Arginine vasotocin binding to isolated branchial cells of the eel: effect of salinity.

abstract：:Barrett's oesophagus (BO) and oesophageal adenocarcinoma (OAC) are regarded as complications of gastro-oesophageal reflux disease, although all the factors that contribute to the development of these lesions are unknown. Acid suppressive drugs are widely used for symptomatic therapy of reflux disease but may induce hy...

journal_title：Journal of molecular endocrinology

authors： Beales IL,Ogunwobi OO

更新日期：2009-04-01 00:00:00

abstract：:The hypothalamic arcuate nucleus (ARC) represents a major component of the neuroendocrine reproductive axis and plays an important role in controlling the onset of puberty as well as age-associated reproductive senescence. Although significant gene expression changes have been observed in the ARC during sexual maturat...

journal_title：Journal of molecular endocrinology

authors： Eghlidi DH,Garyfallou VT,Kohama SG,Urbanski HF

更新日期：2017-08-01 00:00:00

abstract：:Chemotactic cytokines (chemokines) are small secreted proteins that control leukocyte trafficking in immune organs. Chemokines which are induced in the brain during conditions of inflammation play a role in the local immune response. Recently, it has been established in the rodent brain that distinct chemokines and ch...

journal_title：Journal of molecular endocrinology

authors： Stumm R,Höllt V

更新日期：2007-03-01 00:00:00

abstract：:Leptin (Lep) is an anorexigenic hormone and regulates appetite-related neuropeptides in mammals. A number of neuropeptides have also been linked to appetite regulation in teleost fish, but Lep signaling activation and effects on appetite-regulating neurons are poorly elucidated in early vertebrates. This study uses ce...

journal_title：Journal of molecular endocrinology

authors： Gong N,Jönsson E,Björnsson BT

更新日期：2016-04-01 00:00:00

abstract：:Synthesis of the uterine receptor for the hypothalamic hormone oxytocin has been induced in oocytes from Xenopus laevis previously primed with bovine endometrium mRNA. The injected oocytes responded to oxytocin by showing dose-dependent oscillations in membrane currents as recorded by the voltage-clamp method. The res...

journal_title：Journal of molecular endocrinology

authors： Morley SD,Meyerhof W,Schwarz J,Richter D

更新日期：1988-07-01 00:00:00

abstract：:Insulin-like 3 (INSL3), a Leydig cell-specific hormone, is essential for testis descent during foetal life and bone metabolism in adults. Despite its essential roles in male reproductive and bone health, very little is known regarding its transcriptional regulation in Leydig cells. To date, few transcription factors h...

journal_title：Journal of molecular endocrinology

authors： Tremblay MA,Mendoza-Villarroel RE,Robert NM,Bergeron F,Tremblay JJ

更新日期：2016-04-01 00:00:00

abstract：:The effect of steroid hormone treatment on coho salmon (Oncorhynchus kisutch) was examined. The cDNAs for coho salmon FSH beta and LH beta subunits were cloned and sequenced using reverse transcriptase PCR. Northern blot analysis revealed that a single transcript of 1 kb for each of these subunits was present in the p...

journal_title：Journal of molecular endocrinology

authors： Dickey JT,Swanson P

更新日期：1998-12-01 00:00:00

abstract：:Metallothioneins (MTs) are cytoprotective proteins acting as scavengers of toxic metal ions or reactive oxygen species. MTs are upregulated in follicular thyroid carcinoma and are regarded as a marker of thyroid stress in Graves' disease. However, the mechanism of MT regulation in thyrocytes is still elusive. In other...

journal_title：Journal of molecular endocrinology

authors： Bäck CM,Stohr S,Schäfer EA,Biebermann H,Boekhoff I,Breit A,Gudermann T,Büch TR

更新日期：2013-06-04 00:00:00

abstract：:An abundant, seven trans-membrane domain receptor related to the calcitonin receptor has been studied by a number of groups without identification of its ligand. A recent report claimed that the receptor was a type 1 CGRP receptor (Aiyar et al J. Biol. Chem. 271 11325-11329 (1996)). We have studied the equivalent rat ...

journal_title：Journal of molecular endocrinology

authors： Han ZQ,Coppock HA,Smith DM,Van Noorden S,Makgoba MW,Nicholl CG,Legon S

更新日期：1997-06-01 00:00:00

abstract：:The endogenous thyroid hormone (TH) metabolite 3,5-diiodo-l-thyronine (3,5-T2) acts as a metabolically active substance affecting whole-body energy metabolism and hepatic lipid handling in a desirable manner. Considering possible adverse effects regarding thyromimetic action of 3,5-T2 treatment in rodents, the current...

journal_title：Journal of molecular endocrinology

authors： Lietzow J,Golchert J,Homuth G,Völker U,Jonas W,Köhrle J

更新日期：2016-05-01 00:00:00

abstract：:Prolactin (PRL)-releasing peptide (PrRP) is a strong candidate stimulator of pituitary PRL transcription and secretion in teleosts. However, the role in control of extrapituitary PRL expression is unclear even in mammals. To study the possible presence of PrRP-PRL axes not only in the brain-pituitary but also in perip...

journal_title：Journal of molecular endocrinology

authors： Sakamoto T,Amano M,Hyodo S,Moriyama S,Takahashi A,Kawauchi H,Ando M

更新日期：2005-06-01 00:00:00

abstract：:The effects of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3; 10 nmol/l) on the human monomyelocytic cell line U937 were investigated. Addition of 1,25-(OH)2D3 led to a decrease in cell proliferation which fell at 72 h to 67.8 +/- 4.3% (mean +/- S.E.M.) of control values. The presence of CD14, a surface marker found on matur...

journal_title：Journal of molecular endocrinology

authors： Karmali R,Bhalla AK,Farrow SM,Williams MM,Lal S,Lydyard PM,O'Riordan JL

更新日期：1989-07-01 00:00:00

abstract：:Fatty acids are essential nutrients that contribute to several intracellular functions. Fatty acid synthesis and oxidation are known to be regulated by sterol regulatory element-binding proteins (SREBPs), which play a pivotal role in the regulation of cellular triglyceride synthesis and cholesterol biogenesis. Recent ...

journal_title：Journal of molecular endocrinology

authors： Park HY,Kang HS,Im SS

更新日期：2018-10-01 00:00:00

abstract：:The genetic predisposition of the host and the virus is the most important determinant for prediction of the course of human immunodeficiency virus type I (HIV-1) viral infection and acquired immune deficiency syndrome (AIDS) progression. Transcription from the HIV-1 long terminal repeat (LTR) is a crucial step for vi...

journal_title：Journal of molecular endocrinology

authors： Nevado J,Tenbaum SP,Castillo AI,Sánchez-Pacheco A,Aranda A

更新日期：2007-06-01 00:00:00

abstract：:Parathyroid hormone (PTH) is secreted by the chief cells of the parathyroid gland in response to changes in ionized calcium (Ca(2+)) concentrations. In this study, we measured PTH secretion, and PTH mRNA and calcium-sensing receptor (CaR) mRNA expression by equine parathyroid chief cells in vitro. We also evaluated th...

journal_title：Journal of molecular endocrinology

authors： Toribio RE,Kohn CW,Capen CC,Rosol TJ

更新日期：2003-12-01 00:00:00

abstract：:Differences in binding and structural properties of ovine testicular FSH and LH receptors were investigated. The ovine FSH receptor did not discriminate between FSH of different species, although equine FSH was more reactive. In the same tissue, however, the LH receptor showed marked preference for ovine and bovine LH...

journal_title：Journal of molecular endocrinology

authors： Yarney TA,Sairam MR

更新日期：1991-06-01 00:00:00

abstract：:Thyroid hormones are important regulators of bone development and metabolism. We have demonstrated that tri-iodothyronine (T3) increased and 1,25-dihydroxyvitamin D3 (1,25D3) attenuated the T3-stimulated expression of osteocalcin (OCN) in the osteoblast-like cell line MC3T3-E1. By means of transfection of promoter-rep...

journal_title：Journal of molecular endocrinology

authors： Varga F,Spitzer S,Rumpler M,Klaushofer K

更新日期：2003-02-01 00:00:00

abstract：:The GnRH receptor (GnRHR) is expressed in several non-pituitary tissues, notably in gonads. However, mechanisms underlying the gonad-specific expression of Gnrhr are not well understood. Here, Gnrhr expression was analysed in the developing testes and pituitaries of rats and transgenic mice bearing the human placental...

journal_title：Journal of molecular endocrinology

authors： Ishaq M,Schang AL,Magre S,Laverrière JN,Guillou A,Coudouel N,Wargnier R,Cohen-Tannoudji J,Counis R

更新日期：2013-04-23 00:00:00

abstract：:The hormone human chorionic gonadotrophin (hCG) shows extensive sequence homology with LH. Thus, many of the antigenic epitopes on hCG are shared with LH, leading to immunological cross-reaction between these two hormones. Anti-fertility and anti-cancer vaccines based upon hCG should ideally target only the hCG-specif...

journal_title：Journal of molecular endocrinology

authors： Charrel-Dennis M,Jackson AM,Lund T,Lapthorn AJ,Berger P,Roitt IM,Delves PJ

更新日期：2004-04-01 00:00:00

abstract：:This study aimed to determine whether and how the glucagon-like peptide 1 receptor (GLP-1R) agonist liraglutide affects the chemoresistance and chemosensitivity of pancreatic cancer cells to gemcitabine in vitro and in vivo. The GLP-1R and protein kinase A (PKA) levels were compared between the human pancreatic cancer...

journal_title：Journal of molecular endocrinology

authors： Zhao HJ,Jiang X,Hu LJ,Yang L,Deng LD,Wang YP,Ren ZP

更新日期：2020-02-01 00:00:00

abstract：:Glucocorticoid and androgen receptors have been shown to function through the same palindromic glucocorticoid response element (GRE) and yet have differential effects on gene transcription. In this study, we examined the functional and structural relationship of the androgen and glucocorticoid receptors with the andro...

journal_title：Journal of molecular endocrinology

authors： Kasper S,Rennie PS,Bruchovsky N,Lin L,Cheng H,Snoek R,Dahlman-Wright K,Gustafsson JA,Shiu RP,Sheppard PC,Matusik RJ

更新日期：1999-06-01 00:00:00

abstract：:1,25-(OH)2-Vitamin D3 (1,25-D3) and the thyroid hormone tri-iodothyronine (T3) were previously shown to behave as adipogenic agents in murine Ob17 preadipocytes. Moreover, these agents interfere with each other's action during adipocyte differentiation. T3 receptor (TR) expression and a downmodulation of T3 binding si...

journal_title：Journal of molecular endocrinology

authors： Schneider L,El-Yazidi C,Dace A,Maraninchi M,Planells R,Margotat A,Torresani J

更新日期：2005-02-01 00:00:00

abstract：:In previous studies we demonstrated that IGF-I induces proliferation of pituitary lactotrophs. In addition to its mitotrophic actions, IGF-I is known to prevent apoptosis induced by diverse stimuli in several cell types. In this study, we investigated the action of IGF-I on pituitary cell survival and the intracellula...

journal_title：Journal of molecular endocrinology

authors： Fernández M,Sánchez-Franco F,Palacios N,Sánchez I,Fernández C,Cacicedo L

更新日期：2004-08-01 00:00:00

abstract：:Activation of the hypothalamo-pituitary-adrenal (HPA) axis during stress is associated with increased expression of genes that code for regulatory hormones such as corticotrophin-releasing factor (CRF) and ACTH. The identity of the transcription factors that mediate these changes in gene expression is not known. In th...

journal_title：Journal of molecular endocrinology

authors： Whitehead D,Carter DA

更新日期：1997-12-01 00:00:00

abstract：:Follicle-stimulating hormone (FSH) plays fundamental roles in male and female fertility. FSH is a heterodimeric glycoprotein expressed by gonadotrophs in the anterior pituitary. The hormone-specific FSHβ-subunit is non-covalently associated with the common α-subunit that is also present in the luteinizing hormone (LH)...

journal_title：Journal of molecular endocrinology

authors： Das N,Kumar TR

更新日期：2018-04-01 00:00:00

abstract：:The contribution of hypothalamic appetite-regulating peptides to further hyperphagia accompanying the course of lactation in rats was investigated by using PCR array and real-time PCR. Furthermore, changes in the mRNA expression for appetite-regulating peptides in the hypothalamic arcuate nucleus (ARC) were analyzed a...

journal_title：Journal of molecular endocrinology

authors： Suzuki Y,Nakahara K,Maruyama K,Okame R,Ensho T,Inoue Y,Murakami N

更新日期：2014-01-30 00:00:00

abstract：:It has been suggested that the thyroid itself may contribute to the inflammatory process observed in autoimmune thyroiditis by releasing the cytokines interleukin-1 alpha (IL-1 alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8), but studies of cytokine gene expression in thyrocytes have been limited and conflicting...

journal_title：Journal of molecular endocrinology

authors： Watson PF,Pickerill AP,Davies R,Weetman AP

更新日期：1995-08-01 00:00:00

abstract：:The mechanism behind Ca(2)(+) entry into the parathyroid cells has been widely debated, and the molecular identities of the responsible ion channels have not been established yet. In this study, we show that the parathyroid cells lack voltage-operated Ca(2)(+) channels. Passive store depletion by thapsigargin, on the ...

journal_title：Journal of molecular endocrinology

authors： Lu M,Bränström R,Berglund E,Höög A,Björklund P,Westin G,Larsson C,Farnebo LO,Forsberg L

更新日期：2010-05-01 00:00:00

abstract：:In the common brushtail possum (Trichosurus vulpecula) lactation lasts for 200 days and consists of two distinct phases. Milk composition changes dramatically between phase 2 and 3, which correspond to early and late lactation respectively (phase 1 corresponds to pregnancy). RNA expression patterns have been establish...

journal_title：Journal of molecular endocrinology

authors： Demmer J,Ross IK,Ginger MR,Piotte CK,Grigor MR

更新日期：1998-02-01 00:00:00

abstract：:Hypothalamic GHRH controls the release of GH from the pituitary gland and also acts as a growth factor in a variety of cancers. The mitogenetic activity of GHRH is exerted through the binding to the pituitary type receptor (pGHRH-R) and its splice variants, mainly SV1. The intracellular signaling pathways that are act...

journal_title：Journal of molecular endocrinology

authors： Barabutis N,Siejka A,Schally AV,Block NL,Cai R,Varga JL

更新日期：2010-02-01 00:00:00