Abstract：
:Differences in binding and structural properties of ovine testicular FSH and LH receptors were investigated. The ovine FSH receptor did not discriminate between FSH of different species, although equine FSH was more reactive. In the same tissue, however, the LH receptor showed marked preference for ovine and bovine LH, reacting very weakly with other preparations of pituitary LH. Human chorionic gonadotrophin also reacted partly with the ovine LH receptor at 25 degrees C. However, at 4 degrees C, the optimum temperature for binding of the LH receptor to its homologous hormone, the receptor displayed no recognition for chorionic gonadotrophin preparations. Affinity cross-linking studies with ovine testicular membrane suggested that the ovine FSH receptor has an Mr of 70,000, which is very similar to that observed in the porcine ovary. The Mr of the ovine LH receptor was estimated to be 150,000, which is different from those of other mammalian species, including those that have been cloned. The data suggest that the binding and structural properties of the ovine FSH receptor are similar to those of other mammalian FSH receptors, whereas the ovine LH receptor appears to differ from other mammalian LH receptors in having a different Mr and in being more stringent in its requirement for pituitary LH.
journal_name
J Mol Endocrinoljournal_title
Journal of molecular endocrinologyauthors
Yarney TA,Sairam MRdoi
10.1677/jme.0.0060291subject
Has Abstractpub_date
1991-06-01 00:00:00pages
291-7issue
3eissn
0952-5041issn
1479-6813journal_volume
6pub_type
杂志文章abstract：:Tumour necrosis factor superfamily member 11 (TNFSF11) gene, that codes for receptor activator of nuclear factor-kappaB ligand, is one of the candidate genes for the genetic susceptibility to osteoporosis. As variations in the TNFSF11 gene promoter could alter its expression, the aim of the study was to evaluate the f...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1677/JME-08-0003
更新日期：2008-06-01 00:00:00
abstract：:In vertebrates, sex is determined essentially by two means, genetic factors located on sex chromosomes and epigenetic factors such as temperature experienced by the individual during development. Steroids, especially estrogens, are clearly involved in gonadal differentiation in non-mammalian vertebrates. In this regar...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1677/jme.1.01588
更新日期：2004-12-01 00:00:00
abstract：:The nociceptin receptor (NOP) and its endogenous ligand, nociceptin/orphanin FQ (OFQ), are involved in a wide range of biological functions, such as pain, anxiety, learning, and memory. The zebrafish has been proposed as a candidate to study the in vivo effects of several drugs of abuse and to discover new pharmacolog...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1530/JME-10-0130
更新日期：2011-03-03 00:00:00
abstract：:cDNA clones coding for rabbit prolactin were isolated from a pituitary library using a rat prolactin RNA probe. One cDNA contained 873 bases including the entire coding sequence of rabbit prolactin, its signal peptide and the 5' and 3' untranslated regions of 44 and 145 nucleotides respectively. The deduced amino acid...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1677/jme.0.0160027
更新日期：1996-02-01 00:00:00
abstract：:This study investigates the effectiveness and mechanisms of a serum- and glucocorticoid-inducible kinase 1 (SGK1) inhibitor in counteracting hyperglycemia. In an in vivo experiment, we demonstrated that after an 8-week treatment with an SGK1 inhibitor, the fasting blood glucose and HbA1c level significantly decreased ...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1530/JME-15-0285
更新日期：2016-05-01 00:00:00
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journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1677/jme.0.0190047
更新日期：1997-08-01 00:00:00
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journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：
更新日期：2011-08-01 00:00:00
abstract：:Thyroid hormones regulate growth, development, differentiation, and metabolic processes by interacting with and activating thyroid hormone receptors and associated pathways. We investigated the triiodothyronine (T3) modulation of gene expression, in human hepatocellular carcinoma cell lines, via a PCR-based cDNA subtr...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1677/jme.1.01505
更新日期：2004-10-01 00:00:00
abstract：:Twenty-five years have elapsed since the calcium-sensing receptor (CaSR) was first identified in bovine parathyroid and the receptor is now recognized as a fundamental contributor to extracellular Ca2+ (Ca2+ e) homeostasis, regulating parathyroid hormone release and urinary calcium excretion. The CaSR is a class C G-p...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章,评审
doi：10.1530/JME-19-0104
更新日期：2019-08-01 00:00:00
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journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1677/JME-09-0138
更新日期：2010-05-01 00:00:00
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journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1677/jme.0.0120013
更新日期：1994-02-01 00:00:00
abstract：:Abnormal placental function is well-established as a major cause for poor pregnancy outcome. Placental blood flow within the maternal uteroplacental compartment, the fetoplacental circulation or both is a vital factor in mediating placental function. Impairment in flow in either or both vasculatures is a significant r...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章,评审
doi：10.1530/JME-17-0139
更新日期：2018-01-01 00:00:00
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journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1530/JME-10-0177
更新日期：2011-08-01 00:00:00
abstract：:Nuclear receptors (NRs) have been targets of intensive drug development for decades due to their roles as key regulators of multiple developmental, physiological and disease processes. In breast cancer, expression of the estrogen and progesterone receptor remains clinically important in predicting prognosis and determ...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章,评审
doi：10.1530/JME-16-0082
更新日期：2017-04-01 00:00:00
abstract：:Glucocorticoid and androgen receptors have been shown to function through the same palindromic glucocorticoid response element (GRE) and yet have differential effects on gene transcription. In this study, we examined the functional and structural relationship of the androgen and glucocorticoid receptors with the andro...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1677/jme.0.0220313
更新日期：1999-06-01 00:00:00
abstract：:The crystal structures of the leucine-rich repeat domain (LRD) of the FSH receptor (FSHR) in complex with FSH and the TSH receptor (TSHR) LRD in complex with the thyroid-stimulating autoantibody (M22) provide opportunities to assess the molecular basis of the specificity of glycoprotein hormone-receptor binding. A com...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1677/JME-08-0040
更新日期：2008-09-01 00:00:00
abstract：:Type 2 diabetes is characterized by islet dysfunction resulting in hyperglycemia, which can then lead to further deterioration in islet function. A possible mechanism for hyperglycemia-induced islet dysfunction is the accumulation of advanced glycation end products (AGE). The DBA/2 mouse develops pancreatic islet dysf...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1677/jme.1.01720
更新日期：2005-08-01 00:00:00
abstract：:Chemotactic cytokines (chemokines) are small secreted proteins that control leukocyte trafficking in immune organs. Chemokines which are induced in the brain during conditions of inflammation play a role in the local immune response. Recently, it has been established in the rodent brain that distinct chemokines and ch...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章,评审
doi：10.1677/JME-06-0032
更新日期：2007-03-01 00:00:00
abstract：:The human progesterone receptor (PR) is a ligand-dependent transcription factor and two isoforms, (PRA and PRB), can be distinguished. PROGINS, a PR polymorphic variant, affects PRA and PRB and acts as a risk-modulating factor in several gynaecological disorders. Little is known about the functional consequences of th...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1677/jme.1.02170
更新日期：2007-02-01 00:00:00
abstract：:MicroRNAs are endogenous, conserved, and non-coding small RNAs that function as post-transcriptional regulators of fat development and adipogenesis. Adipogenic marker genes, such as CCAAT/enhancer binding protein α (Cebpa), peroxisome proliferator-activated receptor γ (Pparg), adipocyte fatty acid binding protein (Ap2...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1530/JME-14-0013
更新日期：2014-06-01 00:00:00
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journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1677/jme.0.0310123
更新日期：2003-08-01 00:00:00
abstract：:Non-steroidal antioestrogens, such as tamoxifen, inhibit the growth of human breast cancer cells. The experiments described here compare and contrast the efficacy of tamoxifen and the 'pure' antioestrogen, ICI 164384, on the inhibition of proliferation of MCF-7 cells. Previous studies have shown that ICI 164384 has a ...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1677/jme.0.0020225
更新日期：1989-05-01 00:00:00
abstract：:Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone that belongs to a subfamily of endocrine FGFs with evolutionarily conserved functions in C. elegans and fruit flies. FAM20C phosphorylates FGF23 post-translationally, targeting to proteolysis through subtilisin-like proprotein convertase FURIN, resulting i...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章,评审
doi：10.1530/JME-20-0178
更新日期：2020-12-01 00:00:00
abstract：:Parathyroid hormone (PTH), a powerful bone-resorbing agent, is capable of stimulating interstitial collagenase (MMP-13) mRNA production in osteoblastic cells. In this study, a PEA3 consensus binding sequence (-80; AGGAAGT) in addition to a 'TRE-like' sequence (-89; CGACTCA) in the 5' upstream regulatory region of the ...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1677/jme.0.0250073
更新日期：2000-08-01 00:00:00
abstract：:The classical concept of the renin-angiotensin system (RAS) is that of a blood-borne cascade, whose final and bioactive product, angiotensin II, plays an important endocrine role in the maintenance of blood pressure and electrolyte as well as fluid balance. In addition to this circulating RAS, there are an increasing ...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章,评审
doi：10.1677/jme.0.0260155
更新日期：2001-06-01 00:00:00
abstract：:Pancreatic beta-cells are responsible for producing all of the insulin required by an organism to maintain glucose homeostasis. Defects in development, maintenance, or expansion of beta-cell mass can result in impaired glucose metabolism and diabetes. Thus, identifying the molecular regulators of these processes may p...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章,评审
doi：10.1677/JME-06-0053
更新日期：2007-02-01 00:00:00
abstract：:Testicular Leydig cells (LC) are modulated by several pathways, one of them being the histaminergic system. Heme oxygenase-1 (HO-1), whose upregulation comprises the primary response to oxidative noxae, has a central homeostatic role and might dysregulate LC functions when induced. In this report, we aimed to determin...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1530/JME-19-0063
更新日期：2019-10-01 00:00:00
abstract：:Endocannabinoids are endogenous ligands of cannabinoid, vanilloid and peroxisome proliferator-activated receptors that activate multiple signal transduction pathways. Together with their receptor and the enzymes responsible for their synthesis and degradation, these compounds constitute the endocannabinoid system that...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章,评审
doi：10.1530/JME-12-0182
更新日期：2013-01-11 00:00:00
abstract：:The genetic predisposition of the host and the virus is the most important determinant for prediction of the course of human immunodeficiency virus type I (HIV-1) viral infection and acquired immune deficiency syndrome (AIDS) progression. Transcription from the HIV-1 long terminal repeat (LTR) is a crucial step for vi...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章
doi：10.1677/JME-06-0065
更新日期：2007-06-01 00:00:00
abstract：:Reproductive function in mammals is energetically costly and therefore tightly regulated by nutritional status. To enable this integration of metabolic and reproductive function, information regarding peripheral nutritional status must be relayed centrally to the gonadotropin-releasing hormone (GNRH) neurons that driv...
journal_title：Journal of molecular endocrinology
pub_type： 杂志文章,评审
doi：10.1530/JME-16-0212
更新日期：2017-02-01 00:00:00
