Dietary restriction of mice on a high-fat diet induces substrate efficiency and improves metabolic health.

abstract：:We have previously shown that arginine vasopressin (AVP) stimulates the production of aldosterone in isolated superfused adrenal glomerulosa cells by a mechanism that involves an increased turnover of phosphoinositides. In the present study we compared the characteristics of AVP- and angiotensin II (AII)-induced chang...

journal_title：Journal of molecular endocrinology

authors： Enyedi P,Balla T,Antoni FA,Spät A

更新日期：1988-09-01 00:00:00

abstract：:In embryonic growth cartilage, Indian hedgehog (Ihh) and parathyroid hormone-related protein (PTHrP) participate in a negative feedback loop that regulates chondrocyte differentiation. Postnatally, this region undergoes major structural and functional changes. To explore the organization of the Ihh–PTHrP system in pos...

journal_title：Journal of molecular endocrinology

authors： Chau M,Forcinito P,Andrade AC,Hegde A,Ahn S,Lui JC,Baron J,Nilsson O

更新日期：2011-08-01 00:00:00

abstract：:This study determined whether twice-daily intrauterine injections of ovine conceptus secretory proteins (oCSP) containing type-I trophoblast interferon (25 micrograms/uterine horn) from day 11 to day 15 post-oestrus (oestrus = day 0) could alter the binding capacities of endometrial receptors for oxytocin, progesteron...

journal_title：Journal of molecular endocrinology

authors： Mirando MA,Harney JP,Zhou Y,Ogle TF,Ott TL,Moffatt RJ,Bazer FW

更新日期：1993-04-01 00:00:00

abstract：:In this study we examine changes in the cellular properties of FRTL-5 cells as a function of passage number, with particular emphasis on gap junction expression, karyotype, morphology, growth rate and thyroxine (T(4)) release. Early passage FRTL-5 follicular cells transfer dye through gap junctions from injected cell(...

journal_title：Journal of molecular endocrinology

authors： Green LM,Murray DK,Tran DT,Nelson GA,Shah MM,Luben RA

更新日期：2001-10-01 00:00:00

abstract：:The nona-peptide oxytocin (OT) induces contraction of the myometrium by interaction with specific plasma membrane associated OT receptors (OTR), whereas stimulation of beta2-adrenoceptors (beta2AR) causes relaxation. Homologous desensitization of the myometrium to both hormones has been described. However, a possible ...

journal_title：Journal of molecular endocrinology

authors： Engstrøm T,Bratholm P,Vilhardt H,Christensen NJ

更新日期：1998-04-01 00:00:00

abstract：:Somatostatins (SSs) play important roles in the growth, development and metabolism of vertebrates. In this study, cDNAs for two unique somatostatin receptor variants were cloned and sequenced from rainbow trout. The two cDNAs, one consisting of 1755 bp and the other of 1743 bp, share 63.6% identity in nucleotide seque...

journal_title：Journal of molecular endocrinology

authors： Slagter BJ,Sheridan MA

更新日期：2004-02-01 00:00:00

abstract：:Prolactin (PRL)-releasing peptide (PrRP) is a strong candidate stimulator of pituitary PRL transcription and secretion in teleosts. However, the role in control of extrapituitary PRL expression is unclear even in mammals. To study the possible presence of PrRP-PRL axes not only in the brain-pituitary but also in perip...

journal_title：Journal of molecular endocrinology

authors： Sakamoto T,Amano M,Hyodo S,Moriyama S,Takahashi A,Kawauchi H,Ando M

更新日期：2005-06-01 00:00:00

abstract：:The mechanism behind Ca(2)(+) entry into the parathyroid cells has been widely debated, and the molecular identities of the responsible ion channels have not been established yet. In this study, we show that the parathyroid cells lack voltage-operated Ca(2)(+) channels. Passive store depletion by thapsigargin, on the ...

journal_title：Journal of molecular endocrinology

authors： Lu M,Bränström R,Berglund E,Höög A,Björklund P,Westin G,Larsson C,Farnebo LO,Forsberg L

更新日期：2010-05-01 00:00:00

abstract：:Endometriosis is defined as the presence of endometrial tissue outside the uterine cavity. It affects approximately 5-10% of women of reproductive age. Endometriosis is associated with dysmenorrhea, dyspareunia and, often, severe pelvic pain. In addition to pain, women with endometriosis often experience infertility. ...

journal_title：Journal of molecular endocrinology

authors： Cho YJ,Lee SH,Park JW,Han M,Park MJ,Han SJ

更新日期：2018-04-01 00:00:00

abstract：:The genetic predisposition of the host and the virus is the most important determinant for prediction of the course of human immunodeficiency virus type I (HIV-1) viral infection and acquired immune deficiency syndrome (AIDS) progression. Transcription from the HIV-1 long terminal repeat (LTR) is a crucial step for vi...

journal_title：Journal of molecular endocrinology

authors： Nevado J,Tenbaum SP,Castillo AI,Sánchez-Pacheco A,Aranda A

更新日期：2007-06-01 00:00:00

abstract：:The monocarboxylate transporter 8 (MCT8) is a member of the major facilitator superfamily (MFS). These membrane-spanning proteins facilitate translocation of a variety of substrates, MCT8 specifically transports iodothyronines. Mutations in MCT8 are the underlying cause of severe X-linked psychomotor retardation. At t...

journal_title：Journal of molecular endocrinology

authors： Fischer J,Kleinau G,Müller A,Kühnen P,Zwanziger D,Kinne A,Rehders M,Moeller LC,Führer D,Grüters A,Krude H,Brix K,Biebermann H

更新日期：2015-02-01 00:00:00

abstract：:Transportation of vitamin C [also called ascorbic acid (AA)], an important water-soluble antioxidant and cofactor in testis, requires glucose transporter family (GLUTs) and sodium/vitamin C cotransporter family (SVCT1 and SVCT2). There is so far scant information vis-à-vis the functional roles of SVCTs in testis, alth...

journal_title：Journal of molecular endocrinology

authors： Gao G,Zhao Y,Wang K,Wang F

更新日期：2020-12-01 00:00:00

abstract：:Unliganded thyroid hormone receptors (apoTRs) repress transcription of hormone-activated genes by recruiting corepressors to the promoters. In contrast, on promoters containing so-called negative thyroid hormone response elements (nTREs), apoTRs activate transcription. A number of different molecular mechanisms have b...

journal_title：Journal of molecular endocrinology

authors： Nygård M,Becker N,Demeneix B,Pettersson K,Bondesson M

更新日期：2006-06-01 00:00:00

abstract：:The p160 coactivators, steroid receptor coactivator-1 (SRC-1), transcriptional intermediary factor-2 (TIF2) and receptor-associated coactivator-3 (RAC3), as well as the coactivator/integrator CBP, mediate estrogen receptor-alpha (ERalpha)-dependent gene expression. Although these coactivators are widely expressed, ERa...

journal_title：Journal of molecular endocrinology

authors： Jaber BM,Mukopadhyay R,Smith CL

更新日期：2004-02-01 00:00:00

abstract：:Sexual dimorphism has been found in both mitochondrial functionality and adiponectin expression in white adipose tissue, with female rats presenting more functional mitochondria than males and greater adiponectin expression. However, little is known about the role of sex hormones in this dimorphism. The aim was to elu...

journal_title：Journal of molecular endocrinology

authors： Capllonch-Amer G,Lladó I,Proenza AM,García-Palmer FJ,Gianotti M

更新日期：2014-03-06 00:00:00

abstract：:The expression of genes encoding corticotropin-releasing factor (CRF) and its receptor type-1 (CRF1R) and type-2alpha (CRF2R) has been studied in the brain of rats with streptozotocin (STZ)-induced diabetes and adrenalectomy (ADX). Diabetic rats had a lower body weight compared to control rats. Food and water intake w...

journal_title：Journal of molecular endocrinology

authors： Huang Q,Timofeeva E,Richard D

更新日期：2006-10-01 00:00:00

abstract：:Human galanin (hGal) is an important neuro-modulator present in the brain, gastrointestinal system and the hypothalamo-pituitary axis. A specific receptor for hGal has been identified in various areas in human brain. A single class of high affinity binding sites was found on plasma membranes of the amygdala (Kd 0.23 n...

journal_title：Journal of molecular endocrinology

authors： Walli R,Schäfer H,Morys-Wortmann C,Paetzold G,Nustede R,Schmidt WE

更新日期：1994-12-01 00:00:00

abstract：:Enhanced inflammation and reduced apoptosis sustain the growth of endometriotic lesions. Alterations in the expression of estrogen receptor-alpha (ERα) and estrogen receptor-beta (ERβ) accompany the conversion of resident endometrial cells within the normal uterine environment to ectopic lesions located in extrauterin...

journal_title：Journal of molecular endocrinology

authors： Simmen RC,Kelley AS

更新日期：2016-08-01 00:00:00

abstract：:A number of enzymes possessing 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (17HSD/KSR) activities have been described and cloned, but their nomenclature needs specification. To clarify the present situation, descriptions of the eight cloned 17HSD/KSRs are given and guidelines for the classification of...

journal_title：Journal of molecular endocrinology

authors： Peltoketo H,Luu-The V,Simard J,Adamski J

更新日期：1999-08-01 00:00:00

abstract：:The prevalence of non-alcoholic fatty liver disease (NAFLD), a condition characterized by an excessive accumulation of triglycerides (TGs) in hepatocytes, has dramatically increased globally during recent decades. MicroRNAs (miRs) have been suggested to play crucial roles in many complex diseases and lipid metabolism....

journal_title：Journal of molecular endocrinology

authors： Li B,Zhang Z,Zhang H,Quan K,Lu Y,Cai D,Ning G

更新日期：2014-12-01 00:00:00

abstract：:Evidence indicates that central regulation of food intake is well conserved along the vertebrate lineage, at least between teleost fish and mammals. However, several differences arise in the comparison between both groups. In this review, we describe similarities and differences between teleost fish and mammals on an ...

journal_title：Journal of molecular endocrinology

authors： Soengas JL,Cerdá-Reverter JM,Delgado MJ

更新日期：2018-05-01 00:00:00

abstract：:Molecular genetics and other contemporary approaches have contributed to a better understanding of prolactin (PRL) actions at the cellular and organismal levels. In this review, several advances in knowledge of PRL actions are highlighted. Special emphasis is paid to areas of progress with consequences for understandi...

journal_title：Journal of molecular endocrinology

authors： Horseman ND,Gregerson KA

更新日期：2013-12-19 00:00:00

abstract：:Successful human embryo implantation requires a proper differentiation of endometrial stromal cells (ESCs) into decidual cells, during a process called decidualization. ESCs express specific molecules, such as prolactin, insulin-like growth factor-binding protein-1 (IGFBP-1) and connexin-43. Decidual cells are also in...

journal_title：Journal of molecular endocrinology

authors： Duval F,Dos Santos E,Moindjie H,Serazin V,Swierkowski-Blanchard N,Vialard F,Dieudonné MN

更新日期：2017-10-01 00:00:00

abstract：:FSH acts through the Sertoli cell to ensure normal testicular development and function. To identify transcriptional mechanisms through which FSH acts in the testis, we have treated gonadotrophin-deficient hypogonadal (hpg) mice with recombinant FSH and measured changes in testicular transcript levels using microarrays...

journal_title：Journal of molecular endocrinology

authors： Abel MH,Baban D,Lee S,Charlton HM,O'Shaughnessy PJ

更新日期：2009-04-01 00:00:00

abstract：:Genetic studies have reported association of a polyglycine-encoding GGN repeat in exon 1 of the androgen receptor (AR) gene with common human traits. The polyglycine tract is located in the transactivating domain of the AR protein, suggesting an effect of repeat length on receptor function. Here, we compare the functi...

journal_title：Journal of molecular endocrinology

authors： Brockschmidt FF,Nöthen MM,Hillmer AM

更新日期：2007-07-01 00:00:00

abstract：:The presence of retinoic acid receptor (RAR) alpha, beta and gamma mRNA was examined in 16 different kinds of rat tissue using the highly sensitive reverse transcriptase-polymerase chain reaction technique. The data demonstrated that each tissue expressed at least two types of RAR mRNA. Among the three types of RAR mR...

journal_title：Journal of molecular endocrinology

authors： Wan YJ,Wang L,Wu TC

更新日期：1992-12-01 00:00:00

abstract：:Gastroenteropancreatic neuroendocrine tumors (GEP NETs) comprise a heterogenous and diverse group of neoplasms arising from a common neuroendocrine cell origin. The majority of these tumors occur sporadically while ~20% manifest within the context of hereditary syndromes. Germline MEN1 mutations cause a syndrome with ...

journal_title：Journal of molecular endocrinology

authors： Lee ME,Tepede AA,Mandl A,Weinstein LS,Del Rivero J,Agarwal SK,Blau JE

更新日期：2020-08-01 00:00:00

abstract：:Gene related to anergy in lymphocytes (GRAIL) is an E3 ubiquitin ligase that regulates energy in T-lymphocytes. Whereas, the relevance of GRAIL to T lymphocyte function is well established, the role of this protein in other cell types remains unknown. Given that GRAIL is abundant in the liver, we investigated the pote...

journal_title：Journal of molecular endocrinology

authors： Nakamichi S,Senga Y,Inoue H,Emi A,Matsuki Y,Watanabe E,Hiramatsu R,Ogawa W,Kasuga M

更新日期：2009-02-01 00:00:00

abstract：:Oxytocin (OXT) is a peptide hormone that plays a central role in the regulation of parturition and lactation. OXT signaling is mediated by OXT receptor (OXTR), which shows species- and tissue-specific expressions and gene regulation. In the present study, we examined the synthesis of OXT and OXTR in human placenta tis...

journal_title：Journal of molecular endocrinology

authors： Kim SC,Lee JE,Kang SS,Yang HS,Kim SS,An BS

更新日期：2017-10-01 00:00:00

abstract：:Thyroid hormones regulate growth, development, differentiation, and metabolic processes by interacting with and activating thyroid hormone receptors and associated pathways. We investigated the triiodothyronine (T3) modulation of gene expression, in human hepatocellular carcinoma cell lines, via a PCR-based cDNA subtr...

journal_title：Journal of molecular endocrinology

authors： Lin KH,Chen CY,Chen SL,Yen CC,Huang YH,Shih CH,Shen JJ,Yang RC,Wang CS

更新日期：2004-10-01 00:00:00