Abstract:
:Reproductive function in mammals is regulated by the pituitary gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH are secreted by the gonadotrope cell and act on the gonad in a sequential and synergistic manner to initiate sexual maturation and maintain cyclic reproductive function. The synthesis and secretion of LH and FSH are regulated mainly by the pulsatile release of the hypothalamic decapeptide hormone gonadotropin-releasing hormone (GnRH). The control of differential LH and FSH synthesis and secretion is complex and involves the interplay between the gonads, hypothalamus and pituitary. In this review, the transcriptional regulation of the gonadotropin subunit genes is discussed in a physiologic setting, and we aimed to examine the mechanisms that drive those changes.
journal_name
J Mol Endocrinoljournal_title
Journal of molecular endocrinologyauthors
Burger LL,Haisenleder DJ,Dalkin AC,Marshall JCdoi
10.1677/jme.1.01600subject
Has Abstractpub_date
2004-12-01 00:00:00pages
559-84issue
3eissn
0952-5041issn
1479-6813pii
33/3/559journal_volume
33pub_type
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journal_title:Journal of molecular endocrinology
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journal_title:Journal of molecular endocrinology
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