Regulation of fibronectin by thyroid hormone receptors.

abstract：:Mammary explants can be hormonally stimulated to mimic the biochemical changes that occur during lactogenesis. Previous studies using mammary explants concluded that the addition of exogenous macromolecules were required for mammary epithelial cells to remain viable in culture. The present study examines the survival ...

journal_title：Journal of molecular endocrinology

authors： Brennan AJ,Sharp JA,Lefèvre CM,Nicholas KR

更新日期：2008-09-01 00:00:00

abstract：:Previous studies have shown that, in unstimulated mammary epithelial cells from virgin mice, prolactin receptors are retained intracellularly because of their incomplete N-glycosylation. Activation of the nitric oxide/cGMP pathway stimulates Nacetylglucosamine (NAG) transferase I activity, completion of terminal glyco...

journal_title：Journal of molecular endocrinology

authors： Bolander FF Jr

更新日期：2000-06-01 00:00:00

abstract：:The genomic structure and transcriptional regulation of the rat apelin receptor (APJR) were analysed by rapid amplification of 5' cDNA ends (5'-RACE), transient expression assays and DNA-protein interaction. Analysis of the 5'-flanking region of a rat genomic clone shows no TATA box, but a putative CAAT box and severa...

journal_title：Journal of molecular endocrinology

authors： O'Carroll AM,Lolait SJ,Howell GM

更新日期：2006-02-01 00:00:00

abstract：:Decreased suppressors of cytokine signaling (SOCS) activity in human gestational tissues may play a part in the onset/progression of term labor. Since SOCS proteins negatively regulate cytokine-mediated inflammatory processes, we hypothesized that SOCS proteins are elevated in gestational tissues from spontaneous pret...

journal_title：Journal of molecular endocrinology

authors： Blumenstein M,Keelan JA,Bowen-Shauver JM,Mitchell MD

更新日期：2005-08-01 00:00:00

abstract：:A full-length transcript encoding a functional lamprey glycoprotein hormone receptor I (lGpH-R I, GenBank AY750688) was cloned from the testes of the sea lamprey, Petromyzon marinus, using the GpH-R protein fingerprint GLYCHORMONER from the PRINTS database. The present study is the first to identify a GpH-R transcript...

journal_title：Journal of molecular endocrinology

authors： Freamat M,Kawauchi H,Nozaki M,Sower SA

更新日期：2006-08-01 00:00:00

abstract：:Tumour necrosis factor superfamily member 11 (TNFSF11) gene, that codes for receptor activator of nuclear factor-kappaB ligand, is one of the candidate genes for the genetic susceptibility to osteoporosis. As variations in the TNFSF11 gene promoter could alter its expression, the aim of the study was to evaluate the f...

journal_title：Journal of molecular endocrinology

authors： Mencej S,Albagha OM,Prezelj J,Kocjan T,Marc J

更新日期：2008-06-01 00:00:00

abstract：:The angiotensin II (Ang II) type 2 receptor (AT(2)) is a member of the seven-transmembrane domain, G-protein coupled receptor family. This receptor is ubiquitously distributed in the fetus but, in most tIssues, its expression dramatically falls in the first few hours after birth. Based on this observation, the hypothe...

journal_title：Journal of molecular endocrinology

authors： Gendron L,Payet MD,Gallo-Payet N

更新日期：2003-12-01 00:00:00

abstract：:Insulin-like 3 (INSL3), a Leydig cell-specific hormone, is essential for testis descent during foetal life and bone metabolism in adults. Despite its essential roles in male reproductive and bone health, very little is known regarding its transcriptional regulation in Leydig cells. To date, few transcription factors h...

journal_title：Journal of molecular endocrinology

authors： Tremblay MA,Mendoza-Villarroel RE,Robert NM,Bergeron F,Tremblay JJ

更新日期：2016-04-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) as well as its receptors is found in mammalian ovary and follicular cells and its function in oocyte meiotic maturation has also been reported in Xenopus, hamster and rat. But the results are controversial and the physiological mechanism of ANP on oocyte maturation is not clear, especi...

journal_title：Journal of molecular endocrinology

authors： Zhang M,Tao Y,Zhou B,Xie H,Wang F,Lei L,Huo L,Sun Q,Xia G

更新日期：2005-04-01 00:00:00

abstract：:Granulosa cells were prepared from small follicles (less than 3 mm) from the ovaries of 5-month-old gilts. They were cultured in plastic dishes coated with a synthetic adhesion peptide in a chemically defined medium supplemented with 2% serum substitute. After 3 days of culture, the cells reached confluence and expres...

journal_title：Journal of molecular endocrinology

authors： Goxe B,Salesse R,Remy JJ,Genty N,Garnier J

更新日期：1992-04-01 00:00:00

abstract：:Fetal growth restriction is one of the most common obstetrical complications resulting in significant perinatal morbidity and mortality. The most frequent etiology of human singleton fetal growth restriction is placental insufficiency, which occurs secondary to reduced utero-placental perfusion, abnormal placentation,...

journal_title：Journal of molecular endocrinology

authors： Hart B,Morgan E,Alejandro EU

更新日期：2019-02-01 00:00:00

abstract：:Oestrogens have a major impact on reproductive function in both males and females. Two oestrogen receptor genes known as ERalpha (ESR1NR3A1) and ERbeta (ESR2NR3A2) have been cloned. Splice variant isoforms of the ERbeta gene have been identified in human, bovine and rodents and it has been suggested that the existence...

journal_title：Journal of molecular endocrinology

authors： Sierens JE,Scobie GA,Wilson J,Saunders PT

更新日期：2004-06-01 00:00:00

abstract：:Impaired insulin action has been associated with diabetes, dyslipidemia and atherosclerotic vascular disease. The expression of insulin resistance results from the interaction of environmental and genetic factors. Human hepatic lipase (HL) is a lipolytic enzyme that plays a role in the metabolism of several lipoprotei...

journal_title：Journal of molecular endocrinology

authors： Gómez P,Pérez-Jiménez F,Marín C,Moreno JA,Gómez MJ,Bellido C,Pérez-Martínez P,Fuentes F,Paniagua JA,López-Miranda J

更新日期：2005-04-01 00:00:00

abstract：:To assess the functional significance of putative proteins encoded by alternately spliced mRNA of the sheep testicular FSH receptor, a short form cDNA comprising of the first four exons (117 residues mature protein) was engineered for expression in Escherichia coli. The expressed protein of molecular mass 15 kDa was p...

journal_title：Journal of molecular endocrinology

authors： Khan H,Jiang LG,Jayashree GN,Yarney TA,Sairam MR

更新日期：1997-10-01 00:00:00

abstract：:The two structurally and functionally related peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB) play critical roles in many physiological/pathological processes in mammals. However, the information regarding the expression and functionality of avian NMB, GRP and their receptors is limited. Here, we char...

journal_title：Journal of molecular endocrinology

authors： Mo C,Huang L,Cui L,Lv C,Lin D,Song L,Zhu G,Li J,Wang Y

更新日期：2017-07-01 00:00:00

abstract：:The nociceptin receptor (NOP) and its endogenous ligand, nociceptin/orphanin FQ (OFQ), are involved in a wide range of biological functions, such as pain, anxiety, learning, and memory. The zebrafish has been proposed as a candidate to study the in vivo effects of several drugs of abuse and to discover new pharmacolog...

journal_title：Journal of molecular endocrinology

authors： Rivas-Boyero AA,Herrero-Turrión MJ,Gonzalez-Nunez V,Sánchez-Simón FM,Barreto-Valer K,Rodríguez RE

更新日期：2011-03-03 00:00:00

abstract：:The interaction of IGF binding protein-2 (IGFBP-2) with IGF-I and -II has been investigated in solution using nuclear magnetic resonance (NMR) spectroscopy. Chemical shift perturbations in 15N- and 2H/15N-labelled IGF-I or -II upon binding to unlabelled thioredoxin-tagged bovine IGFBP-2 (Trx(1-279)IGFBP-2) have been m...

journal_title：Journal of molecular endocrinology

authors： Carrick FE,Hinds MG,McNeil KA,Wallace JC,Forbes BE,Norton RS

更新日期：2005-06-01 00:00:00

abstract：:A number of enzymes possessing 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (17HSD/KSR) activities have been described and cloned, but their nomenclature needs specification. To clarify the present situation, descriptions of the eight cloned 17HSD/KSRs are given and guidelines for the classification of...

journal_title：Journal of molecular endocrinology

authors： Peltoketo H,Luu-The V,Simard J,Adamski J

更新日期：1999-08-01 00:00:00

abstract：:The hypothalamic arcuate nucleus (ARC) represents a major component of the neuroendocrine reproductive axis and plays an important role in controlling the onset of puberty as well as age-associated reproductive senescence. Although significant gene expression changes have been observed in the ARC during sexual maturat...

journal_title：Journal of molecular endocrinology

authors： Eghlidi DH,Garyfallou VT,Kohama SG,Urbanski HF

更新日期：2017-08-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) analogues were produced with the aim of identifying IGF-I residues that contribute to the specificity of binding to the type 1 IGF receptor as opposed to the insulin receptor. Receptor binding properties of a series of A- and B-domain analogues were compared using rat L6 myoblasts,...

journal_title：Journal of molecular endocrinology

authors： Shooter GK,Magee B,Soos MA,Francis GL,Siddle K,Wallace JC

更新日期：1996-12-01 00:00:00

abstract：:The subcellular distribution of steroidogenic enzymes has so far been studied mostly in classical endocrine glands and in the placenta. In the peripheral intracrine organs which synthesize sex steroids there is no indication about the organelles which contain the enzymes involved in steroid biosynthesis. We have thus ...

journal_title：Journal of molecular endocrinology

authors： Pelletier G,Luu-The V,El-Alfy M,Li S,Labrie F

更新日期：2001-02-01 00:00:00

abstract：:Endometriosis is defined as the presence of endometrial tissue outside the uterine cavity. It affects approximately 5-10% of women of reproductive age. Endometriosis is associated with dysmenorrhea, dyspareunia and, often, severe pelvic pain. In addition to pain, women with endometriosis often experience infertility. ...

journal_title：Journal of molecular endocrinology

authors： Cho YJ,Lee SH,Park JW,Han M,Park MJ,Han SJ

更新日期：2018-04-01 00:00:00

abstract：:To capture immediate cellular changes during diet-induced expansion of adipocyte cell volume and number, we characterized mature adipocytes during a short-term high-fat diet (HFD) intervention. Male C57BL6/J mice were fed chow diet, and then switched to HFD for 2, 4, 6 or 14 days. Systemic glucose clearance was assess...

journal_title：Journal of molecular endocrinology

authors： Hansson B,Wasserstrom S,Morén B,Periwal V,Vikman P,Cushman SW,Göransson O,Storm P,Stenkula KG

更新日期：2018-04-01 00:00:00

abstract：:Endometriosis is an incurable hormone-dependent inflammatory disease that causes chronic pelvic pain and infertility characterized by implantation and growth of endometrial tissue outside the uterine cavity. Symptoms have a major impact on the quality of life of patients resulting in socioeconomic, physical and psycho...

journal_title：Journal of molecular endocrinology

authors： Piccinato CA,Malvezzi H,Gibson DA,Saunders PTK

更新日期：2018-08-01 00:00:00

abstract：:The hyperglycaemia-inducing sulphonamide diazoxide has been previously shown to mediate its effects upon insulin secretion by opening K+ channels and hyperpolarizing the beta-cell membrane. The target site has been characterized as the ATP-regulated K+ (K+ATP) channel protein. In the present study, a detailed investig...

journal_title：Journal of molecular endocrinology

authors： Jaggar JH,Harding EA,Ayton BJ,Dunne MJ

更新日期：1993-02-01 00:00:00

abstract：:The nona-peptide oxytocin (OT) induces contraction of the myometrium by interaction with specific plasma membrane associated OT receptors (OTR), whereas stimulation of beta2-adrenoceptors (beta2AR) causes relaxation. Homologous desensitization of the myometrium to both hormones has been described. However, a possible ...

journal_title：Journal of molecular endocrinology

authors： Engstrøm T,Bratholm P,Vilhardt H,Christensen NJ

更新日期：1998-04-01 00:00:00

abstract：:Tamoxifen acts as an oestrogen antagonist in the breast reducing cell proliferation, but in the uterus as an oestrogen agonist resulting in increased cell proliferation. Tamoxifen exerts its tissue-specific effects through the oestrogen receptors (ERalpha or ERbeta). The levels and functions of the two ERs affect the ...

journal_title：Journal of molecular endocrinology

authors： Horner-Glister E,Maleki-Dizaji M,Guerin CJ,Johnson SM,Styles J,White IN

更新日期：2005-12-01 00:00:00

abstract：:We investigated the mechanisms by which corticosteroids regulate the expression of the mineralocorticoid receptor (MR) in neurones. Aldosterone and dexamethasone produced a dose-dependent increase of MR and mRNA levels in cultured primary hippocampal neurones. Transient transfection of neuroblastoma cells showed that ...

journal_title：Journal of molecular endocrinology

authors： Castrén M,Trapp T,Berninger B,Castrén E,Holsboer F

更新日期：1995-06-01 00:00:00

abstract：:Twenty-five years have elapsed since the calcium-sensing receptor (CaSR) was first identified in bovine parathyroid and the receptor is now recognized as a fundamental contributor to extracellular Ca2+ (Ca2+ e) homeostasis, regulating parathyroid hormone release and urinary calcium excretion. The CaSR is a class C G-p...

journal_title：Journal of molecular endocrinology

authors： Gorvin CM

更新日期：2019-08-01 00:00:00

abstract：:The aim of our studies was to examine whether IGF-binding protein (IGFBP)-4 is involved in the control of the secretion of various ovarian substances and also the mediation of the effects of several hormones and growth factors on this secretion. For this purpose, we carried out the transfection of porcine granulosa ce...

journal_title：Journal of molecular endocrinology

authors： Sirotkin AV,Makarevich AV,Corkins MR,Kotwica J,Bulla J

更新日期：2001-06-01 00:00:00