Characterization of reticuloendotheliosis virus-transformed avian T-lymphoblastoid cell lines infected with Marek's disease virus.

abstract：:HeLa cell nuclei, isolated 17 h after infection with human adenovirus type 2 (Ad2), were treated with 200 mM ammonium sulfate. The extract (S200 fraction) contained 50 to 70% of the nonintegrated Ad2 DNA, which was in the form of nucleoprotein complexes. These complexes contained native, intact Ad2 DNA (with the excep...

journal_title：Journal of virology

authors： Wilhelm J,Brison O,Kedinger C,Chambon P

更新日期：1976-07-01 00:00:00

abstract：:Recently, significant numbers of individuals with primary human immunodeficiency virus (HIV) infection have been found to harbor viral strains with reduced susceptibility to antiretroviral drugs. In one study, HIV from 16% of such antiretroviral-naive individuals was shown to have a susceptibility to nonnucleoside rev...

journal_title：Journal of virology

authors： Brown AJ,Precious HM,Whitcomb JM,Wong JK,Quigg M,Huang W,Daar ES,D'Aquila RT,Keiser PH,Connick E,Hellmann NS,Petropoulos CJ,Richman DD,Little SJ

更新日期：2000-11-01 00:00:00

abstract：:A contiguously linked T-B synthetic viral epitope (110HA120-150HA159,T-B) was investigated for its potency in inducing humoral and cellular immune responses in vivo. The T-cell epitope 110HA120 corresponds to the site 1 hemagglutinin (HA) of the A/PR/8/34 (PR8) influenza virus and is recognized by CD4 T cells in assoc...

journal_title：Journal of virology

authors： Brumeanu TD,Casares S,Bot A,Bot S,Bona CA

更新日期：1997-07-01 00:00:00

abstract：:Proteasome inhibitors (e.g., bortezomib, MG132) are known to enhance adeno-associated virus (AAV) transduction; however, whether this results from pleotropic proteasome inhibition or off-target serine and/or cysteine protease inhibition remains unresolved. Here, we examined recombinant AAV (rAAV) effects of a new prot...

journal_title：Journal of virology

authors： Mitchell AM,Samulski RJ

更新日期：2013-12-01 00:00:00

abstract：:Bovine leukemia virus (BLV) and human T-cell lymphotropic virus type 1 (HTLV-1) belong to the genus of deltaretroviruses. Their entry into the host cell is supposed to be mediated by interactions of the extracellular (SU) envelope glycoproteins with cellular receptors. To gain insight into the mechanisms governing thi...

journal_title：Journal of virology

authors： Gatot JS,Callebaut I,Van Lint C,Demonté D,Kerkhofs P,Portetelle D,Burny A,Willems L,Kettmann R

更新日期：2002-08-01 00:00:00

abstract：:Human papillomavirus (HPV) is a strongly conserved DNA virus, high-risk types of which can cause cervical cancer in persistent infections. The most common type found in HPV-attributable cancer is HPV16, which can be subdivided into four lineages (A to D) with different carcinogenic properties. Studies have shown HPV16...

journal_title：Journal of virology

authors： van der Weele P,Meijer CJLM,King AJ

更新日期：2017-09-12 00:00:00

abstract：:Several transgenic mouse models have been developed which facilitate the transmission of chronic wasting disease (CWD) of cervids and allow prion strain discrimination. The present study was designed to assess the susceptibility of the prototypic mouse line, Tg(CerPrP)1536(+/-), to bovine spongiform encephalopathy (BS...

journal_title：Journal of virology

authors： Vickery CM,Lockey R,Holder TM,Thorne L,Beck KE,Wilson C,Denyer M,Sheehan J,Marsh S,Webb PR,Dexter I,Norman A,Popescu E,Schneider A,Holden P,Griffiths PC,Plater JM,Dagleish MP,Martin S,Telling GC,Simmons MM,Spiro

更新日期：2014-02-01 00:00:00

abstract：:Transfection has been found and characterized in pneumococcus. For replicating omega3 phage DNA extracted from infected cells, transfection was relatively efficient and rose linearly with DNA concentration and quadratically with time, according to T(T - 3.5) min(2). For mature DNA extracted from phage particles, trans...

journal_title：Journal of virology

authors： Porter RD,Guild WR

更新日期：1978-01-01 00:00:00

abstract：:The 2009 H1N1 influenza pandemic provided an opportunity to study human virus-specific T cell responses after infection with a novel influenza virus against which limited humoral immunity existed in the population. Here we describe the magnitude, kinetics, and nature of the virus-specific T cell response using intrace...

journal_title：Journal of virology

authors： Hillaire ML,van Trierum SE,Bodewes R,van Baalen CA,van Binnendijk RS,Koopmans MP,Fouchier RA,Osterhaus AD,Rimmelzwaan GF

更新日期：2011-11-01 00:00:00

abstract：:Ebola viruses (EboV) are enveloped RNA viruses infecting cells by a pH-dependent process mediated by viral glycoproteins (GP) involving endocytosis of virions and their routing into acidic endosomes. As with well-characterized pH-dependent viral entry proteins, in particular influenza virus hemagglutinin, it is though...

journal_title：Journal of virology

authors： Bär S,Takada A,Kawaoka Y,Alizon M

更新日期：2006-03-01 00:00:00

abstract：:Due to various advantageous features there is current interest in retroviral vectors derived from primate foamy viruses (PFVs). Two PFV cis-acting sequences have been mapped in the 5' region of the RNA (pre-)genome and in the 3' pol genomic region. In order to genetically separate PFV packaging constructs from vector ...

journal_title：Journal of virology

authors： Heinkelein M,Thurow J,Dressler M,Imrich H,Neumann-Haefelin D,McClure MO,Rethwilm A

更新日期：2000-04-01 00:00:00

abstract：:A systematic analysis of immune responses on a population level is critical for a human immunodeficiency virus type 1 (HIV-1) vaccine design. Our studies in Botswana on (i) molecular analysis of the HIV-1 subtype C (HIV-1C) epidemic, (ii) frequencies of major histocompatibility complex class I HLA types, and (iii) cyt...

journal_title：Journal of virology

authors： Novitsky V,Cao H,Rybak N,Gilbert P,McLane MF,Gaolekwe S,Peter T,Thior I,Ndung'u T,Marlink R,Lee TH,Essex M

更新日期：2002-10-01 00:00:00

abstract：:Human oncolytic adenoviruses have been used in clinical trials targeting cancers of epithelial origin. To gain a better understanding of the infectious cycle of adenovirus in normal human squamous tissues, we examined the viral infection process in organotypic cultures of primary human keratinocytes. We show that for ...

journal_title：Journal of virology

authors： Noya F,Balagué C,Banerjee NS,Curiel DT,Broker TR,Chow LT

更新日期：2003-06-01 00:00:00

abstract：:Gammaherpesviruses are important human and animal pathogens. Infection control has proven difficult because the key process of transmission is ill understood. Murid herpesvirus 4 (MuHV-4), a gammaherpesvirus of mice, is transmitted sexually. We show that this depends on the major virion envelope glycoprotein gp150. gp...

journal_title：Journal of virology

authors： Zeippen C,Javaux J,Xiao X,Ledecq M,Mast J,Farnir F,Vanderplasschen A,Stevenson P,Gillet L

更新日期：2017-06-09 00:00:00

abstract：:Rotavirus plus-strand RNAs not only direct protein synthesis but also serve as templates for the synthesis of the segmented double-stranded RNA (dsRNA) genome. In this study, we identified short-interfering RNAs (siRNAs) for viral genes 5, 8, and 9 that suppressed the expression of NSP1, a nonessential protein; NSP2, ...

journal_title：Journal of virology

authors： Silvestri LS,Taraporewala ZF,Patton JT

更新日期：2004-07-01 00:00:00

abstract：:The immune response to viral glycoproteins is often directed against conformation- and/or glycosylation-dependent structures; synthetic peptides and bacterially expressed proteins are inadequate probes for the mapping of such epitopes. This report describes a retroviral vector system that presents such native epitopes...

journal_title：Journal of virology

authors： Kayman SC,Wu Z,Revesz K,Chen H,Kopelman R,Pinter A

更新日期：1994-01-01 00:00:00

abstract：:Transduction of the liver with single-stranded adeno-associated virus serotype 2 (AAV2) vectors is inefficient; less than 10% of hepatocytes are permissive for stable transduction, and transgene expression is characterized by a lag phase of up to 6 weeks. AAV2-based vector genomes packaged inside AAV6 or AAV8 capsids ...

journal_title：Journal of virology

authors： Thomas CE,Storm TA,Huang Z,Kay MA

更新日期：2004-03-01 00:00:00

abstract：:Our previous studies have argued persuasively that in murine sarcoma virus ts110 (MuSVts110) the gag and mos genes are fused out of frame due to a approximately 1.5-kilobase (kb) deletion of wild-type murine sarcoma virus 349 (MuSV-349) viral information. As a consequence of this deletion, infected cells grown at 39 d...

journal_title：Journal of virology

authors： Nash MA,Brizzard BL,Wong JL,Murphy EC Jr

更新日期：1985-02-01 00:00:00

abstract：:Autophagy is now known to be an essential component of host innate and adaptive immunity. Several herpesviruses have developed various strategies to evade this antiviral host defense. Herpes simplex virus 1 (HSV-1) blocks autophagy in fibroblasts and in neurons, and the ICP34.5 protein is important for the resistance ...

journal_title：Journal of virology

authors： Lussignol M,Queval C,Bernet-Camard MF,Cotte-Laffitte J,Beau I,Codogno P,Esclatine A

更新日期：2013-01-01 00:00:00

abstract：:Human erythroid progenitor cells are the main target cells of the human parvovirus B19 (B19), and B19 infection induces a transient erythroid aplastic crisis. Several authors have reported that the nonstructural protein 1 (NS-1) encoded by this virus has a cytotoxic effect, but the underlying mechanism of NS-1-induced...

journal_title：Journal of virology

authors： Sol N,Le Junter J,Vassias I,Freyssinier JM,Thomas A,Prigent AF,Rudkin BB,Fichelson S,Morinet F

更新日期：1999-10-01 00:00:00

abstract：:The varicella-zoster virus (VZV) open reading frame 54 (ORF54) gene encodes an 87-kDa monomer that oligomerizes to form the VZV portal protein, pORF54. pORF54 was hypothesized to perform a function similar to that of a previously described herpes simplex virus 1 (HSV-1) homolog, pUL6. pUL6 and the associated viral ter...

journal_title：Journal of virology

authors： Visalli MA,House BL,Selariu A,Zhu H,Visalli RJ

更新日期：2014-07-01 00:00:00

abstract：:Recombination studies have established that retroviral long terminal repeats (LTRs) are important genetic determinants of the viral capacity to induce hematopoietic tumors and to specify the type of cell making up the tumor. Plasmids containing LTRs of several murine leukemia viruses linked to the chloramphenicol acet...

journal_title：Journal of virology

authors： Short MK,Okenquist SA,Lenz J

更新日期：1987-04-01 00:00:00

abstract：:Like almost all of the positive-strand RNA viruses, hepatitis C virus (HCV) induces host intracellular membrane modification to form the membrane-bound viral replication complex (RC), within which viral replicases amplify the viral RNA genome. Despite accumulated information about how HCV co-opts host factors for vira...

journal_title：Journal of virology

authors： Yi Z,Fang C,Zou J,Xu J,Song W,Du X,Pan T,Lu H,Yuan Z

更新日期：2016-10-14 00:00:00

abstract：:Vpu is a 16-kDa membrane-associated phosphoprotein that is expressed from the same, singly spliced message as the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein precursor, gp160. Previous studies suggest that Vpu functions in the late stages of viral replication, possibly in virus egression from the...

journal_title：Journal of virology

authors： Geraghty RJ,Panganiban AT

更新日期：1993-07-01 00:00:00

abstract：:The sensitivity of highly purified human fibroblast interferon and partially purified human leukocyte interferon to several proteolytic and glycolytic enzymes was determined with respect to antiviral activity, isoelectric point, molecular weight, and thermal stability. Leucine aminopeptidase altered the distribution o...

journal_title：Journal of virology

authors： Otto MJ,Sedmak JJ,Grossberg SE

更新日期：1980-08-01 00:00:00

abstract：:H.-H. Lu and E. Wimmer (Proc. Natl. Acad. Sci. USA 93:1412-1417, 1996) have demonstrated that the internal ribosomal entry site (IRES) of poliovirus (PV) can be functionally replaced by the related genetic element from hepatitis C virus (HCV). One important finding of this study was that open reading frame sequences 3...

journal_title：Journal of virology

authors： Zhao WD,Wimmer E,Lahser FC

更新日期：1999-02-01 00:00:00

abstract：:The nondefective adenovirus 2 (Ad2)-simian virus 40 (SV40) hybrid virus, Ad2(+)ND(1), differs from the defective Ad-SV40 hybrid populations previously described, in that this hybrid virus can replicate without the aid of nonhybrid adenovirus helper. Consequently, the deoxyribonucleic acid (DNA) from this virus, which ...

journal_title：Journal of virology

authors： Crumpacker CS,Henry PH,Kakefuda T,Rowe WP,Levin MJ,Lewis AM Jr

更新日期：1971-03-01 00:00:00

abstract：:The replication of positive-strand RNA viral genomes involves various cis-acting RNA sequences. Generally, regulatory RNA sequences are present at or near genomic termini; however, internal replication elements (IREs) also exist. Here we report the structural and functional characterization of an IRE present in the re...

journal_title：Journal of virology

authors： Monkewich S,Lin HX,Fabian MR,Xu W,Na H,Ray D,Chernysheva OA,Nagy PD,White KA

更新日期：2005-04-01 00:00:00

abstract：:Many of the approximately 165 proteins encoded by the African swine fever virus (ASFV) genome do not have significant similarity to known proteins and have not been studied experimentally. One such protein is DP148R. We showed that the DP148R gene is transcribed at early times postinfection. Deletion of this gene did ...

journal_title：Journal of virology

authors： Reis AL,Goatley LC,Jabbar T,Sanchez-Cordon PJ,Netherton CL,Chapman DAG,Dixon LK

更新日期：2017-11-30 00:00:00

abstract：:Adenovirus E1B 55K protein cooperates with E1A gene products to induce cell transformation. E1B 55K mediates its effects by binding to and inhibiting the transcriptional activation and growth-suppression functions of the tumor suppressor p53. Previous studies in vivo have suggested that E1B 55K has an active role in r...

journal_title：Journal of virology

authors： Martin ME,Berk AJ

更新日期：1998-04-01 00:00:00