Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets.

abstract：:The neurohypophysial nonapeptides vasotocin (VT) and mesotocin (MT) are the amphibian counterparts of arginine vasopressin (AVP) and oxytocin (OT). We have here reported the cloning and functional characterization of the receptors for vasotocin (VTR) and mesotocin (MTR) in two species of frog, Rana catesbeiana and Ran...

journal_title：Journal of molecular endocrinology

authors： Acharjee S,Do-Rego JL,Oh DY,Moon JS,Ahn RS,Lee K,Bai DG,Vaudry H,Kwon HB,Seong JY

更新日期：2004-08-01 00:00:00

abstract：:Corticotrophin-releasing hormone (CRH) has been identified in several peripheral tissues, including the female reproductive organs. CRH is expressed in the placenta, myometrium, epithelial endometrium and the endometrial stromal cells at all phases of the menstrual cycle. Similarly, CRH receptors are present in pregna...

journal_title：Journal of molecular endocrinology

authors： Karteris E,Papadopoulou N,Grammatopoulos DK,Hillhouse EW

更新日期：2004-02-01 00:00:00

abstract：:The hyperglycaemia-inducing sulphonamide diazoxide has been previously shown to mediate its effects upon insulin secretion by opening K+ channels and hyperpolarizing the beta-cell membrane. The target site has been characterized as the ATP-regulated K+ (K+ATP) channel protein. In the present study, a detailed investig...

journal_title：Journal of molecular endocrinology

authors： Jaggar JH,Harding EA,Ayton BJ,Dunne MJ

更新日期：1993-02-01 00:00:00

abstract：:The type 1 form of 17beta-hydroxysteroid dehydrogenase (17betaHSD1) was the first isoform to be identified and is capable of converting estrone to 17beta-estradiol. This study was aimed at characterizing the molecular structure of the equine 17betaHSD1 gene and cDNA, as well as its molecular regulation during human ch...

journal_title：Journal of molecular endocrinology

authors： Brown KA,Sayasith K,Bouchard N,Lussier JG,Sirois J

更新日期：2007-02-01 00:00:00

abstract：:MicroRNAs are endogenous, conserved, and non-coding small RNAs that function as post-transcriptional regulators of fat development and adipogenesis. Adipogenic marker genes, such as CCAAT/enhancer binding protein α (Cebpa), peroxisome proliferator-activated receptor γ (Pparg), adipocyte fatty acid binding protein (Ap2...

journal_title：Journal of molecular endocrinology

authors： Chen C,Peng Y,Peng Y,Peng J,Jiang S

更新日期：2014-06-01 00:00:00

abstract：:Impaired insulin action has been associated with diabetes, dyslipidemia and atherosclerotic vascular disease. The expression of insulin resistance results from the interaction of environmental and genetic factors. Human hepatic lipase (HL) is a lipolytic enzyme that plays a role in the metabolism of several lipoprotei...

journal_title：Journal of molecular endocrinology

authors： Gómez P,Pérez-Jiménez F,Marín C,Moreno JA,Gómez MJ,Bellido C,Pérez-Martínez P,Fuentes F,Paniagua JA,López-Miranda J

更新日期：2005-04-01 00:00:00

abstract：:Pancreatic beta-cells are responsible for producing all of the insulin required by an organism to maintain glucose homeostasis. Defects in development, maintenance, or expansion of beta-cell mass can result in impaired glucose metabolism and diabetes. Thus, identifying the molecular regulators of these processes may p...

journal_title：Journal of molecular endocrinology

authors： Ackermann AM,Gannon M

更新日期：2007-02-01 00:00:00

abstract：:In this study we examine changes in the cellular properties of FRTL-5 cells as a function of passage number, with particular emphasis on gap junction expression, karyotype, morphology, growth rate and thyroxine (T(4)) release. Early passage FRTL-5 follicular cells transfer dye through gap junctions from injected cell(...

journal_title：Journal of molecular endocrinology

authors： Green LM,Murray DK,Tran DT,Nelson GA,Shah MM,Luben RA

更新日期：2001-10-01 00:00:00

abstract：:This study aimed to determine whether and how the glucagon-like peptide 1 receptor (GLP-1R) agonist liraglutide affects the chemoresistance and chemosensitivity of pancreatic cancer cells to gemcitabine in vitro and in vivo. The GLP-1R and protein kinase A (PKA) levels were compared between the human pancreatic cancer...

journal_title：Journal of molecular endocrinology

authors： Zhao HJ,Jiang X,Hu LJ,Yang L,Deng LD,Wang YP,Ren ZP

更新日期：2020-02-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor (PPAR) is a member of the steroid hormone receptor superfamily and is activated by a variety of fibrate hypolipidaemic drugs and non-genotoxic rodent hepatocarcinogens that are collectively termed peroxisome proliferators. A key marker of peroxisome proliferator action is...

journal_title：Journal of molecular endocrinology

authors： Issemann I,Prince RA,Tugwood JD,Green S

更新日期：1993-08-01 00:00:00

abstract：:Binding of 125I-labelled arginine vasotocin (AVT) was studied in isolated intact gill cells obtained from eels (Anguilla anguilla) adapted to fresh water (FW) or to sea water (SW). Experiments carried out at 20 degrees C showed maximum and stable binding beyond 10 min of incubation. Specific binding, determined by usi...

journal_title：Journal of molecular endocrinology

authors： Guibbolini ME,Henderson IW,Mosley W,Lahlou B

更新日期：1988-09-01 00:00:00

abstract：:An isolated in-vitro perifused interrenal gland preparation from the dogfish Scyliorhinus canicula was used to study production of quantitatively the major corticosteroid 1 alpha-hydroxycorticosterone (1 alpha-OH-B), measured by radioimmunoassay. Basal secretory rates were 877.1 +/- 145 (S.E.M.) fmol/mg per 15 min (n ...

journal_title：Journal of molecular endocrinology

authors： O'Toole LB,Armour KJ,Decourt C,Hazon N,Lahlou B,Henderson IW

更新日期：1990-08-01 00:00:00

abstract：:Decreased suppressors of cytokine signaling (SOCS) activity in human gestational tissues may play a part in the onset/progression of term labor. Since SOCS proteins negatively regulate cytokine-mediated inflammatory processes, we hypothesized that SOCS proteins are elevated in gestational tissues from spontaneous pret...

journal_title：Journal of molecular endocrinology

authors： Blumenstein M,Keelan JA,Bowen-Shauver JM,Mitchell MD

更新日期：2005-08-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) as well as its receptors is found in mammalian ovary and follicular cells and its function in oocyte meiotic maturation has also been reported in Xenopus, hamster and rat. But the results are controversial and the physiological mechanism of ANP on oocyte maturation is not clear, especi...

journal_title：Journal of molecular endocrinology

authors： Zhang M,Tao Y,Zhou B,Xie H,Wang F,Lei L,Huo L,Sun Q,Xia G

更新日期：2005-04-01 00:00:00

abstract：:In non-mammalian vertebrates, estrogens are key players in ovarian differentiation, but the mechanisms by which they act remain poorly understood. The present study on rainbow trout was designed to investigate whether estrogens trigger the female pathway by activating a group of early female genes (i.e. cyp19a1, foxl2...

journal_title：Journal of molecular endocrinology

authors： Vizziano-Cantonnet D,Baron D,Mahè S,Cauty C,Fostier A,Guiguen Y

更新日期：2008-11-01 00:00:00

abstract：:The genomic structure and transcriptional regulation of the rat apelin receptor (APJR) were analysed by rapid amplification of 5' cDNA ends (5'-RACE), transient expression assays and DNA-protein interaction. Analysis of the 5'-flanking region of a rat genomic clone shows no TATA box, but a putative CAAT box and severa...

journal_title：Journal of molecular endocrinology

authors： O'Carroll AM,Lolait SJ,Howell GM

更新日期：2006-02-01 00:00:00

abstract：:Non-steroidal antioestrogens, such as tamoxifen, inhibit the growth of human breast cancer cells. The experiments described here compare and contrast the efficacy of tamoxifen and the 'pure' antioestrogen, ICI 164384, on the inhibition of proliferation of MCF-7 cells. Previous studies have shown that ICI 164384 has a ...

journal_title：Journal of molecular endocrinology

authors： Wakeling AE,Newboult E,Peters SW

更新日期：1989-05-01 00:00:00

abstract：:Orexin-A and -B are known to stimulate food intake in mammals. However, the critical roles of orexins in birds are not fully understood, since orexins have no stimulatory effect on food intake in the chicken. To understand the physiological role(s) of orexins in birds, we have cloned chicken orexin receptor (cOXR) cDN...

journal_title：Journal of molecular endocrinology

authors： Ohkubo T,Tsukada A,Shamoto K

更新日期：2003-12-01 00:00:00

abstract：:In contrast to the classical model describing the synthesis of androgens and estrogens as restricted to somatic cells, a previous study demonstrated that Xenopus laevis oocytes participate in androgen synthesis. The objective of our study was to determine whether Xenopus oocytes are also involved in estrogen synthesis...

journal_title：Journal of molecular endocrinology

authors： Gohin M,Bodinier P,Fostier A,Bobe J,Chesnel F

更新日期：2011-09-07 00:00:00

abstract：:In vertebrates, sex is determined essentially by two means, genetic factors located on sex chromosomes and epigenetic factors such as temperature experienced by the individual during development. Steroids, especially estrogens, are clearly involved in gonadal differentiation in non-mammalian vertebrates. In this regar...

journal_title：Journal of molecular endocrinology

authors： Kuntz S,Chesnel A,Flament S,Chardard D

更新日期：2004-12-01 00:00:00

abstract：:In the common brushtail possum (Trichosurus vulpecula) lactation lasts for 200 days and consists of two distinct phases. Milk composition changes dramatically between phase 2 and 3, which correspond to early and late lactation respectively (phase 1 corresponds to pregnancy). RNA expression patterns have been establish...

journal_title：Journal of molecular endocrinology

authors： Demmer J,Ross IK,Ginger MR,Piotte CK,Grigor MR

更新日期：1998-02-01 00:00:00

abstract：:The mechanism behind Ca(2)(+) entry into the parathyroid cells has been widely debated, and the molecular identities of the responsible ion channels have not been established yet. In this study, we show that the parathyroid cells lack voltage-operated Ca(2)(+) channels. Passive store depletion by thapsigargin, on the ...

journal_title：Journal of molecular endocrinology

authors： Lu M,Bränström R,Berglund E,Höög A,Björklund P,Westin G,Larsson C,Farnebo LO,Forsberg L

更新日期：2010-05-01 00:00:00

abstract：:Gastroenteropancreatic neuroendocrine tumors (GEP NETs) comprise a heterogenous and diverse group of neoplasms arising from a common neuroendocrine cell origin. The majority of these tumors occur sporadically while ~20% manifest within the context of hereditary syndromes. Germline MEN1 mutations cause a syndrome with ...

journal_title：Journal of molecular endocrinology

authors： Lee ME,Tepede AA,Mandl A,Weinstein LS,Del Rivero J,Agarwal SK,Blau JE

更新日期：2020-08-01 00:00:00

abstract：:The human progesterone receptor (PR) is a ligand-dependent transcription factor and two isoforms, (PRA and PRB), can be distinguished. PROGINS, a PR polymorphic variant, affects PRA and PRB and acts as a risk-modulating factor in several gynaecological disorders. Little is known about the functional consequences of th...

journal_title：Journal of molecular endocrinology

authors： Romano A,Delvoux B,Fischer DC,Groothuis P

更新日期：2007-02-01 00:00:00

abstract：:Androgens promote anabolism in the musculoskeletal system while generally repressing adiposity, leading to lean body composition. Circulating androgens decline with age, contributing to frailty, osteoporosis, and obesity; however, the mechanisms by which androgens modulate body composition are largely unknown. Here, w...

journal_title：Journal of molecular endocrinology

authors： Gentile MA,Nantermet PV,Vogel RL,Phillips R,Holder D,Hodor P,Cheng C,Dai H,Freedman LP,Ray WJ

更新日期：2010-01-01 00:00:00

abstract：:About 70% of breast tumors express estrogen receptor alpha (ERα), which mediates the proliferative effects of estrogens on breast epithelial cells, and are candidates for treatment with antiestrogens, steroidal or non-steroidal molecules designed to compete with estrogens and antagonize ERs. The variable patterns of a...

journal_title：Journal of molecular endocrinology

authors： Traboulsi T,El Ezzy M,Gleason JL,Mader S

更新日期：2017-01-01 00:00:00

abstract：:Obesity is likely to be a multifactorial disease with an important genetic component. Animal models of genetic and experimentally induced obesity suggest that glucocorticoid receptor (GR) activity plays a role in the aetiology and maintenance of the obese state. Glucocorticoid activity appears to be essential for the ...

journal_title：Journal of molecular endocrinology

authors： Weaver JU,Hitman GA,Kopelman PG

更新日期：1992-12-01 00:00:00

abstract：:cDNAs encoding the glycoprotein hormone alpha- and gonadotropin (GTH) II beta-subunits of Japanese eel (Anguilla japonica) pituitary were cloned using the polymerase chain reaction. The nucleotide sequence of the glycoprotein hormone alpha-subunit cDNA was 364 base pairs (bp) long, encoding 117 amino acids, and that o...

journal_title：Journal of molecular endocrinology

authors： Nagae M,Todo T,Gen K,Kato Y,Young G,Adachi S,Yamauchi K

更新日期：1996-04-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone that belongs to a subfamily of endocrine FGFs with evolutionarily conserved functions in C. elegans and fruit flies. FAM20C phosphorylates FGF23 post-translationally, targeting to proteolysis through subtilisin-like proprotein convertase FURIN, resulting i...

journal_title：Journal of molecular endocrinology

authors： Ho BB,Bergwitz C

更新日期：2020-12-01 00:00:00

abstract：:Progesterone's ability to maintain pregnancy in eutherian mammals highlighted this steroid as the 'hormone of pregnancy'. It was the unique 'pro-gestational' bioactivity of progesterone that enabled eventual purification of this ovarian steroid to crystalline form by Willard Myron Allen in the early 1930s. While a fun...

journal_title：Journal of molecular endocrinology

authors： DeMayo FJ,Lydon JP

更新日期：2020-07-01 00:00:00