Prolactin actions.

Abstract:

:Molecular genetics and other contemporary approaches have contributed to a better understanding of prolactin (PRL) actions at the cellular and organismal levels. In this review, several advances in knowledge of PRL actions are highlighted. Special emphasis is paid to areas of progress with consequences for understanding of human PRL actions. The impacts of these advances on future research priorities are analyzed.

journal_name

J Mol Endocrinol

authors

Horseman ND,Gregerson KA

doi

10.1530/JME-13-0220

subject

Has Abstract

pub_date

2013-12-19 00:00:00

pages

R95-106

issue

1

eissn

0952-5041

issn

1479-6813

pii

JME-13-0220

journal_volume

52

pub_type

杂志文章,评审
  • Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth.

    abstract::The mannose 6-phosphate/IGF 2 receptor (IGF2R) is comprised of 15 extra-cellular domains that bind IGF2 and mannose 6-phosphate ligands. IGF2R transports ligands from the Golgi to the pre-lysosomal compartment and thereafter to and from the cell surface. IGF2R regulates growth, placental development, tumour suppressio...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/JME-08-0154

    authors: Rezgui D,Williams C,Savage SA,Prince SN,Zaccheo OJ,Jones EY,Crump MP,Hassan AB

    更新日期:2009-04-01 00:00:00

  • Acute anorexigenic action of leptin in rainbow trout is mediated by the hypothalamic Pi3k pathway.

    abstract::Leptin (Lep) is an anorexigenic hormone and regulates appetite-related neuropeptides in mammals. A number of neuropeptides have also been linked to appetite regulation in teleost fish, but Lep signaling activation and effects on appetite-regulating neurons are poorly elucidated in early vertebrates. This study uses ce...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1530/JME-15-0279

    authors: Gong N,Jönsson E,Björnsson BT

    更新日期:2016-04-01 00:00:00

  • Regulation of LH subunit and prolactin mRNA by gonadal hormones in mice.

    abstract::The effect of castration and gonadal steroid replacement on the concentrations of LH-beta and alpha subunit and prolactin mRNA was examined in mice. Mouse LH-beta, alpha and prolactin mRNAs were approximately 0.8, 0.7 and 1.1 kb in size respectively. After ovariectomy, LH-beta mRNA levels increased 2- to 2.5-fold, whi...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0020213

    authors: Saade G,London DR,Lalloz MR,Clayton RN

    更新日期:1989-05-01 00:00:00

  • Transcriptional induction of rat mineralocorticoid receptor gene in neurones by corticosteroids.

    abstract::We investigated the mechanisms by which corticosteroids regulate the expression of the mineralocorticoid receptor (MR) in neurones. Aldosterone and dexamethasone produced a dose-dependent increase of MR and mRNA levels in cultured primary hippocampal neurones. Transient transfection of neuroblastoma cells showed that ...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0140285

    authors: Castrén M,Trapp T,Berninger B,Castrén E,Holsboer F

    更新日期:1995-06-01 00:00:00

  • A monoclonal antibody to a conserved sequence in the extracellular domain recognizes the angiotensin II AT1 receptor in mammalian target tissues.

    abstract::We have generated hybridomas which secrete monoclonal antibodies to the AT1 subtype of the angiotensin II receptor (AT1 receptor). These were obtained after immunization of Balb C/c mice with synthetic peptides representing sequences from either the extracellular domain (residues 8-17) or the intracellular domain (res...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0110241

    authors: Barker S,Marchant W,Ho MM,Puddefoot JR,Hinson JP,Clark AJ,Vinson GP

    更新日期:1993-10-01 00:00:00

  • A spontaneously arising mutation in connexin32 with repeated passage of FRTL-5 cells coincides with increased growth rate and reduced thyroxine release.

    abstract::In this study we examine changes in the cellular properties of FRTL-5 cells as a function of passage number, with particular emphasis on gap junction expression, karyotype, morphology, growth rate and thyroxine (T(4)) release. Early passage FRTL-5 follicular cells transfer dye through gap junctions from injected cell(...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0270145

    authors: Green LM,Murray DK,Tran DT,Nelson GA,Shah MM,Luben RA

    更新日期:2001-10-01 00:00:00

  • Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion.

    abstract::Pancreatic beta-cells are responsible for producing all of the insulin required by an organism to maintain glucose homeostasis. Defects in development, maintenance, or expansion of beta-cell mass can result in impaired glucose metabolism and diabetes. Thus, identifying the molecular regulators of these processes may p...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章,评审

    doi:10.1677/JME-06-0053

    authors: Ackermann AM,Gannon M

    更新日期:2007-02-01 00:00:00

  • Different effects of corticotropin-releasing factor and urocortin 2 on apoptosis of prostate cancer cells in vitro.

    abstract::Urocortin (Ucn), a corticotropin-releasing factor (CRF)-related neuropeptide binding both CRF type 1 receptor (CRFR1) and CRFR2, has recently been found in prostate cancer. However, no report has yet been known to elucidate the roles of Ucn in prostate cancer via the two receptors. In this study, the expression of bot...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1530/JME-11-0048

    authors: Jin L,Zhang Q,Guo R,Wang L,Wang J,Wan R,Zhang R,Xu Y,Li S

    更新日期:2011-09-07 00:00:00

  • Inhibition of Src tyrosine kinase stimulates adrenal androgen production.

    abstract::A unique characteristic of the primate adrenal is the ability to produce 19-carbon steroids, often called the adrenal androgens. Although it is clear that the major human adrenal androgens, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S), are produced almost solely in the adrenal reticularis, the mechanisms re...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0300287

    authors: Sirianni R,Carr BR,Andò S,Rainey WE

    更新日期:2003-06-01 00:00:00

  • Erythropoietin regulates POMC expression via STAT3 and potentiates leptin response.

    abstract::The arcuate nucleus of the hypothalamus is essential for metabolic homeostasis and responds to leptin by producing several neuropeptides including proopiomelanocortin (POMC). We previously reported that high-dose erythropoietin (Epo) treatment in mice while increasing hematocrit reduced body weight, fat mass, and food...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1530/JME-15-0171

    authors: Dey S,Li X,Teng R,Alnaeeli M,Chen Z,Rogers H,Noguchi CT

    更新日期:2016-02-01 00:00:00

  • Characterization of the extracellular region of the human thyrotrophin receptor expressed as a recombinant protein.

    abstract::DNA encoding the N-terminal 415 residues of the human thyrotrophin receptor (predicted to code for the large extracellular region) was introduced into Chinese hamster ovary (CHO) cells using the glutamine synthetase/cytomegalovirus amplifiable expression system, and into E. coli using the pGEX-3X expression vector. Su...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0090227

    authors: Harfst E,Johnstone AP,Nussey SS

    更新日期:1992-12-01 00:00:00

  • The induction by estrogen of rat alpha 2u-globulin gene expression in mouse L-cells.

    abstract::Expression of the rat alpha 2u-globulin gene family is regulated in the adult male liver by a number of hormones, including growth hormone, thyroid hormone and several steroids. Upon injection into ovariectomized females, estrogens first induce alpha 2u-globulin expression and then suppress this gene after several day...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0200141

    authors: Wang KS,Hodgetts RB,Addison WR

    更新日期:1998-02-01 00:00:00

  • Molecular cloning and nucleotide sequence analysis of complementary DNA for bullfrog prolactin.

    abstract::A prolactin cDNA was cloned from a cDNA expression library constructed from total RNA of bullfrog (Rana catesbeiana) adenohypophyses by immunoscreening with antiserum against bullfrog prolactin. The cDNA clone thus obtained contained a 249 bp insert. Using this clone as a probe, plaque hybridizations were performed an...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0050281

    authors: Takahashi N,Yoshihama K,Kikuyama S,Yamamoto K,Wakabayashi K,Kato Y

    更新日期:1990-12-01 00:00:00

  • A novel oestrogen-regulated gene in human breast cancer cells identified by differential display.

    abstract::Screening by differential display of oestrogen-sensitive MCF7 human breast cancer cells grown in the short-term (6 days) and long-term (70 weeks) absence of oestrogen has led to the identification of a new oestrogen-regulated mRNA. The cDNA isolated by differential display has 100% homology from nucleotides 615 to 859...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0200375

    authors: Stephen R,Corcoran D,Darbre PD

    更新日期:1998-06-01 00:00:00

  • Characterization of a new duplicate delta-opioid receptor from zebrafish.

    abstract::A new full-length cDNA (ZFOR4) that encodes an opioid receptor has been isolated from the teleost zebrafish. The encoded polypeptide is 375 amino acids long and shows high sequence similarity to other delta-opioid receptors, including ZFOR1, the other delta-opioid receptor from zebrafish previously characterized by us...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.1.02136

    authors: Pinal-Seoane N,Martin IR,Gonzalez-Nuñez V,Marron Fernandez de Velasco E,Alvarez FA,Sarmiento RG,Rodriguez RE

    更新日期:2006-12-01 00:00:00

  • Characterization of tyramine β-hydroxylase, an enzyme upregulated by stress in Periplaneta americana.

    abstract::Octopamine (OA) is an important neuroactive substance that modulates several physiological functions and behaviors of various invertebrate species. This biogenic monoamine, structurally related to noradrenaline, acts as a neurotransmitter, a neuromodulator, or a neurohormone in insects. The tyramine β-hydroxylase (TBH...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1530/JME-12-0202

    authors: Châtel A,Murillo L,Bourdin CM,Quinchard S,Picard D,Legros C

    更新日期:2013-01-11 00:00:00

  • Functional expression of the oxytocin receptor in Xenopus laevis oocytes primed with mRNA from bovine endometrium.

    abstract::Synthesis of the uterine receptor for the hypothalamic hormone oxytocin has been induced in oocytes from Xenopus laevis previously primed with bovine endometrium mRNA. The injected oocytes responded to oxytocin by showing dose-dependent oscillations in membrane currents as recorded by the voltage-clamp method. The res...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0010077

    authors: Morley SD,Meyerhof W,Schwarz J,Richter D

    更新日期:1988-07-01 00:00:00

  • Cerebral and gonadal aromatase expressions are differently affected during sex differentiation of Pleurodeles waltl.

    abstract::In vertebrates, sex is determined essentially by two means, genetic factors located on sex chromosomes and epigenetic factors such as temperature experienced by the individual during development. Steroids, especially estrogens, are clearly involved in gonadal differentiation in non-mammalian vertebrates. In this regar...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.1.01588

    authors: Kuntz S,Chesnel A,Flament S,Chardard D

    更新日期:2004-12-01 00:00:00

  • Association between (AC)n dinucleotide repeat polymorphism at the 5'-end of the aldose reductase gene and diabetic nephropathy: a meta-analysis.

    abstract::Association between the (AC)(n) dinucleotide repeat polymorphism at the 5'-end of the aldose reductase gene and the occurrence of diabetic nephropathy was conducted. We examined eight studies consisting of ten Caucasian type 1 diabetes mellitus case-control comparisons and eight studies consisting of nine type 2 diabe...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章,meta分析

    doi:10.1677/JME-07-0152

    authors: Xu M,Chen X,Yan L,Cheng H,Chen W

    更新日期:2008-05-01 00:00:00

  • Androgen-mediated improvement of body composition and muscle function involves a novel early transcriptional program including IGF1, mechano growth factor, and induction of {beta}-catenin.

    abstract::Androgens promote anabolism in the musculoskeletal system while generally repressing adiposity, leading to lean body composition. Circulating androgens decline with age, contributing to frailty, osteoporosis, and obesity; however, the mechanisms by which androgens modulate body composition are largely unknown. Here, w...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/JME-09-0048

    authors: Gentile MA,Nantermet PV,Vogel RL,Phillips R,Holder D,Hodor P,Cheng C,Dai H,Freedman LP,Ray WJ

    更新日期:2010-01-01 00:00:00

  • H(+)-dependent ATPase and K+ channel activities in the rat thyroid cell strain FRTL-5.

    abstract::Using the fluorescent indicators 2',7'-bis(2-carboxyethyl)-5'-(6')-carboxyfluorescein and Oxonol V to monitor intracellular pH (pHi) and cell membrane potential respectively, we have investigated the involvement of H(+)-dependent ATPase and H(+)-dependent K+ channels in the recovery of the rat thyroid cell strain FRTL...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0080079

    authors: Woods DJ,Soden J,Bidey SP

    更新日期:1992-02-01 00:00:00

  • Expression of prolactin-releasing peptide and prolactin in the euryhaline mudskippers (Periophthalmus modestus): prolactin-releasing peptide as a primary regulator of prolactin.

    abstract::Prolactin (PRL)-releasing peptide (PrRP) is a strong candidate stimulator of pituitary PRL transcription and secretion in teleosts. However, the role in control of extrapituitary PRL expression is unclear even in mammals. To study the possible presence of PrRP-PRL axes not only in the brain-pituitary but also in perip...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.1.01768

    authors: Sakamoto T,Amano M,Hyodo S,Moriyama S,Takahashi A,Kawauchi H,Ando M

    更新日期:2005-06-01 00:00:00

  • Insulin-like growth factor (IGF)-I A- and B-domain analogues with altered type 1 IGF and insulin receptor binding specificities.

    abstract::Insulin-like growth factor-I (IGF-I) analogues were produced with the aim of identifying IGF-I residues that contribute to the specificity of binding to the type 1 IGF receptor as opposed to the insulin receptor. Receptor binding properties of a series of A- and B-domain analogues were compared using rat L6 myoblasts,...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0170237

    authors: Shooter GK,Magee B,Soos MA,Francis GL,Siddle K,Wallace JC

    更新日期:1996-12-01 00:00:00

  • Uncoupling the mechanisms that facilitate cell survival in hormone-deprived bovine mammary explants.

    abstract::Mammary explants can be hormonally stimulated to mimic the biochemical changes that occur during lactogenesis. Previous studies using mammary explants concluded that the addition of exogenous macromolecules were required for mammary epithelial cells to remain viable in culture. The present study examines the survival ...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/JME-08-0035

    authors: Brennan AJ,Sharp JA,Lefèvre CM,Nicholas KR

    更新日期:2008-09-01 00:00:00

  • Selective activation of the probasin androgen-responsive region by steroid hormones.

    abstract::Glucocorticoid and androgen receptors have been shown to function through the same palindromic glucocorticoid response element (GRE) and yet have differential effects on gene transcription. In this study, we examined the functional and structural relationship of the androgen and glucocorticoid receptors with the andro...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0220313

    authors: Kasper S,Rennie PS,Bruchovsky N,Lin L,Cheng H,Snoek R,Dahlman-Wright K,Gustafsson JA,Shiu RP,Sheppard PC,Matusik RJ

    更新日期:1999-06-01 00:00:00

  • Quantification of rainbow trout (Oncorhynchus mykiss) estrogen receptor-alpha messenger RNA and its expression in the ovary during the reproductive cycle.

    abstract::This study developed a quantitative reverse transcription-polymerase chain reaction (RT-PCR) method to measure estrogen receptor-alpha (ERalpha) mRNA in the rainbow trout (Oncorhynchus mykiss). Using RT-PCR, and primers based on the known ERalpha DNA sequence in this species, cDNA sequences representing most of the pr...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.0.0250243

    authors: Nagler JJ,Krisfalusi M,Cyr DG

    更新日期:2000-10-01 00:00:00

  • Age-associated gene expression changes in the arcuate nucleus of male rhesus macaques.

    abstract::The hypothalamic arcuate nucleus (ARC) represents a major component of the neuroendocrine reproductive axis and plays an important role in controlling the onset of puberty as well as age-associated reproductive senescence. Although significant gene expression changes have been observed in the ARC during sexual maturat...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1530/JME-17-0094

    authors: Eghlidi DH,Garyfallou VT,Kohama SG,Urbanski HF

    更新日期:2017-08-01 00:00:00

  • Expression of the 1,25-(OH)2 vitamin D3 receptor gene during the differentiation of mouse Ob17 preadipocytes and cross talk with the thyroid hormone receptor signalling pathway.

    abstract::1,25-(OH)2-Vitamin D3 (1,25-D3) and the thyroid hormone tri-iodothyronine (T3) were previously shown to behave as adipogenic agents in murine Ob17 preadipocytes. Moreover, these agents interfere with each other's action during adipocyte differentiation. T3 receptor (TR) expression and a downmodulation of T3 binding si...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1677/jme.1.01572

    authors: Schneider L,El-Yazidi C,Dace A,Maraninchi M,Planells R,Margotat A,Torresani J

    更新日期:2005-02-01 00:00:00

  • Pathway analysis of transcriptomic data shows immunometabolic effects of vitamin D.

    abstract::Unbiased genomic screening analyses have highlighted novel immunomodulatory properties of the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D). However, clearer interpretation of the resulting gene expression data is limited by cell model specificity. The aim of the current study was to provide a broader...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章

    doi:10.1530/JME-17-0186

    authors: Muñoz Garcia A,Kutmon M,Eijssen L,Hewison M,Evelo CT,Coort SL

    更新日期:2018-02-01 00:00:00

  • Agonist-bound nuclear receptors: not just targets of coactivators.

    abstract::Members of the nuclear receptor superfamily of ligand-regulated transcription factors are targets of a wide range of lipophilic signaling molecules as well as several drugs and xenobiotics that modulate many aspects of physiology and metabolism. Agonist binding to receptors is associated with recruitment of coactivato...

    journal_title:Journal of molecular endocrinology

    pub_type: 杂志文章,评审

    doi:10.1677/jme.0.0310001

    authors: Fernandes I,White JH

    更新日期:2003-08-01 00:00:00