH receptor (TRH-R) gene revealed an untranslated exon (exon 1), a single intron and an upstream dinucleotide repeat sequence (d(TG)16.d(AG)21) in the 5' untranslated region (UTR). The coding region was contained almost entirely on a second exon (exon 2), with the final a...

journal_title：Journal of molecular endocrinology

authors： Duthie SM,Taylor PL,Eidne KA

更新日期：1993-10-01 00:00:00

abstract：:cAMP-response element-binding protein (CREB) is required for the induction of adipogenic transcription factors such as CCAAT/enhancer-binding proteins (C/EBPs). Interestingly, it is known from studies in other tissues that LKB1 and its substrates AMP-activated protein kinase (AMPK) and salt-inducible kinases (SIKs) ne...

journal_title：Journal of molecular endocrinology

authors： Gormand A,Berggreen C,Amar L,Henriksson E,Lund I,Albinsson S,Göransson O

更新日期：2014-08-01 00:00:00

abstract：:Estrogen plays an important role in many physiological events including carcinogenesis and the development of human breast cancer. However, the molecular mechanisms of estrogen signaling in cancers have not been clarified hitherto and accurate therapeutic prediction of breast cancer is earnestly desired. We first carr...

journal_title：Journal of molecular endocrinology

authors： Inoue A,Yoshida N,Omoto Y,Oguchi S,Yamori T,Kiyama R,Hayashi S

更新日期：2002-10-01 00:00:00

abstract：:The pancreatic regenerating (reg) gene is proposed to be involved in pancreatic beta-cell growth. Up- or down-regulation of reg gene expression has been shown to parallel variations in beta-cell mass and function in the adult pancreas. In several species at least two nonallelic reg genes have been identified. In this ...

journal_title：Journal of molecular endocrinology

authors： Perfetti R,Raygada M,Wang Y,Zenilman ME,Egan JM,Denno KM,Sadler TW,Shuldiner AR

更新日期：1996-08-01 00:00:00

abstract：:Estrogens are essential for female reproduction and overall well-being, and estrogens in the circulation are largely synthesized in ovarian granulosa cells. Using primary cultures of ovarian granulosa cells from gonadotropin-primed immature rats, we have recently discovered that pituitary FSH and ovarian cytokine tran...

journal_title：Journal of molecular endocrinology

authors： Lai WA,Yeh YT,Fang WL,Wu LS,Harada N,Wang PH,Ke FC,Lee WL,Hwang JJ

更新日期：2014-10-01 00:00:00

abstract：:In the last 15 years, single-cell technologies have become robust and indispensable tools to investigate cell heterogeneity. Beyond transcriptomic, genomic and epigenome analyses, technologies are constantly evolving, in particular toward multi-omics, where analyses of different source materials from a single cell are...

journal_title：Journal of molecular endocrinology

authors： Cheung LYM,Rizzoti K

更新日期：2020-08-01 00:00:00

abstract：:We have previously shown that arginine vasopressin (AVP) stimulates the production of aldosterone in isolated superfused adrenal glomerulosa cells by a mechanism that involves an increased turnover of phosphoinositides. In the present study we compared the characteristics of AVP- and angiotensin II (AII)-induced chang...

journal_title：Journal of molecular endocrinology

authors： Enyedi P,Balla T,Antoni FA,Spät A

更新日期：1988-09-01 00:00:00

abstract：:The subcellular distribution of steroidogenic enzymes has so far been studied mostly in classical endocrine glands and in the placenta. In the peripheral intracrine organs which synthesize sex steroids there is no indication about the organelles which contain the enzymes involved in steroid biosynthesis. We have thus ...

journal_title：Journal of molecular endocrinology

authors： Pelletier G,Luu-The V,El-Alfy M,Li S,Labrie F

更新日期：2001-02-01 00:00:00

abstract：:Two forms of prolactin (tiPRLI and tiPRLII), with only 69% sequence identity, have been previously described in the cichlid fish tilapia (Oreochromis species). In the present study we have attempted to investigate the biological activity of these two prolactin forms during adaptation to a hyperosmotic environment. For...

journal_title：Journal of molecular endocrinology

authors： Auperin B,Rentier-Delrue F,Martial JA,Prunet P

更新日期：1994-02-01 00:00:00

abstract：:Oestrogens have a major impact on reproductive function in both males and females. Two oestrogen receptor genes known as ERalpha (ESR1NR3A1) and ERbeta (ESR2NR3A2) have been cloned. Splice variant isoforms of the ERbeta gene have been identified in human, bovine and rodents and it has been suggested that the existence...

journal_title：Journal of molecular endocrinology

authors： Sierens JE,Scobie GA,Wilson J,Saunders PT

更新日期：2004-06-01 00:00:00

abstract：:In the present study, the molecular mechanism underlying the up-regulatory effect of estradiol (E2) on mouse insulin receptor substrate-1 (IRS-1) promoter was investigated in CHO cells on which the same promoter had first been functionally characterized. The mouse IRS-1 promoter bears four consensus half Estrogen Resp...

journal_title：Journal of molecular endocrinology

authors： Panno ML,Mauro L,Marsico S,Bellizzi D,Rizza P,Morelli C,Salerno M,Giordano F,Andò S

更新日期：2006-02-01 00:00:00

abstract：:The mechanisms underlying sex determination and differentiation in fishes are labile in response to environmental parameters. Sex-specific phenotypes are largely regulated by sex steroids, and the inhibition or the stimulation of aromatase can reverse sex as well as alter secondary sexual characteristics in fishes. Am...

journal_title：Journal of molecular endocrinology

authors： Orlando EF,Katsu Y,Miyagawa S,Iguchi T

更新日期：2006-10-01 00:00:00

abstract：:The Siberian hamster (Phodopus sungorus) survives winter by decreasing food intake and catabolizing abdominal fat reserves, resulting in a sustained, profound loss of body weight. Hypothalamic tanycytes are pivotal for this process. In these cells, short-winter photoperiods upregulate deiodinase 3, an enzyme that regu...

journal_title：Journal of molecular endocrinology

authors： Lewis JE,Brameld JM,Hill P,Wilson D,Barrett P,Ebling FJ,Jethwa PH

更新日期：2016-02-01 00:00:00

abstract：:Natriuretic peptides (NPs) have been reported to have critical roles in follicular development and oocyte maturation in rodents. This study aimed to extend our current understanding of NP-mediated signalling pathways and mechanisms of action in the follicles of a monovulatory species. Ovine granulosa cells (GCs) and t...

journal_title：Journal of molecular endocrinology

authors： Alhamdan R,Maalouf W,Campbell BK,Hernandez-Medrano JH,Marsters P

更新日期：2020-05-01 00:00:00

abstract：:High energy intake and, specifically, high dietary fat intake challenge the mammalian metabolism and correlate with many metabolic disorders such as obesity and diabetes. However, dietary restriction (DR) is known to prevent the development of metabolic disorders. The current western diets are highly enriched in fat, ...

journal_title：Journal of molecular endocrinology

authors： Duivenvoorde LP,van Schothorst EM,Bunschoten A,Keijer J

更新日期：2011-08-01 00:00:00

abstract：:Barrett's oesophagus (BO) and oesophageal adenocarcinoma (OAC) are regarded as complications of gastro-oesophageal reflux disease, although all the factors that contribute to the development of these lesions are unknown. Acid suppressive drugs are widely used for symptomatic therapy of reflux disease but may induce hy...

journal_title：Journal of molecular endocrinology

authors： Beales IL,Ogunwobi OO

更新日期：2009-04-01 00:00:00

abstract：:The effect of steroid hormone treatment on coho salmon (Oncorhynchus kisutch) was examined. The cDNAs for coho salmon FSH beta and LH beta subunits were cloned and sequenced using reverse transcriptase PCR. Northern blot analysis revealed that a single transcript of 1 kb for each of these subunits was present in the p...

journal_title：Journal of molecular endocrinology

authors： Dickey JT,Swanson P

更新日期：1998-12-01 00:00:00

abstract：:Cardiovascular disease (CVD) remains the leading cause of death worldwide. Low levels of vitamin D are associated with high risk of myocardial infarction, even after controlling for factors associated with coronary artery disease. A growing body of evidence indicates that vitamin D plays an important role in CVD-relat...

journal_title：Journal of molecular endocrinology

authors： Hlaing SM,Garcia LA,Contreras JR,Norris KC,Ferrini MG,Artaza JN

更新日期：2014-12-01 00:00:00

abstract：:Chronic inflammation is involved in the genitourinary syndrome of menopause (GSM) and beneficial effects of androgens in the vagina have been described. We investigated the potential involvement of human vagina smooth muscle cells (hvSMCs) in the inflammatory response and the immunomodulatory effect of androgen recept...

journal_title：Journal of molecular endocrinology

authors： Maseroli E,Cellai I,Filippi S,Comeglio P,Cipriani S,Rastrelli G,Rosi M,Sorbi F,Fambrini M,Petraglia F,Amoriello R,Ballerini C,Lombardelli L,Piccinni MP,Sarchielli E,Guarnieri G,Morelli A,Maggi M,Vignozzi L

更新日期：2020-10-01 00:00:00

abstract：:In non-mammalian vertebrates, estrogens are key players in ovarian differentiation, but the mechanisms by which they act remain poorly understood. The present study on rainbow trout was designed to investigate whether estrogens trigger the female pathway by activating a group of early female genes (i.e. cyp19a1, foxl2...

journal_title：Journal of molecular endocrinology

authors： Vizziano-Cantonnet D,Baron D,Mahè S,Cauty C,Fostier A,Guiguen Y

更新日期：2008-11-01 00:00:00

abstract：:Both 17beta-estradiol and prolactin play important roles in the mammary gland, raising the possibility of functional cross-talk between the two signaling pathways. Here, we demonstrate that estrogen receptor-alpha (ERalpha) and -beta (ERbeta) are both able to potentiate transcription from a Stat5-responsive promoter w...

journal_title：Journal of molecular endocrinology

authors： Björnström L,Kilic E,Norman M,Parker MG,Sjöberg M

更新日期：2001-08-01 00:00:00

abstract：:Human thyroid hormone receptor (c-erb A protein) produced by Escherichia coli expression vector plasmid was purified sequentially using polyethylenimine precipitation of DNA, hydroxylapatite column chromatography, ammonium sulphate precipitation, Sephacryl S-300 gel filtration and mono Q-Sepharose column chromatograph...

journal_title：Journal of molecular endocrinology

authors： Ichikawa K,Hashizume K,Nishii Y,Takeda T,Kobayashi M,Suzuki S,Yamada T

更新日期：1991-10-01 00:00:00

abstract：:Basal and thyroid hormone-regulated expression of constructs containing varying lengths of 5' flanking sequence of the human glycoprotein hormone alpha subunit gene ligated to the reporter gene encoding chloramphenicol acetyl transferase (CAT) were examined in transfected pituitary GH3 cells. CAT gene expression was q...

journal_title：Journal of molecular endocrinology

authors： Balfour NJ,Franklyn JA,Gurr JA,Sheppard MC

更新日期：1990-04-01 00:00:00

abstract：:An abundant, seven trans-membrane domain receptor related to the calcitonin receptor has been studied by a number of groups without identification of its ligand. A recent report claimed that the receptor was a type 1 CGRP receptor (Aiyar et al J. Biol. Chem. 271 11325-11329 (1996)). We have studied the equivalent rat ...

journal_title：Journal of molecular endocrinology

authors： Han ZQ,Coppock HA,Smith DM,Van Noorden S,Makgoba MW,Nicholl CG,Legon S

更新日期：1997-06-01 00:00:00

abstract：:In this study we examine changes in the cellular properties of FRTL-5 cells as a function of passage number, with particular emphasis on gap junction expression, karyotype, morphology, growth rate and thyroxine (T(4)) release. Early passage FRTL-5 follicular cells transfer dye through gap junctions from injected cell(...

journal_title：Journal of molecular endocrinology

authors： Green LM,Murray DK,Tran DT,Nelson GA,Shah MM,Luben RA

更新日期：2001-10-01 00:00:00

abstract：:Malic enzyme 1 (ME1) is a cytosolic protein that catalyzes the conversion of malate to pyruvate while concomitantly generating NADPH from NADP. Early studies identified ME1 as a mediator of intermediary metabolism primarily through its participatory roles in lipid and cholesterol biosynthesis. ME1 was one of the first...

journal_title：Journal of molecular endocrinology

authors： Simmen FA,Alhallak I,Simmen RCM

更新日期：2020-11-01 00:00:00