Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth.

abstract：:Estrogen plays an important role in many physiological events including carcinogenesis and the development of human breast cancer. However, the molecular mechanisms of estrogen signaling in cancers have not been clarified hitherto and accurate therapeutic prediction of breast cancer is earnestly desired. We first carr...

journal_title：Journal of molecular endocrinology

authors： Inoue A,Yoshida N,Omoto Y,Oguchi S,Yamori T,Kiyama R,Hayashi S

更新日期：2002-10-01 00:00:00

abstract：:The genetic predisposition of the host and the virus is the most important determinant for prediction of the course of human immunodeficiency virus type I (HIV-1) viral infection and acquired immune deficiency syndrome (AIDS) progression. Transcription from the HIV-1 long terminal repeat (LTR) is a crucial step for vi...

journal_title：Journal of molecular endocrinology

authors： Nevado J,Tenbaum SP,Castillo AI,Sánchez-Pacheco A,Aranda A

更新日期：2007-06-01 00:00:00

abstract：:The mechanism behind Ca(2)(+) entry into the parathyroid cells has been widely debated, and the molecular identities of the responsible ion channels have not been established yet. In this study, we show that the parathyroid cells lack voltage-operated Ca(2)(+) channels. Passive store depletion by thapsigargin, on the ...

journal_title：Journal of molecular endocrinology

authors： Lu M,Bränström R,Berglund E,Höög A,Björklund P,Westin G,Larsson C,Farnebo LO,Forsberg L

更新日期：2010-05-01 00:00:00

abstract：:A new full-length cDNA (ZFOR4) that encodes an opioid receptor has been isolated from the teleost zebrafish. The encoded polypeptide is 375 amino acids long and shows high sequence similarity to other delta-opioid receptors, including ZFOR1, the other delta-opioid receptor from zebrafish previously characterized by us...

journal_title：Journal of molecular endocrinology

authors： Pinal-Seoane N,Martin IR,Gonzalez-Nuñez V,Marron Fernandez de Velasco E,Alvarez FA,Sarmiento RG,Rodriguez RE

更新日期：2006-12-01 00:00:00

abstract：:The pancreatic regenerating (reg) gene is proposed to be involved in pancreatic beta-cell growth. Up- or down-regulation of reg gene expression has been shown to parallel variations in beta-cell mass and function in the adult pancreas. In several species at least two nonallelic reg genes have been identified. In this ...

journal_title：Journal of molecular endocrinology

authors： Perfetti R,Raygada M,Wang Y,Zenilman ME,Egan JM,Denno KM,Sadler TW,Shuldiner AR

更新日期：1996-08-01 00:00:00

abstract：:Impaired insulin action has been associated with diabetes, dyslipidemia and atherosclerotic vascular disease. The expression of insulin resistance results from the interaction of environmental and genetic factors. Human hepatic lipase (HL) is a lipolytic enzyme that plays a role in the metabolism of several lipoprotei...

journal_title：Journal of molecular endocrinology

authors： Gómez P,Pérez-Jiménez F,Marín C,Moreno JA,Gómez MJ,Bellido C,Pérez-Martínez P,Fuentes F,Paniagua JA,López-Miranda J

更新日期：2005-04-01 00:00:00

abstract：:The cloning and characterization of the mouse TRH receptor (TRH-R) gene revealed an untranslated exon (exon 1), a single intron and an upstream dinucleotide repeat sequence (d(TG)16.d(AG)21) in the 5' untranslated region (UTR). The coding region was contained almost entirely on a second exon (exon 2), with the final a...

journal_title：Journal of molecular endocrinology

authors： Duthie SM,Taylor PL,Eidne KA

更新日期：1993-10-01 00:00:00

abstract：:The presence of retinoic acid receptor (RAR) alpha, beta and gamma mRNA was examined in 16 different kinds of rat tissue using the highly sensitive reverse transcriptase-polymerase chain reaction technique. The data demonstrated that each tissue expressed at least two types of RAR mRNA. Among the three types of RAR mR...

journal_title：Journal of molecular endocrinology

authors： Wan YJ,Wang L,Wu TC

更新日期：1992-12-01 00:00:00

abstract：:We used the Crm1 inhibitor leptomycin B (LMB) to examine a possible involvement of nuclear export in estrogen receptor alpha (ER) level and function in MCF-7 breast carcinoma cells. As revealed by immunofluorescence microscopy and western blotting with anti-ER antibodies, LMB produced an accumulation of ER in cell nuc...

journal_title：Journal of molecular endocrinology

authors： Nonclercq D,Journé F,Laïos I,Chaboteaux C,Toillon RA,Leclercq G,Laurent G

更新日期：2007-08-01 00:00:00

abstract：:Differences in binding and structural properties of ovine testicular FSH and LH receptors were investigated. The ovine FSH receptor did not discriminate between FSH of different species, although equine FSH was more reactive. In the same tissue, however, the LH receptor showed marked preference for ovine and bovine LH...

journal_title：Journal of molecular endocrinology

authors： Yarney TA,Sairam MR

更新日期：1991-06-01 00:00:00

abstract：:Parathyroid hormone (PTH), a powerful bone-resorbing agent, is capable of stimulating interstitial collagenase (MMP-13) mRNA production in osteoblastic cells. In this study, a PEA3 consensus binding sequence (-80; AGGAAGT) in addition to a 'TRE-like' sequence (-89; CGACTCA) in the 5' upstream regulatory region of the ...

journal_title：Journal of molecular endocrinology

authors： Quinn CO,Rajakumar RA,Agapova OA

更新日期：2000-08-01 00:00:00

abstract：:About 70% of breast tumors express estrogen receptor alpha (ERα), which mediates the proliferative effects of estrogens on breast epithelial cells, and are candidates for treatment with antiestrogens, steroidal or non-steroidal molecules designed to compete with estrogens and antagonize ERs. The variable patterns of a...

journal_title：Journal of molecular endocrinology

authors： Traboulsi T,El Ezzy M,Gleason JL,Mader S

更新日期：2017-01-01 00:00:00

abstract：:We recently reported that genetic deletion of myeloperoxidase (MPO) alleviates obesity-related insulin resistance in mice in vivo. How MPO impairs insulin sensitivity in adipocytes is poorly characterized. As hypochlorous acid (HOCl) is a principal oxidant product generated by MPO, we evaluated the effects of HOCl on ...

journal_title：Journal of molecular endocrinology

authors： Zhou J,Wang Q,Ding Y,Zou MH

更新日期：2015-02-01 00:00:00

abstract：:Using the fluorescent indicators 2',7'-bis(2-carboxyethyl)-5'-(6')-carboxyfluorescein and Oxonol V to monitor intracellular pH (pHi) and cell membrane potential respectively, we have investigated the involvement of H(+)-dependent ATPase and H(+)-dependent K+ channels in the recovery of the rat thyroid cell strain FRTL...

journal_title：Journal of molecular endocrinology

authors： Woods DJ,Soden J,Bidey SP

更新日期：1992-02-01 00:00:00

abstract：:Reproductive function in mammals is energetically costly and therefore tightly regulated by nutritional status. To enable this integration of metabolic and reproductive function, information regarding peripheral nutritional status must be relayed centrally to the gonadotropin-releasing hormone (GNRH) neurons that driv...

journal_title：Journal of molecular endocrinology

authors： Evans MC,Anderson GM

更新日期：2017-02-01 00:00:00

abstract：:In the mouse, GH-binding protein (GHBP) and GH receptor (GHR) are encoded by a single gene via alternative splicing. We previously demonstrated that the steady-state levels of the GHR and GHBP mRNAs are significantly elevated in mouse liver during pregnancy. Hepatic GHR and GHBP mRNAs are associated primarily with one...

journal_title：Journal of molecular endocrinology

authors： Ilkbahar YN,Southard JN,Talamantes F

更新日期：1999-08-01 00:00:00

abstract：:Expression of the rat alpha 2u-globulin gene family is regulated in the adult male liver by a number of hormones, including growth hormone, thyroid hormone and several steroids. Upon injection into ovariectomized females, estrogens first induce alpha 2u-globulin expression and then suppress this gene after several day...

journal_title：Journal of molecular endocrinology

authors： Wang KS,Hodgetts RB,Addison WR

更新日期：1998-02-01 00:00:00

abstract：:Obesity is likely to be a multifactorial disease with an important genetic component. Animal models of genetic and experimentally induced obesity suggest that glucocorticoid receptor (GR) activity plays a role in the aetiology and maintenance of the obese state. Glucocorticoid activity appears to be essential for the ...

journal_title：Journal of molecular endocrinology

authors： Weaver JU,Hitman GA,Kopelman PG

更新日期：1992-12-01 00:00:00

abstract：:Gene related to anergy in lymphocytes (GRAIL) is an E3 ubiquitin ligase that regulates energy in T-lymphocytes. Whereas, the relevance of GRAIL to T lymphocyte function is well established, the role of this protein in other cell types remains unknown. Given that GRAIL is abundant in the liver, we investigated the pote...

journal_title：Journal of molecular endocrinology

authors： Nakamichi S,Senga Y,Inoue H,Emi A,Matsuki Y,Watanabe E,Hiramatsu R,Ogawa W,Kasuga M

更新日期：2009-02-01 00:00:00

abstract：:Natriuretic peptides (NPs) have been reported to have critical roles in follicular development and oocyte maturation in rodents. This study aimed to extend our current understanding of NP-mediated signalling pathways and mechanisms of action in the follicles of a monovulatory species. Ovine granulosa cells (GCs) and t...

journal_title：Journal of molecular endocrinology

authors： Alhamdan R,Maalouf W,Campbell BK,Hernandez-Medrano JH,Marsters P

更新日期：2020-05-01 00:00:00

abstract：:In vitro studies have indicated that the maturation-inducing hormone 17α,20β-dihydroxy-4-pregnen-3-one (17α,20β-DP, DHP), probably through nuclear progestin receptor (Pgr), might be involved in the proliferation of spermatogonial cells and the initiation of meiosis in several fish species. However, further in vivo evi...

journal_title：Journal of molecular endocrinology

authors： Liu G,Luo F,Song Q,Wu L,Qiu Y,Shi H,Wang D,Zhou L

更新日期：2014-08-01 00:00:00

abstract：:Receptive endometrium is a prerequisite for successful embryo implantation, and it follows that poor endometrial receptivity is a leading cause of implantation failure. miRNAs play important roles as epigenetic regulators of endometrial receptivity and embryo implantation through post-transcriptional modifications. Ho...

journal_title：Journal of molecular endocrinology

authors： Akbar R,Ullah K,Rahman TU,Cheng Y,Pang HY,Jin LY,Wang QJ,Huang HF,Sheng JZ

更新日期：2020-01-01 00:00:00

abstract：:Studies have demonstrated that heat shock is associated with alteration in energy metabolism. In this study, we investigated the effect of heat shock on gene expression and secretion of adiponectin and leptin, and gene expression of Hspa2 and Ppargamma in 3T3-L1 adipocytes. Compared with 37 degrees C, adiponectin mRNA...

journal_title：Journal of molecular endocrinology

authors： Bernabucci U,Basiricò L,Morera P,Lacetera N,Ronchi B,Nardone A

更新日期：2009-02-01 00:00:00

abstract：:Somatostatins (SSs) play important roles in the growth, development and metabolism of vertebrates. In this study, cDNAs for two unique somatostatin receptor variants were cloned and sequenced from rainbow trout. The two cDNAs, one consisting of 1755 bp and the other of 1743 bp, share 63.6% identity in nucleotide seque...

journal_title：Journal of molecular endocrinology

authors： Slagter BJ,Sheridan MA

更新日期：2004-02-01 00:00:00

abstract：:We have previously shown that arginine vasopressin (AVP) stimulates the production of aldosterone in isolated superfused adrenal glomerulosa cells by a mechanism that involves an increased turnover of phosphoinositides. In the present study we compared the characteristics of AVP- and angiotensin II (AII)-induced chang...

journal_title：Journal of molecular endocrinology

authors： Enyedi P,Balla T,Antoni FA,Spät A

更新日期：1988-09-01 00:00:00

abstract：:GPRC6A is a seven-transmembrane receptor mediating signaling by a wide range of L-alpha-amino acids, a signaling augmented by the divalent cations Ca(2)(+) and Mg(2)(+). GPRC6A transcripts are detected in numerous mammalian tissues, but the physiological role of the receptor is thus far elusive. Analogously to the clo...

journal_title：Journal of molecular endocrinology

authors： Wellendorph P,Johansen LD,Jensen AA,Casanova E,Gassmann M,Deprez P,Clément-Lacroix P,Bettler B,Bräuner-Osborne H

更新日期：2009-03-01 00:00:00

abstract：:Insulin is important for optimal fetal and neonatal growth and development. Its continued availability is due, in part, to ongoing islet cell growth within the pancreas. IGFs and IGF-binding proteins (IGFBPs) have been implicated as paracrine regulators of islet cell growth within the developing pancreas. The purpose ...

journal_title：Journal of molecular endocrinology

authors： Hogg J,Hill DJ,Han VK

更新日期：1994-08-01 00:00:00

abstract：:The aim of our studies was to examine whether IGF-binding protein (IGFBP)-4 is involved in the control of the secretion of various ovarian substances and also the mediation of the effects of several hormones and growth factors on this secretion. For this purpose, we carried out the transfection of porcine granulosa ce...

journal_title：Journal of molecular endocrinology

authors： Sirotkin AV,Makarevich AV,Corkins MR,Kotwica J,Bulla J

更新日期：2001-06-01 00:00:00

abstract：:Non-steroidal antioestrogens, such as tamoxifen, inhibit the growth of human breast cancer cells. The experiments described here compare and contrast the efficacy of tamoxifen and the 'pure' antioestrogen, ICI 164384, on the inhibition of proliferation of MCF-7 cells. Previous studies have shown that ICI 164384 has a ...

journal_title：Journal of molecular endocrinology

authors： Wakeling AE,Newboult E,Peters SW

更新日期：1989-05-01 00:00:00

abstract：:Both 17beta-estradiol and prolactin play important roles in the mammary gland, raising the possibility of functional cross-talk between the two signaling pathways. Here, we demonstrate that estrogen receptor-alpha (ERalpha) and -beta (ERbeta) are both able to potentiate transcription from a Stat5-responsive promoter w...

journal_title：Journal of molecular endocrinology

authors： Björnström L,Kilic E,Norman M,Parker MG,Sjöberg M

更新日期：2001-08-01 00:00:00