Diagnosis and Management of Pediatric Autoimmune Liver Disease: ESPGHAN Hepatology Committee Position Statement.

Abstract:

:Paediatric autoimmune liver disease is characterized by inflammatory liver histology, circulating autoantibodies, and increased levels of IgG, in the absence of a known etiology. Three conditions have a likely autoimmune pathogenesis: autoimmune hepatitis (AIH), autoimmune sclerosing cholangitis, and de novo AIH after liver transplantation. Two types of pediatric AIH are recognized according to seropositivity for smooth muscle and/or antinuclear antibody (AIH-1) or liver kidney microsomal type 1 and/or anti-liver cytosol type 1 antibodies (AIH-2).Pertinent issues addressing the diagnosis, treatment, and long-term follow-up were formulated by a core group of ESPGHAN members. They have commissioned the first authors with execution of this project. Initially, they have performed a systematic literature search on MEDLINE, ResearchGate, and Mendeley databases during the last 30 years and produced a document focusing on prospective and retrospective studies in children. The ESPGHAN core group and ESPGHAN Hepatology Committee members voted on each recommendation, using a formal voting technique.

authors

Mieli-Vergani G,Vergani D,Baumann U,Czubkowski P,Debray D,Dezsofi A,Fischler B,Gupte G,Hierro L,Indolfi G,Jahnel J,Smets F,Verkade HJ,Hadžić N

doi

10.1097/MPG.0000000000001801

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

345-360

issue

2

eissn

0277-2116

issn

1536-4801

pii

00005176-201802000-00033

journal_volume

66

pub_type

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