Insulin-like growth factor (IGF)-I A- and B-domain analogues with altered type 1 IGF and insulin receptor binding specificities.

abstract：:A unique characteristic of the primate adrenal is the ability to produce 19-carbon steroids, often called the adrenal androgens. Although it is clear that the major human adrenal androgens, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S), are produced almost solely in the adrenal reticularis, the mechanisms re...

journal_title：Journal of molecular endocrinology

authors： Sirianni R,Carr BR,Andò S,Rainey WE

更新日期：2003-06-01 00:00:00

abstract：:In contrast to the classical model describing the synthesis of androgens and estrogens as restricted to somatic cells, a previous study demonstrated that Xenopus laevis oocytes participate in androgen synthesis. The objective of our study was to determine whether Xenopus oocytes are also involved in estrogen synthesis...

journal_title：Journal of molecular endocrinology

authors： Gohin M,Bodinier P,Fostier A,Bobe J,Chesnel F

更新日期：2011-09-07 00:00:00

abstract：:The development of an efficient expression system for insulin-like growth factor-I (IGF-I) in Escherichia coli as a fusion protein is described. The fusion protein consists of an N-terminal extension made up of the first 46 amino acids of methionyl porcine GH ([Met1]-pGH) followed by the dipeptide Val-Asn. The latter ...

journal_title：Journal of molecular endocrinology

authors： King R,Wells JR,Krieg P,Snoswell M,Brazier J,Bagley CJ,Wallace JC,Ballard FJ,Ross M,Francis GL

更新日期：1992-02-01 00:00:00

abstract：:The monocarboxylate transporter 8 (MCT8) is a member of the major facilitator superfamily (MFS). These membrane-spanning proteins facilitate translocation of a variety of substrates, MCT8 specifically transports iodothyronines. Mutations in MCT8 are the underlying cause of severe X-linked psychomotor retardation. At t...

journal_title：Journal of molecular endocrinology

authors： Fischer J,Kleinau G,Müller A,Kühnen P,Zwanziger D,Kinne A,Rehders M,Moeller LC,Führer D,Grüters A,Krude H,Brix K,Biebermann H

更新日期：2015-02-01 00:00:00

abstract：:Progesterone's ability to maintain pregnancy in eutherian mammals highlighted this steroid as the 'hormone of pregnancy'. It was the unique 'pro-gestational' bioactivity of progesterone that enabled eventual purification of this ovarian steroid to crystalline form by Willard Myron Allen in the early 1930s. While a fun...

journal_title：Journal of molecular endocrinology

authors： DeMayo FJ,Lydon JP

更新日期：2020-07-01 00:00:00

abstract：:This study examined fetal steroidogenic enzyme expression and function during pregnancy in the pig. Northern and Western analyses were performed to detect the cytochrome P450 enzyme 17 alpha-hydroxylase/17-20 lyase (P450c17) and that for cholesterol side-chain cleavage (P450scc), as well as 3 beta-hydroxysteroid dehyd...

journal_title：Journal of molecular endocrinology

authors： Conley AJ,Rainey WE,Mason JI

更新日期：1994-04-01 00:00:00

abstract：:Pancreatic beta-cells are responsible for producing all of the insulin required by an organism to maintain glucose homeostasis. Defects in development, maintenance, or expansion of beta-cell mass can result in impaired glucose metabolism and diabetes. Thus, identifying the molecular regulators of these processes may p...

journal_title：Journal of molecular endocrinology

authors： Ackermann AM,Gannon M

更新日期：2007-02-01 00:00:00

abstract：:It has been suggested that the thyroid itself may contribute to the inflammatory process observed in autoimmune thyroiditis by releasing the cytokines interleukin-1 alpha (IL-1 alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8), but studies of cytokine gene expression in thyrocytes have been limited and conflicting...

journal_title：Journal of molecular endocrinology

authors： Watson PF,Pickerill AP,Davies R,Weetman AP

更新日期：1995-08-01 00:00:00

abstract：:Insulin is important for optimal fetal and neonatal growth and development. Its continued availability is due, in part, to ongoing islet cell growth within the pancreas. IGFs and IGF-binding proteins (IGFBPs) have been implicated as paracrine regulators of islet cell growth within the developing pancreas. The purpose ...

journal_title：Journal of molecular endocrinology

authors： Hogg J,Hill DJ,Han VK

更新日期：1994-08-01 00:00:00

abstract：:Prolactin (PRL)-releasing peptide (PrRP) is a strong candidate stimulator of pituitary PRL transcription and secretion in teleosts. However, the role in control of extrapituitary PRL expression is unclear even in mammals. To study the possible presence of PrRP-PRL axes not only in the brain-pituitary but also in perip...

journal_title：Journal of molecular endocrinology

authors： Sakamoto T,Amano M,Hyodo S,Moriyama S,Takahashi A,Kawauchi H,Ando M

更新日期：2005-06-01 00:00:00

abstract：:Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue. At a given age, bone mass results from the amount of bone acquired during growth, i.e. the peak bone mass (Bonjour et al., 1991, Theintz et al. 1992) minus the age-related bone loss which par...

journal_title：Journal of molecular endocrinology

authors： Rizzoli R,Bonjour JP,Ferrari SL

更新日期：2001-04-01 00:00:00

abstract：:cDNAs encoding the glycoprotein hormone alpha- and gonadotropin (GTH) II beta-subunits of Japanese eel (Anguilla japonica) pituitary were cloned using the polymerase chain reaction. The nucleotide sequence of the glycoprotein hormone alpha-subunit cDNA was 364 base pairs (bp) long, encoding 117 amino acids, and that o...

journal_title：Journal of molecular endocrinology

authors： Nagae M,Todo T,Gen K,Kato Y,Young G,Adachi S,Yamauchi K

更新日期：1996-04-01 00:00:00

abstract：:Tumor malignancy is associated with the epithelial-mesenchymal transition (EMT) process and resistance to chemotherapy. However, little is known about the relationship between the EMT and the multidrug-resistance gene in thyroid tumor progression. We investigated whether the expression of the ABCG2/BCRP gene is associ...

journal_title：Journal of molecular endocrinology

authors： Mato E,González C,Moral A,Pérez JI,Bell O,Lerma E,de Leiva A

更新日期：2014-04-28 00:00:00

abstract：:The effects of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3; 10 nmol/l) on the human monomyelocytic cell line U937 were investigated. Addition of 1,25-(OH)2D3 led to a decrease in cell proliferation which fell at 72 h to 67.8 +/- 4.3% (mean +/- S.E.M.) of control values. The presence of CD14, a surface marker found on matur...

journal_title：Journal of molecular endocrinology

authors： Karmali R,Bhalla AK,Farrow SM,Williams MM,Lal S,Lydyard PM,O'Riordan JL

更新日期：1989-07-01 00:00:00

abstract：:Cellular changes that affect the androgen receptor (AR) can cause prostate cancer to transition from androgen dependent to androgen independent, which is usually lethal. One common change in prostate tumors is overexpression of the AR, which has been shown to lead to androgen-independent growth of prostate cancer cell...

journal_title：Journal of molecular endocrinology

authors： Hsieh CL,Cai C,Giwa A,Bivins A,Chen SY,Sabry D,Govardhan K,Shemshedini L

更新日期：2008-07-01 00:00:00

abstract：:We investigated the mechanisms by which corticosteroids regulate the expression of the mineralocorticoid receptor (MR) in neurones. Aldosterone and dexamethasone produced a dose-dependent increase of MR and mRNA levels in cultured primary hippocampal neurones. Transient transfection of neuroblastoma cells showed that ...

journal_title：Journal of molecular endocrinology

authors： Castrén M,Trapp T,Berninger B,Castrén E,Holsboer F

更新日期：1995-06-01 00:00:00

abstract：:Intracellular glucocorticoid (GC) receptor (GR) function determines tissue sensitivity to GCs and strongly affects the development of type 2 diabetes and obesity. 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) mediates intracellular steroid exposure to mouse liver GR by prereceptor reactivation of GCs and is...

journal_title：Journal of molecular endocrinology

authors： Liu Y,Nakagawa Y,Wang Y,Liu L,Du H,Wang W,Ren X,Lutfy K,Friedman TC

更新日期：2008-08-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is synthesized from a precursor, which includes the PACAP-related peptide (PRP; formerly known as GHRH-like peptide). PRP can act as a hypophysiotropic factor in teleosts by stimulating GH secretion. However, no information points to this peptide as a regulato...

journal_title：Journal of molecular endocrinology

authors： Levy G,Degani G

更新日期：2011-03-03 00:00:00

abstract：:The p160 coactivators, steroid receptor coactivator-1 (SRC-1), transcriptional intermediary factor-2 (TIF2) and receptor-associated coactivator-3 (RAC3), as well as the coactivator/integrator CBP, mediate estrogen receptor-alpha (ERalpha)-dependent gene expression. Although these coactivators are widely expressed, ERa...

journal_title：Journal of molecular endocrinology

authors： Jaber BM,Mukopadhyay R,Smith CL

更新日期：2004-02-01 00:00:00

abstract：:FSH acts through the Sertoli cell to ensure normal testicular development and function. To identify transcriptional mechanisms through which FSH acts in the testis, we have treated gonadotrophin-deficient hypogonadal (hpg) mice with recombinant FSH and measured changes in testicular transcript levels using microarrays...

journal_title：Journal of molecular endocrinology

authors： Abel MH,Baban D,Lee S,Charlton HM,O'Shaughnessy PJ

更新日期：2009-04-01 00:00:00

abstract：:Eight amino acids are considered essential for human nutrition, and three of them, including leucine, isoleucine and valine, are called as branched-chain amino acids (BCAAs). We recently discovered that dietary deficiency of any BCAA for 7 days rapidly reduces the abdominal fat mass in mice. The goal of this study was...

journal_title：Journal of molecular endocrinology

authors： Xiao F,Du Y,Lv Z,Chen S,Zhu J,Sheng H,Guo F

更新日期：2016-11-01 00:00:00

abstract：:The hormone human chorionic gonadotrophin (hCG) shows extensive sequence homology with LH. Thus, many of the antigenic epitopes on hCG are shared with LH, leading to immunological cross-reaction between these two hormones. Anti-fertility and anti-cancer vaccines based upon hCG should ideally target only the hCG-specif...

journal_title：Journal of molecular endocrinology

authors： Charrel-Dennis M,Jackson AM,Lund T,Lapthorn AJ,Berger P,Roitt IM,Delves PJ

更新日期：2004-04-01 00:00:00

abstract：:Testicular Leydig cells (LC) are modulated by several pathways, one of them being the histaminergic system. Heme oxygenase-1 (HO-1), whose upregulation comprises the primary response to oxidative noxae, has a central homeostatic role and might dysregulate LC functions when induced. In this report, we aimed to determin...

journal_title：Journal of molecular endocrinology

authors： Raices T,Varela ML,Monzón CM,Correa Torrado MF,Pagotto RM,Besio Moreno M,Mondillo C,Pignataro OP,Pereyra EN

更新日期：2019-10-01 00:00:00

abstract：:Numerous mouse models of prostate carcinogenesis have been developed, but hitherto there has been no model in which the prostate gland could be imaged in live animals. The transgenic model generated here targeted mouse prostate gland using a firefly luciferase enzyme under the control of a small but highly active and ...

journal_title：Journal of molecular endocrinology

authors： Hsieh CL,Xie Z,Liu ZY,Green JE,Martin WD,Datta MW,Yeung F,Pan D,Chung LW

更新日期：2005-10-01 00:00:00

abstract：:Fetal growth restriction is one of the most common obstetrical complications resulting in significant perinatal morbidity and mortality. The most frequent etiology of human singleton fetal growth restriction is placental insufficiency, which occurs secondary to reduced utero-placental perfusion, abnormal placentation,...

journal_title：Journal of molecular endocrinology

authors： Hart B,Morgan E,Alejandro EU

更新日期：2019-02-01 00:00:00

abstract：:Unbiased genomic screening analyses have highlighted novel immunomodulatory properties of the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D). However, clearer interpretation of the resulting gene expression data is limited by cell model specificity. The aim of the current study was to provide a broader...

journal_title：Journal of molecular endocrinology

authors： Muñoz Garcia A,Kutmon M,Eijssen L,Hewison M,Evelo CT,Coort SL

更新日期：2018-02-01 00:00:00

abstract：:Glucocorticoid and androgen receptors have been shown to function through the same palindromic glucocorticoid response element (GRE) and yet have differential effects on gene transcription. In this study, we examined the functional and structural relationship of the androgen and glucocorticoid receptors with the andro...

journal_title：Journal of molecular endocrinology

authors： Kasper S,Rennie PS,Bruchovsky N,Lin L,Cheng H,Snoek R,Dahlman-Wright K,Gustafsson JA,Shiu RP,Sheppard PC,Matusik RJ

更新日期：1999-06-01 00:00:00

abstract：:The interaction between human papillomaviruses (HPV) and the apolipoprotein-B mRNA-editing catalytic polypeptide-like (APOBEC)3 (A3) genes has garnered increasing attention in recent years, with considerable efforts focused on understanding their apparent roles in both viral editing and in HPV-driven carcinogenesis. H...

journal_title：Journal of molecular endocrinology

authors： Smith NJ,Fenton TR

更新日期：2019-05-01 00:00:00

abstract：:We have studied the action of peripheral blood lymphocytes (PBLs) and intrathyroidal lymphocytes (ITLs) on the biochemical and hormonal metabolism of autologous thyrocytes cultured in follicles in a collagen gel. The production of tumour necrosis factor alpha (TNF-alpha) in culture was also measured. Thyroid tissues a...

journal_title：Journal of molecular endocrinology

authors： Massart C,Gibassier J,Raoul ML,Le Gall F,Lancien G,Genetet N,Denais A,Darcel F,Lucas C

更新日期：1997-04-01 00:00:00

abstract：:Oligonucleotide microarrays were used to analyse gene expression profiles in human ZR75-1 breast cancer cells in the presence of 17beta-oestradiol and oestrogen antagonists. Differential gene expression of a number of genes was confirmed by quantitative RNA analysis. In addition to known oestrogen-responsive genes, an...

journal_title：Journal of molecular endocrinology

authors： Soulez M,Parker MG

更新日期：2001-12-01 00:00:00