Exocrine pancreatic function in children with progressive familial intrahepatic cholestasis type 2.

Abstract:

:In progressive familial intrahepatic cholestasis type 2 (PFIC-2), severe steatorrhea is often documented. However, pancreatic exocrine secretion has not yet been studied. In 14 children with PFIC-2, pancreatic function was assessed using standard fecal tests. Normal fecal lipase concentrations excluded isolated lipase deficiency. No differences in fecal elastase-1 concentrations and chymotrypsin activities were detected between PFIC-2 patients with or without steatorrhea, nor between these patients and healthy subjects. In conclusion, pancreatic exocrine function in patients with PFIC-2 is normal. Steatorrhea observed in those patients is not related to pancreatic insufficiency.

authors

Walkowiak J,Jankowska I,Pawlowska J,Strautnieks S,Bull L,Thompson R,Herzig KH,Socha J

doi

10.1097/01.mpg.0000218154.26792.6a

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

416-8

issue

4

eissn

0277-2116

issn

1536-4801

pii

00005176-200604000-00011

journal_volume

42

pub_type

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