Abstract：
:BE is a disorder that occurs in children likely as a consequence of prolonged GE reflux of gastroduodenal contents. It usually presents with complications of GE reflux, but it also may be relatively silent in childhood and then present with adenocarcinoma in childhood or present in adulthood. Although seldom recognized in children until relatively recently, it is being diagnosed with greater frequency but not always accurately. The diagnosis of BE can be made with certainty only if landmarks are carefully documented, and a detailed histologic map is made from multiple, large biopsies taken under direct vision at endoscopy; the diagnosis should be reserved for those patients where Barrett's specialized epithelium i.e., goblet cell metaplasia, is present. BE is a diagnosis that should be made with thorough documentation because of the implications for regression, cancer, and the need for follow-up and endoscopic biopsy surveillance. For treatment of complications and because there may be a chance for regression of a young (i.e., childhood) lesion, antireflux surgery or indefinite aggressive acid suppressing medical therapy is required. Because bile reflux may have a pathogenic role in BE, and because of the proven benefits of surgery in producing partial regression and prevention of dysphagia and cancer in some patients, the author's preference at present is for surgery. For children who are poor candidates for surgery, long-term omeprazole should be used (159). Adenocarcinoma does occur in childhood as a complication of BE. Because it can be recognized early, regular surveillance of children with bona fide BE is advisable.
journal_name
J Pediatr Gastroenterol Nutrjournal_title
Journal of pediatric gastroenterology and nutritionauthors
Hassall Esubject
Has Abstractpub_date
1993-05-01 00:00:00pages
345-64issue
4eissn
0277-2116issn
1536-4801journal_volume
16pub_type
杂志文章,评审abstract：:We measured plasma concentration of endothelin-1 in three children with Byler's disease, five with biliary atresia after portoenterostomy, and nine controls. No patients had ascites or hepatorenal syndrome. Plasma endothelin-1 levels were significantly higher in patients with Byler's disease than in the controls (5.19...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/00005176-199508000-00015
更新日期：1995-08-01 00:00:00
abstract：BACKGROUND:Primary sclerosing cholangitis is a rare chronic cholestatic condition of unknown etiology, frequently associated with inflammatory bowel disease and characterized by diffuse fibrosing and inflammatory destruction of the intra- and/or extrahepatic biliary duct system. PATIENTS AND METHODS:The study involved...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0b013e31816fee95
更新日期：2008-07-01 00:00:00
abstract：OBJECTIVES:A large retrospective multicentre study was conducted in Spain to evaluate the efficiency of the new European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) criteria for the diagnosis of coeliac disease (CD). METHODS:The study protocol was approved by the ethics committee of Hos...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章,多中心研究
doi：10.1097/MPG.0000000000000870
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:In 2011, the United States Surgeon General issued a call to action to "identify and address obstacles to greater availability of safe banked donor milk for fragile infants." The purpose of the present study is to analyze patterns in donor human milk (DHM) and fortifier use in level 2, 3, and 4 neonatal facili...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0000000000001790
更新日期：2018-04-01 00:00:00
abstract：OBJECTIVES:Dual sofosbuvir/daclatasvir (SOF/DCV) therapy is currently recommended by the European Association for Study of Liver (EASL) as an option for the treatment of chronic hepatitis C virus (HCV) infection in adults for all genotypes; however, it is still not considered for patients younger than 18 years old. We ...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章,多中心研究
doi：10.1097/MPG.0000000000001968
更新日期：2018-07-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the accuracy of reduced-dose ¹³C-urea breath test (¹³C-UBT) and early sampling of exhaled breath for the detection of Helicobacter pylori infection in children and adolescents. METHODS:Patients up to 20 years old that underwent upper gastrointestinal endoscopy with gastr...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章,多中心研究
doi：10.1097/MPG.0b013e3182a02608
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVES:The role of infliximab in treating pediatric ulcerative colitis (UC) is not defined. The authors previously have described their experience with the open label use of infliximab in nine children with moderate to severe UC. The aim of this study was to describe the outcome of these patients after a minimum 2-...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/00005176-200403000-00013
更新日期：2004-03-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to document the process of achieving full enteral feeding in infants with omphalocele and to identify factors that affect feeding success. METHODS:After institutional review board approval (study no. 5100169), 123 infants with omphalocele, born between 1993 and 2011 were reviewed. ...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0000000000001463
更新日期：2019-06-01 00:00:00
abstract：:Preterm infant formulas (PIFs) for very-low-birth-weight (VLBW) infants (birth weight, < 1,500 g) are augmented to provide daily riboflavin and pyridoxine at levels up to five-fold greater than in term infant formula and 18-fold greater than in human milk. We evaluated plasma riboflavin and pyridoxine concentrations i...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 临床试验,杂志文章
doi：10.1097/00005176-199608000-00008
更新日期：1996-08-01 00:00:00
abstract：OBJECTIVES:The aim of the present study was to determine the incidence of peptic ulcer bleeding (PUB) in pediatric patients. METHODS:A hospital inpatient database, Premier Perspective, and an insurance claims database, MarketScan, were analyzed to estimate upper and lower limits for the annual incidence of PUB in the ...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0b013e31824fb7f9
更新日期：2012-06-01 00:00:00
abstract：AIM AND OBJECTIVE:: Chronic models of inflammatory bowel disease are lacking in preadult rodents. The primary goal of our study was to develop a chronic model of hapten-induced intestinal inflammation and fibrosis in young rats. Second, we aimed to determine the profiles of key Th-1, Th-2, and Th-17 proinflammatory and...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0b013e3181cb8f4a
更新日期：2010-03-01 00:00:00
abstract：AIM:Anti-neutrophil cytoplasmic antibodies (ANCAs) detected by indirect immunofluorescence have been found in patients with inflammatory bowel disease (IBD). Nevertheless, specific antibodies against proteinase-3 (PR3) are rare in this context. METHODS:Sera from 30 consecutive pediatric patients with IBD were evaluate...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0b013e31829d4e9e
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVES:Defects of PRSS1, SPINK1, CFTR and AAT are considered causative or predisposing to pancreatitis. The aim of this study was to evaluate the impact of these defects into molecular pathology of chronic pancreatitis (CP) and acute recurrent pancreatitis (ARP). METHODS:Ninety-two children with CP or ARP, 55 fami...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/01.mpg.0000232570.48773.df
更新日期：2006-09-01 00:00:00
abstract：:Lactose malabsorption is not a cause of diarrhea during phototherapy. Jaundiced neonates under phototherapy develop diarrhea or loose stools during the treatment. These phenomena were attributed to an induced lactase deficiency caused by bilirubin breakdown products. We investigated lactose malabsorption in 59 neonate...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/00005176-198504000-00007
更新日期：1985-04-01 00:00:00
abstract：OBJECTIVES:Beneficial therapeutic effect of probiotics has been reported in children with the irritable bowel syndrome (IBS) but not consistently in other functional abdominal pain-related disorders. The aim of the present study was to investigate the effect of Lactobacillus reuteri DSM 17938 in the treatment of functi...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1097/MPG.0000000000001478
更新日期：2017-06-01 00:00:00
abstract：:The clinical usefulness of serum gamma-glutamyl transpeptidase (gamma GT) assay for the diagnosis of liver disease in children was assessed retrospectively in 398 children investigated from 1981 to 1986, in whom diagnosis was ascertained according to currently accepted criteria including liver histology in each case. ...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/00005176-199101000-00005
更新日期：1991-01-01 00:00:00
abstract：:A pseudocyst of the pancreas in a 6-year-old girl persisted for 2 months despite bowel rest and nutritional support. Following percutaneous introduction of a catheter into the cyst under ultrasound guidance and external catheter drainage for 11 days, the pseudocyst resolved completely and permanently. Nonoperative per...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章,评审
doi：
更新日期：1991-04-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to summarize short-term effectiveness, safety, and cost of using infliximab biosimilar (IFX-B) drugs, (Inflectra [Hospira] and Remsima [NAAP]) compared to originator infliximab (IFX-O) (Remicade [MSD]) in biologic naive pediatric inflammatory bowel disease in the United Kingdom. MET...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0000000000002011
更新日期：2018-10-01 00:00:00
abstract：:Hepatitis B virus (HBV) infection is endemic among institutionalized retarded patients, who usually have mild, anicteric hepatitis following nonparenteral exposure. We evaluated the risk of HBV infection (as evidenced by serologic studies) among their contacts, including noninstitutional caretakers, during brief home ...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/00005176-198401000-00015
更新日期：1984-01-01 00:00:00
abstract：OBJECTIVES:: Given dietary gluten exposure, growing children with celiac disease may experience malabsorption of nutrients, negatively affecting bone health. The purpose of this study was to determine the prevalence of low bone mass in children with celiac disease, according to the presence of symptoms at diagnosis. M...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0b013e31819ca18e
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to assess the efficacy and safety of cyproheptadine (CY) use in infants and young children with poor growth treated at our multidisciplinary pediatric feeding program, and to describe changes in their weight and feeding behaviors. METHODS:A retrospective chart review of children tre...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0000000000000467
更新日期：2014-11-01 00:00:00
abstract：:This document provides recommendations developed by the ESPGHAN Working Group on Probiotics and Prebiotics on the role of probiotics in the prevention of nosocomial diarrhea in children based on a systematic review of previously completed systematic reviews and of subsequently published randomized controlled trials. T...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章,实务指引
doi：10.1097/MPG.0000000000001637
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVES:Inadequate response of the innate immune system to bacterial antigens present in the intestinal flora may play a role in the development of necrotizing enterocolitis (NEC). Pattern recognition receptors such as CD14, toll-like receptor (TLR) 4, and caspase-recruitment domain (CARD) 15 bind bacterial lipopoly...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/01.mpg.0000192246.47959.b2
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to characterize the enteral feeding practices in infants after gastrointestinal surgery. METHODS:We performed a retrospective analysis of infants who underwent intestinal surgery at age <6 months who survived to be fed enterally between January 2012 and June 2017. Demographics, surg...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0000000000002128
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVES:Infectious diarrhea, a leading cause of morbidity and deaths, is less prevalent in breastfed infants compared with infants fed infant formula. The dominant human milk oligosaccharide (HMO), α-1,2-fucosyllactose (2'-FL), has structural homology to bacterial adhesion sites in the intestine and may in part expl...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0000000000001276
更新日期：2017-02-01 00:00:00
abstract：:Four hundred ninety-eight acetylcholinesterase-stained suction rectal biopsies from 456 children were examined to assess the occurrence of "isolated" or "primary" intestinal neuronal dysplasia at Children's Hospital of Pittsburgh. Cases of proven Hirschsprung's disease were excluded. In 38 biopsies from 38 patients, w...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/00005176-199102000-00008
更新日期：1991-02-01 00:00:00
abstract：OBJECTIVE:The aim of the study was to quantify the differences in viscosity of over a range of commercial food-based formulas and home-prepared blenderized feeds used for enteral feeding in the clinical management of gastroesophageal reflux and gastroesophageal reflux-related aspiration in children with oropharyngeal d...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/MPG.0000000000002657
更新日期：2020-06-01 00:00:00
abstract：:Class II MHC antigen expression in the intestinal epithelium of 28 small bowel biopsies from 23 celiac patients were studied by means of indirect immunofluorescence and immunoperoxidase using monoclonal antibodies. Patients were divided on the basis of diet into two subgroups: 15 subjects on a gluten-containing diet (...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/00005176-198910000-00002
更新日期：1989-10-01 00:00:00
abstract：:Although bolus and continuous tube feedings are common, little is known about their effect on the developing small intestine. To compare their effect on small-intestinal growth and differentiation, six pairs of 3-day-old piglet littermates were randomized to receive similar volumes of sow milk replacer, either by bolu...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章
doi：10.1097/00005176-199404000-00017
更新日期：1994-04-01 00:00:00
abstract：:In a prospective, double-blind, placebo-controlled trial, the efficacy and safety of ursodeoxycholic acid (UDCA) was evaluated in preterm infants, in terms of its potential impact on fat absorption, advancement of enteral feeding, development of cholestasis, growth, nutritional status, and metabolic status. Although f...
journal_title：Journal of pediatric gastroenterology and nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1097/MPG.0b013e3181560524
更新日期：2008-02-01 00:00:00
