FSH and TSH binding to their respective receptors: similarities, differences and implication for glycoprotein hormone specificity.

abstract：:The diagnosis of conventional and oncocytic poorly differentiated (oPD) thyroid carcinomas is difficult. The aim of this study is to characterise their largely unknown miRNA expression profile and to compare it with well-differentiated thyroid tumours, as well as to identify miRNAs which could potentially serve as dia...

journal_title：Journal of molecular endocrinology

authors： Dettmer MS,Perren A,Moch H,Komminoth P,Nikiforov YE,Nikiforova MN

更新日期：2014-03-06 00:00:00

abstract：:Cardiovascular disease (CVD) remains the leading cause of death worldwide. Low levels of vitamin D are associated with high risk of myocardial infarction, even after controlling for factors associated with coronary artery disease. A growing body of evidence indicates that vitamin D plays an important role in CVD-relat...

journal_title：Journal of molecular endocrinology

authors： Hlaing SM,Garcia LA,Contreras JR,Norris KC,Ferrini MG,Artaza JN

更新日期：2014-12-01 00:00:00

abstract：:Transportation of vitamin C [also called ascorbic acid (AA)], an important water-soluble antioxidant and cofactor in testis, requires glucose transporter family (GLUTs) and sodium/vitamin C cotransporter family (SVCT1 and SVCT2). There is so far scant information vis-à-vis the functional roles of SVCTs in testis, alth...

journal_title：Journal of molecular endocrinology

authors： Gao G,Zhao Y,Wang K,Wang F

更新日期：2020-12-01 00:00:00

abstract：:A transgenic mouse line (EGF/Tag) has been established in which expression of SV40 T-antigen is directed by a 5.5 kb fragment of the 5'-flanking region of the mouse epidermal growth factor (EGF) gene. Of the two principal sites of EGF expression in mice, submaxillary gland and kidney, T-antigen mRNA and protein were d...

journal_title：Journal of molecular endocrinology

authors： Pascall IC,Surani MA,Barton SC,Vaughan TJ,Brown KD

更新日期：1994-06-01 00:00:00

abstract：:DNA encoding the N-terminal 415 residues of the human thyrotrophin receptor (predicted to code for the large extracellular region) was introduced into Chinese hamster ovary (CHO) cells using the glutamine synthetase/cytomegalovirus amplifiable expression system, and into E. coli using the pGEX-3X expression vector. Su...

journal_title：Journal of molecular endocrinology

authors： Harfst E,Johnstone AP,Nussey SS

更新日期：1992-12-01 00:00:00

abstract：:The type 1 form of 17beta-hydroxysteroid dehydrogenase (17betaHSD1) was the first isoform to be identified and is capable of converting estrone to 17beta-estradiol. This study was aimed at characterizing the molecular structure of the equine 17betaHSD1 gene and cDNA, as well as its molecular regulation during human ch...

journal_title：Journal of molecular endocrinology

authors： Brown KA,Sayasith K,Bouchard N,Lussier JG,Sirois J

更新日期：2007-02-01 00:00:00

abstract：:Enhanced inflammation and reduced apoptosis sustain the growth of endometriotic lesions. Alterations in the expression of estrogen receptor-alpha (ERα) and estrogen receptor-beta (ERβ) accompany the conversion of resident endometrial cells within the normal uterine environment to ectopic lesions located in extrauterin...

journal_title：Journal of molecular endocrinology

authors： Simmen RC,Kelley AS

更新日期：2016-08-01 00:00:00

abstract：:Breast cancer is a heterogeneous disease, and the complexity of breast carcinogenesis is associated with epigenetic modification. There are several major classes of epigenetic enzymes that regulate chromatin activity. This review will focus on the nine mammalian protein arginine methyltransferases (PRMTs) and the dysr...

journal_title：Journal of molecular endocrinology

authors： Wang SM,Dowhan DH,Muscat GEO

更新日期：2019-04-01 00:00:00

abstract：:Sucrose density gradient purified plasma membranes isolated from brown adipose tissue of cold-acclimated hamsters (4-10 weeks at 0-4 degreesC) were analysed for the content of the short (GsalphaS) and long (GsalphaL) variants of Gsalpha protein (the alpha subunit of the stimulatory G protein) and compared with the mem...

journal_title：Journal of molecular endocrinology

authors： Bourová L,Novotn J,Svoboda P

更新日期：1999-02-01 00:00:00

abstract：:Metallothioneins (MTs) are cytoprotective proteins acting as scavengers of toxic metal ions or reactive oxygen species. MTs are upregulated in follicular thyroid carcinoma and are regarded as a marker of thyroid stress in Graves' disease. However, the mechanism of MT regulation in thyrocytes is still elusive. In other...

journal_title：Journal of molecular endocrinology

authors： Bäck CM,Stohr S,Schäfer EA,Biebermann H,Boekhoff I,Breit A,Gudermann T,Büch TR

更新日期：2013-06-04 00:00:00

abstract：:The major mission of the ovarian follicle is the timely production of the mature fertilizable oocyte, and this is achieved by gonadotropin-regulated, gap junction-mediated cell-cell communication between the oocyte and surrounding nurturing granulosa cells. We have demonstrated that FSH and transforming growth factor ...

journal_title：Journal of molecular endocrinology

authors： Fang WL,Lai SY,Lai WA,Lee MT,Liao CF,Ke FC,Hwang JJ

更新日期：2015-12-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is synthesized from a precursor, which includes the PACAP-related peptide (PRP; formerly known as GHRH-like peptide). PRP can act as a hypophysiotropic factor in teleosts by stimulating GH secretion. However, no information points to this peptide as a regulato...

journal_title：Journal of molecular endocrinology

authors： Levy G,Degani G

更新日期：2011-03-03 00:00:00

abstract：:Esculetin, an antioxidant, has been used in the treatment of a variety of diseases. This study aimed to investigate the protective effect of esculetin in attenuating streptozotocin (STZ)-induced type I diabetic nephropathy and to understand the molecular mechanism involved in it. Sprague-Dawley rats were rendered diab...

journal_title：Journal of molecular endocrinology

authors： Surse VM,Gupta J,Tikoo K

更新日期：2011-06-09 00:00:00

abstract：:Malic enzyme 1 (ME1) is a cytosolic protein that catalyzes the conversion of malate to pyruvate while concomitantly generating NADPH from NADP. Early studies identified ME1 as a mediator of intermediary metabolism primarily through its participatory roles in lipid and cholesterol biosynthesis. ME1 was one of the first...

journal_title：Journal of molecular endocrinology

authors： Simmen FA,Alhallak I,Simmen RCM

更新日期：2020-11-01 00:00:00

abstract：:A prolactin cDNA was cloned from a cDNA expression library constructed from total RNA of bullfrog (Rana catesbeiana) adenohypophyses by immunoscreening with antiserum against bullfrog prolactin. The cDNA clone thus obtained contained a 249 bp insert. Using this clone as a probe, plaque hybridizations were performed an...

journal_title：Journal of molecular endocrinology

authors： Takahashi N,Yoshihama K,Kikuyama S,Yamamoto K,Wakabayashi K,Kato Y

更新日期：1990-12-01 00:00:00

abstract：:The interaction between human papillomaviruses (HPV) and the apolipoprotein-B mRNA-editing catalytic polypeptide-like (APOBEC)3 (A3) genes has garnered increasing attention in recent years, with considerable efforts focused on understanding their apparent roles in both viral editing and in HPV-driven carcinogenesis. H...

journal_title：Journal of molecular endocrinology

authors： Smith NJ,Fenton TR

更新日期：2019-05-01 00:00:00

abstract：:Leptin (Lep), an adipose-derived hormone, exerts very important functions in the body mainly on energy storage and availability. The physiological effects of Lep controlling the body weight and suppressing appetite are mediated by the long form of Lep receptor in the hypothalamus. Lep receptor activates several downst...

journal_title：Journal of molecular endocrinology

authors： Folch J,Pedrós I,Patraca I,Sureda F,Junyent F,Beas-Zarate C,Verdaguer E,Pallàs M,Auladell C,Camins A

更新日期：2012-10-10 00:00:00

abstract：:In this study we examine changes in the cellular properties of FRTL-5 cells as a function of passage number, with particular emphasis on gap junction expression, karyotype, morphology, growth rate and thyroxine (T(4)) release. Early passage FRTL-5 follicular cells transfer dye through gap junctions from injected cell(...

journal_title：Journal of molecular endocrinology

authors： Green LM,Murray DK,Tran DT,Nelson GA,Shah MM,Luben RA

更新日期：2001-10-01 00:00:00

abstract：:A subset of over-expressed microRNAs (miRNAs) identified in parathyroid carcinomas (Ca) compared to normal glands belongs to C19MC, a cluster on chromosome 19q13.4 involved in stem cell biology and tumourigenesis. In this study, the expression of C19MC-MIR371-3 clusters and the molecular mechanisms presiding their mod...

journal_title：Journal of molecular endocrinology

authors： Vaira V,Elli F,Forno I,Guarnieri V,Verdelli C,Ferrero S,Scillitani A,Vicentini L,Cetani F,Mantovani G,Spada A,Bosari S,Corbetta S

更新日期：2012-07-26 00:00:00

abstract：:The genomic structure and transcriptional regulation of the rat apelin receptor (APJR) were analysed by rapid amplification of 5' cDNA ends (5'-RACE), transient expression assays and DNA-protein interaction. Analysis of the 5'-flanking region of a rat genomic clone shows no TATA box, but a putative CAAT box and severa...

journal_title：Journal of molecular endocrinology

authors： O'Carroll AM,Lolait SJ,Howell GM

更新日期：2006-02-01 00:00:00

abstract：:The neurohypophysial nonapeptides vasotocin (VT) and mesotocin (MT) are the amphibian counterparts of arginine vasopressin (AVP) and oxytocin (OT). We have here reported the cloning and functional characterization of the receptors for vasotocin (VTR) and mesotocin (MTR) in two species of frog, Rana catesbeiana and Ran...

journal_title：Journal of molecular endocrinology

authors： Acharjee S,Do-Rego JL,Oh DY,Moon JS,Ahn RS,Lee K,Bai DG,Vaudry H,Kwon HB,Seong JY

更新日期：2004-08-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare tumour arising from neural crest-derived parafollicular C-cells. Metastatic MTC patients are incurable because the cancer does not respond to radiotherapy or chemotherapy. The REarranged during Transfection (RET) proto-oncogene plays a key role in the development of MTC. How...

journal_title：Journal of molecular endocrinology

authors： Cerrato A,De Falco V,Santoro M

更新日期：2009-10-01 00:00:00

abstract：:Reproductive function in mammals is energetically costly and therefore tightly regulated by nutritional status. To enable this integration of metabolic and reproductive function, information regarding peripheral nutritional status must be relayed centrally to the gonadotropin-releasing hormone (GNRH) neurons that driv...

journal_title：Journal of molecular endocrinology

authors： Evans MC,Anderson GM

更新日期：2017-02-01 00:00:00

abstract：:Prolactin (PRL)-releasing peptide (PrRP) is a strong candidate stimulator of pituitary PRL transcription and secretion in teleosts. However, the role in control of extrapituitary PRL expression is unclear even in mammals. To study the possible presence of PrRP-PRL axes not only in the brain-pituitary but also in perip...

journal_title：Journal of molecular endocrinology

authors： Sakamoto T,Amano M,Hyodo S,Moriyama S,Takahashi A,Kawauchi H,Ando M

更新日期：2005-06-01 00:00:00

abstract：:Orexin-A and -B are known to stimulate food intake in mammals. However, the critical roles of orexins in birds are not fully understood, since orexins have no stimulatory effect on food intake in the chicken. To understand the physiological role(s) of orexins in birds, we have cloned chicken orexin receptor (cOXR) cDN...

journal_title：Journal of molecular endocrinology

authors： Ohkubo T,Tsukada A,Shamoto K

更新日期：2003-12-01 00:00:00

abstract：:Using the fluorescent indicators 2',7'-bis(2-carboxyethyl)-5'-(6')-carboxyfluorescein and Oxonol V to monitor intracellular pH (pHi) and cell membrane potential respectively, we have investigated the involvement of H(+)-dependent ATPase and H(+)-dependent K+ channels in the recovery of the rat thyroid cell strain FRTL...

journal_title：Journal of molecular endocrinology

authors： Woods DJ,Soden J,Bidey SP

更新日期：1992-02-01 00:00:00

abstract：:This study aimed to determine whether and how the glucagon-like peptide 1 receptor (GLP-1R) agonist liraglutide affects the chemoresistance and chemosensitivity of pancreatic cancer cells to gemcitabine in vitro and in vivo. The GLP-1R and protein kinase A (PKA) levels were compared between the human pancreatic cancer...

journal_title：Journal of molecular endocrinology

authors： Zhao HJ,Jiang X,Hu LJ,Yang L,Deng LD,Wang YP,Ren ZP

更新日期：2020-02-01 00:00:00

abstract：:The endogenous thyroid hormone (TH) metabolite 3,5-diiodo-l-thyronine (3,5-T2) acts as a metabolically active substance affecting whole-body energy metabolism and hepatic lipid handling in a desirable manner. Considering possible adverse effects regarding thyromimetic action of 3,5-T2 treatment in rodents, the current...

journal_title：Journal of molecular endocrinology

authors： Lietzow J,Golchert J,Homuth G,Völker U,Jonas W,Köhrle J

更新日期：2016-05-01 00:00:00

abstract：:It has been suggested that the thyroid itself may contribute to the inflammatory process observed in autoimmune thyroiditis by releasing the cytokines interleukin-1 alpha (IL-1 alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8), but studies of cytokine gene expression in thyrocytes have been limited and conflicting...

journal_title：Journal of molecular endocrinology

authors： Watson PF,Pickerill AP,Davies R,Weetman AP

更新日期：1995-08-01 00:00:00

abstract：:Estrogen plays an important role in many physiological events including carcinogenesis and the development of human breast cancer. However, the molecular mechanisms of estrogen signaling in cancers have not been clarified hitherto and accurate therapeutic prediction of breast cancer is earnestly desired. We first carr...

journal_title：Journal of molecular endocrinology

authors： Inoue A,Yoshida N,Omoto Y,Oguchi S,Yamori T,Kiyama R,Hayashi S

更新日期：2002-10-01 00:00:00