Acute anorexigenic action of leptin in rainbow trout is mediated by the hypothalamic Pi3k pathway.

abstract：:The hormone human chorionic gonadotrophin (hCG) shows extensive sequence homology with LH. Thus, many of the antigenic epitopes on hCG are shared with LH, leading to immunological cross-reaction between these two hormones. Anti-fertility and anti-cancer vaccines based upon hCG should ideally target only the hCG-specif...

journal_title：Journal of molecular endocrinology

authors： Charrel-Dennis M,Jackson AM,Lund T,Lapthorn AJ,Berger P,Roitt IM,Delves PJ

更新日期：2004-04-01 00:00:00

abstract：:Reproductive hormone imbalance in infertile women is correlated to high levels of phthalates and alkylphenols, which are among endocrine-disrupting chemicals (EDCs). Previous studies have shown that they interfere with gene expression by deregulating levels of microRNAs (miRs), small non-coding RNAs targeting mRNAs en...

journal_title：Journal of molecular endocrinology

authors： Patiño-García D,Cruz-Fernandes L,Buñay J,Orellana R,Moreno RD

更新日期：2020-11-01 00:00:00

abstract：:Orexin-A and -B are known to stimulate food intake in mammals. However, the critical roles of orexins in birds are not fully understood, since orexins have no stimulatory effect on food intake in the chicken. To understand the physiological role(s) of orexins in birds, we have cloned chicken orexin receptor (cOXR) cDN...

journal_title：Journal of molecular endocrinology

authors： Ohkubo T,Tsukada A,Shamoto K

更新日期：2003-12-01 00:00:00

abstract：:In contrast to the classical model describing the synthesis of androgens and estrogens as restricted to somatic cells, a previous study demonstrated that Xenopus laevis oocytes participate in androgen synthesis. The objective of our study was to determine whether Xenopus oocytes are also involved in estrogen synthesis...

journal_title：Journal of molecular endocrinology

authors： Gohin M,Bodinier P,Fostier A,Bobe J,Chesnel F

更新日期：2011-09-07 00:00:00

abstract：:Gastroenteropancreatic neuroendocrine tumors (GEP NETs) comprise a heterogenous and diverse group of neoplasms arising from a common neuroendocrine cell origin. The majority of these tumors occur sporadically while ~20% manifest within the context of hereditary syndromes. Germline MEN1 mutations cause a syndrome with ...

journal_title：Journal of molecular endocrinology

authors： Lee ME,Tepede AA,Mandl A,Weinstein LS,Del Rivero J,Agarwal SK,Blau JE

更新日期：2020-08-01 00:00:00

abstract：:Leptin is a cytokine secreted from adipose tissue at a rate commensurate with the size of the body's fat stores. In addition to its anorectic and thermogenic central actions, leptin is known to act on peripheral tissues, including the pancreatic beta-cell where it inhibits insulin secretion and reduces insulin transcr...

journal_title：Journal of molecular endocrinology

authors： Morton NM,Emilsson V,de Groot P,Pallett AL,Cawthorne MA

更新日期：1999-04-01 00:00:00

abstract：:Obesity is likely to be a multifactorial disease with an important genetic component. Animal models of genetic and experimentally induced obesity suggest that glucocorticoid receptor (GR) activity plays a role in the aetiology and maintenance of the obese state. Glucocorticoid activity appears to be essential for the ...

journal_title：Journal of molecular endocrinology

authors： Weaver JU,Hitman GA,Kopelman PG

更新日期：1992-12-01 00:00:00

abstract：:The major mission of the ovarian follicle is the timely production of the mature fertilizable oocyte, and this is achieved by gonadotropin-regulated, gap junction-mediated cell-cell communication between the oocyte and surrounding nurturing granulosa cells. We have demonstrated that FSH and transforming growth factor ...

journal_title：Journal of molecular endocrinology

authors： Fang WL,Lai SY,Lai WA,Lee MT,Liao CF,Ke FC,Hwang JJ

更新日期：2015-12-01 00:00:00

abstract：:Cellular changes that affect the androgen receptor (AR) can cause prostate cancer to transition from androgen dependent to androgen independent, which is usually lethal. One common change in prostate tumors is overexpression of the AR, which has been shown to lead to androgen-independent growth of prostate cancer cell...

journal_title：Journal of molecular endocrinology

authors： Hsieh CL,Cai C,Giwa A,Bivins A,Chen SY,Sabry D,Govardhan K,Shemshedini L

更新日期：2008-07-01 00:00:00

abstract：:We have previously shown that arginine vasopressin (AVP) stimulates the production of aldosterone in isolated superfused adrenal glomerulosa cells by a mechanism that involves an increased turnover of phosphoinositides. In the present study we compared the characteristics of AVP- and angiotensin II (AII)-induced chang...

journal_title：Journal of molecular endocrinology

authors： Enyedi P,Balla T,Antoni FA,Spät A

更新日期：1988-09-01 00:00:00

abstract：:In vertebrates, sex is determined essentially by two means, genetic factors located on sex chromosomes and epigenetic factors such as temperature experienced by the individual during development. Steroids, especially estrogens, are clearly involved in gonadal differentiation in non-mammalian vertebrates. In this regar...

journal_title：Journal of molecular endocrinology

authors： Kuntz S,Chesnel A,Flament S,Chardard D

更新日期：2004-12-01 00:00:00

abstract：:Screening by differential display of oestrogen-sensitive MCF7 human breast cancer cells grown in the short-term (6 days) and long-term (70 weeks) absence of oestrogen has led to the identification of a new oestrogen-regulated mRNA. The cDNA isolated by differential display has 100% homology from nucleotides 615 to 859...

journal_title：Journal of molecular endocrinology

authors： Stephen R,Corcoran D,Darbre PD

更新日期：1998-06-01 00:00:00

abstract：:Insulin-regulated aminopeptidase (IRAP, EC 3.4.11.3) in adipocytes is well known to traffic between high (HDM) and low (LDM) density microsomal fractions toward the plasma membrane (MF) under stimulation by insulin. However, its catalytic preference for aminoacyl substrates with N-terminal Leu or Cys is controversial....

journal_title：Journal of molecular endocrinology

authors： Alponti RF,Viana LG,Yamanouye N,Silveira PF

更新日期：2015-08-01 00:00:00

abstract：:Human thyroid hormone receptor (c-erb A protein) produced by Escherichia coli expression vector plasmid was purified sequentially using polyethylenimine precipitation of DNA, hydroxylapatite column chromatography, ammonium sulphate precipitation, Sephacryl S-300 gel filtration and mono Q-Sepharose column chromatograph...

journal_title：Journal of molecular endocrinology

authors： Ichikawa K,Hashizume K,Nishii Y,Takeda T,Kobayashi M,Suzuki S,Yamada T

更新日期：1991-10-01 00:00:00

abstract：:MicroRNAs are endogenous, conserved, and non-coding small RNAs that function as post-transcriptional regulators of fat development and adipogenesis. Adipogenic marker genes, such as CCAAT/enhancer binding protein α (Cebpa), peroxisome proliferator-activated receptor γ (Pparg), adipocyte fatty acid binding protein (Ap2...

journal_title：Journal of molecular endocrinology

authors： Chen C,Peng Y,Peng Y,Peng J,Jiang S

更新日期：2014-06-01 00:00:00

abstract：:Tumor malignancy is associated with the epithelial-mesenchymal transition (EMT) process and resistance to chemotherapy. However, little is known about the relationship between the EMT and the multidrug-resistance gene in thyroid tumor progression. We investigated whether the expression of the ABCG2/BCRP gene is associ...

journal_title：Journal of molecular endocrinology

authors： Mato E,González C,Moral A,Pérez JI,Bell O,Lerma E,de Leiva A

更新日期：2014-04-28 00:00:00

abstract：:Bisphenol A (BPA) is a xenobiotic endocrine-disrupting chemical. In vitro and in vivo studies have indicated that BPA alters endocrine-metabolic pathways in adipose tissue, which increases the risk of metabolic disorders and obesity. BPA can affect adipose tissue and increase fat cell numbers or sizes by regulating th...

journal_title：Journal of molecular endocrinology

authors： Menale C,Piccolo MT,Cirillo G,Calogero RA,Papparella A,Mita L,Del Giudice EM,Diano N,Crispi S,Mita DG

更新日期：2015-06-01 00:00:00

abstract：:The interaction between human papillomaviruses (HPV) and the apolipoprotein-B mRNA-editing catalytic polypeptide-like (APOBEC)3 (A3) genes has garnered increasing attention in recent years, with considerable efforts focused on understanding their apparent roles in both viral editing and in HPV-driven carcinogenesis. H...

journal_title：Journal of molecular endocrinology

authors： Smith NJ,Fenton TR

更新日期：2019-05-01 00:00:00

abstract：:The constitutive expression of 25-hydroxyvitamin D3-24-hydroxylase (25-(OH)D3-24-hydroxylase) activity has been studied in an adherent variant (Ad-HL60) of the human promyelomonocytic leukaemia cell line HL60. The Ad-HL60 cells have a more differentiated phenotype than the non-adherent cells from which they were deriv...

journal_title：Journal of molecular endocrinology

authors： Hayes ME,Bayley D,Mawer EB

更新日期：1991-12-01 00:00:00

abstract：:We have generated hybridomas which secrete monoclonal antibodies to the AT1 subtype of the angiotensin II receptor (AT1 receptor). These were obtained after immunization of Balb C/c mice with synthetic peptides representing sequences from either the extracellular domain (residues 8-17) or the intracellular domain (res...

journal_title：Journal of molecular endocrinology

authors： Barker S,Marchant W,Ho MM,Puddefoot JR,Hinson JP,Clark AJ,Vinson GP

更新日期：1993-10-01 00:00:00

abstract：:We investigated the mechanisms by which corticosteroids regulate the expression of the mineralocorticoid receptor (MR) in neurones. Aldosterone and dexamethasone produced a dose-dependent increase of MR and mRNA levels in cultured primary hippocampal neurones. Transient transfection of neuroblastoma cells showed that ...

journal_title：Journal of molecular endocrinology

authors： Castrén M,Trapp T,Berninger B,Castrén E,Holsboer F

更新日期：1995-06-01 00:00:00

abstract：:Transformation of Escherichia coli cells with a recombinant plasmid containing modified mouse prolactin (mPRL) cDNA and a pKK223-3 vector resulted in efficient expression of mPRL protein. Cloned mPRL cDNA was modified by removing the 5' non-translating sequence as well as the sequence which encoded the signal peptide ...

journal_title：Journal of molecular endocrinology

authors： Yamamoto M,Harigaya T,Ichikawa T,Hoshino K,Nakashima K

更新日期：1992-04-01 00:00:00

abstract：:In the last 15 years, single-cell technologies have become robust and indispensable tools to investigate cell heterogeneity. Beyond transcriptomic, genomic and epigenome analyses, technologies are constantly evolving, in particular toward multi-omics, where analyses of different source materials from a single cell are...

journal_title：Journal of molecular endocrinology

authors： Cheung LYM,Rizzoti K

更新日期：2020-08-01 00:00:00

abstract：:Barrett's oesophagus (BO) and oesophageal adenocarcinoma (OAC) are regarded as complications of gastro-oesophageal reflux disease, although all the factors that contribute to the development of these lesions are unknown. Acid suppressive drugs are widely used for symptomatic therapy of reflux disease but may induce hy...

journal_title：Journal of molecular endocrinology

authors： Beales IL,Ogunwobi OO

更新日期：2009-04-01 00:00:00

abstract：:Soluble guanylyl cyclase is a cytosolic enzyme which catalyzes conversion of GTP to the second messenger cyclic GMP. The transcriptional regulation at the promoter levels of four soluble guanylyl cyclase subunits, termed alpha1, alpha2, beta1, and beta2, is largely unknown. In this study, we identified the transcripti...

journal_title：Journal of molecular endocrinology

authors： Jiang Y,Stojilkovic SS

更新日期：2006-12-01 00:00:00

abstract：:Previous studies have demonstrated that TRH is a potent stimulator of alpha-MSH secretion from frog pituitary melanotrophs. In order to determine the intracellular events responsible for TRH-evoked alpha-MSH release, we have investigated the effect of TRH on polyphosphoinositide breakdown in frog pars intermedia. Neur...

journal_title：Journal of molecular endocrinology

authors： Desrues L,Tonon MC,Vaudry H

更新日期：1990-10-01 00:00:00

abstract：:The two structurally and functionally related peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB) play critical roles in many physiological/pathological processes in mammals. However, the information regarding the expression and functionality of avian NMB, GRP and their receptors is limited. Here, we char...

journal_title：Journal of molecular endocrinology

authors： Mo C,Huang L,Cui L,Lv C,Lin D,Song L,Zhu G,Li J,Wang Y

更新日期：2017-07-01 00:00:00

abstract：:Association between the (AC)(n) dinucleotide repeat polymorphism at the 5'-end of the aldose reductase gene and the occurrence of diabetic nephropathy was conducted. We examined eight studies consisting of ten Caucasian type 1 diabetes mellitus case-control comparisons and eight studies consisting of nine type 2 diabe...

journal_title：Journal of molecular endocrinology

authors： Xu M,Chen X,Yan L,Cheng H,Chen W

更新日期：2008-05-01 00:00:00

abstract：:Hypogonadal (hpg) mutant mice, with a congenital deficiency of hypothalamic gonadotrophin-releasing hormone (GnRH), and testicular feminized (tfm) mice, which lack a functional androgen receptor, were used to study the effects of the potent GnRH agonist 'Zoladex' (ICI 118630; D-Ser (Bu(t))6, Azgly10-GnRH) on pituitary...

journal_title：Journal of molecular endocrinology

authors： Scott IS,Bennett MK,Porter-Goff AE,Harrison CJ,Cox BS,Grocock CA,O'Shaughnessy PJ,Clayton RN,Craven R,Furr BJ

更新日期：1992-06-01 00:00:00

abstract：:Estrogens are essential for female reproduction and overall well-being, and estrogens in the circulation are largely synthesized in ovarian granulosa cells. Using primary cultures of ovarian granulosa cells from gonadotropin-primed immature rats, we have recently discovered that pituitary FSH and ovarian cytokine tran...

journal_title：Journal of molecular endocrinology

authors： Lai WA,Yeh YT,Fang WL,Wu LS,Harada N,Wang PH,Ke FC,Lee WL,Hwang JJ

更新日期：2014-10-01 00:00:00