A novel oestrogen-regulated gene in human breast cancer cells identified by differential display.

abstract：:FSH acts through the Sertoli cell to ensure normal testicular development and function. To identify transcriptional mechanisms through which FSH acts in the testis, we have treated gonadotrophin-deficient hypogonadal (hpg) mice with recombinant FSH and measured changes in testicular transcript levels using microarrays...

journal_title：Journal of molecular endocrinology

authors： Abel MH,Baban D,Lee S,Charlton HM,O'Shaughnessy PJ

更新日期：2009-04-01 00:00:00

abstract：:Protein kinase C (PKC) has been identified in islets of Langerhans and insulin-secreting tumour cells. Diacylglycerols (DAGs, the endogenous PKC activators) are generated in response to insulin secretagogues, although nutrient and non-nutrient secretagogues generate DAGs of different compositions and of different pote...

journal_title：Journal of molecular endocrinology

authors： Jones PM,Persaud SJ,Howell SL

更新日期：1991-04-01 00:00:00

abstract：:A prolactin cDNA was cloned from a cDNA expression library constructed from total RNA of bullfrog (Rana catesbeiana) adenohypophyses by immunoscreening with antiserum against bullfrog prolactin. The cDNA clone thus obtained contained a 249 bp insert. Using this clone as a probe, plaque hybridizations were performed an...

journal_title：Journal of molecular endocrinology

authors： Takahashi N,Yoshihama K,Kikuyama S,Yamamoto K,Wakabayashi K,Kato Y

更新日期：1990-12-01 00:00:00

abstract：:Urocortin (Ucn1), a member of the corticotrophin-releasing hormone (CRH) family, has been reported to participate in inflammation. The increased expression of intercellular adhesion molecule 1 (ICAM1) plays important roles in inflammation and immune responses. Our previous results demonstrated that Ucn1 significantly ...

journal_title：Journal of molecular endocrinology

authors： Wan R,Liu Y,Li L,Zhu C,Jin L,Li S

更新日期：2013-12-20 00:00:00

abstract：:Luteotropic glycoprotein hormones (LGH) include luteinizing hormone (LH) and chorionic gonadotropin (CG). The order Primates is the only phylogenetic clad known to exhibit more than one LGHbeta subunit gene per haploid genome. In the present study, we report the discovery of a second case of LGHbeta gene replication, ...

journal_title：Journal of molecular endocrinology

authors： Lund LA,Sherman GB

更新日期：1998-08-01 00:00:00

abstract：:Sexual dimorphism has been found in both mitochondrial functionality and adiponectin expression in white adipose tissue, with female rats presenting more functional mitochondria than males and greater adiponectin expression. However, little is known about the role of sex hormones in this dimorphism. The aim was to elu...

journal_title：Journal of molecular endocrinology

authors： Capllonch-Amer G,Lladó I,Proenza AM,García-Palmer FJ,Gianotti M

更新日期：2014-03-06 00:00:00

abstract：:Unliganded thyroid hormone receptors (apoTRs) repress transcription of hormone-activated genes by recruiting corepressors to the promoters. In contrast, on promoters containing so-called negative thyroid hormone response elements (nTREs), apoTRs activate transcription. A number of different molecular mechanisms have b...

journal_title：Journal of molecular endocrinology

authors： Nygård M,Becker N,Demeneix B,Pettersson K,Bondesson M

更新日期：2006-06-01 00:00:00

abstract：:Parathyroid hormone (PTH) is secreted by the chief cells of the parathyroid gland in response to changes in ionized calcium (Ca(2+)) concentrations. In this study, we measured PTH secretion, and PTH mRNA and calcium-sensing receptor (CaR) mRNA expression by equine parathyroid chief cells in vitro. We also evaluated th...

journal_title：Journal of molecular endocrinology

authors： Toribio RE,Kohn CW,Capen CC,Rosol TJ

更新日期：2003-12-01 00:00:00

abstract：:The somatostatin receptor subtype 2 (sst2) mediates inhibition of hormone secretion and cell proliferation, and modulates neurotransmission. Its expression is widespread in various normal tissues and many malignant cells, and is up-regulated by estrogen in breast cancer cells. This study was undertaken to investigate ...

journal_title：Journal of molecular endocrinology

authors： Kimura N,Takamatsu N,Yaoita Y,Osamura RY,Kimura N

更新日期：2008-02-01 00:00:00

abstract：:Unbiased genomic screening analyses have highlighted novel immunomodulatory properties of the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D). However, clearer interpretation of the resulting gene expression data is limited by cell model specificity. The aim of the current study was to provide a broader...

journal_title：Journal of molecular endocrinology

authors： Muñoz Garcia A,Kutmon M,Eijssen L,Hewison M,Evelo CT,Coort SL

更新日期：2018-02-01 00:00:00

abstract：:Most pro-neuropeptides are processed by the prohormone convertases, PC1 and PC2. We previously reported that changes in thyroid status altered anterior pituitary PC1 mRNA and this regulation was due to triiodothyronine (T(3))-dependent interaction of thyroid hormone receptor (TR) with negative thyroid hormone response...

journal_title：Journal of molecular endocrinology

authors： Shen X,Li QL,Brent GA,Friedman TC

更新日期：2004-08-01 00:00:00

abstract：:GPRC6A is a seven-transmembrane receptor mediating signaling by a wide range of L-alpha-amino acids, a signaling augmented by the divalent cations Ca(2)(+) and Mg(2)(+). GPRC6A transcripts are detected in numerous mammalian tissues, but the physiological role of the receptor is thus far elusive. Analogously to the clo...

journal_title：Journal of molecular endocrinology

authors： Wellendorph P,Johansen LD,Jensen AA,Casanova E,Gassmann M,Deprez P,Clément-Lacroix P,Bettler B,Bräuner-Osborne H

更新日期：2009-03-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone that belongs to a subfamily of endocrine FGFs with evolutionarily conserved functions in C. elegans and fruit flies. FAM20C phosphorylates FGF23 post-translationally, targeting to proteolysis through subtilisin-like proprotein convertase FURIN, resulting i...

journal_title：Journal of molecular endocrinology

authors： Ho BB,Bergwitz C

更新日期：2020-12-01 00:00:00

abstract：:Human 3beta-hydroxysteroid dehydrogenase/steroid Delta(5)-Delta(4)-isomerase (3beta-HSD/isomerase) is a bifunctional, single enzyme protein that is membrane-bound in the endoplasmic reticulum (microsomes) and mitochondria of cells in the placenta (type I) and in the adrenals and gonads (type II). Two membrane-binding ...

journal_title：Journal of molecular endocrinology

authors： Thomas JL,Evans BW,Blanco G,Mason JI,Strickler RC

更新日期：1999-10-01 00:00:00

abstract：:Type 2 diabetes is characterized by islet dysfunction resulting in hyperglycemia, which can then lead to further deterioration in islet function. A possible mechanism for hyperglycemia-induced islet dysfunction is the accumulation of advanced glycation end products (AGE). The DBA/2 mouse develops pancreatic islet dysf...

journal_title：Journal of molecular endocrinology

authors： Kooptiwut S,Kebede M,Zraika S,Visinoni S,Aston-Mourney K,Favaloro J,Tikellis C,Thomas MC,Forbes JM,Cooper ME,Dunlop M,Proietto J,Andrikopoulos S

更新日期：2005-08-01 00:00:00

abstract：:Soluble guanylyl cyclase is a cytosolic enzyme which catalyzes conversion of GTP to the second messenger cyclic GMP. The transcriptional regulation at the promoter levels of four soluble guanylyl cyclase subunits, termed alpha1, alpha2, beta1, and beta2, is largely unknown. In this study, we identified the transcripti...

journal_title：Journal of molecular endocrinology

authors： Jiang Y,Stojilkovic SS

更新日期：2006-12-01 00:00:00

abstract：:The aim of our studies was to examine whether IGF-binding protein (IGFBP)-4 is involved in the control of the secretion of various ovarian substances and also the mediation of the effects of several hormones and growth factors on this secretion. For this purpose, we carried out the transfection of porcine granulosa ce...

journal_title：Journal of molecular endocrinology

authors： Sirotkin AV,Makarevich AV,Corkins MR,Kotwica J,Bulla J

更新日期：2001-06-01 00:00:00

abstract：:Several hormone agonists exert their physiological actions by triggering an inositol phospholipid-Ca2+ signalling cascade and cytosolic alkalinization. Although calcium ionophores have been used extensively to probe the role of Ca2+ in the regulation of steroidogenesis in granulosa cells, the precise relationship betw...

journal_title：Journal of molecular endocrinology

authors： Asem EK,Li M,Tsang BK

更新日期：1992-08-01 00:00:00

abstract：:Molecular genetics and other contemporary approaches have contributed to a better understanding of prolactin (PRL) actions at the cellular and organismal levels. In this review, several advances in knowledge of PRL actions are highlighted. Special emphasis is paid to areas of progress with consequences for understandi...

journal_title：Journal of molecular endocrinology

authors： Horseman ND,Gregerson KA

更新日期：2013-12-19 00:00:00

abstract：:Testicular Leydig cells (LC) are modulated by several pathways, one of them being the histaminergic system. Heme oxygenase-1 (HO-1), whose upregulation comprises the primary response to oxidative noxae, has a central homeostatic role and might dysregulate LC functions when induced. In this report, we aimed to determin...

journal_title：Journal of molecular endocrinology

authors： Raices T,Varela ML,Monzón CM,Correa Torrado MF,Pagotto RM,Besio Moreno M,Mondillo C,Pignataro OP,Pereyra EN

更新日期：2019-10-01 00:00:00

abstract：:Activity of acetyl-CoA carboxylase (ACC)-alpha is rate limiting for de novo synthesis of fatty acids. The encoding gene is expressed by three different promoters. We characterized promoter III (PIII) from cow, previously only known from sheep. Quantitation of transcripts by RNAse protection assays and real time PCR re...

journal_title：Journal of molecular endocrinology

authors： Mao J,Molenaar AJ,Wheeler TT,Seyfert HM

更新日期：2002-08-01 00:00:00

abstract：:The classical concept of the renin-angiotensin system (RAS) is that of a blood-borne cascade, whose final and bioactive product, angiotensin II, plays an important endocrine role in the maintenance of blood pressure and electrolyte as well as fluid balance. In addition to this circulating RAS, there are an increasing ...

journal_title：Journal of molecular endocrinology

authors： Leung PS,Carlsson PO

更新日期：2001-06-01 00:00:00

abstract：:Pancreatic beta-cells are responsible for producing all of the insulin required by an organism to maintain glucose homeostasis. Defects in development, maintenance, or expansion of beta-cell mass can result in impaired glucose metabolism and diabetes. Thus, identifying the molecular regulators of these processes may p...

journal_title：Journal of molecular endocrinology

authors： Ackermann AM,Gannon M

更新日期：2007-02-01 00:00:00

abstract：:Eight amino acids are considered essential for human nutrition, and three of them, including leucine, isoleucine and valine, are called as branched-chain amino acids (BCAAs). We recently discovered that dietary deficiency of any BCAA for 7 days rapidly reduces the abdominal fat mass in mice. The goal of this study was...

journal_title：Journal of molecular endocrinology

authors： Xiao F,Du Y,Lv Z,Chen S,Zhu J,Sheng H,Guo F

更新日期：2016-11-01 00:00:00

abstract：:The two structurally and functionally related peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB) play critical roles in many physiological/pathological processes in mammals. However, the information regarding the expression and functionality of avian NMB, GRP and their receptors is limited. Here, we char...

journal_title：Journal of molecular endocrinology

authors： Mo C,Huang L,Cui L,Lv C,Lin D,Song L,Zhu G,Li J,Wang Y

更新日期：2017-07-01 00:00:00

abstract：:Insulin-regulated aminopeptidase (IRAP, EC 3.4.11.3) in adipocytes is well known to traffic between high (HDM) and low (LDM) density microsomal fractions toward the plasma membrane (MF) under stimulation by insulin. However, its catalytic preference for aminoacyl substrates with N-terminal Leu or Cys is controversial....

journal_title：Journal of molecular endocrinology

authors： Alponti RF,Viana LG,Yamanouye N,Silveira PF

更新日期：2015-08-01 00:00:00

abstract：:A number of enzymes possessing 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (17HSD/KSR) activities have been described and cloned, but their nomenclature needs specification. To clarify the present situation, descriptions of the eight cloned 17HSD/KSRs are given and guidelines for the classification of...

journal_title：Journal of molecular endocrinology

authors： Peltoketo H,Luu-The V,Simard J,Adamski J

更新日期：1999-08-01 00:00:00

abstract：:A subset of over-expressed microRNAs (miRNAs) identified in parathyroid carcinomas (Ca) compared to normal glands belongs to C19MC, a cluster on chromosome 19q13.4 involved in stem cell biology and tumourigenesis. In this study, the expression of C19MC-MIR371-3 clusters and the molecular mechanisms presiding their mod...

journal_title：Journal of molecular endocrinology

authors： Vaira V,Elli F,Forno I,Guarnieri V,Verdelli C,Ferrero S,Scillitani A,Vicentini L,Cetani F,Mantovani G,Spada A,Bosari S,Corbetta S

更新日期：2012-07-26 00:00:00

abstract：:The crystal structures of the leucine-rich repeat domain (LRD) of the FSH receptor (FSHR) in complex with FSH and the TSH receptor (TSHR) LRD in complex with the thyroid-stimulating autoantibody (M22) provide opportunities to assess the molecular basis of the specificity of glycoprotein hormone-receptor binding. A com...

journal_title：Journal of molecular endocrinology

authors： Núñez Miguel R,Sanders J,Chirgadze DY,Blundell TL,Furmaniak J,Rees Smith B

更新日期：2008-09-01 00:00:00

abstract：:Basal and thyroid hormone-regulated expression of constructs containing varying lengths of 5' flanking sequence of the human glycoprotein hormone alpha subunit gene ligated to the reporter gene encoding chloramphenicol acetyl transferase (CAT) were examined in transfected pituitary GH3 cells. CAT gene expression was q...

journal_title：Journal of molecular endocrinology

authors： Balfour NJ,Franklyn JA,Gurr JA,Sheppard MC

更新日期：1990-04-01 00:00:00