Abstract:
:Activins are cytokines of the transforming growth factor beta family, which plays a central role in the determination of cell fate and the regulation of tissue balance. Family members are composed of two subunits and this dimerization is critical for liganding their cognate receptors and execution of proper functions. In the current study we focused on the localization of activin betaA, betaB, betaC and betaE subunits in the adult rat and analyzed the composition of putative activin beta dimers. By dissecting tissue distribution of various activins, we found that the liver, in particular the hepatocytes, is the major source for activin betaC and betaE transcripts, since other tissues almost failed to express these isoforms. In sharp contrast, the emergence of activin betaA and betaB appeared ubiquitous. Using a highly selective proteome approach, we were able to identify homo- as well as heterodimers of individual activin subunits, indicating a high redundancy of ligand composition. Certainly, this broad potential to homo- and heterodimerize has to be considered in future studies on activin function.
journal_name
J Mol Endocrinoljournal_title
Journal of molecular endocrinologyauthors
Vejda S,Cranfield M,Peter B,Mellor SL,Groome N,Schulte-Hermann R,Rossmanith Wdoi
10.1677/jme.0.0280137subject
Has Abstractpub_date
2002-04-01 00:00:00pages
137-48issue
2eissn
0952-5041issn
1479-6813pii
JME1072coljournal_volume
28pub_type
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