Ursodeoxycholic acid treatment in preterm infants: a pilot study for the prevention of cholestasis associated with total parenteral nutrition.

Abstract:

:In a prospective, double-blind, placebo-controlled trial, the efficacy and safety of ursodeoxycholic acid (UDCA) was evaluated in preterm infants, in terms of its potential impact on fat absorption, advancement of enteral feeding, development of cholestasis, growth, nutritional status, and metabolic status. Although fecal fat excretion slightly decreased and achievement of full enteral feeding was earlier in the UDCA group, these differences were not significant. Interestingly, whereas serum gamma-glutamyl transferase activity increased during the parenteral nutrition period in the placebo group, we observed a constant and significant decrease in the UDCA group. This observation warrants further investigation to determine the utility of prophylactic UDCA in preventing cholestasis in infants with prolonged parenteral nutrition.

authors

Arslanoglu S,Moro GE,Tauschel HD,Boehm G

doi

10.1097/MPG.0b013e3181560524

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

228-31

issue

2

eissn

0277-2116

issn

1536-4801

pii

00005176-200802000-00022

journal_volume

46

pub_type

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