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Role of oestradiol-17 beta in the regulation of synthesis and secretion of human chorionic gonadotrophin by first trimester human placenta.

Abstract：

:Inhibition of aromatase, a key enzyme in the biosynthesis of oestradiol-17 beta, by the addition of 1,4,6-androstatrien-3,17-dione resulted in a significant increase in the levels of immunoreactive human chorionic gonadotrophin (hCG) in the medium and tissue. This increase was partially reversed by the simultaneous addition of oestradiol-17 beta. These effects on the levels of immunoreactive hCG were also reflected by the increased levels of mRNA specific for the alpha and beta subunits of hCG following the addition of the aromatase inhibitor. However, addition of tamoxifen resulted in a drastic decrease in the levels of both the messages. Based on these results, it is suggested that the synthesis of hCG is negatively modulated by oestradiol-17 beta in the human placenta.

journal_name

J Mol Endocrinol

journal_title

Journal of molecular endocrinology

authors

Sharma SC,Purohit P,Rao AJ

doi

10.1677/jme.0.0110091

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

91-101

issue

1

eissn

0952-5041

issn

1479-6813

journal_volume

11

pub_type

杂志文章

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