Abstract:
:The somatostatin (SRIF) system, which includes the SRIF ligand and receptors, regulates anterior pituitary gland function, mainly inhibiting hormone secretion and to some extent pituitary tumor cell growth. SRIF-14 via its cognate G-protein-coupled receptors (subtypes 1-5) activates multiple cellular signaling pathways including adenylate cyclase/cAMP, MAPK, ion channel-dependent pathways, and others. In addition, recent data have suggested SRIF-independent constitutive SRIF receptor activity responsible for GH and ACTH inhibition in vitro. This review summarizes current knowledge on ligand-dependent and independent SRIF receptor molecular and functional effects on hormone-secreting cells in the anterior pituitary gland.
journal_name
J Mol Endocrinoljournal_title
Journal of molecular endocrinologyauthors
Eigler T,Ben-Shlomo Adoi
10.1530/JME-14-0034subject
Has Abstractpub_date
2014-08-01 00:00:00pages
R1-19issue
1eissn
0952-5041issn
1479-6813pii
JME-14-0034journal_volume
53pub_type
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