Calcium ionophores increase intracellular pH in chicken granulosa cells.

abstract：:Reproductive hormone imbalance in infertile women is correlated to high levels of phthalates and alkylphenols, which are among endocrine-disrupting chemicals (EDCs). Previous studies have shown that they interfere with gene expression by deregulating levels of microRNAs (miRs), small non-coding RNAs targeting mRNAs en...

journal_title：Journal of molecular endocrinology

authors： Patiño-García D,Cruz-Fernandes L,Buñay J,Orellana R,Moreno RD

更新日期：2020-11-01 00:00:00

abstract：:Studies have demonstrated that heat shock is associated with alteration in energy metabolism. In this study, we investigated the effect of heat shock on gene expression and secretion of adiponectin and leptin, and gene expression of Hspa2 and Ppargamma in 3T3-L1 adipocytes. Compared with 37 degrees C, adiponectin mRNA...

journal_title：Journal of molecular endocrinology

authors： Bernabucci U,Basiricò L,Morera P,Lacetera N,Ronchi B,Nardone A

更新日期：2009-02-01 00:00:00

abstract：:Nuclear receptors (NRs) have been targets of intensive drug development for decades due to their roles as key regulators of multiple developmental, physiological and disease processes. In breast cancer, expression of the estrogen and progesterone receptor remains clinically important in predicting prognosis and determ...

journal_title：Journal of molecular endocrinology

authors： Doan TB,Graham JD,Clarke CL

更新日期：2017-04-01 00:00:00

abstract：:Glucocorticoid and androgen receptors have been shown to function through the same palindromic glucocorticoid response element (GRE) and yet have differential effects on gene transcription. In this study, we examined the functional and structural relationship of the androgen and glucocorticoid receptors with the andro...

journal_title：Journal of molecular endocrinology

authors： Kasper S,Rennie PS,Bruchovsky N,Lin L,Cheng H,Snoek R,Dahlman-Wright K,Gustafsson JA,Shiu RP,Sheppard PC,Matusik RJ

更新日期：1999-06-01 00:00:00

abstract：:Hypogonadal (hpg) mutant mice, with a congenital deficiency of hypothalamic gonadotrophin-releasing hormone (GnRH), and testicular feminized (tfm) mice, which lack a functional androgen receptor, were used to study the effects of the potent GnRH agonist 'Zoladex' (ICI 118630; D-Ser (Bu(t))6, Azgly10-GnRH) on pituitary...

journal_title：Journal of molecular endocrinology

authors： Scott IS,Bennett MK,Porter-Goff AE,Harrison CJ,Cox BS,Grocock CA,O'Shaughnessy PJ,Clayton RN,Craven R,Furr BJ

更新日期：1992-06-01 00:00:00

abstract：:The biologically active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (VD3), exerts its tissue-specific actions through binding to its intracellular vitamin D receptor (VDR) which functions as a heterodimer with retinoid X receptor (RXR) to recognize vitamin D response elements (VDRE) and activate target genes. Up...

journal_title：Journal of molecular endocrinology

authors： Tsoumpra MK,Sawatsubashi S,Imamura M,Fukumoto S,Takeda S,Matsumoto T,Aoki Y

更新日期：2020-04-01 00:00:00

abstract：:Corticotrophin-releasing hormone (CRH) has been identified in several peripheral tissues, including the female reproductive organs. CRH is expressed in the placenta, myometrium, epithelial endometrium and the endometrial stromal cells at all phases of the menstrual cycle. Similarly, CRH receptors are present in pregna...

journal_title：Journal of molecular endocrinology

authors： Karteris E,Papadopoulou N,Grammatopoulos DK,Hillhouse EW

更新日期：2004-02-01 00:00:00

abstract：:Parathyroid hormone (PTH) is secreted by the chief cells of the parathyroid gland in response to changes in ionized calcium (Ca(2+)) concentrations. In this study, we measured PTH secretion, and PTH mRNA and calcium-sensing receptor (CaR) mRNA expression by equine parathyroid chief cells in vitro. We also evaluated th...

journal_title：Journal of molecular endocrinology

authors： Toribio RE,Kohn CW,Capen CC,Rosol TJ

更新日期：2003-12-01 00:00:00

abstract：:Somatostatins (SSs) play important roles in the growth, development and metabolism of vertebrates. In this study, cDNAs for two unique somatostatin receptor variants were cloned and sequenced from rainbow trout. The two cDNAs, one consisting of 1755 bp and the other of 1743 bp, share 63.6% identity in nucleotide seque...

journal_title：Journal of molecular endocrinology

authors： Slagter BJ,Sheridan MA

更新日期：2004-02-01 00:00:00

abstract：:Enhanced inflammation and reduced apoptosis sustain the growth of endometriotic lesions. Alterations in the expression of estrogen receptor-alpha (ERα) and estrogen receptor-beta (ERβ) accompany the conversion of resident endometrial cells within the normal uterine environment to ectopic lesions located in extrauterin...

journal_title：Journal of molecular endocrinology

authors： Simmen RC,Kelley AS

更新日期：2016-08-01 00:00:00

abstract：:The neurohypophysial nonapeptides vasotocin (VT) and mesotocin (MT) are the amphibian counterparts of arginine vasopressin (AVP) and oxytocin (OT). We have here reported the cloning and functional characterization of the receptors for vasotocin (VTR) and mesotocin (MTR) in two species of frog, Rana catesbeiana and Ran...

journal_title：Journal of molecular endocrinology

authors： Acharjee S,Do-Rego JL,Oh DY,Moon JS,Ahn RS,Lee K,Bai DG,Vaudry H,Kwon HB,Seong JY

更新日期：2004-08-01 00:00:00

abstract：:The p160 coactivators, steroid receptor coactivator-1 (SRC-1), transcriptional intermediary factor-2 (TIF2) and receptor-associated coactivator-3 (RAC3), as well as the coactivator/integrator CBP, mediate estrogen receptor-alpha (ERalpha)-dependent gene expression. Although these coactivators are widely expressed, ERa...

journal_title：Journal of molecular endocrinology

authors： Jaber BM,Mukopadhyay R,Smith CL

更新日期：2004-02-01 00:00:00

abstract：:Parathyroid hormone (PTH), a powerful bone-resorbing agent, is capable of stimulating interstitial collagenase (MMP-13) mRNA production in osteoblastic cells. In this study, a PEA3 consensus binding sequence (-80; AGGAAGT) in addition to a 'TRE-like' sequence (-89; CGACTCA) in the 5' upstream regulatory region of the ...

journal_title：Journal of molecular endocrinology

authors： Quinn CO,Rajakumar RA,Agapova OA

更新日期：2000-08-01 00:00:00

abstract：:Obesity is likely to be a multifactorial disease with an important genetic component. Animal models of genetic and experimentally induced obesity suggest that glucocorticoid receptor (GR) activity plays a role in the aetiology and maintenance of the obese state. Glucocorticoid activity appears to be essential for the ...

journal_title：Journal of molecular endocrinology

authors： Weaver JU,Hitman GA,Kopelman PG

更新日期：1992-12-01 00:00:00

abstract：:The genetic predisposition of the host and the virus is the most important determinant for prediction of the course of human immunodeficiency virus type I (HIV-1) viral infection and acquired immune deficiency syndrome (AIDS) progression. Transcription from the HIV-1 long terminal repeat (LTR) is a crucial step for vi...

journal_title：Journal of molecular endocrinology

authors： Nevado J,Tenbaum SP,Castillo AI,Sánchez-Pacheco A,Aranda A

更新日期：2007-06-01 00:00:00

abstract：:Successful human embryo implantation requires a proper differentiation of endometrial stromal cells (ESCs) into decidual cells, during a process called decidualization. ESCs express specific molecules, such as prolactin, insulin-like growth factor-binding protein-1 (IGFBP-1) and connexin-43. Decidual cells are also in...

journal_title：Journal of molecular endocrinology

authors： Duval F,Dos Santos E,Moindjie H,Serazin V,Swierkowski-Blanchard N,Vialard F,Dieudonné MN

更新日期：2017-10-01 00:00:00

abstract：:The effects of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3; 10 nmol/l) on the human monomyelocytic cell line U937 were investigated. Addition of 1,25-(OH)2D3 led to a decrease in cell proliferation which fell at 72 h to 67.8 +/- 4.3% (mean +/- S.E.M.) of control values. The presence of CD14, a surface marker found on matur...

journal_title：Journal of molecular endocrinology

authors： Karmali R,Bhalla AK,Farrow SM,Williams MM,Lal S,Lydyard PM,O'Riordan JL

更新日期：1989-07-01 00:00:00

abstract：:The two structurally and functionally related peptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB) play critical roles in many physiological/pathological processes in mammals. However, the information regarding the expression and functionality of avian NMB, GRP and their receptors is limited. Here, we char...

journal_title：Journal of molecular endocrinology

authors： Mo C,Huang L,Cui L,Lv C,Lin D,Song L,Zhu G,Li J,Wang Y

更新日期：2017-07-01 00:00:00

abstract：:The development and growth of prostate cancer is dependent on androgens; thus, the identification of androgen-regulated genes in prostate cancer cells is vital for defining the mechanisms of prostate cancer development and progression and developing new markers and targets for prostate cancer treatment. Glycine N-meth...

journal_title：Journal of molecular endocrinology

authors： Ottaviani S,Brooke GN,O'Hanlon-Brown C,Waxman J,Ali S,Buluwela L

更新日期：2013-11-07 00:00:00

abstract：:Studies were performed to determine whether ARP-1, which is an orphan receptor of the steroid receptor superfamily, inhibits basal activity of the human placental lactogen (hPL) promoter and the increase in hPL promoter activity in response to the receptors for thyroid hormone (TR) and retinoic acid (RAR). Co-transfec...

journal_title：Journal of molecular endocrinology

authors： Stephanou A,Shah M,Richardson B,Handwerger S

更新日期：1996-06-01 00:00:00

abstract：:Esculetin, an antioxidant, has been used in the treatment of a variety of diseases. This study aimed to investigate the protective effect of esculetin in attenuating streptozotocin (STZ)-induced type I diabetic nephropathy and to understand the molecular mechanism involved in it. Sprague-Dawley rats were rendered diab...

journal_title：Journal of molecular endocrinology

authors： Surse VM,Gupta J,Tikoo K

更新日期：2011-06-09 00:00:00

abstract：:The GnRH receptor (GnRHR) is expressed in several non-pituitary tissues, notably in gonads. However, mechanisms underlying the gonad-specific expression of Gnrhr are not well understood. Here, Gnrhr expression was analysed in the developing testes and pituitaries of rats and transgenic mice bearing the human placental...

journal_title：Journal of molecular endocrinology

authors： Ishaq M,Schang AL,Magre S,Laverrière JN,Guillou A,Coudouel N,Wargnier R,Cohen-Tannoudji J,Counis R

更新日期：2013-04-23 00:00:00

abstract：:We used the Crm1 inhibitor leptomycin B (LMB) to examine a possible involvement of nuclear export in estrogen receptor alpha (ER) level and function in MCF-7 breast carcinoma cells. As revealed by immunofluorescence microscopy and western blotting with anti-ER antibodies, LMB produced an accumulation of ER in cell nuc...

journal_title：Journal of molecular endocrinology

authors： Nonclercq D,Journé F,Laïos I,Chaboteaux C,Toillon RA,Leclercq G,Laurent G

更新日期：2007-08-01 00:00:00

abstract：:Differences in binding and structural properties of ovine testicular FSH and LH receptors were investigated. The ovine FSH receptor did not discriminate between FSH of different species, although equine FSH was more reactive. In the same tissue, however, the LH receptor showed marked preference for ovine and bovine LH...

journal_title：Journal of molecular endocrinology

authors： Yarney TA,Sairam MR

更新日期：1991-06-01 00:00:00

abstract：:In vertebrates, sex is determined essentially by two means, genetic factors located on sex chromosomes and epigenetic factors such as temperature experienced by the individual during development. Steroids, especially estrogens, are clearly involved in gonadal differentiation in non-mammalian vertebrates. In this regar...

journal_title：Journal of molecular endocrinology

authors： Kuntz S,Chesnel A,Flament S,Chardard D

更新日期：2004-12-01 00:00:00

abstract：:The mechanisms underlying sex determination and differentiation in fishes are labile in response to environmental parameters. Sex-specific phenotypes are largely regulated by sex steroids, and the inhibition or the stimulation of aromatase can reverse sex as well as alter secondary sexual characteristics in fishes. Am...

journal_title：Journal of molecular endocrinology

authors： Orlando EF,Katsu Y,Miyagawa S,Iguchi T

更新日期：2006-10-01 00:00:00

abstract：:We have analysed the expression of the IGF-I receptor gene in lymphocytes of patients with low levels of circulating IGF-I (four patients with isolated GH deficiency (IGHD) and one Laron-type dwarf (LTD)) in comparison with a control group exhibiting normal serum IGF-I levels and endocrine profiles. 125I-Labelled IGF-...

journal_title：Journal of molecular endocrinology

authors： Eshet R,Werner H,Klinger B,Silbergeld A,Laron Z,LeRoith D,Roberts CT Jr

更新日期：1993-04-01 00:00:00

abstract：:Basal and thyroid hormone-regulated expression of constructs containing varying lengths of 5' flanking sequence of the human glycoprotein hormone alpha subunit gene ligated to the reporter gene encoding chloramphenicol acetyl transferase (CAT) were examined in transfected pituitary GH3 cells. CAT gene expression was q...

journal_title：Journal of molecular endocrinology

authors： Balfour NJ,Franklyn JA,Gurr JA,Sheppard MC

更新日期：1990-04-01 00:00:00

abstract：:We recently reported that genetic deletion of myeloperoxidase (MPO) alleviates obesity-related insulin resistance in mice in vivo. How MPO impairs insulin sensitivity in adipocytes is poorly characterized. As hypochlorous acid (HOCl) is a principal oxidant product generated by MPO, we evaluated the effects of HOCl on ...

journal_title：Journal of molecular endocrinology

authors： Zhou J,Wang Q,Ding Y,Zou MH

更新日期：2015-02-01 00:00:00

abstract：:Barrett's oesophagus (BO) and oesophageal adenocarcinoma (OAC) are regarded as complications of gastro-oesophageal reflux disease, although all the factors that contribute to the development of these lesions are unknown. Acid suppressive drugs are widely used for symptomatic therapy of reflux disease but may induce hy...

journal_title：Journal of molecular endocrinology

authors： Beales IL,Ogunwobi OO

更新日期：2009-04-01 00:00:00