Reversal of fortune: estrogen receptor-β in endometriosis.

abstract：:Translocation of protein kinase C (PKC) from the cytosol to the plasma membranes is believed to reflect activation of the enzyme. We have studied translocation of PKC in lactotroph-enriched anterior pituitary cell cultures by measuring the incorporation of gamma-32P from [gamma-32P]ATP into a synthetic peptide substra...

journal_title：Journal of molecular endocrinology

authors： Mau SE,Saermark T,Vilhardt H

更新日期：1994-06-01 00:00:00

abstract：:Reproductive function in mammals is regulated by the pituitary gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH are secreted by the gonadotrope cell and act on the gonad in a sequential and synergistic manner to initiate sexual maturation and maintain cyclic reproductive functi...

journal_title：Journal of molecular endocrinology

authors： Burger LL,Haisenleder DJ,Dalkin AC,Marshall JC

更新日期：2004-12-01 00:00:00

abstract：:Hormones are dynamically collected by fenestrated capillaries to generate pulses, which are then decoded by target tissues to mount a biological response. To generate hormone pulses, endocrine systems have evolved mechanisms to tightly regulate blood perfusion and oxygenation, coordinate endocrine cell responses to se...

journal_title：Journal of molecular endocrinology

authors： Schaeffer M,Hodson DJ,Lafont C,Mollard P

更新日期：2011-08-25 00:00:00

abstract：:Insulin-regulated aminopeptidase (IRAP, EC 3.4.11.3) in adipocytes is well known to traffic between high (HDM) and low (LDM) density microsomal fractions toward the plasma membrane (MF) under stimulation by insulin. However, its catalytic preference for aminoacyl substrates with N-terminal Leu or Cys is controversial....

journal_title：Journal of molecular endocrinology

authors： Alponti RF,Viana LG,Yamanouye N,Silveira PF

更新日期：2015-08-01 00:00:00

abstract：:This study examined fetal steroidogenic enzyme expression and function during pregnancy in the pig. Northern and Western analyses were performed to detect the cytochrome P450 enzyme 17 alpha-hydroxylase/17-20 lyase (P450c17) and that for cholesterol side-chain cleavage (P450scc), as well as 3 beta-hydroxysteroid dehyd...

journal_title：Journal of molecular endocrinology

authors： Conley AJ,Rainey WE,Mason JI

更新日期：1994-04-01 00:00:00

abstract：:The constitutive expression of 25-hydroxyvitamin D3-24-hydroxylase (25-(OH)D3-24-hydroxylase) activity has been studied in an adherent variant (Ad-HL60) of the human promyelomonocytic leukaemia cell line HL60. The Ad-HL60 cells have a more differentiated phenotype than the non-adherent cells from which they were deriv...

journal_title：Journal of molecular endocrinology

authors： Hayes ME,Bayley D,Mawer EB

更新日期：1991-12-01 00:00:00

abstract：:Expression of the rat alpha 2u-globulin gene family is regulated in the adult male liver by a number of hormones, including growth hormone, thyroid hormone and several steroids. Upon injection into ovariectomized females, estrogens first induce alpha 2u-globulin expression and then suppress this gene after several day...

journal_title：Journal of molecular endocrinology

authors： Wang KS,Hodgetts RB,Addison WR

更新日期：1998-02-01 00:00:00

abstract：:Parathyroid hormone (PTH) is secreted by the chief cells of the parathyroid gland in response to changes in ionized calcium (Ca(2+)) concentrations. In this study, we measured PTH secretion, and PTH mRNA and calcium-sensing receptor (CaR) mRNA expression by equine parathyroid chief cells in vitro. We also evaluated th...

journal_title：Journal of molecular endocrinology

authors： Toribio RE,Kohn CW,Capen CC,Rosol TJ

更新日期：2003-12-01 00:00:00

abstract：:Relaxin is a peptide hormone which is produced in human reproductive tissues including the ovary and prostate gland. Little is known of the molecular events regulating relaxin gene transcription. We have studied this question using gene transfer of relaxin promoter/reporter gene constructs into a relaxin-expressing ce...

journal_title：Journal of molecular endocrinology

authors： Gunnersen JM,Roche PJ,Tregear GW,Crawford RJ

更新日期：1995-10-01 00:00:00

abstract：:The somatostatin (SRIF) system, which includes the SRIF ligand and receptors, regulates anterior pituitary gland function, mainly inhibiting hormone secretion and to some extent pituitary tumor cell growth. SRIF-14 via its cognate G-protein-coupled receptors (subtypes 1-5) activates multiple cellular signaling pathway...

journal_title：Journal of molecular endocrinology

authors： Eigler T,Ben-Shlomo A

更新日期：2014-08-01 00:00:00

abstract：:This study developed a quantitative reverse transcription-polymerase chain reaction (RT-PCR) method to measure estrogen receptor-alpha (ERalpha) mRNA in the rainbow trout (Oncorhynchus mykiss). Using RT-PCR, and primers based on the known ERalpha DNA sequence in this species, cDNA sequences representing most of the pr...

journal_title：Journal of molecular endocrinology

authors： Nagler JJ,Krisfalusi M,Cyr DG

更新日期：2000-10-01 00:00:00

abstract：:Type 2 diabetes is characterized by islet dysfunction resulting in hyperglycemia, which can then lead to further deterioration in islet function. A possible mechanism for hyperglycemia-induced islet dysfunction is the accumulation of advanced glycation end products (AGE). The DBA/2 mouse develops pancreatic islet dysf...

journal_title：Journal of molecular endocrinology

authors： Kooptiwut S,Kebede M,Zraika S,Visinoni S,Aston-Mourney K,Favaloro J,Tikellis C,Thomas MC,Forbes JM,Cooper ME,Dunlop M,Proietto J,Andrikopoulos S

更新日期：2005-08-01 00:00:00

abstract：:This study investigates the effectiveness and mechanisms of a serum- and glucocorticoid-inducible kinase 1 (SGK1) inhibitor in counteracting hyperglycemia. In an in vivo experiment, we demonstrated that after an 8-week treatment with an SGK1 inhibitor, the fasting blood glucose and HbA1c level significantly decreased ...

journal_title：Journal of molecular endocrinology

authors： Li P,Hao Y,Pan FH,Zhang M,Ma JQ,Zhu DL

更新日期：2016-05-01 00:00:00

abstract：:Mammary explants can be hormonally stimulated to mimic the biochemical changes that occur during lactogenesis. Previous studies using mammary explants concluded that the addition of exogenous macromolecules were required for mammary epithelial cells to remain viable in culture. The present study examines the survival ...

journal_title：Journal of molecular endocrinology

authors： Brennan AJ,Sharp JA,Lefèvre CM,Nicholas KR

更新日期：2008-09-01 00:00:00

abstract：:We have studied the action of peripheral blood lymphocytes (PBLs) and intrathyroidal lymphocytes (ITLs) on the biochemical and hormonal metabolism of autologous thyrocytes cultured in follicles in a collagen gel. The production of tumour necrosis factor alpha (TNF-alpha) in culture was also measured. Thyroid tissues a...

journal_title：Journal of molecular endocrinology

authors： Massart C,Gibassier J,Raoul ML,Le Gall F,Lancien G,Genetet N,Denais A,Darcel F,Lucas C

更新日期：1997-04-01 00:00:00

abstract：:The hyperglycaemia-inducing sulphonamide diazoxide has been previously shown to mediate its effects upon insulin secretion by opening K+ channels and hyperpolarizing the beta-cell membrane. The target site has been characterized as the ATP-regulated K+ (K+ATP) channel protein. In the present study, a detailed investig...

journal_title：Journal of molecular endocrinology

authors： Jaggar JH,Harding EA,Ayton BJ,Dunne MJ

更新日期：1993-02-01 00:00:00

abstract：:Tight regulation of fatty acid metabolism in pancreatic beta-cells is important for beta-cell viability and function. Chronic exposure to elevated concentrations of fatty acid is associated with beta-cell lipotoxicity. Glucose is known to repress fatty acid oxidation and hence to augment the toxicity of fatty acids. T...

journal_title：Journal of molecular endocrinology

authors： Ravnskjaer K,Boergesen M,Dalgaard LT,Mandrup S

更新日期：2006-04-01 00:00:00

abstract：:Microarray studies have identified many genes that are down-regulated in uterine leiomyoma compared with myometrium, including early growth response gene-1 (EGR1). However, the mechanisms underlying coordinated down-regulation of this gene cohort remain unknown. To address the transcriptional role of EGR1 in leiomyoma...

journal_title：Journal of molecular endocrinology

authors： Ishikawa H,Shozu M,Okada M,Inukai M,Zhang B,Kato K,Kasai T,Inoue M

更新日期：2007-11-01 00:00:00

abstract：:Inhibition of aromatase, a key enzyme in the biosynthesis of oestradiol-17 beta, by the addition of 1,4,6-androstatrien-3,17-dione resulted in a significant increase in the levels of immunoreactive human chorionic gonadotrophin (hCG) in the medium and tissue. This increase was partially reversed by the simultaneous ad...

journal_title：Journal of molecular endocrinology

authors： Sharma SC,Purohit P,Rao AJ

更新日期：1993-08-01 00:00:00

abstract：:Several hormone agonists exert their physiological actions by triggering an inositol phospholipid-Ca2+ signalling cascade and cytosolic alkalinization. Although calcium ionophores have been used extensively to probe the role of Ca2+ in the regulation of steroidogenesis in granulosa cells, the precise relationship betw...

journal_title：Journal of molecular endocrinology

authors： Asem EK,Li M,Tsang BK

更新日期：1992-08-01 00:00:00

abstract：:Several authors have shown that angiotensin II stimulates hepatic angiotensinogen synthesis in vivo, ex vivo and in vitro. In previous studies we have demonstrated that this effect of angiotensin II depends mainly on a transient inhibition of adenylyl cyclase and is the consequence of a stabilization of angiotensinoge...

journal_title：Journal of molecular endocrinology

authors： Klett C,Bader M,Schwemmle M,Ganten D,Hackenthal E

更新日期：1995-04-01 00:00:00

abstract：:A unique characteristic of the primate adrenal is the ability to produce 19-carbon steroids, often called the adrenal androgens. Although it is clear that the major human adrenal androgens, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S), are produced almost solely in the adrenal reticularis, the mechanisms re...

journal_title：Journal of molecular endocrinology

authors： Sirianni R,Carr BR,Andò S,Rainey WE

更新日期：2003-06-01 00:00:00

abstract：:Studies have demonstrated that heat shock is associated with alteration in energy metabolism. In this study, we investigated the effect of heat shock on gene expression and secretion of adiponectin and leptin, and gene expression of Hspa2 and Ppargamma in 3T3-L1 adipocytes. Compared with 37 degrees C, adiponectin mRNA...

journal_title：Journal of molecular endocrinology

authors： Bernabucci U,Basiricò L,Morera P,Lacetera N,Ronchi B,Nardone A

更新日期：2009-02-01 00:00:00

abstract：:In an attempt to define novel genetic loci involved in the pathophysiology of primary aldosteronism, a mutagenesis screen after treatment with the alkylating agent N-ethyl-N-nitrosourea was established for the parameter aldosterone. One of the generated mouse lines with hyperaldosteronism was phenotypically and geneti...

journal_title：Journal of molecular endocrinology

authors： Perez-Rivas LG,Rhayem Y,Sabrautzki S,Hantel C,Rathkolb B,Hrabě de Angelis M,Reincke M,Beuschlein F,Spyroglou A

更新日期：2017-02-01 00:00:00

abstract：:Twenty-five years have elapsed since the calcium-sensing receptor (CaSR) was first identified in bovine parathyroid and the receptor is now recognized as a fundamental contributor to extracellular Ca2+ (Ca2+ e) homeostasis, regulating parathyroid hormone release and urinary calcium excretion. The CaSR is a class C G-p...

journal_title：Journal of molecular endocrinology

authors： Gorvin CM

更新日期：2019-08-01 00:00:00

abstract：:Excess maternal glucocorticoids reduce placental amino acid transport and fetal growth, but whether these effects are mediated directly on the syncytiotrophoblast remains unknown. We hypothesised that glucocorticoids inhibit mechanistic target of rapamycin (mTOR) signaling and insulin-stimulated System A amino acid tr...

journal_title：Journal of molecular endocrinology

authors： Vaughan OR,Powell TL,Jansson T

更新日期：2019-11-01 00:00:00

abstract：:We studied the effects of 2-methoxyestradiol (2-ME2) and 16alpha-hydroxyestrone (16alpha-OHE1), two metabolites of estradiol (E2), on DNA synthesis, cell cycle progression and cyclin D1 protein levels in estrogen receptor-positive MCF-7 cells. E2 and 16alpha-OHE1 stimulated DNA synthesis, and 2-ME2 inhibited the stimu...

journal_title：Journal of molecular endocrinology

authors： Lewis JS,Thomas TJ,Pestell RG,Albanese C,Gallo MA,Thomas T

更新日期：2005-02-01 00:00:00

abstract：:Metformin improves obesity-associated metabolic dysregulation, but has controversial effects on adipose tissue inflammation. The objective of the study is to examine the direct effect of metformin on adipocyte inflammatory responses and elucidate the underlying mechanisms. Adipocytes were differentiated from 3T3-L1 ce...

journal_title：Journal of molecular endocrinology

authors： Qi T,Chen Y,Li H,Pei Y,Woo SL,Guo X,Zhao J,Qian X,Awika J,Huo Y,Wu C

更新日期：2017-07-01 00:00:00

abstract：:Esculetin, an antioxidant, has been used in the treatment of a variety of diseases. This study aimed to investigate the protective effect of esculetin in attenuating streptozotocin (STZ)-induced type I diabetic nephropathy and to understand the molecular mechanism involved in it. Sprague-Dawley rats were rendered diab...

journal_title：Journal of molecular endocrinology

authors： Surse VM,Gupta J,Tikoo K

更新日期：2011-06-09 00:00:00

abstract：:Endometriosis is an incurable hormone-dependent inflammatory disease that causes chronic pelvic pain and infertility characterized by implantation and growth of endometrial tissue outside the uterine cavity. Symptoms have a major impact on the quality of life of patients resulting in socioeconomic, physical and psycho...

journal_title：Journal of molecular endocrinology

authors： Piccinato CA,Malvezzi H,Gibson DA,Saunders PTK

更新日期：2018-08-01 00:00:00